Combinatorial biosynthesis of antimicrobials and other natural products

Current Opinion in Microbiology

Volumn 4, Issue 5, 2001, Pages 526-534

  Rodriguez, Eduardo ^a   McDaniel, Robert ^a  

^a KOSAN BIOSCIENCES INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; DEOXYSUGAR; ERYTHROMYCIN DERIVATIVE; NATURAL PRODUCT; POLYKETIDE SYNTHASE;

BIOSYNTHESIS; COMBINATORIAL CHEMISTRY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME MODIFICATION; ENZYMOLOGY; REVIEW;

EID: 0034788156     PISSN: 13695274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1369-5274(00)00246-0     Document Type: Review

References (49)

1. Molecular mechanisms that confer antibacterial drug resistance
2. Harnessing the biosynthetic code: Combinations, permutations, and mutations
3. The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthases
4. Polyketide and nonribosomal polypeptide biosynthesis
5. Modular organization of genes required for complex polyketide biosynthesis
6. An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea
7. Manipulation of modular polyketide synthases
8. Novel macrolides through genetic engineering
9. Multiple genetic modifications of the erythromycin gene cluster to produce a library of novel 'unnatural' natural products
10. Engineered biosynthesis of novel polyketides
11. A multi-plasmid approach to preparing large libraries of polyketides
12. A two-vector system for the production of recombinant polyketides in Streptomyces
13. Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': Evidence for the derailment of an aromatic polyketide synthase
14. A two-plasmid system for the glycosylation of polyketide antibiotics: Bioconversion of ε-rhodomycinone to rhodomycin D
15. Construction of desosamine containing polyketide libraries using a glycosyltransferase with broad substrate specificity
16. Cloning and heterologous expression of the epothilone gene cluster
17. Cloning, characterization and heterologous expression of a polyketide synthase and P-450 oxidase involved in the biosynthesis of the antibiotic oleandomycin
18. Biosynthesis of the anti-parasitic agent megalomicin: Transformation of erythromycin to megalomicin in Saccharopolyspora erythraea
19. Elucidating the mechanism of chain termination switching in the picromycin/methymycin polyketide synthase
20. The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase
21. The mycosubtilin synthetase of Bacillus subtilis ATCC6633: A multifunctional hybrid between a peptide synthetase, an amino transferase, and a fatty acid synthase
22. New lessons for combinatorial biosynthesis from myxobacteria. The myxothiazol biosynthetic gene cluster of Stigmatella aurantiaca DW4/3-1
23. Polyketide synthase gene coupled to the peptide synthetase module involved in the biosynthesis of the cyclic heptapeptide microcystin
24. Identification of a cyclohexylcarbonyl CoA biosynthetic gene cluster and application in the production of doramectin
25. The FK520 gene cluster of Streptomces hygroscopicus var. ascomycetius (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units
26. Recombinant polyketide synthesis in Streptomyces: Engineering of improved host strains
27. A host-vector system for the analysis and manipulation of rifamycin polyketide biosynthesis in Amycolatopsis mediterranei
28. A gene cluster for the macrolide antibiotic biosynthesis in Streptomyces venezuelae: Architecture of metabolic diversity
29. Biosynthesis of desosamine: Construction of a new methymycin/neomethymycin analogue by deletion of a desosamine biosynthetic gene
30. Engineering a methymycin/pikromycin-calicheamicin hybrid: Construciton of two new macrolides carrying a designed sugar moiety
31. Mechanisms of molecular recognition in the pikromycin polyketide synthase
32. Production of a polyketide natural product in nonpolyketide-producing prokaryotic and eukaryotic hosts
33. Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli
34. Genetic and biochemical characterization of the α and β components of a propionyl-CoA carboxylase complex of Streptomyces coelicolor A3(2)
35. Dissecting and exploiting intermodular communication in polyketide synthases
36. Formation of functional heterologous complexes using subunits from the picromycin, erythromycin, and oleandomycin polyketide synthases
37. Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase
38. Selective protein-protein interactions direct channeling of intermediates between polyketide synthase modules
39. Engineered intermodular and intramodular polyketide synthase fusions
40. Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps; a route to simple statin analogues
41. Construction of hybrid peptide synthetases by module and domain fusions
42. Dipeptide formation on engineered hybrid peptide synthetases
43. Analysis of the molecular recognition features of individual modules derived from the erythromycin polyketide synthase
44. Precursor-directed biosynthesis of 16-membered macrolides by the erythromycin polyketide synthase
45. Aminoacyl-SNACs as small-molecule substrates for the condensation domains of nonribosomal peptide synthetases
46. Production of the antitumor drug epirubicin (4′-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius
47. Interspecies complementation in Saccharopolyspora erythraea: Elucidation of the function of oleP1, oleG1, and oleG2 from the olenadomycin biosynthetic gene cluster of Streptomyces antibioticus and generation of new erythromycin analogs
48. A defined system for hybrid macrolide biosynthesis in Saccharopolyspora erythraea