Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3+ CD25+ CD4+ regulatory T cells

International Immunology

Volumn 16, Issue 8, 2004, Pages 1189-1201

  Nishimura, Eiji ^a,b   Sakihama, Toshiko ^a,e   Setoguchi, Ruka ^a   Tanaka, Koichi ^b   Sakaguchi, Shimon ^a,c,d  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^e UNIVERSITY OF TOKYO   (Japan)

Author keywords

CTLA 4; GITR; Transplantation tolerance

Indexed keywords

ALLOANTIGEN; CD4 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GLUCOCORTICOID; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNE DISEASE; CELL ACTIVITY; CELL TRANSFER; CONTROLLED STUDY; FEMALE; GRAFT REJECTION; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; CD4-POSITIVE T-LYMPHOCYTES; CELL COUNT; CELLS, CULTURED; DNA-BINDING PROTEINS; FORKHEAD TRANSCRIPTION FACTORS; MICE; MICE, INBRED BALB C; RECEPTORS, INTERLEUKIN-2; RECEPTORS, NERVE GROWTH FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR; SKIN TRANSPLANTATION; TRANSPLANTATION TOLERANCE; TRANSPLANTATION, HOMOLOGOUS;

EID: 4344653864     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/dxh122     Document Type: Article

References (59)

1. + regulatory T cells: their common role in controlling autoimmunity, tumor immunity and transplantation tolerance. Immunol. Rev. 182:18.
2. Maloy, K. J. and Powrie, F. 2001. Regulatory T cells in the control of immune pathology. Nat. Immunol. 2:816.
3. + suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2:389.
4. Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M. and Toda, M. 1995. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155:1151.
5. Asano, M., Toda, M., Sakaguchi, N. and Sakaguchi, S. 1996. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. 184:387.
6. + T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J. Immunol. 160:1212.
7. + T cells: a common basis between tumor immunity and autoimmunity. J. Immunol. 163:5211.
8. + regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses. J. Exp. Med. 194:823.
9. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J. Immunol. 162:5317.
10. + naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int. Immunol. 10:1969.
11. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188:287.
12. + immunoregulatory T cells is antigen nonspecific. J. Immunol. 164:183.
13. + immunoregulatory T cells that control autoimmune diabetes. Immunity 12:431.
14. + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 192:303.
15. + regulatory cells that control intestinal inflammation. J. Exp. Med. 192:295.
16. + regulatory T cells through GITR breaks immunological self-tolerance. Nat. Immunol. 3:135.
17. + immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 16:311.
18. - regulatory T cells. Proc. Natl Acad. Sci. USA 99:13031.
19. Caramalho, I., Lopes-Carvalho, T., Ostler, D., Zelenay, S., Haury, M. and Demengeot, J. 2003. Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide. J. Exp. Med. 197:403.
20. Hori, S., Nomura, T. and Sakaguchi, S. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science 299:1057.
21. + T regulatory cells. Nat. Immunol. 4:337.
22. + regulatory T cells. Nat. Immunol. 4:330.
23. + regulatory T cells in vivo. J. Exp. Med. 198:249.
24. Klein, L., Khazaie, K. and von Boehmer, H. 2003. In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro. Proc. Natl Acad. Sci. USA 100: 8886.
25. + regulatory T cells by antigen-processing dendritic cells. J. Exp. Med. 198:235.
26. + T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10. J. Immunol. 166:3008.
27. + suppressor T cells in vivo. Nat. Immunol. 3:33.
28. + regulatory T cells in the steady state. J. Exp. Med. 198:737.
29. + regulatory T cells: implications of their broad repertoire and high self-reactivity for the maintenance of immunological self-tolerance. Novartis Found. Symp. 252:6.
30. + suppressor cell and its mechanisms of action. J. Exp. Med. 171:141.
31. Cobbold, S. P., Qin, S., Leong, L. Y., Martin, G. and Waldmann, H. 1992. Reprogramming the immune system for peripheral tolerance with CD4 and CD8 monoclonal antibodies. Immunol. Rev. 129:165.
32. Hara, M., Kingsley, C. I., Niimi, M., Read, S., Turvey, S. E., Bushell, A. R., Morris, P. J., Powrie, F. and Wood, K. J. 2001. IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. J. Immunol. 166:3789.
33. + immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade. J. Exp. Med. 193:1311.
34. Gregori, S., Casorati, M., Amuchastegui, S., Smiroldo, S., Davalli, A. M. and Adorini, L. 2001. Regulatory T cells induced by 1 alpha,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance. J. Immunol. 167:1945.
35. + T cells induced by donor dendritic cells in allograft tolerance by LF15-0195 treatment. J. Immunol. 168:5058.
36. Qin, S., Cobbold, S. P., Pope, H., Elliott, J., Kioussis, D., Davies, J. and Waldmann, H. 1993. 'Infectious' transplantation tolerance. Science 259:974.
37. + T helper cells. J. Exp. Med. 196:255.
38. + regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells [corrected]. J. Exp. Med. 196:247.
39. MacDonald, H. R., Schneider, R., Lees, R. K., Howe, R. C., Acha-Orbea, H., Festenstein, H., Zinkernagel, R. M. and Hengartner, H. 1988. T-cell receptor V beta use predicts reactivity and tolerance to Mlsa-encoded antigens. Nature 332:40.
40. MacDonald, H. R., Blanc, C., Lees, R. K. and Sordat, B. 1986. Abnormal distribution of T cell subsets in athymic mice. J. Immunol. 136:4337.
41. Auchincloss, J. J., Sykes, M. and Sachs, D. H. 1999. Transplantation Immunology. In Paul, W. E., ed., Fundamental Immunology, 4th edition, p. 1175. Lippincott-Raven, Philadelphia.
42. Graca, L., Cobbold, S. P. and Waldmann, H. 2002. Identification of regulatory T cells in tolerated allografts. J. Exp. Med. 195:1641.
43. Barthlott, T., Kassiotis, G. and Stockinger, B. 2003. T cell regulation as a side effect of homeostasis and competition. J. Exp. Med. 197:451.
44. + T cell numbers. J. Immunol. 169:4850.
45. + T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation. Int. Immunol. 12:1145.
46. + regulatory T cell function. J. Exp. Med. 196:851.
47. + T cells. Proc. Natl Acad. Sci. USA 99:8832.
48. - regulatory cells mediate dominant transplantation tolerance. J. Immunol. 168:5558.
49. + regulatory T cells prevent graft rejection: CTLA-4- and L-10-dependent immunoregulation of alloresponses. J. Immunol. 168:1080.
50. Stephens, L. A. and Mason, D. 2000. CD25 is a marker for CD4+ thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are found in both CD25+ and CD25- subpopulations. J. Immunol. 165:3105.
51. + regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 22:531.
52. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389:737.
53. + T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J. Exp. Med. 195:603.
54. + regulatory T cells by TGF-beta induction of transcription factor Foxp3. J. Exp. Med. 198:1875.
55. + immune regulatory cells inhibits graft-versus-host disease lethality. Blood 99:3493.
56. + immunoregulatory T cells: new therapeutics for graft-versus-host disease. J. Exp. Med. 196:401.
57. Lenardo, M. J. 1991. Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis. Nature 353:858.
58. Chatenoud, L. 2003. CD3-specific antibody-induced active tolerance: from bench to bedside. Nat. Rev. Immunol. 3:123.
59. Samstein, B. and Emond, J. 2001. Liver transplants from living related donors. Annu. Rev. Med. 52:147.