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Volumn 114, Issue 9, 2004, Pages 1209-1217

CD4+ Tregs and immune control

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; MOLECULAR MARKER; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; FORKHEAD TRANSCRIPTION FACTOR; FOXP1 PROTEIN, HUMAN; INTERLEUKIN 2 RECEPTOR; LIGAND; REPRESSOR PROTEIN;

EID: 14844345227     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200423395     Document Type: Review
Times cited : (369)

References (112)
  • 1
    • 2442484053 scopus 로고    scopus 로고
    • Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses
    • Sakaguchi, S. 2004. Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 22:531-562.
    • (2004) Annu. Rev. Immunol. , vol.22 , pp. 531-562
    • Sakaguchi, S.1
  • 2
    • 0026603775 scopus 로고
    • Revisiting and revising suppressor T cells
    • Bloom, B.R., Salgame, P., and Diamond, B. 1992. Revisiting and revising suppressor T cells. Immunol. Today. 13:131-136.
    • (1992) Immunol. Today , vol.13 , pp. 131-136
    • Bloom, B.R.1    Salgame, P.2    Diamond, B.3
  • 3
    • 0038434099 scopus 로고    scopus 로고
    • Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis
    • Gambineri, E., Torgerson, T.R., and Ochs, H.D. 2003. Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis. Curr. Opin. Rheumatol. 15:430-435.
    • (2003) Curr. Opin. Rheumatol. , vol.15 , pp. 430-435
    • Gambineri, E.1    Torgerson, T.R.2    Ochs, H.D.3
  • 5
    • 0035186416 scopus 로고    scopus 로고
    • Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells
    • Weiner, H.L. 2001. Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells. Immunol. Rev. 182:207-214.
    • (2001) Immunol. Rev. , vol.182 , pp. 207-214
    • Weiner, H.L.1
  • 6
    • 0037364804 scopus 로고    scopus 로고
    • Natural versus adaptive regulatory T cells
    • Bluestone, J.A., and Abbas, A.K. 2003. Natural versus adaptive regulatory T cells. Nat. Rev. Immunol. 3:253-257.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 253-257
    • Bluestone, J.A.1    Abbas, A.K.2
  • 7
    • 0020451946 scopus 로고
    • Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis
    • Sakaguchi, S., Takahashi, T., and Nishizuka, Y. 1982. Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis J. Exp. Med. 156:1577-1586.
    • (1982) J. Exp. Med. , vol.156 , pp. 1577-1586
    • Sakaguchi, S.1    Takahashi, T.2    Nishizuka, Y.3
  • 8
    • 0021997185 scopus 로고
    • Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease
    • Sakaguchi, S., Fukuma, K., Kuribayashi, K., and Masuda, T. 1985. Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease. J. Exp. Med. 161:72-87.
    • (1985) J. Exp. Med. , vol.161 , pp. 72-87
    • Sakaguchi, S.1    Fukuma, K.2    Kuribayashi, K.3    Masuda, T.4
  • 9
    • 0029788211 scopus 로고    scopus 로고
    • Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation
    • Asano, M., Toda, M., Sakaguchi, N., and Sakaguchi. S. 1996. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. 184:387-396.
    • (1996) J. Exp. Med. , vol.184 , pp. 387-396
    • Asano, M.1    Toda, M.2    Sakaguchi, N.3    Sakaguchi, S.4
  • 10
    • 0015908120 scopus 로고
    • Spontaneous thyroiditis in thymectomized and irradiated Wistar rats
    • Penhale, W.J., Farmer, A., McKenna, R.P., and Irvine, W.J. 1973. Spontaneous thyroiditis in thymectomized and irradiated Wistar rats. Clin. Exp. Immunol. 15:225-236.
    • (1973) Clin. Exp. Immunol. , vol.15 , pp. 225-236
    • Penhale, W.J.1    Farmer, A.2    McKenna, R.P.3    Irvine, W.J.4
  • 11
    • 0027509812 scopus 로고
    • Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential
    • Fowell, D., and Mason, D. 1993. Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential. J. Exp. Med. 177:627-636.
    • (1993) J. Exp. Med. , vol.177 , pp. 627-636
    • Fowell, D.1    Mason, D.2
  • 12
    • 0024500755 scopus 로고
    • T cell-mediated inhibition of the transfer of autoimmune diabetes in NOD mice
    • Boitard, C., Yasunami, R., Dardenne, M., and Bach, J.F. 1989. T cell-mediated inhibition of the transfer of autoimmune diabetes in NOD mice. J. Exp. Med. 169:1669-1680.
    • (1989) J. Exp. Med. , vol.169 , pp. 1669-1680
    • Boitard, C.1    Yasunami, R.2    Dardenne, M.3    Bach, J.F.4
  • 13
    • 0023267515 scopus 로고
    • Depletion of RT6.1+ T lymphocytes induces diabetes in resistant biobreeding/Worcester (BB/W) rats
    • Greiner, D.L., et al. 1987. Depletion of RT6.1+ T lymphocytes induces diabetes in resistant biobreeding/Worcester (BB/W) rats. J. Exp. Med. 166:461-475.
    • (1987) J. Exp. Med. , vol.166 , pp. 461-475
    • Greiner, D.L.1
  • 14
    • 0025572276 scopus 로고
    • OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: Prevention by the OX-22low subset
    • Powrie, F., and Mason, D. 1990. OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset. J. Exp. Med. 172:1701-1708.
    • (1990) J. Exp. Med. , vol.172 , pp. 1701-1708
    • Powrie, F.1    Mason, D.2
  • 15
    • 0027517545 scopus 로고
    • Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice
    • Powrie, F., Leach, M.W., Mauze, S., Caddle, L.B., and Coffman, R.L. 1993. Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. Int. Immunol. 5:1461-1471.
    • (1993) Int. Immunol. , vol.5 , pp. 1461-1471
    • Powrie, F.1    Leach, M.W.2    Mauze, S.3    Caddle, L.B.4    Coffman, R.L.5
  • 16
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M., and Toda, M. 1995. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155:1151-1164.
    • (1995) J. Immunol. , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 17
    • 0033136302 scopus 로고    scopus 로고
    • Thymus and autoimmunity: Production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance
    • Itoh, M., et al. 1999. Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J. Immunol. 162:5317-5326.
    • (1999) J. Immunol. , vol.162 , pp. 5317-5326
    • Itoh, M.1
  • 18
    • 0034141684 scopus 로고    scopus 로고
    • The third function of the thymus
    • Seddon, B., and Mason, D. 2000. The third function of the thymus. Immunol. Today. 21:95-99.
    • (2000) Immunol. Today , vol.21 , pp. 95-99
    • Seddon, B.1    Mason, D.2
  • 19
    • 0035320679 scopus 로고    scopus 로고
    • Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide
    • Jordan, M.S., et al. 2001. Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2:301-306.
    • (2001) Nat. Immunol. , vol.2 , pp. 301-306
    • Jordan, M.S.1
  • 20
    • 0036568942 scopus 로고    scopus 로고
    • Generation of CD4(+)CD25(+) regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression
    • Kawahata, K., et al. 2002. Generation of CD4(+)CD25(+) regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression. J. Immunol. 168:4399-4405.
    • (2002) J. Immunol. , vol.168 , pp. 4399-4405
    • Kawahata, K.1
  • 21
    • 0037621729 scopus 로고    scopus 로고
    • Decreasing the threshold for thymocyte activation biases CD4+ T cells toward a regulatory (CD4+CD25+) lineage
    • Stephens, G.L., and Ignatowicz, L. 2003. Decreasing the threshold for thymocyte activation biases CD4+ T cells toward a regulatory (CD4+CD25+) lineage. Eur. J. Immunol. 33:1282-1291.
    • (2003) Eur. J. Immunol. , vol.33 , pp. 1282-1291
    • Stephens, G.L.1    Ignatowicz, L.2
  • 22
    • 2142818492 scopus 로고    scopus 로고
    • Thymic generation and selection of CD25+CD4+ regulatory T cells: Implications of their broad repertoire and high self-reactivity for the maintenance of immunological self-tolerance
    • Sakaguchi, S., et al. 2003. Thymic generation and selection of CD25+CD4+ regulatory T cells: implications of their broad repertoire and high self-reactivity for the maintenance of immunological self-tolerance. Novartis Found. Symp. 252:6-16.
    • (2003) Novartis Found. Symp. , vol.252 , pp. 6-16
    • Sakaguchi, S.1
  • 23
    • 4143066714 scopus 로고    scopus 로고
    • Recognition of the peripheral self by naturally arising CD25(+) CD4(+) T cell receptors
    • Hsieh, C.S., et al. 2004. Recognition of the peripheral self by naturally arising CD25(+) CD4(+) T cell receptors. Immunity. 21:267-277.
    • (2004) Immunity , vol.21 , pp. 267-277
    • Hsieh, C.S.1
  • 24
    • 0033682056 scopus 로고    scopus 로고
    • B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes
    • Salomon, B., et al. 2000. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity. 12:431-440.
    • (2000) Immunity , vol.12 , pp. 431-440
    • Salomon, B.1
  • 25
    • 0035164360 scopus 로고    scopus 로고
    • Increased T cell autoreactivity in the absence of CD40-CD40 ligand interactions: A role of CD40 in regulatory T cell development
    • Kumanogoh, A., et al. 2001. Increased T cell autoreactivity in the absence of CD40-CD40 ligand interactions: a role of CD40 in regulatory T cell development. J. Immunol. 166:353-360.
    • (2001) J. Immunol. , vol.166 , pp. 353-360
    • Kumanogoh, A.1
  • 26
    • 0036791004 scopus 로고    scopus 로고
    • Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells
    • Lehmann, J., et al. 2002. Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells. Proc. Natl. Acad. Sci. U. S. A. 99:13031-13036.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 13031-13036
    • Lehmann, J.1
  • 27
    • 0034679560 scopus 로고    scopus 로고
    • Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
    • Takahashi, T., et al. 2000. Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 192:303-310.
    • (2000) J. Exp. Med. , vol.192 , pp. 303-310
    • Takahashi, T.1
  • 28
    • 0034679567 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation
    • Read, S., Malmstrom, V., and Powrie, F. 2000. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. J. Exp. Med. 192:295-302.
    • (2000) J. Exp. Med. , vol.192 , pp. 295-302
    • Read, S.1    Malmstrom, V.2    Powrie, F.3
  • 29
    • 0036170938 scopus 로고    scopus 로고
    • Stimulation of CD25(+)CD4(+) regulatory T cells through GITreg breaks immunological self-tolerance
    • Shimizu, J., Yamazaki, S., Takahashi, T., Ishida, Y., and Sakaguchi, S. 2002. Stimulation of CD25(+)CD4(+) regulatory T cells through GITreg breaks immunological self-tolerance. Nat. Immunol. 3:135-142.
    • (2002) Nat. Immunol. , vol.3 , pp. 135-142
    • Shimizu, J.1    Yamazaki, S.2    Takahashi, T.3    Ishida, Y.4    Sakaguchi, S.5
  • 30
    • 0036195161 scopus 로고    scopus 로고
    • CD4(+)CD25(+) immunoregulatory T cells: Gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor
    • McHugh, R.S., et al. 2002. CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity. 16:311-323.
    • (2002) Immunity , vol.16 , pp. 311-323
    • McHugh, R.S.1
  • 31
    • 1642347202 scopus 로고    scopus 로고
    • Neuropilin-1: A surface marker of regulatory T cells
    • Bruder, D., et al. 2004. Neuropilin-1: a surface marker of regulatory T cells. Eur. J. Immunol. 34:623-630.
    • (2004) Eur. J. Immunol. , vol.34 , pp. 623-630
    • Bruder, D.1
  • 32
  • 33
    • 0036839102 scopus 로고    scopus 로고
    • Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers
    • Almeida, A.R., Legrand, N., Papiernik, M., and Freitas, A.A. 2002. Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J. Immunol. 169:4850-4860.
    • (2002) J. Immunol. , vol.169 , pp. 4850-4860
    • Almeida, A.R.1    Legrand, N.2    Papiernik, M.3    Freitas, A.A.4
  • 34
    • 0036669298 scopus 로고    scopus 로고
    • CD4 regulatory T cells prevent lethal autoimmunity in lL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2
    • Malek, T.R., Yu, A., Vincek, V., Scibelli, P., and Kong, L. 2002. CD4 regulatory T cells prevent lethal autoimmunity in lL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. Immunity. 17:167-178.
    • (2002) Immunity , vol.17 , pp. 167-178
    • Malek, T.R.1    Yu, A.2    Vincek, V.3    Scibelli, P.4    Kong, L.5
  • 35
    • 7144259082 scopus 로고    scopus 로고
    • Regulatory CD4 T cells: Expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency
    • Papiernik, M., de Moraes, M.L., Pontoux, C., Vasseur, F., and Penit, C. 1998. Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency. Int. Immunol. 10:371-378.
    • (1998) Int. Immunol. , vol.10 , pp. 371-378
    • Papiernik, M.1    De Moraes, M.L.2    Pontoux, C.3    Vasseur, F.4    Penit, C.5
  • 36
    • 2942532501 scopus 로고    scopus 로고
    • Costimulation via glucocorticoid-induced TNF receptor in both conventional and CD25+ regulatory CD4+ T cells
    • Kanamaru, F., et al. 2004. Costimulation via glucocorticoid-induced TNF receptor in both conventional and CD25+ regulatory CD4+ T cells. J. Immunol. 172:7306-7314.
    • (2004) J. Immunol. , vol.172 , pp. 7306-7314
    • Kanamaru, F.1
  • 37
    • 6344279933 scopus 로고    scopus 로고
    • Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells
    • Stephens, G.L. et al. 2004. Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells. J. Immunol. 173:5008-5020.
    • (2004) J. Immunol. , vol.173 , pp. 5008-5020
    • Stephens, G.L.1
  • 38
    • 0345598872 scopus 로고    scopus 로고
    • Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells
    • Tone, M., et al. 2003. Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells. Proc. Natl. Acad. Sci. U. S. A. 100:15059-15064.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 15059-15064
    • Tone, M.1
  • 39
    • 0028171297 scopus 로고
    • CD4+CD8- T cells are the effector cells in disease pathogenesis in the scurfy (sf) mouse
    • Blair, P.J., et al. 1994. CD4+CD8- T cells are the effector cells in disease pathogenesis in the scurfy (sf) mouse. J. Immunol. 153:3764-3774.
    • (1994) J. Immunol. , vol.153 , pp. 3764-3774
    • Blair, P.J.1
  • 40
    • 0026043866 scopus 로고
    • Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in a sf thymic environment: Potential model for thymic education
    • Godfrey, V.L., Wilkinson, J.E., Rinchik, E.M., and Russell, L.B. 1991. Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in a sf thymic environment: potential model for thymic education. Proc. Natl. Acad. Sci. U. S. A. 88:5528-5532.
    • (1991) Proc. Natl. Acad. Sci. U. S. A. , vol.88 , pp. 5528-5532
    • Godfrey, V.L.1    Wilkinson, J.E.2    Rinchik, E.M.3    Russell, L.B.4
  • 41
    • 0025317650 scopus 로고
    • The scurfy mouse mutant has previously unrecognized hematological abnormalities and resembles Wiskott-Aldrich syndrome
    • Lyon, M.F., Peters, J., Glenister, P.H., Ball, S., and Wright, E. 1990. The scurfy mouse mutant has previously unrecognized hematological abnormalities and resembles Wiskott-Aldrich syndrome. Proc. Natl. Acad. Sci. U. S. A. 87:2433-2437.
    • (1990) Proc. Natl. Acad. Sci. U. S. A. , vol.87 , pp. 2433-2437
    • Lyon, M.F.1    Peters, J.2    Glenister, P.H.3    Ball, S.4    Wright, E.5
  • 42
    • 0035162560 scopus 로고    scopus 로고
    • Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
    • Brunkow, M.E., et al. 2001. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat. Genet. 27:68-73.
    • (2001) Nat. Genet. , vol.27 , pp. 68-73
    • Brunkow, M.E.1
  • 43
    • 0035167967 scopus 로고    scopus 로고
    • The immune dysregulation, polyendocrinopathy, enteropathy, X-Iinked syndrome (IPEX) is caused by mutations of FOXP3
    • Bennett, C.L., et al. 2001. The immune dysregulation, polyendocrinopathy, enteropathy, X-Iinked syndrome (IPEX) is caused by mutations of FOXP3. Nat. Genet. 27:20-21.
    • (2001) Nat. Genet. , vol.27 , pp. 20-21
    • Bennett, C.L.1
  • 44
    • 0035813231 scopus 로고    scopus 로고
    • Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation
    • Schubert, L.A., Jeffery, E., Zhang, Y., Ramsdell, F., and Ziegler, S.F. 2001. Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation. J. Biol. Chem. 276:37672-37679.
    • (2001) J. Biol. Chem. , vol.276 , pp. 37672-37679
    • Schubert, L.A.1    Jeffery, E.2    Zhang, Y.3    Ramsdell, F.4    Ziegler, S.F.5
  • 45
    • 0037385314 scopus 로고    scopus 로고
    • An essential role for Scurfin in CD4+CD25+ T regulatory cells
    • Khattri, R., Cox, T., Yasayko, S.A., and Ramsdell, F. 2003. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat. Immunol. 4:337-342.
    • (2003) Nat. Immunol. , vol.4 , pp. 337-342
    • Khattri, R.1    Cox, T.2    Yasayko, S.A.3    Ramsdell, F.4
  • 46
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori, S., Nomura, T, and Sakaguchi, S. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science. 299:1057-1061.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 47
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot, J.D., Gavin, M.A., and Rudensky, A.Y. 2003. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 4:330-336.
    • (2003) Nat. Immunol. , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 48
    • 19344374571 scopus 로고    scopus 로고
    • HIV infection of naturally occurring and genetically reprogrammed human regulatory T-cells
    • Oswald-Richter, K., et al. 2004. HIV infection of naturally occurring and genetically reprogrammed human regulatory T-Cells. PLoS Biol. 2:E198.
    • (2004) PLoS Biol. , vol.2
    • Oswald-Richter, K.1
  • 49
    • 8644280556 scopus 로고    scopus 로고
    • Human immunodeficiency virus-driven expansion of CD4+CD25+ regulatory T cells which suppress HIV-specific CD4 T-cell responses in HIV-infected patients
    • doi: 10.1182/blood-2004-01-0365
    • Weiss, L., et al. 2004. Human immunodeficiency virus-driven expansion of CD4+CD25+ regulatory T cells which suppress HIV-specific CD4 T-cell responses in HIV-infected patients. Blood. doi: 10.1182/blood-2004-01-0365.
    • (2004) Blood
    • Weiss, L.1
  • 50
    • 0346969978 scopus 로고    scopus 로고
    • - T cells
    • doi:10.1172/JCI200319441
    • - T cells. J. Clin. Invest. 112:1437-1443. doi:10.1172/JCI200319441.
    • (2003) J. Clin. Invest. , vol.112 , pp. 1437-1443
    • Walker, M.R.1
  • 51
    • 8344275995 scopus 로고    scopus 로고
    • Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells
    • In press
    • Yagi, H., et al. 2004. Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells. Int. Immunol. In press.
    • (2004) Int. Immunol.
    • Yagi, H.1
  • 52
    • 2942733256 scopus 로고    scopus 로고
    • Human CD25+ regulatory T cells: Two subsets defined by the integrins alpha 4 beta 7 or alpha 4 beta 1 confer distinct suppressive properties upon CD4+ T helper cells
    • Stassen, M., et al. 2004. Human CD25+ regulatory T cells: two subsets defined by the integrins alpha 4 beta 7 or alpha 4 beta 1 confer distinct suppressive properties upon CD4+ T helper cells. Eur. J. Immunol. 34:1303-1311.
    • (2004) Eur. J. Immunol. , vol.34 , pp. 1303-1311
    • Stassen, M.1
  • 53
    • 1642410432 scopus 로고    scopus 로고
    • Induction of FOXP3-expressing regulatory CD4pos T cells by human mature autologous dendritic cells
    • Verhasselt, V., et al. 2004. Induction of FOXP3-expressing regulatory CD4pos T cells by human mature autologous dendritic cells. Eur. J. Immunol. 34:762-772.
    • (2004) Eur. J. Immunol. , vol.34 , pp. 762-772
    • Verhasselt, V.1
  • 54
    • 0036379775 scopus 로고    scopus 로고
    • X-chromosome inactivation analysis in a female carrier of FOXP3 mutation
    • Tommasini, A., et al. 2002. X-chromosome inactivation analysis in a female carrier of FOXP3 mutation. Clin. Exp. Immunol. 130:127-130.
    • (2002) Clin. Exp. Immunol. , vol.130 , pp. 127-130
    • Tommasini, A.1
  • 55
    • 0037243827 scopus 로고    scopus 로고
    • CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms
    • Maloy, K.J., et al. 2003. CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. J. Exp. Med. 197:111-119.
    • (2003) J. Exp. Med. , vol.197 , pp. 111-119
    • Maloy, K.J.1
  • 56
    • 0347480215 scopus 로고    scopus 로고
    • CD40 ligation releases immature dendritic cells from the control of regulatory CD4+CD25+ T cells
    • Serra, P., et al. 2003. CD40 ligation releases immature dendritic cells from the control of regulatory CD4+CD25+ T cells. Immunity. 19:877-889.
    • (2003) Immunity , vol.19 , pp. 877-889
    • Serra, P.1
  • 57
    • 0034077559 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells down-regulate costimulatory molecules on antigen-presenting cells
    • Cederbom, L., Hall, H., and Ivars, F. 2000. CD4+CD25+ regulatory T cells down-regulate costimulatory molecules on antigen-presenting cells. Eur. J. Immunol. 30:1538-1543.
    • (2000) Eur. J. Immunol. , vol.30 , pp. 1538-1543
    • Cederbom, L.1    Hall, H.2    Ivars, F.3
  • 58
    • 0031647622 scopus 로고    scopus 로고
    • Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: Induction of autoimmune disease by breaking their anergic/suppressive state
    • Takahashi, T., et al. 1998. Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int. Immunol. 10:1969-1980.
    • (1998) Int. Immunol. , vol.10 , pp. 1969-1980
    • Takahashi, T.1
  • 59
    • 0031821875 scopus 로고    scopus 로고
    • CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
    • Thornton, A.M., and Shevach, E.M. 1998. CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188:287-296.
    • (1998) J. Exp. Med. , vol.188 , pp. 287-296
    • Thornton, A.M.1    Shevach, E.M.2
  • 60
    • 0142242113 scopus 로고    scopus 로고
    • CD4+CD25+ T cells lyse antigen-presenting B cells by Fas-Fas ligand interaction in an epitope-specific manner
    • Janssens, W., Carlier, V., Wu, B., VanderElst, L., Jacquemin, M.G., and Saint-Remy, J.M. 2003. CD4+CD25+ T cells lyse antigen-presenting B cells by Fas-Fas ligand interaction in an epitope-specific manner. J. Immunol. 171:4604-4612.
    • (2003) J. Immunol. , vol.171 , pp. 4604-4612
    • Janssens, W.1    Carlier, V.2    Wu, B.3    VanderElst, L.4    Jacquemin, M.G.5    Saint-Remy, J.M.6
  • 61
    • 2442637772 scopus 로고    scopus 로고
    • Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function
    • Thornton, A.M., Donovan, E.E., Piccirillo, C.A., and Shevach, E.M. 2004. Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function. J. Immunol. 172:6519-6523.
    • (2004) J. Immunol. , vol.172 , pp. 6519-6523
    • Thornton, A.M.1    Donovan, E.E.2    Piccirillo, C.A.3    Shevach, E.M.4
  • 62
    • 1642390941 scopus 로고    scopus 로고
    • Activation requirements for the induction of CD4+CD25+ T cell suppressor function
    • Thornton, A.M., Piccirillo, C.A., and Shevach, E.M. 2004. Activation requirements for the induction of CD4+CD25+ T cell suppressor function. Eur. J. Immunol. 34:366-376.
    • (2004) Eur. J. Immunol. , vol.34 , pp. 366-376
    • Thornton, A.M.1    Piccirillo, C.A.2    Shevach, E.M.3
  • 63
    • 0042512461 scopus 로고    scopus 로고
    • Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells
    • Yamazaki, S., et al. 2003. Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells. J. Exp. Med. 198:235-247.
    • (2003) J. Exp. Med. , vol.198 , pp. 235-247
    • Yamazaki, S.1
  • 64
    • 0037436119 scopus 로고    scopus 로고
    • Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
    • Pasare, C., and Medzhitov, R. 2003. Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science. 299:1033-1036.
    • (2003) Science , vol.299 , pp. 1033-1036
    • Pasare, C.1    Medzhitov, R.2
  • 66
    • 0033523607 scopus 로고    scopus 로고
    • An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
    • Asseman, C., Mauze, S., Leach, M.W., Coffman, R.L., and Powrie, F. 1999. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 190:995-1004.
    • (1999) J. Exp. Med. , vol.190 , pp. 995-1004
    • Asseman, C.1    Mauze, S.2    Leach, M.W.3    Coffman, R.L.4    Powrie, F.5
  • 67
    • 0034967640 scopus 로고    scopus 로고
    • Differential cytokine requirements for regulation of autoimmune gastritis and colitis by CD4(+)CD25(+) T cells
    • Suri-Payer, E., and Cantor, H. 2001. Differential cytokine requirements for regulation of autoimmune gastritis and colitis by CD4(+)CD25(+) T cells. J. Autoimmun. 16:115-123.
    • (2001) J. Autoimmun. , vol.16 , pp. 115-123
    • Suri-Payer, E.1    Cantor, H.2
  • 68
    • 0029813545 scopus 로고    scopus 로고
    • Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses
    • Berg, D.J., et al. 1996. Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses. J. Clin. Invest. 98:1010-1020.
    • (1996) J. Clin. Invest. , vol.98 , pp. 1010-1020
    • Berg, D.J.1
  • 69
    • 0029956024 scopus 로고    scopus 로고
    • A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells
    • Powrie, F., Carlino, J., Leach, M.W., Mauze, S., and Coffman, R.L. 1996. A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells. J. Exp. Med. 183:2669-2674.
    • (1996) J. Exp. Med. , vol.183 , pp. 2669-2674
    • Powrie, F.1    Carlino, J.2    Leach, M.W.3    Mauze, S.4    Coffman, R.L.5
  • 70
    • 0035801335 scopus 로고    scopus 로고
    • Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta
    • Nakamura, K., Kitani, A., and Strober, W. 2001. Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J. Exp. Med. 194:629-644.
    • (2001) J. Exp. Med. , vol.194 , pp. 629-644
    • Nakamura, K.1    Kitani, A.2    Strober, W.3
  • 71
    • 0037371301 scopus 로고    scopus 로고
    • CD4+CD25- T cells that express latency-associated peptide on the surface suppress CD4+CD45RBhigh-induced colitis by a TGF-beta-dependent mechanism
    • Oida, T., et al. 2003. CD4+CD25- T cells that express latency-associated peptide on the surface suppress CD4+CD45RBhigh-induced colitis by a TGF-beta-dependent mechanism. J. Immunol. 170:2516-2522.
    • (2003) J. Immunol. , vol.170 , pp. 2516-2522
    • Oida, T.1
  • 72
    • 0037099613 scopus 로고    scopus 로고
    • CD4(+)CD25(+) regulatory T cells can mediate suppressor function in ehe absence of transforming growth factor beta1 production and responsiveness
    • Piccirillo, C.A., et al. 2002. CD4(+)CD25(+) regulatory T cells can mediate suppressor function in ehe absence of transforming growth factor beta1 production and responsiveness. J. Exp. Med. 196:237-246.
    • (2002) J. Exp. Med. , vol.196 , pp. 237-246
    • Piccirillo, C.A.1
  • 73
    • 0035887739 scopus 로고    scopus 로고
    • Activation of CD25(+)CD4(+) regulatory T cells by oral antigen administration
    • Zhang, X., Izikson, L., Liu, L., and Weiner, H.L. 2001. Activation of CD25(+)CD4(+) regulatory T cells by oral antigen administration. J. Immunol. 167:4245-4253.
    • (2001) J. Immunol. , vol.167 , pp. 4245-4253
    • Zhang, X.1    Izikson, L.2    Liu, L.3    Weiner, H.L.4
  • 74
    • 4644369302 scopus 로고    scopus 로고
    • Interleukin-2 is essential for CD4(+)CD25(+) regulatory T cell function
    • De La Rosa, M., Rutz, S., Dorninger, H., and Scheffold, A. 2004. Interleukin-2 is essential for CD4(+)CD25(+) regulatory T cell function. Eur. J. Immunol. 34:2480-2488.
    • (2004) Eur. J. Immunol. , vol.34 , pp. 2480-2488
    • De La Rosa, M.1    Rutz, S.2    Dorninger, H.3    Scheffold, A.4
  • 75
    • 0036852170 scopus 로고    scopus 로고
    • CTLA-4-Ig regulates tryptophan catabolism in vivo
    • Grohmann, U., et al. 2002. CTLA-4-Ig regulates tryptophan catabolism in vivo. Nat. Immunol. 3:1097-1101.
    • (2002) Nat. Immunol. , vol.3 , pp. 1097-1101
    • Grohmann, U.1
  • 76
    • 0346119234 scopus 로고    scopus 로고
    • Modulation of tryptophan catabolism by regulatory T cells
    • Fallarino, F., et al. 2003. Modulation of tryptophan catabolism by regulatory T cells. Nat. Immunol. 4:1206-1212.
    • (2003) Nat. Immunol. , vol.4 , pp. 1206-1212
    • Fallarino, F.1
  • 77
    • 1642396607 scopus 로고    scopus 로고
    • Ligation of B7-1/B7-2 by human CD4(+) T cells triggers indoleamine 2,3-dioxygenase activity in dendritic cells
    • Munn, D.H., Sharma, M.D., and Mellor, A.L 2004. Ligation of B7-1/B7-2 by human CD4(+) T cells triggers indoleamine 2,3-dioxygenase activity in dendritic cells. J. Immunol. 172:4100-4110.
    • (2004) J. Immunol. , vol.172 , pp. 4100-4110
    • Munn, D.H.1    Sharma, M.D.2    Mellor, A.L.3
  • 78
    • 0036669785 scopus 로고    scopus 로고
    • The interaction properties of costimulatory molecules revisited
    • Collins, A.V., et al. 2002. The interaction properties of costimulatory molecules revisited. Immunity. 17:201-210.
    • (2002) Immunity , vol.17 , pp. 201-210
    • Collins, A.V.1
  • 79
    • 0035421654 scopus 로고    scopus 로고
    • Cutting edge: Control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells
    • Piccirillo, C.A., and Shevach, E.M. 2001. Cutting edge: control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells. J. Immunol. 167:1137-1140.
    • (2001) J. Immunol. , vol.167 , pp. 1137-1140
    • Piccirillo, C.A.1    Shevach, E.M.2
  • 80
    • 3142708571 scopus 로고    scopus 로고
    • Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease
    • Paust, S., Lu, L., McCarty, N., and Cantor, H. 2004. Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease. Proc. Natl. Acad. Sci. U. S. A. 101:10398-10403.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 10398-10403
    • Paust, S.1    Lu, L.2    McCarty, N.3    Cantor, H.4
  • 81
    • 0031092641 scopus 로고    scopus 로고
    • B7.2 expressed by T cells does not induce CD28-mediated costimulatory activity but retains CTLA4 binding: Implications for induction of antitumor immunity to T cell tumors
    • Greenfield, E.A., et al. 1997. B7.2 expressed by T cells does not induce CD28-mediated costimulatory activity but retains CTLA4 binding: implications for induction of antitumor immunity to T cell tumors. J. Immunol. 158:2025-2034.
    • (1997) J. Immunol. , vol.158 , pp. 2025-2034
    • Greenfield, E.A.1
  • 82
    • 0028963227 scopus 로고
    • Reciprocal expression of co-stimulatory molecules, B7-1 and B7-2, on murine T cells following activation
    • Prabhu Das, M.R., et al. 1995. Reciprocal expression of co-stimulatory molecules, B7-1 and B7-2, on murine T cells following activation. Eur. J. Immunol. 25:207-211.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 207-211
    • Prabhu Das, M.R.1
  • 83
    • 0038068048 scopus 로고    scopus 로고
    • The CD4-related molecule, LAG-3 (CD223), regulates the expansion of activated T cells
    • Workman, C.J., and Vignali, D.A. 2003. The CD4-related molecule, LAG-3 (CD223), regulates the expansion of activated T cells. Eur. J. Immunol. 33:970-979.
    • (2003) Eur. J. Immunol. , vol.33 , pp. 970-979
    • Workman, C.J.1    Vignali, D.A.2
  • 84
    • 5644263642 scopus 로고    scopus 로고
    • Role of LAG-3 in regulatory T cells
    • In press
    • Huang, C.-T., et al. Role of LAG-3 in regulatory T cells. Immunity. In press.
    • Immunity
    • Huang, C.-T.1
  • 85
    • 2542420993 scopus 로고    scopus 로고
    • In vivo instruction of suppressor commitment in naive T cells
    • Apostolou, I., and Von Boehmer, H. 2004. In vivo instruction of suppressor commitment in naive T cells. J. Exp. Med. 199:1401-1408.
    • (2004) J. Exp. Med. , vol.199 , pp. 1401-1408
    • Apostolou, I.1    Von Boehmer, H.2
  • 86
    • 0002384347 scopus 로고
    • Induction of immunological paralysis in two zones of dosage
    • Mitchison, N.A. 1964. Induction of immunological paralysis in two zones of dosage. Proc. R. Soc. Lond. B Biol. Sci. 161:275-292.
    • (1964) Proc. R. Soc. Lond. B Biol. Sci. , vol.161 , pp. 275-292
    • Mitchison, N.A.1
  • 87
    • 0036372440 scopus 로고    scopus 로고
    • Transforming growth factor-beta in T-Cell biology
    • Gorelik, L., and Flavell, R.A. 2002. Transforming growth factor-beta in T-Cell biology. Nat. Rev. Immunol. 2:46-53.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 46-53
    • Gorelik, L.1    Flavell, R.A.2
  • 88
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    • Chen, W., et al. 2003. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J. Exp. Med. 198:1875-1886.
    • (2003) J. Exp. Med. , vol.198 , pp. 1875-1886
    • Chen, W.1
  • 89
    • 0030704726 scopus 로고    scopus 로고
    • A CD4+ T-cell subset inhibits antigen-specific T-Cell responses and prevents colitis
    • Groux, H., et al. 1997. A CD4+ T-cell subset inhibits antigen-specific T-Cell responses and prevents colitis. Nature. 389:737-742.
    • (1997) Nature , vol.389 , pp. 737-742
    • Groux, H.1
  • 90
    • 0028037782 scopus 로고
    • Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
    • Chen, Y., Kuchroo, V.K., Inobe, J., Hafler, D.A., and Weiner, H.L. 1994. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science. 265:1237-1240.
    • (1994) Science , vol.265 , pp. 1237-1240
    • Chen, Y.1    Kuchroo, V.K.2    Inobe, J.3    Hafler, D.A.4    Weiner, H.L.5
  • 91
    • 0038631849 scopus 로고    scopus 로고
    • Type 1 T-regulatory cells: Their role in the control of immune responses
    • Groux, H. 2003. Type 1 T-regulatory cells: their role in the control of immune responses. Transplantation. 75(Suppl. 9):8S-12S.
    • (2003) Transplantation , vol.75 , Issue.SUPPL. 9
    • Groux, H.1
  • 92
    • 0037018104 scopus 로고    scopus 로고
    • In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines
    • Barrat, F.J., et al. 2002. In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J. Exp. Med. 195:603-616.
    • (2002) J. Exp. Med. , vol.195 , pp. 603-616
    • Barrat, F.J.1
  • 93
    • 2442450433 scopus 로고    scopus 로고
    • IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells
    • Vieira, P.L., et al. 2004. IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells. J. Immunol. 172:5986-5993.
    • (2004) J. Immunol. , vol.172 , pp. 5986-5993
    • Vieira, P.L.1
  • 94
    • 0035881234 scopus 로고    scopus 로고
    • Regulatory T cells induced by 1 alpha,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance
    • Gregori, S., et al. 2001. Regulatory T cells induced by 1 alpha,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance. J. Immunol. 167:1945-1953.
    • (2001) J. Immunol. , vol.167 , pp. 1945-1953
    • Gregori, S.1
  • 95
    • 0347895101 scopus 로고    scopus 로고
    • Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype
    • Kemper, C., et al. 2003. Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype. Nature. 421:388-392.
    • (2003) Nature , vol.421 , pp. 388-392
    • Kemper, C.1
  • 96
    • 0037339812 scopus 로고    scopus 로고
    • Regulatory dendritic cells protect mice from murine acute graft-versus-host disease and leukemia relapse
    • Sato, K., Yamashita, N., Baba, M., and Matsuyama, T. 2003. Regulatory dendritic cells protect mice from murine acute graft-versus-host disease and leukemia relapse. Immunity. 18:367-379.
    • (2003) Immunity , vol.18 , pp. 367-379
    • Sato, K.1    Yamashita, N.2    Baba, M.3    Matsuyama, T.4
  • 97
    • 0012391130 scopus 로고    scopus 로고
    • Modified myeloid dendritic cells act as regulatory dendritic cells to induce anergic and regulatory T cells
    • Sato, K., Yamashita, N., Baba, M., and Matsuyama, T. 2003. Modified myeloid dendritic cells act as regulatory dendritic cells to induce anergic and regulatory T cells. Blood. 101:3581-3589.
    • (2003) Blood , vol.101 , pp. 3581-3589
    • Sato, K.1    Yamashita, N.2    Baba, M.3    Matsuyama, T.4
  • 98
    • 0034613767 scopus 로고    scopus 로고
    • Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells
    • Jonuleit, H., Schmitt, E., Schuler, G., Knop, J., and Enk, A.H. 2000. Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J. Exp. Med. 192:1213-1222.
    • (2000) J. Exp. Med. , vol.192 , pp. 1213-1222
    • Jonuleit, H.1    Schmitt, E.2    Schuler, G.3    Knop, J.4    Enk, A.H.5
  • 100
    • 0033571105 scopus 로고    scopus 로고
    • Induction of tumor immunity by removing CD25+CD4+ T cells: A common basis between tumor immunity and autoimmunity
    • Shimizu, J., Yamazaki, S., and Sakaguchi, S. 1999. Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity. J. Immunol. 163:5211-5218.
    • (1999) J. Immunol. , vol.163 , pp. 5211-5218
    • Shimizu, J.1    Yamazaki, S.2    Sakaguchi, S.3
  • 101
    • 0035903324 scopus 로고    scopus 로고
    • Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses
    • Sutmuller, R.P., etal. 2001. Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses. J. Exp. Med. 194:823-832.
    • (2001) J. Exp. Med. , vol.194 , pp. 823-832
    • Sutmuller, R.P.1
  • 102
    • 0141461418 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation
    • Edinger, M., et al. 2003. CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat. Med. 9:1144-1150.
    • (2003) Nat. Med. , vol.9 , pp. 1144-1150
    • Edinger, M.1
  • 103
    • 0346690399 scopus 로고    scopus 로고
    • + regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia
    • doi:10.1172/JCI200317702
    • + regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia. J. Clin. Invest. 112:1688-1696. doi:10.1172/JCI200317702.
    • (2003) J. Clin. Invest. , vol.112 , pp. 1688-1696
    • Trenado, A.1
  • 104
    • 4344653864 scopus 로고    scopus 로고
    • Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3+CD25+CD4+ regulatory T cells
    • Nishimura, E., Sakihama, T., Setoguchi, R., Tanaka, K., and Sakaguchi, S. 2004. Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3+CD25+CD4+ regulatory T cells. Int. Immunol. 16:1189-1201.
    • (2004) Int. Immunol. , vol.16 , pp. 1189-1201
    • Nishimura, E.1    Sakihama, T.2    Setoguchi, R.3    Tanaka, K.4    Sakaguchi, S.5
  • 105
    • 0037025943 scopus 로고    scopus 로고
    • Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation
    • Hoffmann, P., Ermann, J., Edinger, M., Fathman, C.G., and Strober, S. 2002. Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J. Exp. Med. 196:389-399.
    • (2002) J. Exp. Med. , vol.196 , pp. 389-399
    • Hoffmann, P.1    Ermann, J.2    Edinger, M.3    Fathman, C.G.4    Strober, S.5
  • 106
    • 3543097547 scopus 로고    scopus 로고
    • Suppressor T cells in human diseases
    • Baecher-Allan, C., and Hafler, D.A. 2004. Suppressor T cells in human diseases. J. Exp. Med. 200:273-276.
    • (2004) J. Exp. Med. , vol.200 , pp. 273-276
    • Baecher-Allan, C.1    Hafler, D.A.2
  • 107
    • 1842732224 scopus 로고    scopus 로고
    • Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis
    • Viglietta, V., Baecher-Allan, C., Weiner, H.L., and Hafler, D.A. 2004. Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J. Exp. Med. 199:971-979.
    • (2004) J. Exp. Med. , vol.199 , pp. 971-979
    • Viglietta, V.1    Baecher-Allan, C.2    Weiner, H.L.3    Hafler, D.A.4
  • 108
    • 3042594506 scopus 로고    scopus 로고
    • Allergen-responsive CD4+CD25+ regulatory T cells in children who have outgrown cow's milk allergy
    • Karlsson, M.R., Rugtveit, J., and Brandtzaeg, P. 2004. Allergen-responsive CD4+CD25+ regulatory T cells in children who have outgrown cow's milk allergy. J. Exp. Med. 199:1679-1688.
    • (2004) J. Exp. Med. , vol.199 , pp. 1679-1688
    • Karlsson, M.R.1    Rugtveit, J.2    Brandtzaeg, P.3
  • 109
    • 3543140687 scopus 로고    scopus 로고
    • Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFα therapy
    • Ehrenstein, M.R., et al. 2004. Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFα therapy. J. Exp. Med. 200:277-285.
    • (2004) J. Exp. Med. , vol.200 , pp. 277-285
    • Ehrenstein, M.R.1
  • 110
    • 3543098686 scopus 로고    scopus 로고
    • CD25+CD4+ regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4+ and CD8+ HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status
    • Kinter, A.L., et al. 2004. CD25+CD4+ regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4+ and CD8+ HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status. J. Exp. Med. 200:331-343.
    • (2004) J. Exp. Med. , vol.200 , pp. 331-343
    • Kinter, A.L.1
  • 111
    • 0037261145 scopus 로고    scopus 로고
    • Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis
    • Cao, D., et al. 2003. Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis. Eur. J. Immunol. 33:215-223.
    • (2003) Eur. J. Immunol. , vol.33 , pp. 215-223
    • Cao, D.1
  • 112
    • 15244361536 scopus 로고    scopus 로고
    • CD25brightCD4+ regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease
    • Cao, D., van Vollenhoven, R., Klareskog, L., Trollmo, C., and Malmstrom, V. 2004. CD25brightCD4+ regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease. Arthritis Res. Ther. 6:R335-R346.
    • (2004) Arthritis Res. Ther. , vol.6
    • Cao, D.1    Van Vollenhoven, R.2    Klareskog, L.3    Trollmo, C.4    Malmstrom, V.5


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