PPARα activators inhibit tissue factor expression and activity in human monocytes

Circulation

Volumn 103, Issue 2, 2001, Pages 213-219

  Marx, Nikolaus ^a   Mackman, Nigel ^b   Schönbeck, Uwe ^c   Yilmaz, Nurcan ^a   Hombach, Vinzenz ^a   Libby, Peter ^c   Plutzky, Jorge ^c  

^a UNIVERSITY OF ULM   (Germany)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Coagulation; Genes; Leukocytes; Thrombosis

Indexed keywords

5,8,11,14 ICOSATETRAYNOIC ACID; DELTA12 PROSTAGLANDIN J2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PIRINIXIC ACID; ROSIGLITAZONE; THROMBOPLASTIN; TUMOR NECROSIS FACTOR ALPHA; CELL RECEPTOR; DNA; PEROXISOME PROLIFERATOR; PYRIMIDINE DERIVATIVE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR REL; TRANSCRIPTION FACTOR RELA;

ARTICLE; ATHEROSCLEROTIC PLAQUE; ENZYME INHIBITION; GENE ACTIVITY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MACROPHAGE; MONOCYTE; PRIORITY JOURNAL; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; GENETICS; METABOLISM; PROMOTER REGION;

5,8,11,14-EICOSATETRAYNOIC ACID; CELLS, CULTURED; DNA; HUMANS; LIPOPOLYSACCHARIDES; MACROPHAGES; MONOCYTES; NF-KAPPA B; PEROXISOME PROLIFERATORS; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-REL; PYRIMIDINES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER; THROMBOPLASTIN; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035895326     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.103.2.213     Document Type: Article

References (31)

1. Tissue factor and hemostasis
2. Initiation and regulation of tissue factor-dependent blood coagulation
3. Localization of tissue factor in the normal vessel wall and in the atherosclerotic plaque
4. Tissue-factor antigen and activity in human coronary atherosclerotic plaques
5. The endotoxin-induced coagulant activity of human monocytes
6. Activation of monocyte/macrophage functions related to acute atheroma complication by ligation of CD40: Induction of collagenase, stromelysin, and tissue factor
7. Simultaneous expression of tissue factor and tissue factor pathway inhibitor by human monocytes: A potential mechanism for localized control of blood coagulation
8. Lipopolysaccharide-mediated transcriptional activation of the human tissue factor gene in THP-1 monocytic cells requires both activator protein 1 and nuclear factor kappa B binding sites
9. Lipopolysaccharide induction of tissue factor gene expression in monocytic cells is mediated by binding of c-Re1/p65 heterodimers to a kappa B-like site
10. Regulation of the tissue factor gene
11. Plaque rupture, thrombosis, and therapeutic implications
12. Interruption of vascular thrombus formation and vascular lesion formation by dietary n-3 fatty acids in fish oil in nonhuman primates
13. N-3 fatty acid ethyl ester administration to healthy subjects and to hypertriglyceridemic patients reduces tissue factor activity in adherent monocytes
14. Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers
15. Peroxisome proliferator-activated receptors, orphans with ligands and functions
16. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta
17. Activation of human aortic smooth-muscle cells is inhibited by PPARalpha but not by PPARgamma activators
18. PPARα activators inhibit cytokine-induced vascular cell adhesion molecule 1 expression in human endothelial cells
19. Retinoic acid selectively inhibits lipopolysaccharide induction of tissue factor gene expression in human monocytes
20. Peroxisome proliferator activated receptor gamma activators inhibit gene expression and migration in human vascular smooth muscle cells
21. PPARgamma agonists inhibit production of monocyte inflammatory cytokines
22. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation
23. Macrophages in human atheroma contain PPARgamma: Differentiation-dependent peroxisome proliferator-activated receptor gamma expression and reduction of MMP-9 activity through PPARgamma activation in mononuclear phagocytes in vitro
24. Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages
25. Role of cyclic AMP response element-binding protein in cyclic AMP inhibition of NF-kappaB-mediated transcription
26. p300 functions as a coactivator for the peroxisome proliferator-activated receptor alpha
27. Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kappaB and AP-1
28. A transcriptional co-repressor that interacts with nuclear hormone receptors
29. Effect of a Mediterranean type of diet on the rate of cardiovascular complications in patients with coronary artery disease: Insights into the cardioprotective effect of certain nutriments
30. Primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia: Safety of treatment, changes in risk factors, and incidence of coronary heart disease
31. Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol: Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group