Allergen-responsive CD4+CD25+ regulatory T cells in children who have outgrown cow's milk allergy

Journal of Experimental Medicine

Volumn 199, Issue 12, 2004, Pages 1679-1688

  Karlsson, Malin R ^a,c   Rugtveit, Jarle ^a,b   Brandtzaeg, Per ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Cytokines; Food allergy; Human; Oral tolerance; Regulatory T cells

Indexed keywords

BETA LACTOGLOBULIN; CD4 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR; PHYTOHEMAGGLUTININ; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CLINICAL ARTICLE; CYTOKINE RELEASE; EFFECTOR CELL; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; IMMUNOLOGICAL TOLERANCE; INFANT; LYMPHOCYTE PROLIFERATION; MILK ALLERGY; MUCOSAL IMMUNITY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRESCHOOL CHILD; PRIORITY JOURNAL; PROVOCATION TEST; T LYMPHOCYTE;

EID: 3042594506     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20032121     Document Type: Article

References (60)

1. Brandtzaeg, P.E. 2002. Current understanding of gastrointestinal immunoregulation and its relation to food allergy. Ann. NY Acad. Sci. 964:13-45.
2. Waldo, F.B., A.W. van den Wall Bake, J. Mestecky, and S. Husby. 1994. Suppression of the immune response by nasal immunization. Clin. Immunol. Immunopathol. 72:30-34.
3. Husby, S., J. Mestecky, Z. Moldoveanu, S. Holland, and C.O. Elson. 1994. Oral tolerance in humans. T cell but not B cell tolerance after antigen feeding. J. Immunol. 152:4663-4670.
4. Yazdanbakhsh, M., P.G. Kremsner, and R. van Ree. 2002. Allergy, parasites, and the hygiene hypothesis. Science. 296: 490-494.
5. Wildin, R.S., S. Smyk-Pearson, and A.H. Filipovich. 2002. Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome. J. Med. Genet. 39:537-545.
6. Chatila, T.A., F. Blaeser, N. Ho, H.M. Lederman, C. Voulgaropoulos, C. Helms, and A.M. Bowcock. 2000. JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome. J. Clin. Invest. 106:R75-R81.
7. +CD4 T cells in vivo after induction of peripheral tolerance with intravenous or oral antigen. J. Immunol. 167:188-195.
8. + regulatory T cells by oral antigen administration. J. Immunol. 167:4245-4253.
9. Karlsson, M.R., H. Kahu, L.A. Hanson, E. Telemo, and U.I. Dahlgren. 2000. Tolerance and bystander suppression, with involvement of CD25-positive cells, is induced in rats receiving serum from ovalbumin-fed donors. Immunology. 100: 326-333.
10. + regulatory cells. Scand. J. Immunol. 55:470-477.
11. + mucosal regulatory T cells are induced in gut-draining lymphoid tissue within 48 h after oral antigen application. Eur. J. Immunol. 33:2801-2810.
12. Weiner, H.L. 2001. Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells. Immunol. Rev. 182:207-214.
13. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature. 389:737-742.
14. Trop, S., D. Samsonov, I. Gotsman, R. Alper, J. Diment, and Y. Ilan. 1999. Liver-associated lymphocytes expressing NK1.1 are essential for oral immune tolerance induction in a murine model. Hepatology. 29:746-755.
15. Baecher-Allan, C., V. Viglietta, and D.A. Hafler. 2004. Human CD4+CD25+ regulatory T cells. Semin. Immunol. 16: 89-97.
16. Belkaid, Y., C.A. Piccirillo, S. Mendez, E.M. Shevach, and D.L. Sacks. 2002. CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature. 420: 502-507.
17. + regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol. Rev. 182:18-32.
18. + T cell-mediated graft rejection: implications for anti-CD154 immunotherapy. J. Immunol. 169:5401-5404.
19. + regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat. Med. 9:1144-1150.
20. + regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J. Exp. Med. 196:389-399.
21. + T cells responding to serologically defined autoantigens suppress antitumor immune responses. Proc. Natl. Acad. Sci. USA. 100:10902-10906.
22. Azuma, T., T. Takahashi, A. Kunisato, T. Kitamura, and H. Hirai. 2003. Human CD4+ CD25+ regulatory T cells suppress NKT cell functions. Cancer Res. 63:4516-4520.
23. + regulatory T cells in patients with gastrointestinal malignancies: possible involvement of regulatory T cells in disease progression. Cancer. 98:1089-1099.
24. Ichihara, F., K. Kono, A. Takahashi, H. Kawaida, H. Sugai, and H. Fujii. 2003. Increased populations of regulatory T cells in peripheral blood and tumor-infiltrating lymphocytes in patients with gastric and esophageal cancers. Clin. Cancer Res. 9:4404-4408.
25. + T cells: a highly differentiated and apoptosis-prone population. Eur. J. Immunol. 31:1122-1131.
26. + regulatory T cells by antigen-processing dendritic cells. J. Exp. Med. 198:235-247.
27. + regulatory cells that control intestinal inflammation. J. Exp. Med. 192:295-302.
28. + regulatory T cells through GITR breaks immunological self-tolerance. Nat. Immunol. 3:135-142.
29. + immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity. 16:311-323.
30. + T cells in thymus, cord and adult blood. Immunology. 106:190-199.
31. Hori, S., T. Nomura, and S. Sakaguchi. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science. 299:1057-1061.
32. + regulatory T cells. Nat. Immunol. 4:330-336.
33. + T regulatory cells. Nat. Immunol. 4:337-342.
34. - T cells act respectively as inducer and effector T suppressor cells in superantigen-induced tolerance. J. Immunol. 171:3475-3484.
35. Ramsdell, F. 2003. Foxp3 and natural regulatory T cells: key to a cell lineage? Immunity. 19:165-168.
36. + Th cells resembling regulatory T cells that inhibit chronic colitis differentiate in the absence of interactions between CD4 and class II MHC. J. Immunol. 171:2279-2286.
37. + regulatory thymocytes. Blood. 102:4107-4114.
38. - T cells. J. Clin. Invest. 112:1437-1443.
39. high regulatory cells in human peripheral blood. J. Immunol. 167:1245-1253.
40. Fowler, S., and F. Powrie. 1999. Control of immune pathology by IL-10-secreting regulatory T cells. Springer Semin. Immunopathol. 21:287-294.
41. + T cells. J. Exp. Med. 183:2669-2674.
42. Wills-Karp, M., J. Santeliz, and C.L. Karp. 2001. The germ-less theory of allergic disease: revisiting the hygiene hypothesis. Nat. Rev. Immunol. 1:69-75.
43. Johansson, S.G., J.O. Hourihane, J. Bousquet, C. Bruijnzeel-Koomen, S. Dreborg, T. Haahtela, M.L. Kowalski, N. Mygind, J. Ring, P. van Cauwenberge, et al. 2001. A revised nomenclature for allergy. An EAACI position statement from the EAACI nomenclature task force. Allergy. 56:813-824.
44. Majamaa, H., P. Moisio, K. Holm, H. Kautiainen, and K. Turjanmaa. 1999. Cow's milk allergy: diagnostic accuracy of skin prick and patch tests and specific IgE. Allergy. 54:346-351.
45. Bischoff, S.C., J.H. Mayer, and M.P. Manns. 2000. Allergy and the gut. Int. Arch. Allergy Immunol. 121:270-283.
46. Takabayashi, K., L. Libet, D. Chisholm, J. Zubeldia, and A.A. Horner. 2003. Intranasal immunotherapy is more effective than intradermal immunotherapy for the induction of airway allergen tolerance in Th2-sensitized mice. J. Immunol. 170:3898-3905.
47. + regulatory T cells in vivo. J. Exp. Med. 198:249-258.
48. Kunkel, E.J., D.J. Campbell, and E.C. Butcher. 2003. Chemokines in lymphocyte trafficking and intestinal immunity. Microcirculation. 10:313-323.
49. Eigenmann, P.A., L. Tropia, and C. Hauser. 1999. The mucosal adhesion receptor alpha4beta7 integrin is selectively increased in lymphocytes stimulated with beta-lactoglobulin in children allergic to cow's milk. J. Allergy Clin. Immunol. 103: 931-936.
50. + T cells with regulatory properties from human blood. J. Exp. Med. 193:1303-1310.
51. + T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J. Exp. Med. 193:1295-1302.
52. + T cells with regulatory properties isolated from peripheral blood. J. Exp. Med. 193:1285-1294.
53. Annacker, O., and F. Powrie. 2002. Homeostasis of intestinal immune regulation. Microbes Infect. 4:567-574.
54. Singh, B., S. Read, C. Asseman, V. Malmstrom, C. Mottet, L.A. Stephens, R. Stepankova, H. Tlaskalova, and F. Powrie. 2001. Control of intestinal inflammation by regulatory T cells. Immunol. Rev. 182:190-200.
55. + cells: a naturally occurring population of regulatory T cells. Blood. 98:2736-2744.
56. Blazar, B.R., B.M. Carreno, A. Panoskaltsis-Mortari, L. Carter, Y. Iwai, H. Yagita, H. Nishimura, and P.A. Taylor. 2003. Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism. J. Immunol. 171:1272-1277.
57. Mowat, A.M. 2003. Anatomical basis of tolerance and immunity to intestinal antigens. Nat. Rev. Immunol. 3:331-341.
58. Perez-Machado, M.A., P. Ashwood, M.A. Thomson, F. Latcham, R. Sim, J.A. Walker-Smith, and S.H. Murch. 2003. Reduced transforming growth factor-β1-producing T cells in the duodenal mucosa of children with food allergy. Eur. J. Immunol. 33:2307-2315.
59. + immunoregulatory T cells. J. Exp. Med. 194:427-438.
60. Karlsson, M., S. Lundin, U. Dahlgren, H. Kahu, I. Pettersson, and E. Telemo. 2001. "Tolerosomes" are produced by intestinal epithelial cells. Eur. J. Immunol. 31:2892-2900.