Peroxisome proliferator-activated receptor α reduces cholesterol esterification in macrophages

Circulation Research

Volumn 92, Issue 2, 2003, Pages 212-217

  Chinetti, G ^a,b   Lestavel, S ^a   Fruchart, J C ^a   Clavey, V ^a   Staels, B ^a  

^a INSERM   (France)

^b INSTITUT PASTEUR DE LILLE   (France)

Author keywords

Atherosclerosis; Cholesterol homeostasis; Gene regulation; Nuclear receptor

Indexed keywords

CARNITINE PALMITOYLTRANSFERASE; CHOLESTEROL; CHOLESTEROL ACYLTRANSFERASE; CHOLESTEROL ESTER; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; SPHINGOMYELIN PHOSPHODIESTERASE; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CATABOLISM; CHOLESTEROL ESTERIFICATION; ENZYME ACTIVATION; ENZYME ACTIVITY; FATTY ACID METABOLISM; FOAM CELL; GENE EXPRESSION; HOMEOSTASIS; HUMAN; HUMAN CELL; MACROPHAGE; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

CARNITINE O-PALMITOYLTRANSFERASE; CELLS, CULTURED; CHOLESTEROL; CHOLESTEROL ESTERS; ENZYME ACTIVATION; ESTERIFICATION; FOAM CELLS; GENE EXPRESSION; HOMEOSTASIS; HUMANS; LIGANDS; MACROPHAGES; PEROXISOME PROLIFERATORS; PYRIMIDINES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER; SPHINGOMYELIN PHOSPHODIESTERASE; STEROL O-ACYLTRANSFERASE; TRANSCRIPTION FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037423555     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000053386.46813.E9     Document Type: Article

References (25)

1. Pineda Torra I, Gervois P, Staels B. Peroxisome proliferator-activated receptor alpha in metabolic disease, inflammation, atherosclerosis and aging. Curr Opin Lipidol. 1999;10:151-159.
2. Chinetti G, Fruchart JC, Staels B. Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation. Inflamm Rev. 2000;49:497-505.
3. Chinetti G, Gbaguidi GF, Griglio S, Mallat Z, Antonucci M, Poulain P, Chapman J, Fruchart JC, Tedgui A, Najib-Fruchart J, Staels B. CLAI/SR-BI is expressed in atherosclerotic lesion macrophages and regulated by activators of peroxisome proliferator-activated receptors. Circulation. 2000;101:2411-2417.
4. Chinetti G, Lestavel S, Bocher V, Remaley AT, Neve B, Pineda Torra I, Teissier E, Minnich A, Jaye M, Duverger N, Brewer BH, Fruchart JC, Clavey V, Staels B. PPARα and PPARγ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway. Nat Med. 2001;7:53-58.
5. Tabas I. Cholesterol and phospholipid metabolism in macrophages. Biochim Biophys Acta. 2000; 1529:164-174.
6. Buhman KF, Accad M, Farese RV. Mammalian acyl-CoA:cholesterol acyltransferases. Biochim Biophys Acta. 2000;1529:142-154.
7. McGarry JD, Brown NF. The mitochondrial camitine palmitoyltransferase system: from concept to molecular analysis. Eur J Biochem. 1997;244:1-14.
8. Panousis CG, Zuckerman SH. Regulation of cholesterol distribution in macrophage-derived foam cells by interferon-gamma. J Lipid Res. 2000;41:75-83.
9. Maung K, Miyazaki A, Nomiyama H, Chang CC, Chang TY, Horiuchi S. Induction of acyl-coenzyme A:cholesterol acyltransferase-1 by 1,25-dihydroxyvitamin D(3) or 9-cis-retinoic acid in undifferentiated THP-1 cells. J Lipid Res. 2001;42:181-187.
10. Chatterjee S. Neutral sphingomyelinase action stimulates signal transduction of tumor necrosis factor-alpha in the synthesis of cholesteryl esters in human fibroblasts. J Biol Chem. 1994;269:879-882.
11. Chinetti G, Griglio S, Antonucci M, Pineda Torra I, Delerive P, Majd Z, Fruchart JC, Chapman J, Najib J, Staels B. Activation of peroxisome proliferator-activated receptors α and γ induces apoptosis of human monocyte-derived macrophages. J Biol Chem. 1998;273:25573-25580.
12. Wang H, Germain SJ, Benfield PP, Gillies PJ. Gene expression of acyl-coenzyme-A:cholesterol-acyltransferase is upregulated in human monocytes during differentiation and foam cell formation. Arterioscler Throm Vasc Biol. 1996;16:809-814.
13. Basu SK, Goldstein JL, Anderson GW, Brown MS. Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts. Proc Natl Acad Sci USA. 1976;73:3178-3182.
14. Schmitz G, Niemann R, Brennhausen B, Krause R, Assmann G. Regulation of high density lipoprotein receptors in cultured macrophages: role of acyl-CoA: cholesterol acyltransferase. EMBO J. 1985;4:2773-2779.
15. Willson TM, Brown PJ, Sternbach DD, Henke BR. The PPARs: from orphan receptors to drug discovery. J Med Chem. 2000;43:527-550.
16. Brown PJ, Stuart LW, Hurley KP, Lewis MC, Winegar DA, Wilson JG, Wilkison WO, Ittoop OR, Willson TM. Identification of a subtype selective human PPARα agonist through parallel-array synthesis. Bioorg Med Chem Lett. 2001;11:1225-1227.
17. Mascaro C, Acosta E, Ortiz J, Marrero P, Hegardt F, Haro D. Control of human muscle-type camitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptor. J Biol Chem. 1998;273:8560-8563.
18. Yu GS, Lu YC, Gulick T. Co-regulation of tissue-specific alternative human camitine palmitoyltransferase Iβ gene promoters by fatty acid enzyme substrate. J Biol Chem. 1998;273:32901-32909.
19. Moinat M, Kossovsky M, Chevey JM, Giacobino JP. Balance between fatty acid degradation and lipid accumulation in cultured smooth muscle cells and IC-21 macrophages exposed to oleic acid. Comp Biochem Physiol B. 1991;98:147-150.
20. Gbaguidi GF, Chinetti G, Milosavljevic D, Teissier E, Chapman J, Olivecrona G, Fruchart JC, Griglio S, Fruchart-Najib J, Staels B. Peroxisome proliferator-activated receptor (PPAR) agonists decrease lipoprotein lipase secretion and glycated LDL uptake by human macrophages. FEBS Lett. 2002;512:85-90.
21. Hsu H, Shu HB, Pan MG, Goeddel DV. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell. 1996;84:299-308.
22. Galis ZS, Sukhova GK, Kranzhofer R, Clark S, Libby P. Macrophage foam cells from experimental atheroma constitutively produce matrixdegrading proteinases. Proc Natl Acad Sci U S A. 1995;92:402-406.
23. Shu H, Wong B, Zhou G, Li Y, Berger J, Woofds JW, Wright SD, Cai T-C. Activation of PPARα or γ reduces secretion of matrix metalloproteinase 9 but not interleukin 8 from human monocytic THP-1 cells. Biochem Biophys Res Commun. 2000;267:345-349.
24. Libby P, Aikawa M, Schonbeck U. Cholesterol and atherosclerosis. Biochim Biophys Acta. 2000;1529:299-309.
25. Duez H, Chao YS, Hernandez M, Torpier G, Poulain P, Mundt S, Mallat Z, Teissier E, Burton CA, Tedgui A, Fruchart JC, Fievet C, Wright SD, Staels B. Reduction of atherosclerosis by the PPARα agonist fenofibrate in mice. J Biol Chem. 2002;277:48051-48057.