CD4+ CD25high regulatory cells in human peripheral blood

Journal of Immunology

Volumn 167, Issue 3, 2001, Pages 1245-1253

  Baecher Allan, C ^a   Brown, J A ^a   Freeman, G J ^a   Hafler, D A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; T LYMPHOCYTE RECEPTOR; ABATACEPT; ANTIBODY CONJUGATE; B7 ANTIGEN; CD274 PROTEIN, HUMAN; CD4 ANTIGEN; CD45 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; CYTOTOXIC T-LYMPHOCYTE ANTIGEN 4; DIFFERENTIATION ANTIGEN; HLA DR ANTIGEN; IMMUNOSUPPRESSIVE AGENT; LEUKOCYTE ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN; MESSENGER RNA; PEPTIDE; PLASMA PROTEIN;

ARTICLE; AUTOIMMUNE DISEASE; CELL FUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; CROSS LINKING; CYTOKINE RELEASE; HUMAN; HUMAN CELL; IMMUNOREGULATION; PRIORITY JOURNAL; T LYMPHOCYTE; THYMECTOMY; BIOSYNTHESIS; BLOOD; CD4+ T LYMPHOCYTE; CELL CULTURE; COCULTURE; DRUG ANTAGONISM; GENETICS; IMMUNOLOGY; KINETICS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION;

ANTIGENS, CD; ANTIGENS, CD4; ANTIGENS, CD45; ANTIGENS, CD80; ANTIGENS, DIFFERENTIATION; BLOOD PROTEINS; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; COCULTURE TECHNIQUES; HLA-DR ANTIGENS; HUMANS; IMMUNOCONJUGATES; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-2; KINETICS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MEMBRANE GLYCOPROTEINS; PEPTIDES; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, INTERLEUKIN-2; RNA, MESSENGER; SIGNAL TRANSDUCTION; T-LYMPHOCYTE SUBSETS;

EID: 0035413350     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.3.1245     Document Type: Article

References (36)

1. Recognition of human insulin in the context of HLA-DRB1*0406 products by T cells of insulin autoimmune syndrome patients and healthy donors
2. A method to study induction of autoimmunity in vitro: Co-culture of lacrimal cells and autologous immune system cells
3. T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis
4. Genetic susceptibility to post-thymectomy autoimmune diseases in mice
5. Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance: Deficit of a T cell subset as a possible cause of autoimmune disease
6. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation
7. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25): Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
8. + immunoregulatory T cells that control autoimmune diabetes
9. + regulatory cells that control intestinal inflammation
10. + T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells
11. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
12. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance
13. Regulatory CD4 T cells: Expression of IL-2R α chain, resistance to clonal deletion and IL-2 dependency
14. - regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
15. + thymocytes and peripheral T cells have immune suppressive activity in vitro
16. PD-L2 is a second ligand for PD-I and inhibits T cell activation
17. Paradoxical inhibition of T-cell function in response to CTLA-4 blockade: Heterogeneity within the human T-cell population
18. PCR analysis of cytokine induction profiles associated with mouse strain variation in susceptibility to pulmonary fibrosis
19. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
20. Ia determinants on stimulated human T lymphocytes: Occurrence on mitogen- and antigen-activated T cells
21. Transferrin receptor in T cell activation and transplantation
22. + T cells
23. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
24. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
25. Interleukin-4 and interleukin-10 synergize to inhibit cell-mediated immunity in vivo
26. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death
27. Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes
28. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
29. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
30. CD28/B7 costimulation: A review
31. Activation-induced expression of human programmed death-1 gene in T-lymphocytes
32. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
33. Regulatory T cells: Key controllers of immunologic self-tolerance
34. - subpopulations
35. Expression of a hypoglycosylated form of CD86 (B7-2) on human T cells with altered binding properties to CD28 and CTLA-4
36. Early signaling defects in human T cells anergized by T cell presentation of autoantigen