Enzymes in the synthesis of bioactive compounds: The prodigious decades

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 8, 2004, Pages 1817-1834

  García Junceda, Eduardo ^a   García García, Juan Francisco ^a   Bastida, Agatha ^a   Fernández Mayoralas, Alfonso ^a  

^a INSTITUTO DE QUÍMICA ORGÁNICA GENERAL   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE; ENZYME; FRUCTOSE BISPHOSPHATE ALDOLASE; GLYCOSIDASE; GLYCOSYLTRANSFERASE; OLIGOSACCHARIDE;

AQUEOUS SOLUTION; ASYMMETRIC SYNTHESIS; BIOSYNTHESIS; CATALYSIS; CATALYST; CHEMICAL BOND; CHIRALITY; COMBINATORIAL CHEMISTRY; ENANTIOMER; ENZYME IMMOBILIZATION; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; REVIEW;

ANIMALS; CATALYSIS; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; ENZYME INDUCTION; ENZYMES, IMMOBILIZED; HUMANS; STEREOISOMERISM;

EID: 1642635126     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.01.032     Document Type: Review

References (199)

1. Klibanov A.M. Chemtech. 16:1986;354.
2. Mullis K.B., Faloona F.A. Methods Enzymol. 155:1987;335.
3. Douglas K.T. Curr. Opin. Biotechnol. 3:1992;370.
4. Harris J.L., Craik C.S. Curr. Opin. Chem. Biol. 2:1998;127.
5. Powell K.A., Ramer S.W., del Cardayré S.B., Stemmer W.P.C., Tobin M.B., Longchamp P.F., Huisman G.W.C. Angew. Chem., Int. Ed. 40:2001;3948.
6. Lerner R.A., Benkovic S.J., Schultz P.G. Science. 252:1991;659.
7. Hannig G., Makrides S.C. Trends Biotechnol. 16:1998;54.
8. Baneyx F. Curr. Opin. Biotechnol. 10:1999;411.
9. Jonasson P., Liljeqvist S., Nygren P.-Å., Ståhl S. Biotechnol. Appl. Biochem. 35:2002;91.
10. Tischer W., Kasche V. Trends Biotechnol. 17:1999;326.
11. Patel R.N. Adv. Appl. Microbiol. 43:1999;91.
12. Sugai T. Curr. Org. Chem. 3:1999;373.
13. Pesti J.A., Dicosimo R. Curr. Opin. Drug Discov. Dev. 3:2000;764.
14. Gotor V. Biocat. Biotrans. 18:2000;87.
15. Roberts S.M. J. Chem. Soc., Perkin Trans. 1. 2001;1475.
16. Zak A. Curr. Opin. Chem. Biol. 5:2001;130.
17. Koeller K.M., Wong C.-H. Nature. 409:2001;232.
18. Thomas S.M., DiCosimo R., Nagarajan V. Trends Biotechnol. 20:2002;238.
19. Enzyme Catalysis in Organic Synthesis: A Comprehensive Handbook. 2nd ed. ; Drauz, K., Waldmann, H. Eds., Wiley VCH. 2002.
20. Faber K. Biotransformation in Organic Chemistry. 5th ed. 2004;Springer-Verlag, Berlín.
21. Khmelnitsky Y.L., Levashov A.V., Klyachko N.L., Martinek K. Enzyme Microb. Technol. 10:1988;710.
22. Brink L.E.S., Tramper J., Luyben K.Ch.A.M., Van't Riet K. Enzyme Microb. Technol. 10:1988;736.
23. Dordick J.S. Enzyme Microb. Technol. 11:1989;194.
24. Carrea G., Riva S. Angew. Chem., Int. Ed. 39:2000;2226.
25. Klibanov A.M. Nature. 409:2001;241.
26. Klibanov A.M. Trends Biotechnol. 15:1997;97.
27. Zaks A., Klibanov A.M. J. Biol. Chem. 263:1988;3194.
28. Klibanov A.M. Nature. 374:1995;596.
29. Halling P.J. Curr. Opin. Chem. Biol. 4:2000;74.
30. Madeira-Lau R., van Rantwijk F., Seddon K.R., Sheldon R.A. Org. Lett. 2:2000;4189.
31. Lozano P., de Diego T., Guegan J.-P., Vaultier M., Iborra J.L. Biotechnol. Bioeng. 75:2001;563.
32. Schoefer S.H., Kaftzik N., Wasserscheid P., Kragl U. Chem. Commun. 2001;425.
33. Kim K.-W., Song B., Choi M.-Y., Kim M.-J. Org. Lett. 3:2001;1507.
34. Immobilized Enzymes. Methods in Enzymology. Vol. 44. Mosbach, K. Ed.; Academic Press Inc. London. 1976.
35. Klibanov A.M. Adv. Appl. Microbiol. 1:1982;1.
36. Guisán J.M., Bastida A., Cuesta C., Fernandez-Lafuente R., Rosell C.M. Biotechnol. Bioeng. 38:1991;1144.
37. Niehaus F., Bertoldo C., Kahler M., Antranikian G. Appl. Microbiol. Biotechnol. 51:1999;711.
38. Leung D.W., Chen E., Goeddel D.V. Technique. 1:1989;11.
39. Sutherland J.D. Curr. Opin. Chem. Biol. 4:2000;263.
40. Stemmer W.P.C. Nature. 370:1994;389.
41. Stemmer W.P.C. Proc. Natl. Acad. Sci. U.S.A. 91:1994;10747.
42. Ostermeier M., Nixon A.E., Shim J.H., Benkovic S.J. Proc. Natl. Acad. Sci. U.S.A. 96:1999;3562.
43. Zhao H., Giver L., Shao Z., Affholter J.A., Arnold F.H. Nat. Biotechnol. 16:1998;258.
44. Shao Z., Zhao H., Giver L., Arnold F.H. Nucleic Acids Res. 26:1998;681.
45. Taylor S.V., Kast P., Hilvert D. Angew. Chem., Int. Ed. 40:2001;3310.
46. Cohen N., Abramov S., Dror Y., Freeman A. Trends Biotechnol. 19:2001;507.
47. Wahler D., Reymond J.-L. Curr. Opin. Biotechnol. 12:2001;535.
48. Zhang J.-H., Dawes G., Stemmer W.P.C. Proc. Natl. Acad. Sci. U.S.A. 94:1997;4504.
49. Takato Y., Shinya O., Hiroyuki K. Proc. Natl. Acad. Sci. U.S.A. 95:1998;5511.
50. Fong S., Machajewski D., Mak C.C., Wong C.-H. Chem. Biol. 7:2000;873.
51. Bessler C., Schmitt J., Maurer K.-H., Schmid R.D. Protein Sci. 12:2003;2141.
52. Williams G.J., Domann S., Nelson A., Berry A. Proc. Natl. Acad. Sci. U.S.A. 100:2003;3143.
53. May O., Nguyen P.T., Arnold F.H. Nat. Biotechnol. 18:2000;317.
54. Alexeeva M., Eright A., Dawson M.J., Mahmoudian M., Turner N.J. Angew. Chem., Int. Ed. 41:2002;3177.
55. Kikuchi M., Delarue M., Harayama S. Gene. 236:1999;159.
56. Cherry J.R., Lamsa M.H., Schneider P., Vind J., Svendsen A., Jones A., Pedersen A.H. Nat. Biotechnol. 17:1999;379.
57. Chen K., Arnold F.H. Proc. Natl. Acad. Sci. U.S.A. 90:1993;5618.
58. Moore J.C., Arnold F.H. Nat. Biotechnol. 14:1996;458.
59. Brakmann S. ChemBioChem. 2:2001;865.
60. Dalby P.A. Curr. Opin. Struct. Biol. 13:2003;500.
61. Jencks W.P. Catalysis in Chemistry and Enzymology. 1969;McGraw-Hill, New York.
62. Tramontano A., Janda K.D., Lerner R.A. Science. 234:1986;1566.
63. Pollack S.J., Jacobs J.W., Schultz P.G. Science. 234:1986;1570.
64. Hilvert D. Annu. Rev. Biochem. 69:2000;751.
65. Golinelli-Pimpaneau B. Curr. Opin. Struct. Biol. 10:2000;697.
66. Wirsching P., Ashley J.A., Lo C.-H.L., Janda K.D., Lerner R.A. Science. 270:1995;1775.
67. Hilvert D., Carpenter S.H., Nared K.D., Auditor M.-T.M. Proc. Natl. Acad. Sci. U.S.A. 85:1988;4953.
68. Jackson D.Y., Jacobs J.W., Sugasawara R., Reich S.H., Barlett P.A., Schultz P.G. J. Am. Chem. Soc. 85:1988;4953.
69. Jackson D.Y., Liang M.N., Bartlett P.A., Schultz P.G. Angew. Chem., Int. Ed. Engl. 31:1992;182.
70. Haynes M.R., Stura E.A., Hilvert D., Wilson I.A. Science. 263:1994;646.
71. Wagner J., Lerner R.A., Barbas C.F. III Science. 270:1995;1797.
72. Barbas C.F. III, Heine A., Zhong G., Hoffmann T., Gramatikova S., Björnestedt R., List B., Anderson J., Stura E.A., Wilson I.A., Lerner R.A. Science. 278:1997;2085.
73. Hoffmann T., Zhong G., List B., Shabat D., Anderson J., Gramatikova S., Lerner R.A., Barbas C.F. III J. Am. Chem. Soc. 120:1998;2768.
74. Tawfik D.S., Gree B.S., Chap R., Sela M., Eshhar Z. Proc. Natl. Acad. Sci. U.S.A. 90:1993;373.
75. Janda K.D., Lo L.-C., Lo C.-H.L., Sim M.-M., Wang R., Wong C.-H., Lerner R.A. Science. 275:1997;945.
76. Triggle D.J. Drug Discov. Today. 2:1997;138.
77. Margolin A.L. Enzyme Microb. Technol. 15:1993;266.
78. Johnson C.R. Acc. Chem. Res. 31:1998;333.
79. Patel R.N. Adv. Synth. Catal. 343:2001;527.
80. Hanson R., Schwinden M.D., Banerjee A., Brzozowski D., Chen B.-C., Patel B.P., McNamee C., Kodersha G., Kronenthal D., Patel R.N., Szarka L.J. Bioorg. Med. Chem. 7:1999;2247.
81. Cirino P.C., Arnold F.H. Curr. Opin. Chem. Biol. 6:2002;130.
82. Boyd D.R., Sharma N.D., Allen C.C.R. Curr. Opin. Biotechnol. 12:2001;564.
83. Johnson D.V., Zabelinskaja-Mackova A.A., Griengl H. Curr. Opin. Chem. Biol. 4:2000;103.
84. Schmid R.D., Verger R. Angew. Chem., Int. Ed. 37:1998;1608.
85. Kitamura M., Tokunaga M., Noyori R. J. Am. Chem. Soc. 115:1993;144.
86. Brown S.A., Parker M.-C., Turner N.J. Tetrahedron Asymmetr. 11:2000;1687.
87. Pàmies O., Bäckwall J.-E. Chem. Rev. 103:2003;3247.
88. Dehli J.R., Gotor V. Chem. Soc. Rev. 31:2002;365.
89. Mischitz M., Faber K. Tetrahedron Lett. 35:1994;81.
90. Dwek R.A. Chem. Rev. 96:1996;683.
91. Persidis A. Nat. Biotechnol. 15:1997;479.
92. Fessner W.-D., Sinerius G., Schneider A., Dreyer M., Schulz G.E., Badia J., Aguilar J. Angew. Chem., Int. Ed. Engl. 30:1991;555.
93. Espelt L., Parella T., Bujons J., Solans C., Joglar J., Delgado A., Clapés P. Chem. Eur. J. 9:2003;4887.
94. Gijsen H.J.M., Qiao L., Fitz W., Wong C.-H. Chem. Rev. 1996;443.
95. Fessner W.-D. Curr. Opin. Chem. Biol. 2:1998;85.
96. Henderson D.F., Toone E.J. Pinto B.M. Comprehensive Natural Product Chemistry, Vol. 3. 1999;367-441 Elsevier Science B.V. Amsterdam.
97. Machajewski T.D., Wong C.-H. Angew. Chem., Int. Ed. 39:2000;1352.
98. Fessner W.-D., Helaine V. Curr. Opin. Biotechnol. 12:2001;574.
99. Shelton M.C., Cotterill I.C., Novak S.T.A., Poonawala R.M., Sudarshan S., Toone E.J. J. Am. Chem. Soc. 118:1996;2117.
100. Barbas C.F. III, Wang Y.-F., Wong C.-H. J. Am. Chem. Soc. 112:1990;2013.
101. Chen L., Dumas D.P., Wong C.-H. J. Am. Chem. Soc. 114:1992;741.
102. Wong C.-H., García-Junceda E., Chen L., Blanco O., Gijsen H.J.M., Steensma D.H. J. Am. Chem. Soc. 117:1995;3333.
103. Gijsen H.J.M., Wong C.-H. J. Am. Chem. Soc. 116:1994;8422.
104. Gijsen H.J.M., Wong C.-H. J. Am. Chem. Soc. 117:1995;2947.
105. Gijsen H.J.M., Wong C.-H. J. Am. Chem. Soc. 117:1995;7585.
106. Liu J., Wong C.-H. Angew. Chem., Int. Ed. 41:2002;1404.
107. Liu J.Q., Dairi T., Itoh N., Kataoka M., Shimizu S., Yamada H. J. Mol. Catal. B: Enzym. 10:2000;107.
108. Kimura T., Vassilev V.P., Shen G.-J., Wong C.-H. J. Am. Chem. Soc. 119:1998;11734.
109. Uchiyama T., Vassilev V.P., Kajimoto T., Wong W., Huang H., Lin C.-C., Wong C.-H. J. Am. Chem. Soc. 117:1995;5395.
110. Wong C.-H., Moris-Varas F., Hung S.-C., Marron T.G., Lin C.-C., Gong K.W., Weitz-Schmidt G. J. Am. Chem. Soc. 119:1997;8152.
111. Shibata K., Shingu K., Vassilev V.P., Nishide K., Fujita T., Node M., Kajimoto T., Wong C.-H. Tetrahedron Lett. 37:1996;2791.
112. Nilsson K.G.I. Trends Biotechnol. 7:1988;145.
113. Crout D.H.G., Vic G. Curr. Opin. Chem. Biol. 2:1998;98.
114. Fernández-Mayoralas A. Top. Curr. Chem. 186:1997;1.
115. López R., Fernández-Mayoralas A. J. Org. Chem. 59:1994;737.
116. Mori T., Fujita S., Okahata Y. Carbohydr. Res. 298:1997;65.
117. Mackenzie L.F., Wang Q., Warren R.A.J., Withers S.G. J. Am. Chem. Soc. 120:1998;5583.
118. Ly H.D., Withers S.G. Annu. Rev. Biochem. 68:1999;487.
119. Ducros V.M.-A., Tarling C.A., Zechel D.L., Brzozowski A.M., Frandsen T.P., von Ossowski I., Schülein M., Withers S.G., Davies G. J. Chem. Biol. 10:2003;619.
120. Williams S.J., Withers S.G. Carbohydr. Res. 327:2000;27.
121. Malet C., Planas A. FEBS Lett. 440:1998;208.
122. Faijes M., Fairweather J.K., Driguez H., Planas A. Chem. Eur. J. 7:2001;4651.
123. Beyer A.T., Sadler J.E., Rearick J.I., Paulson J.C., Hill R.L. Adv. Enzymol. 52:1981;24.
124. Öhrlein R. Top. Curr. Chem. 2000:1999;227.
125. Sears P., Wong C.-H. Cell. Mol. Life Sci. 54:1998;223.
126. Palcic M.M. Curr. Opin. Biotechnol. 10:1999;616.
127. Koeller K.M., Wong C.-H. Glycobiology. 10:2000;1157.
128. Lisowska E. Cell. Mol. Life Sci. 59:2002;445.
129. Witte K., Sears P., Martin R., Wong C.-H. J. Am. Chem. Soc. 119:1997;2114.
130. Wang L.-X., Tang M., Suzuki T., Kitajima K., Inoue Y., Inoue S., Fan J.-Q., Lee Y.C. J. Am. Chem. Soc. 119:1997;11137.
131. Tolbert T.J., Wong C.-H. J. Am. Chem. Soc. 122:2000;5421.
132. Hallis T.M., Liu H.-W. Acc. Chem. Res. 32:1999;579.
133. Thorson J.S., Hosted T.J. Jr., Jiang J., Biggins J.B., Ahlert J., Ruppen M. Curr. Org. Chem. 5:2001;89.
134. Izumi M., Shen G.-J., Wacowich-Sgarbi S., Nakatani T., Plettenburg O., Wong C.-H. J. Am. Chem. Soc. 123:2001;10909.
135. Bastida A., Fernández-Mayoralas A., Gómez Arrayás R., Iradier F., Carretero J.C., García-Junceda E. Chem. Eur. J. 7:2001;2390.
136. Bastida A., Fernández-Mayoralas A., García-Junceda E. Bioorg. Med. Chem. 10:2002;737.
137. Unverzagt C., Kunz H., Paulson J.C. J. Am. Chem. Soc. 112:1990;9038.
138. Wong C.-H., Haynie S.L., Whitesides G.M. J. Am. Chem. Soc. 47:1982;5416.
139. Wong C.-H., Wang R., Ichikawa Y. J. Org. Chem. 57:1992;4343.
140. Elling L., Grothus M., Kula M.-R. Glycobiology. 3:1993;349.
141. Look G.C., Ichikawa Y., Shen G.-J., Cheng P.-W., Wong C.-H. J. Org. Chem. 58:1993;4326.
142. Gygax D., Spies P., Winkler T., Pfaar U. Tetrahedron. 47:1991;5119.
143. Ichikawa Y., Shen G.-J., Wong C.-H. J. Am. Chem. Soc. 113:1991;4698.
144. Wang P., Shen G.-J., Wang Y.-F., Ichikawa Y., Wong C.-H. J. Org. Chem. 58:1993;3985.
145. Ichikawa Y., Lin Y.-C., Dumas D.P., Shen G.-J., García-Junceda E., Williams M.A., Bayer R., Ketcham C., Walker L.E., Paulson J.C., Wong C.-H. J. Am. Chem. Soc. 114:1992;9283.
146. Gilbert M., Bayer R., Cunningham A.-M., DeFrees S., Gao Y., Watson D.C., Young M.N., Wakarchuk W.W. Nat. Biotechnol. 16:1998;769.
147. Chen X., Liu Z., Wang J., Fang J., Fan H., Wang P.G. J. Biol. Chem. 275:2000;31594.
148. Chen X., Fang J., Zhang J., Liu Z., Shao J., Kowal P., Andreana P., Wang P.G. J. Am. Chem. Soc. 123:2001;2081.
149. Liu Z.-Y., Zhang J.-B., Chen X., Wang P.G. ChemBioChem. 3:2002;348.
150. Shao J., Zhang J., Nahálka J., Wang P.G. Chem. Commun. 2586:2002;2586.
151. Nahálka J., Liu Z., Chen X., Wang P.G. Chem. Eur. J. 9:2003;372.
152. Lin C.-H., Shen G.-J., García-Junceda E., Wong C.-H. J. Am. Chem. Soc. 17:1995;8031.
153. Burkart M.D., Izumi M., Wong C.-H. Angew. Chem., Int. Ed. 38:1999;2747.
154. Molecular Diversity and Combinatorial Chemistry: Libraries and Drug Discovery. Chaiken, I., Janda, K. Eds., ACS, Washington, 1996.
155. Reents R., Duraiswamy A.J., Waldmann H. Adv. Synth. Catal. 343:2001;501.
156. Sauerbrei B., Jungmann V., Waldmann H. Angew. Chem., Int. Ed. 37:1998;1143.
157. Schuster M., Wang P., Paulson J.C., Wong C.-H. J. Am. Chem. Soc. 116:1994;1135.
158. Halcomb R.L., Huang H.M., Wong C.-H. J. Am. Chem. Soc. 116:1994;11315.
159. Blixt O., Norberg T. J. Org. Chem. 63:1998;2705.
160. Lubineau A., Malleron A., Le Narvor C. Tetrahedron Lett. 41:2000;8887.
161. Brinkmann N., Malissard M., Ramuz M., Römer U., Schumacher T., Berger E.G., Elling L., Wandrey C., Liese A. Bioorg. Med. Chem. Lett. 11:2001;2503.
162. Zehavi U. React. Funct. Polym. 41:1999;59.
163. Corrales G., Fernández-Mayoralas A., García-Junceda E., Rodríguez Y. Biocat. Biotrans. 18:2000;271.
164. Schmidt D., Thiem J. Chem. Comm. 2000;1919.
165. Ulijn R.V., Baragaña B., Halling P.J., Flitsch S.L. J. Am. Chem. Soc. 124:2002;10988.
166. Khmelnitsky Y.L., Michels P.C., Dordick J.S., Clark D.S. Chaiken I., Janda K. Molecular Diversity and Combinatorial Chemistry: Libraries and Drug Discovery. 1996;144-157 ACS, Washington.
167. Michels P.C., Khmelnitsky Y.L., Dordick J.S., Clark D.S. Trends Biotechnol. 16:1998;210.
168. Krstenansky J.L., Khmelnitsky Y. Bioorg. Med. Chem. 7:1999;2157.
169. Altreuter D.H., Clark D.S. Curr. Opin. Biotechnol. 10:1999;130.
170. Rich J.O., Michels P.C., Khmelnitsky Y.L. Curr. Opin. Chem. Biol. 6:2002;161.
171. Herrmann G.F., Wang P., Shen G.-J., Wong C.-H. Angew. Chem., Int. Ed. Engl. 33:1994;1241.
172. Herrmann G.F., Elling L., Krezdorn C.-H., Kleene R., Berger E.G., Wandrey C. Bioorg. Med. Chem. Lett. 5:1995;673.
173. Lubineau A., Narvor C.L., Auge C., Gallet P.F., Petit J.M., Julien R. J. Mol. Catal. B: Enzym. 5:1998;229.
174. Zervosen A., Elling L. J. Am. Chem. Soc. 118:1996;1836.
175. Chen X., Zhang J., Kowal P., Liu Z., Andreana P.R., Lu Y., Wang P.G. J. Am. Chem. Soc. 123:2001;8866.
176. Endo T., Koizumi S. Curr. Opin. Struct. Biol. 10:2000;536.
177. Koizumi S., Endo T., Tabata K., Ozaki A. Nat. Biotechnol. 16:1998;847.
178. Tabata K., Koizumi S., Endo T., Ozaki A. Biotechnol. Lett. 22:2000;479.
179. Koizumi S., Endo T., Tabata K., Nagano H., Ohnishi J., Ozaki A. J. Ind. Microbiol. Biotechnol. 25:2000;213.
180. Endo T., Koizumi S., Tabata K., Ozaki A. Appl. Microbiol. Biotechnol. 53:2000;257.
181. Endo T., Koizumi S., Tabata K., Kakita S., Ozaki A. Carbohydr. Res. 316:1999;179.
182. Borchardt J.K. Modern Drug Discov. 2:1999;23.
183. Hutchinson C.R. Curr. Opin. Microbiol. 1:1998;319.
184. Cane D.E., Walsh C.T., Khosla C. Science. 282:1998;63.
185. McDaniel R., Ebert-Khosla S., Hopwood D.A., Khosla C. Science. 262:1993;1546.
186. McDaniel R., Ebert-Khosla S., Hopwood D.A., Khosla C. Nature. 375:1995;549.
187. Kao C.M., McPherson M., McDaniel R.N., Fu H., Cane D.E., Khosla C. J. Am. Chem. Soc. 119:1997;11339.
188. McDaniel R., Thamchaipenet A., Gustafsson A., Fu H., Betlach M., Betlach M., Ashley G. Proc. Natl. Acad. Sci. U.S.A. 96:1999;1846.
189. Meurer G., Gerlitz M., Wendt-Pienkowski E., Vining L.C., Rohr J., Hutchinson C.R. Chem. Biol. 4:1997;433.
190. Gerlitz M., Meurer G., Wendt-Pienkowski E., Madduri K., Hutchinson C.R. J. Am. Chem. Soc. 119:1997;7392.
191. Rodriguez E., McDaniel R. Curr. Opin. Microbiol. 4:2001;526.
192. Reeves C.D. Crit. Rev. Biotechnol. 23:2003;95.
193. Mendez C., Salas J.A. Trends Biotechnol. 19:2001;449.
194. Trefzer A., Salas J.A., Bechthold A. Nat. Prod. Rep. 16:1999;283.
195. Borisova S.A., Zhao L., Sherman D.H., Liu H.W. Org. Lett. 1:1999;133.
196. Blanco G., Patallo E.P., Braña A.F., Trefzer A., Bechthold A., Rohr J., Mendez C., Salas J.A. Chem. Biol. 8:2001;253.
197. Madduri K., Kennedy J., Rivola G., Inventi-Solari A., Filippini S., Zanuso G., Colombo A.L., Gewain K.M., Occi J.L., MacNeil D.J., Hutchinson C.R. Nat. Biotechnol. 16:1998;69.
198. Decker H., Haag S., Udvarnoki G., Rohr J. Angew. Chem., Int. Ed. Engl. 34:1995;1107.
199. Wohlert S.-E., Blanco G., Lombó F., Fernández E., Braña A.F., Reich S., Udvarnoki G., Méndez C., Decker H., Frevert J., Salas J.A., Rohr J. J. Am. Chem. Soc. 120:1998;10596.