Enzymes for chemical synthesis

Nature

Volumn 409, Issue 6817, 2001, Pages 232-240

  Koeller, K M ^a   Wong, C H ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ORGANIC COMPOUND;

CATALYSIS; CHEMICAL INDUSTRY; CHEMICAL STRUCTURE; ENZYME SYNTHESIS; MEDICAL RESEARCH; ORGANIC CHEMISTRY; PRIORITY JOURNAL; REACTION ANALYSIS; REVIEW;

CARBON; CATALYSIS; CHEMICAL INDUSTRY; COENZYMES; ENDOPEPTIDASES; ENZYMES; FORECASTING; GLYCOSIDE HYDROLASES; HYDROLYSIS;

EID: 0035843122     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35051706     Document Type: Review

References (74)

1. Enzymes in organic synthesis
2. Resolution of enantiomers via biocatalysis
3. Enzymes in organic synthesis: Application to the problems of carbohydrate recognition. Parts 1 and 2
4. Enantioselective synthesis through enzymatic asymmetrization
5. Why are enzymes less active in organic solvents than in water?
6. Lipases: Interfacial enzymes with attractive applications
7. Biotransformations in the discovery and development of pharmaceuticals
8. Application of enzyme- and microorganism-catalyzed reactions to organic synthesis
9. Properties and synthetic applications of enzymes in organic solvents
10. The catalytic asymmetric aldol reaction
11. Enzymes in organic synthesis: Alteration of reversible reactions to irreversible processes
12. Molecular modeling and biocatalysis: Explanations, predictions, limitations, and opportunities
13. Dynamic enzymatic resolution of thioesters
14. Ruthenium- and enzyme-catalyzed dynamic kinetic resolution of secondary alcohols
15. Designing enzymatic resolution of amines
16. Enzymes and protecting group chemistry
17. Bioorganic synthesis of lipid-modified proteins for the study of signal transduction
18. A multienzyme system for a one-pot synthesis of sialyl T-antigen
19. Enzymatic regeneration of 3′-phosphoadenosine-5′-phosphosulfate using aryl sulfotransferase for the preparative enzymatic synthesis of sulfated carbohydrates
20. Enzymatic synthesis of hyaluronic acid with regeneration of sugar nucleotides
21. The synthesis of sialylated oligosaccharides using a CMP-Neu5Ac synthetase/sialyltransferase fusion
22. Enhanced inhibition of human anti-gal antibody binding to mammalian cells by synthetic α-gal epitope polymers
23. Large-scale production of CMP-NeuAc and sialylated oligosaccharides through bacterial coupling
24. Use of Escherichia coli polyphosphate kinase for oligosaccharide synthesis
25. Chemoenzymatic synthesis of α(1,3)-Gal (NAc)-terminating glycosides of complex tertiary sugar alcohols
26. A novel β-1,4-galactosyltransferase reaction to yield β-D-galactopyranosyl-(1-3)-linked disaccharides from L-sugars
27. UDP-N-acetyl-5-thio-galactosamine is a substrate of lactose synthase
28. Efficient enzymatic synthesis of the core trisaccharide of N-glycans with a recombinant β-mannosyltransferase
29. Combined preparative enzymatic synthesis of dTDP-6-deoxy-4- keto-D-glucose from dTDP and sucrose
30. Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation
31. Recombinant baker's yeast as a whole-cell catalyst for asymmetric Baeyer-Villiger oxadations
32. The reaction cycle of isopenicillin N-synthase observed by X-ray diffraction
33. The catalytic pathway of cytochrome P450cam at atomic resolution
34. Regio- and stereoselectivity of particulate methane monooxygenase from Methylococcus capsulatus
35. Geometry of the soluble methane monooxygenase catalytic diiron center in two oxidation states
36. Glyoxylic acid production using microbial transformant catalysts
37. Enantioselective epoxidation of w-bromo-2-methyl-1-alkenes catalyzed by chloroperoxidase. Effect of chain length on selectivity and efficiency
38. Selective oxidation catalyzed by peroxidases
39. Cross-linked enzyme crystals as novel materials for catalysis and chromatography
40. Novel biocatalysts by chemical modification of known enzymes: Cross-linked microcrystals of the semisynthetic peroxidase seleno-subtilisin
41. Enzymatic oxidative phenolic coupling
42. Amidation of bioactive peptides: The structure of peptidylglycine α-hydroxylating monooxygenase
43. Toluene dioxygenase-mediated cis-hydroxylation of aromatics in enantioselective synthesis. Asymmetric total syntheses of pancratistatin and 7-deoxypancratistatin, promising antitumor agents
44. Reaction mechanism of L-2-haloacid dehalogenase of Pseudomonas sp. YL
45. Substrate mimetic mediated peptide synthesis: An irreversible ligation strategy that is independent of substrate specificity
46. Modulation of esterase and amidase activity of subtilisin Bacillus lentus by chemical modification of cysteine mutants
47. Solution- and solid-phase synthesis of N-protected peptide esters of the benzyl type as substrates for subtilisin-catalyzed glycopeptide coupling
48. A designed peptide ligase for total synthesis of ribonuclease A with unnatural catalytic residues
49. Breaking the low barrier hydrogen bond in a serine protease
50. Intein-mediated synthesis of proteins containing carbohydrates and other molecular probes
51. Combined chemical and enzymatic synthesis of a C-glycopeptide and its inhibitory activity toward glycoamidases
52. Glycosynthases: Mutant glycosidases for oligosaccharide synthesis
53. Highly efficient synthesis of β(1,4)-oligo- and polysaccharides using a mutant cellulase
54. Synthesis of artificial chitin: Irreversible catalytic behavior of a glycosyl hydrolase through a transition state analogue substrate
55. A practical method for the synthesis of N-acetyl-D -lactosamine derivatives by the tandem use of galactose oxidase and β-galactosidase
56. Transfer of ganglioside GM3 oligosaccharide from a water soluble polymer to ceramide by ceramide glycanase. A novel approach for the chemical-enzymatic synthesis of glycosphingolipids
57. Fructose-1,6-bisphosphate aldolase from Staphylococcus carnosus overexpression, structure prediction, stereoselectivity, and application in the synthesis of bicyclic sugars
58. 2-Keto-3-deoxy-6-phosphogluconate aldolases as catalysts for stereocontrolled carbon-carbon bond formation
59. 13C]-Gal-β-(1,4)-Gl cNAc-β- sequence onto glycoprotein
60. Synthesis of vanillin from glucose
61. Aldolase antibodies of remarkable scope
62. Design by directed evolution
63. Enantioselective enzymes for organic synthesis created by directed evolution
64. Directed evolution of D-2-keto-3-deoxy-6-phosphogluconate aldolase to new variants for the efficient synthesis of D- and L-sugars
65. Chemical selection for catalysis in combinatorial antibody libraries
66. A method for the selection of catalytic activity using phage display and proximity coupling
67. Harnessing the biosynthetic code: Combinations, permutations, and mutations
68. Screening of novel microbial enzymes for the production of biologically and chemically useful compounds
69. Application of enzymes in industrial organic synthesis