Activation of CD25+CD4+ regulatory T cells by oral antigen administration

Journal of Immunology

Volumn 167, Issue 8, 2001, Pages 4245-4253

  Zhang, X ^a   Izikson, L ^a   Liu, L ^a   Weiner, H L ^a  

^a Brigham and Women's Hospital Center for Neurologic Diseases   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CD4 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR; OVALBUMIN; TRANSFORMING GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; CELL PROLIFERATION; CLONAL ANERGY; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; FLOW CYTOMETRY; FOOD ALLERGY; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TRANSGENIC MOUSE;

EID: 0035887739     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.8.4245     Document Type: Article

References (41)

1. Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. 1. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease
2. Self tolerance and localized autoimmunity: Mouse models of autoimmune disease that suggest tissue-specific suppressor T cells are involved in self tolerance
3. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
4. Control of immune pathology by regulatory T cells
5. The third function of the thymus
6. Regulatory T-cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
7. + T-cells are important for the balance between protective and pathogenic cell-mediated immunity
8. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation
9. + T-cells inhibit both the induction and effector function of autoreactive T-cells and represent a unique lineage of immunoregulatory cells
10. + naturally anergic and suppressive T cells: Induction of autoimmune disease by breaking their anergic/suppressive state
11. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
12. Regulatory CD4 T-cells: Expression of IL-2Rα-chain, resistance to clonal deletion and IL-2 dependency
13. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance
14. + T cells: A common basis between tumor immunity and autoimmunity
15. Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor α) monoclonal antibody
16. Post-thymectomy autoimmune gastritis: Fine specificity and pathogenicity of anti-H/K ATPase-reactive T cells
17. + immunoregulatory T cells is antigen nonspecific
18. + cells regulate CD8 cell anergy in neonatal tolerant mice
19. + T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation
20. + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
21. + regulatory cells that control intestinal inflammation
22. + immunoregulatory T cells that control autoimmune diabetes
23. - subpopulations
24. + regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells
25. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor a-chains (CD25): Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
26. The regulation of immune responses to dietary protein antigens
27. Oral tolerance: Mechanisms and therapeutic applications
28. Peripheral deletion of antigen-reactive T-cells in oral tolerance
29. Oral tolerance in myelin basic protein T-cell receptor transgenic mice: Suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells
30. low thymocytes in vivo
31. Mice lacking NK cells develop an efficient Th1 response and control cutaneous Leishmania major infection
32. IL-4 is a differentiation factor for transforming growth factor-β secreting Th3 cells and oral administration of IL-4 enhances oral tolerance in experimental allergic encephalomyelitis
33. CD28-mediated signaling co-stimulates murine T-cells and prevents induction of anergy in T-cell clones
34. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
35. + T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10
36. + T-cells
37. Suppressor T-cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of TGF-β following antigen specific triggering
38. B7.2 (CD86) but not B7.1 (CD80) costimulation is required for the induction of low dose oral tolerance
39. CTLA-4 is required for the induction of high dose oral tolerance
40. + regulatory T cells is mediated by cell surface-bound transforming growth factor β
41. + T cells in vivo after induction of peripheral tolerance with intravenous or oral antigen