Cutting edge: Control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells

Journal of Immunology

Volumn 167, Issue 3, 2001, Pages 1137-1140

  Piccirillo, C A ^a   Shevach, E M ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; POLYCLONAL ANTIBODY; TETRAMER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY SPECIFICITY; ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; FEMALE; IMMUNOREGULATION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION; T LYMPHOCYTE;

EID: 0035421654     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.3.1137     Document Type: Article

References (23)

1. Suppressor T cells: Rebirth, function and homeostasis
2. + T cell subset that inhibits this autoimmune potential
3. Regulatory T cells: Key controllers of immunologic self-tolerance
4. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25): Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
5. + T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice
6. T cell-mediated maintenance of natural self-tolerance: Its breakdown as a possible cause of various autoimmune diseases
7. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation
8. + immunoregulatory T cells that control autoimmune diabetes
9. + naturally anergic and suppressive T cells: Induction of autoimmune disease by breaking their anergic/suppressive state
10. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
11. + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
12. + immunoregulatory T cells is antigen nonspecific
13. + regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells
14. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance
15. + T cells do not require costimulation for proliferation and differentiation into cytotoxic effector cells
16. Regulation of self-tolerance by CD80/CD86 interactions
17. CD28, IL-2-independent costimulatory pathways for CD8 T lymphocyte activation
18. + T cells in organ-specific autoimmune diseases: Insight from transgenic mouse models
19. A mouse CD8 T cell-mediated acute autoimmune diabetes independent of the perforin and Fas cytotoxic pathways: Possible role of membrane TNF
20. CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells
21. The role of CD4 and CD8 T cells in type I diabetes in the NOD mouse
22. + T cells promotes minimal cell cycling but maximal cytokine synthesis and autonomous proliferation subsequently: A mechanism of self-regulation
23. + T cells