PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL

Cell

Volumn 93, Issue 2, 1998, Pages 241-252

  Tontonoz, Peter ^a,c   Nagy, Laszlo ^a,b   Alvarez, Jacqueline G A ^a   Thomazy, Vilmos A ^d   Evans, Ronald M ^a,b  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

15 DEOXY DELTA 12,14 PROSTAGLANDIN J 2; ALITRETINOIN; CD36 ANTIGEN; LG 268; LIGAND; OXIDIZED LOW DENSITY LIPOPROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PHORBOL 13 ACETATE 12 MYRISTATE; PROSTAGLANDIN J2; RETINOID; RETINOID X RECEPTOR; ROSIGLITAZONE; SCAVENGER RECEPTOR; TROGLITAZONE; UNCLASSIFIED DRUG; 15 DEOXY DELTA(12,14) PROSTAGLANDIN J2; 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J2; 2,4 THIAZOLIDINEDIONE DERIVATIVE; CELL RECEPTOR; DRUG DERIVATIVE; IMMUNOGLOBULIN RECEPTOR; LIPOPROTEIN RECEPTOR; LOW DENSITY LIPOPROTEIN; MEMBRANE PROTEIN; PROSTAGLANDIN D2; RETINOIC ACID; RETINOIC ACID RECEPTOR; SCARB1 PROTEIN, MOUSE; SCAVENGER RECEPTOR B; THIAZOLE DERIVATIVE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; ATHEROGENESIS; CELL DIFFERENTIATION; CONTROLLED STUDY; FOAM CELL; HUMAN; HUMAN CELL; LIPID METABOLISM; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; ARTERIOSCLEROSIS; CELL STRAIN HL 60; CHEMISTRY; CYTOLOGY; DIMERIZATION; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROMOTER REGION; SIGNAL TRANSDUCTION; TRANSACTIVATION; TRANSGENIC MOUSE;

ANIMALIA;

ANIMALS; ANTIGENS, CD36; ARTERIOSCLEROSIS; CELL DIFFERENTIATION; DIMERIZATION; FOAM CELLS; HL-60 CELLS; HUMANS; LIGANDS; LIPOPROTEINS, LDL; MACROPHAGES; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MONOCYTES; PROMOTER REGIONS (GENETICS); PROSTAGLANDIN D2; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, IMMUNOLOGIC; RECEPTORS, LIPOPROTEIN; RECEPTORS, RETINOIC ACID; RECEPTORS, SCAVENGER; RETINOID X RECEPTORS; SCAVENGER RECEPTORS, CLASS B; SIGNAL TRANSDUCTION; THIAZOLES; THIAZOLIDINEDIONES; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRETINOIN;

EID: 0032540012     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)81575-5     Document Type: Article

References (55)

1. Abumrad, N.A., el-Maghrabi, M.R., Amri, E.Z., Lopez, E., and Grimaldi, P.A. (1993). Cloning of a rat adipocyte membrane protein implicated in binding or transport of long chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36. J. Biol. Chem. 268, 17665-17668.
2. Acton, S.L., Scherer, P.E., Lodish, H.F., and Krieger, M. (1994). Expression cloning of SR-BI, aCD36-related Class B scavenger receptor. J. Biol. Chem. 269, 21003-21009.
3. Armesilla, A.L., and Vega, M.A. (1994). Structural organization of the gene for human CD36 glycoprotein. J. Biol. Chem. 269, 18985-18991.
4. Asch, A.S., Barnwell, J., Silverstein, R.L., and Nachman, R.L. (1987). Isolation of thethrombospondin membrane receptor. J. Clin. Invest. 79, 1054-1059.
5. Boehm, M., Zhang, L., Zhi, L., McClurg, M., Berger, E., Wagoner, M., Mais, D., Suto, C., Davies, J., Heyman, R.A., et al. (1995). Design and synthesis of potent retinoid X receptor selective ligands that induce apoptosis in leukemia cells. J. Med. Chem. 38, 3146-3155.
6. Brown, M.S., and Goldstein, J.L. (1983). Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis. Annu. Rev. Biochem. 52, 223-261.
7. Buja, L.M., Kita, T., Goldstein, J.L., Watanabe, Y., and Brown, M.S. (1983). Cellular pathology of progressive atherosclerosis in the WHHL rabbit: an animal model of familial hypercholesterolemia. Arteriosclerosis 3, 87-101.
8. Chawla, A., Schwarz, E.J., Dimaculangen, D.D., and Lazar, M.A. (1994). Peroxisome proliferator-activated receptor γ: adipose-predominant expression and induction early in adipocyte differentiation. Endocrinology 135, 798-800.
9. Chen, J.Y., Clifford, J., Zusi, C., Starrett, J., Tortolani, D., Ostrowski, J., Reczek, P.R., Chambon, P., and Gronemeyer, H. (1996). Two distinct actions of retinoid receptor ligands. Nature 382, 819-822.
10. Endemann, G., Stanton, L.W., Madden, K.S., Bryant, C.M., White, R.T., and Protter, A.A. (1993). CD36 is a receptor for oxidized low density lipoprotein. J. Biol. Chem. 268, 11811-11816.
11. 2 is a ligand for the adipocyte determination factor PPARγ. Cell 83, 803-812.
12. Forman, B.M., Umesono, K., Chen, J., and Evans, R.M. (1995b). Unique response pathways are established by allosteric interactions among nuclear hormone receptors. Cell 81, 541-550.
13. Goldstein, J.L., Ho, Y.K., Basu, S.K., and Brown, M.S. (1979). Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoproteins. Proc. Natl. Acad. Sci. USA 76, 333-337.
14. Graves, R.A., Tontonoz, P., and Spiegelman, B.M. (1992). Analysis of a tissue-specific enhancer: ARF6 regulates adipogenic gene expression. Mol. Cell. Biol. 12, 1202-1208.
15. Greene, M.E., Blumberg, B., McBride, O.W., Yi, H.F., Kronquist, K., Kwan, K., Hsieh, L., Greene, G., and Nimer, S.D. (1995). Isolation of the human peroxisome proliferator activated receptor γ cDNA: expression in hematopoietic cells and chromosomal mapping. Gene Expr. 4, 281-299.
16. Greenwalt, D.E., Scheck, S.H., and Rhinehart-Jones, T. (1995). Heart CD36 expression is increased in murine models of diabetes and in mice fed a high fat diet. J. Clin. Invest. 96, 1382-1388.
17. Hamilton, T.A., Major, J.A., and Chisholm, G.M. (1995). The effects of oxidized low density lipoprotein on inducible mouse macrophage gene expression are gene and stimulus dependent. J. Clin. Invest. 95, 2020-2027.
18. Han, J., Hajjar, D.P., Febbraio, M., and Nicholson, A.C. (1997). Native and modified low density lipoproteins increase the functional expression of the macrophage class B scavenger receptor, CD36. J. Biol. Chem. 272, 21654-21659.
19. Jiang, C., Ting, A.T., and Seed, B. (1998). PPARγ agonists inhibit production of monocyte inflammatory cytokines. Nature 391, 82-86.
20. Kliewer, S.A., Umesono, K., Mangelsdorf, D.J., and Evans, R.M. (1992a). Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone, and vitamin D3 signaling. Nature 355, 446-449.
21. Kliewer, S.A., Umesono, K., Noonan, D., Heyman, R., and Evans, R.M. (1992b). Convergence of 9-cis retinoic acid and peroxisome proliferator signaling pathways through heterodimer formation of their receptors. Nature 358, 771-774.
22. Kliewer, S.A., Lenhard, J.M., Wilson, T.M., Patel, I., Morris, D.C., and Lehmann, J.M. (1995). A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell 83, 813-819.
23. Kodama, T., Reddy, P., Kishimoto, P.C., and Krieger, M. (1988). Purification and characterization of a bovine acetyl low density lipoprotein receptor. Proc. Natl. Acad. Sci. USA 85, 9238-9242.
24. Kurokawa, R., DiRenzo, J., Boehm, M., Sugarman, J., Gloss, B., Rosenfeld, M.G., Heyman, R.A., and Glass, C.K. (1994). Regulation of retinoid signaling by receptor polarity and allosteric control of ligand binding. Nature 371, 528-531.
25. Laborda, J. (1991). 36B4 cDNA used as an estradiol-independent mRNA control is the cDNA for human acidic ribosomal phosphoprotein PO. Nucleic Acids Res. 19, 3998.
26. Lehmann, J.M., Moore, L.B., Smith-Oliver, T.A., Wilkison, W.O., Wilson, T.M., and Kliewer, S.A. (1995). An antidiabetic thiazolidinedione is a high affinity ligand for perosixome proliferator-activated receptor γ (PPARγ). J. Biol. Chem. 270, 12953-12956.
27. Leid, M., Kastner, P., Lyons, R., Nakshatri, H., Saunders, M., Zacharewski, T., Chen, J.Y., Staub, A., Gamier, J.M., Mader, S., et al. (1992). Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently. Cell 68, 377-395.
28. Lubbert, M., Herrmann, F., and Koeffler, H.P. (1991). Expression and regulation of myeloid-specific genes in normal and leukemic myeloid cells. Blood 77, 909-924.
29. Matsumoto, A., Naito, M., Itakura, H., Ikemoto, S., Asaoka, H., Hayakawa, I., Kanamori, H., Aburatani, H., Takaku, F., Susuki, H., et al. (1990). Human macrophage scavenger receptors: primary structure, expression and localization in atherosclerotic lesion. Proc. Natl. Acad. Sci. USA 87, 9133-9137.
30. Minucci, S., Leid, M., Toyama, R., Saint-Jeannet, J.P., Peterson, V.J., Horn, V., Ishmael, J.E., Bhattacharyya, N., Dey, A., Dawid, I.E., et al. (1997). Retinoid X receptor (RXR) within the RXR-retinoic acid receptor heterodimer binds its ligand and enhances retinoid-dependent gene expression. Mol. Cell. Biol. 17, 644-655.
31. Moulton, K.S., Wu, H., Barnett, J., Parthasarathy, S., and Glass, C.K. (1992). Regulated expression of the human acetylated low density lipoprotein receptor gene and isolation of promoter sequences. Proc. Natl. Acad. Sci. USA 89, 8102-8106.
32. Mueller, E., Sarraf, P., Tontonoz, P., Evans, R.M., Martin, K.J., Zhang, M., Fletcher, C., Singer, S., and Spiegelman, B.M. (1998). Terminal differentiation of human breast cancer: through PPARγ. Mol. Cell 1, 465-470.
33. Mukherjee, R., Davies, P.J., Crombie, D.L., Bischoff, E.D., Cesario, R.M., Jow, L., Hamann, L.G., Boehm, M.F., Mondan, C.E., Nadzan, A.M., and Heyman, R.A. (1997). Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists. Nature 356, 407-410.
34. Nagelkerke, J.F., Havekes, L., van Hinsbergh, V.W., and Berkel, T.J. (1984). In vivo catabolism of biologically modified LDL. Arteriosclerosis 4, 256-264.
35. Nagy, L., Thomazy, V.A., Shipley, G.L., Fesus, L., Lamph, W., Heyman, R.A., Chandraratna, R.A.C., and Davies, P.J.A. (1995). Activation of retinoid X receptors (RXR) induces apoptosis in HL-60 cell lines. Mol. Cell. Biol. 15, 3540-3551.
36. Nagy, L., Tontonoz, P., Alvarez, J., Chen, H., and Evans, R.M. (1998). Oxidized LDL regulates macrophage gene expression through ligand activation of PPARγ. Cell 93, this issue, 229-240.
37. Nozaki, S., Kashiwagi, H., Yamashita, S., Nakagawa, T., Kostner, B., Tomiyama, Y., Nakata, A., Ishigami, M., Miyagawa, J., Takemura, K., et al. (1995). Reduced uptake of oxidized low density lipoproteins in monocyte-derived macrophages from CD36-deficient subjects. J. Clin. Invest. 96, 1859-1865.
38. Ramprasad, M.P., Terpstra, V., Kondratenko, N., Quehenberger, O., and Steinberg, D. (1996). Cell surface expression of mouse macrosialin and human CD68 and their role as macrophage receptors for oxidized low density lipoprotein. Proc. Natl. Acad. Sci. USA 93, 14833-14838.
39. Ricote, M., Li, A.C., Willson, T.M., Kelly, C.J., and Glass, C.K. (1998). The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation. Nature 391, 79-82.
40. Ross, T.K., Darwish, H.M., and DeLuca, H.F. (1994). Molecular biology of vitamin D action. In Vitamins and Hormones, G. Litwak, ed. (San Diego, CA: Academic Press), pp. 281-326.
41. Sanan, D.A., Newland, D.L., Tao, R., Marcovina, S., Wang, J., Mooser, V., Hammer, R.E., and Hobbs, H.H. (1998). LDL receptor-negative mice expressing human apoB-100 develop complex atherosclerotic lesions on an low fat diet: no accentuation by apolipoprotein(a). Proc. Acad. Natl. Sci. USA, in press.
42. Schoonjans, K., Peinado-Onsurbe, J., Lefebvre, A.-M., Heyman, R.A., Briggs, M., Deeb, S., Staels, B., and Auwerx, J. (1996). PPARα and PPARγ activators direct adistinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene. EMBO J. 15, 5336-5348.
43. Sears, I.B., MacGinnitie, M.A., Kovacs, L.G., and Graves, R.A. (1996). Differentiation-dependent expression of the brown adipocyte uncoupling protein gene: regulation by peroxisome proliferator activated receptor γ. Mol. Cell. Biol. 16, 3410-3418.
44. Sfeir, Z., Ibrahimi, A., Amri, E.Z., Grimaldi, P.A., and Abumrad, N.A. (1997). Regulation of FAT/CD36 gene expression: further evidence in support of a role of the protein in fatty acid binding/transport. Prostaglandins Leukot. Essent. Fatty Acids 57, 17-21.
45. Stanton, L.W., White, R.T., Bryant, C.M., Protter, A.A., and Endemann, G. (1992). A macrophage Fc receptorfor IgG is also a receptor for oxidized low density lipoprotein. J. Biol. Chem. 267, 22446-22451.
46. Stary, H.C., Chandler, A.B., Glagov, S., Guyton, J.R., Insull, W., Rosenfeld, M.E., Shaffer, S.A., Schwartz, C.J., Wagner, W.D., and Wissler, R.W. (1994). A definition of initial, fatty streak and intermediate lesions of atherosclerosis: a report from the committee on vascular lesions of the council on arteriosclerosis, American Heart Association. Arterioscler. Thromb. Vasc. Biol. 14, 840-856.
47. Steinberg, D., Parthasarathy, S., Carew, T.E., Khoo, J.C., and Witztum, J.L. (1989). Beyond cholesterol. N. Engl. J. Med. 320, 915-924.
48. Suzuki, H., Kurihara, Y., Takeya, M., Kamada, N., Kataoka, M., Jishage, K., Ueda, O., Sakaguchi, H., Higashi, T., Suzuki, T., et al. (1997). A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Nature 386, 292-295.
49. Tontonoz, P., Hu, E., Graves, R.A., Budavari, A.I., and Spiegelman, B.M. (1994a). mPPARγ2: tissue-specific regulator of an adipocyte enhancer. Genes Dev. 8, 1224-1234.
50. Tontonoz, P., Hu, E., and Spiegelman, B.M. (1994b). Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor. Cell 79, 1147-1156.
51. Tontonoz, P., Hu, E., Devine, J., Beale, E.G., and Spiegelman, B.M. (1995). PPARγ2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene. Mol. Cell. Biol. 15, 351-357.
52. Tontonoz, P., Singer, S., Forman, B.M., Sarraf, P., Fletcher, J., Fletcher, C.D.M., Brun, R.P., Mueller, E., Altiok, S., Oppenheim, H., et al. (1997). Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator activated receptor γ and retinoid X receptor. Proc. Natl. Acad. Sci. USA. 94, 237-241.
53. Wang, N., Tabas, I., Winchester, R., Ravalli, S., Rabbani, L., and Tall, A. (1996). Interleukin 8 is induced by cholesterol loading of macrophages and expressed by macrophage foam cells in human atheroma. J. Biol. Chem. 271, 8837-8842.
54. Yesner, L.M., Huh, H.Y., Pearce, S.F., and Silverstein, R.L. (1996). Regulation of monocyteCD36 and thrombospondin-1 expression by soluble mediators. Arterioscler. Thromb. Vasc. Biol. 16, 1019-1025.
55. Yu, V.C., Delsert, C., Andersen, B., Holloway, J.M., Devary, O.V., Naar, A.M., Kim, S.Y., Boutin, J.M., Glass, C.K., and Rosenfeld, M.G. (1991). RXRβ: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements. Cell 67, 1251-1266.