Class A scavenger receptors, macrophages, and atherosclerosis

Current Opinion in Lipidology

Volumn 12, Issue 5, 2001, Pages 489-495

  Linton, M F ^a   Fazio, S ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; SCAVENGER RECEPTOR; SCAVENGER RECEPTOR A; UNCLASSIFIED DRUG;

ATHEROGENESIS; ATHEROSCLEROSIS; FOAM CELL; GENE OVEREXPRESSION; GENETIC MANIPULATION; HUMAN; HYPERLIPIDEMIA; LIPID OXIDATION; LIPOPROTEIN METABOLISM; MACROPHAGE ACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIGENS, CD36; ARTERIOSCLEROSIS; DISEASE MODELS, ANIMAL; FOAM CELLS; GENE DELETION; HUMANS; HYPERLIPIDEMIAS; MACROPHAGES; MICE; MICE, INBRED C57BL; RECEPTORS, IMMUNOLOGIC; RECEPTORS, LDL; RECEPTORS, SCAVENGER; SCAVENGER RECEPTORS, CLASS A;

EID: 0034780794     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041433-200110000-00003     Document Type: Review

References (55)

1. Lipoprotein metabolism in the macrophage: Implications for cholesterol deposition in atherosclerosis
2. Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition
3. Structures and functions of multiligand lipoprotein receptors: Macrophage scavenger receptors and LDL receptor-related protein (LRP)
4. Recent progress in defining the role of scavenger receptors in lipid transport, atherosclerosis and host defence
5. Type I macrophage scavenger receptor contains α-helical and collagen-like coiled coils
6. Purification and characterization of a bovine acetyl low density lipoprotein receptor
7. Mouse macrophage receptor for acetylated low density lipoprotein: Demonstration of a fully functional subunit in the membrane and with purified receptor
8. Coiled-coil fibrous domains mediate ligand binding by macrophage scavenger receptor type II
9. A naturally occurring isoform of the human macrophage scavenger receptor (SR-A) gene generated by alternative splicing blocks modified LDL uptake
10. An ancient, highly conserved family of cysteine-rich protein domains revealed by cloning type I and type II murine macrophage scavenger receptors
11. Coexpression of type I and type II human macrophage scavenger receptors in macrophages of various organs and foam cells in atherosclerotic lesions
12. Analysis of macrophage scavenger receptor (SR-A) expression in human aortic atherosclerotic lesions
13. Human macrophage scavenger receptors: Primary structure, expression, and localization in atherosclerotic lesions
14. Gene expression in macrophage-rich human atherosclerotic lesions. 15-Lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts
15. Expression of LDL receptor, VLDL receptor, LDL receptor-related protein, and scavenger receptor in rabbit atherosclerotic lesions: Marked induction of scavenger receptor and VLDL receptor expression during lesion development
16. Expression of the acetyl low density lipoprotein receptor by rabbit fibroblasts and smooth muscle cells. Up-regulation by phorbol esters
17. Rabbit aortic smooth muscle cells express inducible macrophage scavenger receptor messenger RNA that is absent from endothelial cells
18. Regulation of scavenger receptor expression in smooth muscle cells by protein kinase C: A role for oxidative stress
19. Regulation of smooth muscle cell scavenger receptor expression in vivo by atherogenic diets and in vitro by cytokines
20. Class A scavenger receptors: Recent advances in elucidation of structure-function relationships and their role in atherosclerosis
21. Differential expression of scavenger receptor isoforms during monocyte-macrophage differentiation and foam cell formation
22. Expression of the macrophage scavenger receptor in atheroma. Relationship to immune activation and the T-cell cytokine interferon-gamma
23. Polymorphism of class A scavenger receptors in C57BL/6 mice
24. Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages
25. Lipoproteins modulate expression of the macrophage scavenger receptor
26. Minimally oxidized low-density lipoprotein increases expression of scavenger receptor A, CD36, and macrosialin in resident mouse peritoneal macrophages
27. PPAR-gamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL
28. Induction of CD36 expression by oxidized LDL and IL-4 by a common signaling pathway dependent on protein kinase C and PPAR-gamma
29. Interleukin-4 augments acetylated LDL-induced cholesterol esterification in macrophages
30. Identification of a γ-interferon-responsive responsive element in the promoter of the human macrophage scavenger receptor A gene
31. Expression of type I and type II bovine scavenger receptors in Chinese hamster ovary cells: Lipid droplet accumulation and nonreciprocal cross competition by acetylated and oxidized low density lipoprotein
32. Macrophage specific overexpression of the human macrophage scavenger receptor in transgenic mice, using a 180-kb yeast artificial chromosome, leads to enhanced foam cell formation of isolated peritoneal macrophages
33. Nonoxidative modifications of lipoproteins in atherogenesis
34. Characterization of inherited scavenger receptor overexpression and abnormal macrophage phenotype in a normolipidemic subject with planar xanthomas
35. Expression of gamma-IFN responsive genes in scavenger receptor over-expressing monocytes is associated with xanthomatosis
36. A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism
37. Scavenging new insights into atherogenesis
38. High affinity saturable uptake of oxidized low density lipoprotein by macrophages from mice lacking the scavenger receptor class A type I/II
39. Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice
40. Adenovirus-mediated gene transfer of a secreted form of human macrophage scavenger receptor inhibits modified low-density lipoprotein degradation and foam-cell formation in macrophages
41. Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species
42. Dextran sulfate, a competitive inhibitor for scavenger receptor, prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemia rabbits
43. Hepatic overexpression of bovine scavenger receptor type I in transgenic mice prevents diet-induced hyperbetalipoproteinemia
44. Macrophage cholesterol metabolism, apolipoprotein E, and scavenger receptor AI/II mRNA in atherosclerosis-susceptible and -resistant mice
45. A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection
46. Role of macrophage scavenger receptors in diet-induced atherosclerosis in mice
47. Scavenger receptor deficiency leads to more complex atherosclerotic lesions in APOE3Leiden transgenic mice
48. Scavenger receptors in atherosclerosis
49. Reduction of isoprostanes and regression of advanced atherosclerosis by apolipoprotein E
50. Are studies in genetically altered mice out of control?
51. Variation in susceptibility to atherosclerosis among inbred strains of mice
52. Reduced atherosclerotic lesions in mice deficient for total or macrophage-specific expression of scavenger receptor-A
53. Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice
54. Effect of human scavenger receptor class A overexpression in bone marrow-derived cells on lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knockout mice
55. Effect of human scavenger receptor class A overexpression in bone marrow-derived cells on cholesterol levels and atherosclerosis in ApoE-deficient mice