Inverting enantioselectivity by directed evolution of hydantoinase for improved production of L-methionine

Nature Biotechnology

Volumn 18, Issue 3, 2000, Pages 317-320

  May, Oliver ^a   Nguyen, Peter T ^a   Arnold, Frances H ^a  

^a California Institute of Technology   (United States)

Author keywords

Biocatalysis; Chiral chemicals; Directed evolution; Enantioselectivity; Hydantoinase

Indexed keywords

DIHYDROPYRIMIDINASE; HYDANTOIN DERIVATIVE; METHIONINE; METHIONINE DERIVATIVE; RACEMASE;

AMINO ACID SYNTHESIS; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DIRECTED MOLECULAR EVOLUTION; ENANTIOMER; ENZYME ACTIVITY; ENZYME SPECIFICITY; ESCHERICHIA COLI; MUTAGENESIS; PRIORITY JOURNAL;

AMIDOHYDROLASES; DIRECTED MOLECULAR EVOLUTION; ESCHERICHIA COLI; METHIONINE; MODELS, CHEMICAL; MUTAGENESIS; PEPTIDE LIBRARY; POLYMERASE CHAIN REACTION; STEREOISOMERISM; TIME FACTORS;

ARTHROBACTER SP.; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 0034059496     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/73773     Document Type: Article

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