-
1
-
-
0029562554
-
The RXR heterodimers and orphan receptors
-
Mangelsdorf DJ, Evans RM. The RXR heterodimers and orphan receptors. Cell 1995;83:841-850.
-
(1995)
Cell
, vol.83
, pp. 841-850
-
-
Mangelsdorf, D.J.1
Evans, R.M.2
-
2
-
-
0029182179
-
The molecular and genetic dissection of the retinoid signaling pathway
-
Chambon P. The molecular and genetic dissection of the retinoid signaling pathway. Recent Prog Horm Res. 1995;50:317-332.
-
(1995)
Recent Prog Horm Res
, vol.50
, pp. 317-332
-
-
Chambon, P.1
-
3
-
-
0028332036
-
Differential recognition of target genes by nuclear receptor monomers, dimers and heterodimers
-
Glass CK. Differential recognition of target genes by nuclear receptor monomers, dimers and heterodimers. Endocr Rev. 1994;15:1503-1519.
-
(1994)
Endocr Rev
, vol.15
, pp. 1503-1519
-
-
Glass, C.K.1
-
4
-
-
0034650893
-
The coregulator exchange in transcriptional functions of nuclear receptors
-
Glass CK, Rosenfeld MG. The coregulator exchange in transcriptional functions of nuclear receptors. Genes and Dev. 2000;14:121-141.
-
(2000)
Genes and Dev
, vol.14
, pp. 121-141
-
-
Glass, C.K.1
Rosenfeld, M.G.2
-
5
-
-
0033305213
-
Peroxisome proliferator-activated receptors: Nuclear control of metabolism
-
Desvergne B, Wahli W. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endo Revs. 1999;20:649-688.
-
(1999)
Endo Revs
, vol.20
, pp. 649-688
-
-
Desvergne, B.1
Wahli, W.2
-
7
-
-
0029805887
-
An oxysterol signalling pathway mediated by the nuclear receptor LXRα
-
Janowski BA, Willy PJ, Devi TR, Falck JR, Mangelsdorf DJ. An oxysterol signalling pathway mediated by the nuclear receptor LXRα. Nature 1996;383:728-731.
-
(1996)
Nature
, vol.383
, pp. 728-731
-
-
Janowski, B.A.1
Willy, P.J.2
Devi, T.R.3
Falck, J.R.4
Mangelsdorf, D.J.5
-
8
-
-
14444285707
-
Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway
-
Lehmann JM, Kliewer SA, Moore LB, Smith-Oliver TA, Oliver BB, Su JL, Sundseth SS, Winegar DA, Blanchard DE, Spencer TA, Willson TM. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J Biol Chem. 1997;272:3137-3140.
-
(1997)
J Biol Chem
, vol.272
, pp. 3137-3140
-
-
Lehmann, J.M.1
Kliewer, S.A.2
Moore, L.B.3
Smith-Oliver, T.A.4
Oliver, B.B.5
Su, J.L.6
Sundseth, S.S.7
Winegar, D.A.8
Blanchard, D.E.9
Spencer, T.A.10
Willson, T.M.11
-
9
-
-
0030885520
-
The orphan nuclear receptor LXRalpha is positively and negatively regulated by distinct products of mevalonate metabolism
-
Forman BM, Ruan B, Chen J, Schroepfer GJ, Jr., Evans RM. The orphan nuclear receptor LXRalpha is positively and negatively regulated by distinct products of mevalonate metabolism. Proc Natl Acad Sci U S A 1997;94:10588-10593.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 10588-10593
-
-
Forman, B.M.1
Ruan, B.2
Chen, J.3
Schroepfer Jr., G.J.4
Evans, R.M.5
-
10
-
-
0026705751
-
Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors
-
Kliewer SA, Umesono K, Noonan DJ, Heyman RA, Evans RM. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Nature 1992;358:771-774.
-
(1992)
Nature
, vol.358
, pp. 771-774
-
-
Kliewer, S.A.1
Umesono, K.2
Noonan, D.J.3
Heyman, R.A.4
Evans, R.M.5
-
11
-
-
0027526301
-
Interaction of the peroxisome-proliferator-activated receptor and retinoid X receptor
-
Gearing KL, Gottlicher M, Teboul M, Widmark E, Gustafsson JA. Interaction of the peroxisome-proliferator-activated receptor and retinoid X receptor. Proc Natl Acad Sci U S A 1993;90:1440-1444.
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, pp. 1440-1444
-
-
Gearing, K.L.1
Gottlicher, M.2
Teboul, M.3
Widmark, E.4
Gustafsson, J.A.5
-
12
-
-
0027161015
-
PPAR-RXR heterodimer activates a peroxisome proliferator response element upstream of the bifunctional enzyme gene
-
Bardot O, Aldridge TC, Latruffe N, Green S. PPAR-RXR heterodimer activates a peroxisome proliferator response element upstream of the bifunctional enzyme gene. Biochem Biophys Res Commun. 1993;192:37-45.
-
(1993)
Biochem Biophys Res Commun
, vol.192
, pp. 37-45
-
-
Bardot, O.1
Aldridge, T.C.2
Latruffe, N.3
Green, S.4
-
13
-
-
0026570218
-
9-cis retinoic acid is a high affinity ligand for the retinoid X receptor
-
Heyman RA, Mangelsdorf DJ, Dyck JA, Stein RB, Eichele G, Evans RM, Thaller C. 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor. Cell 1992;68:397-406.
-
(1992)
Cell
, vol.68
, pp. 397-406
-
-
Heyman, R.A.1
Mangelsdorf, D.J.2
Dyck, J.A.3
Stein, R.B.4
Eichele, G.5
Evans, R.M.6
Thaller, C.7
-
14
-
-
0034672081
-
Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain
-
Mata de Urquiza AM, Liu S, Sjoberg M, Zetterstrom RH, Griffiths W, Sjovall J, Perlmann T. Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain. Science 2000;290:2140-2144.
-
(2000)
Science
, vol.290
, pp. 2140-2144
-
-
Mata De Urquiza, A.M.1
Liu, S.2
Sjoberg, M.3
Zetterstrom, R.H.4
Griffiths, W.5
Sjovall, J.6
Perlmann, T.7
-
15
-
-
0031886864
-
The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
-
Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK. The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation. Nature 1998;391:79-82.
-
(1998)
Nature
, vol.391
, pp. 79-82
-
-
Ricote, M.1
Li, A.C.2
Willson, T.M.3
Kelly, C.J.4
Glass, C.K.5
-
16
-
-
0032475922
-
Activation of proliferator-activated receptors α and γ induces apoptosis of human monocyte-derived macrophages
-
Chinetti G, Griglio S, Antonucci M, Torra IP, Delerive P, Majd Z, Fruchart J-C, Chapman J, Najib J, Staels B. Activation of proliferator-activated receptors α and γ induces apoptosis of human monocyte-derived macrophages. J Biol Chem. 1998;273:25573-25580.
-
(1998)
J Biol Chem
, vol.273
, pp. 25573-25580
-
-
Chinetti, G.1
Griglio, S.2
Antonucci, M.3
Torra, I.P.4
Delerive, P.5
Majd, Z.6
Fruchart, J.-C.7
Chapman, J.8
Najib, J.9
Staels, B.10
-
17
-
-
0037324340
-
Reciprocal regulation of inflammation and lipid metabolism by liver X receptors
-
Joseph SB, Castrillo A, Laffitte BA, Mangelsdorf DJ, Tontonoz P. Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat Med. 2003;9:213-219.
-
(2003)
Nat Med
, vol.9
, pp. 213-219
-
-
Joseph, S.B.1
Castrillo, A.2
Laffitte, B.A.3
Mangelsdorf, D.J.4
Tontonoz, P.5
-
18
-
-
0027753736
-
Xenopus peroxisome proliferator activated receptors: Genomic organization, response element recognition, heterodimer formation with retinoid X receptor and activation by fatty acids
-
Krey G, Keller H, Mahfoudi A, Medin J, Ozato K, Dreyer C, Wahli W. Xenopus peroxisome proliferator activated receptors: genomic organization, response element recognition, heterodimer formation with retinoid X receptor and activation by fatty acids. J Steroid Biochem Mol Biol. 1993;47:65-73.
-
(1993)
J Steroid Biochem Mol Biol
, vol.47
, pp. 65-73
-
-
Krey, G.1
Keller, H.2
Mahfoudi, A.3
Medin, J.4
Ozato, K.5
Dreyer, C.6
Wahli, W.7
-
19
-
-
0030818756
-
Polarity and specific sequence requirements of peroxisome proliferator-activated receptor (PPAR)/retinoid X receptor heterodimer binding to DNA. A functional analysis of the malic enzyme gene PPAR response element
-
A IJ, Jeannin E, Wahli W, Desvergne B. Polarity and specific sequence requirements of peroxisome proliferator-activated receptor (PPAR)/ retinoid X receptor heterodimer binding to DNA. A functional analysis of the malic enzyme gene PPAR response element. J Biol Chem. 1997;272:20108-20117.
-
(1997)
J Biol Chem
, vol.272
, pp. 20108-20117
-
-
Jeannin, E.1
Wahli, W.2
Desvergne, B.3
-
20
-
-
0032816777
-
Peroxisome proliferator-activated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis
-
Fruchart JC, Duriez P, Staels B. Peroxisome proliferator-activated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis. Curr Opin Lipidol. 1999;10:245-257.
-
(1999)
Curr Opin Lipidol
, vol.10
, pp. 245-257
-
-
Fruchart, J.C.1
Duriez, P.2
Staels, B.3
-
21
-
-
0032506273
-
Mechanism of action of fibrates on lipid and lipoprotein metabolism
-
Staels B, Dallongeville J, Auwerx J, Schoonjans K, Leitersdorf E, Fruchart JC. Mechanism of action of fibrates on lipid and lipoprotein metabolism. Circulation 1998;98:2088-2093.
-
(1998)
Circulation
, vol.98
, pp. 2088-2093
-
-
Staels, B.1
Dallongeville, J.2
Auwerx, J.3
Schoonjans, K.4
Leitersdorf, E.5
Fruchart, J.C.6
-
22
-
-
0035936764
-
Obesity and the regulation of energy balance
-
Spiegelman BM, Flier JS. Obesity and the regulation of energy balance. Cell 2001;104:531-543.
-
(2001)
Cell
, vol.104
, pp. 531-543
-
-
Spiegelman, B.M.1
Flier, J.S.2
-
23
-
-
0037900979
-
Minireview: Lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors
-
Lee CH, Olson P, Evans RM. Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors. Endocrinology 2003;144:2201-2207.
-
(2003)
Endocrinology
, vol.144
, pp. 2201-2207
-
-
Lee, C.H.1
Olson, P.2
Evans, R.M.3
-
24
-
-
0030062325
-
The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones
-
Willson TM, Cobb JE, Cowan DJ, Wiethe RW, Correa ID, Prakash SR, Beck KD, Moore LB, Kliewer SA, Lehmann JM. The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones. J Med Chem. 1996;39:665-668.
-
(1996)
J Med Chem
, vol.39
, pp. 665-668
-
-
Willson, T.M.1
Cobb, J.E.2
Cowan, D.J.3
Wiethe, R.W.4
Correa, I.D.5
Prakash, S.R.6
Beck, K.D.7
Moore, L.B.8
Kliewer, S.A.9
Lehmann, J.M.10
-
25
-
-
0037453718
-
Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity
-
Wang YX, Lee CH, Tiep S, Yu RT, Ham J, Kang H, Evans RM. Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity. Cell 2003;113:159-170.
-
(2003)
Cell
, vol.113
, pp. 159-170
-
-
Wang, Y.X.1
Lee, C.H.2
Tiep, S.3
Yu, R.T.4
Ham, J.5
Kang, H.6
Evans, R.M.7
-
26
-
-
0035942162
-
A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport
-
Oliver WR, Jr., Shenk JL, Snaith MR, Russell CS, Plunket KD, Bodkin NL, Lewis MC, Winegar DA, Sznaidman ML, Lambert MH, Xu HE, Sternbach DD, Kliewer SA, Hansen BC, Willson TM. A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport. Proc Natl Acad Sci USA 2001;98:5306-5311.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 5306-5311
-
-
Oliver Jr., W.R.1
Shenk, J.L.2
Snaith, M.R.3
Russell, C.S.4
Plunket, K.D.5
Bodkin, N.L.6
Lewis, M.C.7
Winegar, D.A.8
Sznaidman, M.L.9
Lambert, M.H.10
Xu, H.E.11
Sternbach, D.D.12
Kliewer, S.A.13
Hansen, B.C.14
Willson, T.M.15
-
27
-
-
0035921419
-
Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice
-
Michalik L, Desvergne B, Tan NS, Basu-Modak S, Escher P, Rieusset J, Peters JM, Kaya G, Gonzalez FJ, Zakany J, Metzger D, Chambon P, Duboule D, Wahli W. Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice. J Cell Biol. 2001;154:799-814.
-
(2001)
J Cell Biol
, vol.154
, pp. 799-814
-
-
Michalik, L.1
Desvergne, B.2
Tan, N.S.3
Basu-Modak, S.4
Escher, P.5
Rieusset, J.6
Peters, J.M.7
Kaya, G.8
Gonzalez, F.J.9
Zakany, J.10
Metzger, D.11
Chambon, P.12
Duboule, D.13
Wahli, W.14
-
28
-
-
0035893364
-
Critical roles of PPAR beta/delta in keratinocyte response to inflammation
-
Tan NS, Michalik L, Noy N, Yasmin R, Pacot C, Heim M, Fluhmann B, Desvergne B, Wahli W. Critical roles of PPAR beta/delta in keratinocyte response to inflammation. Genes Dev. 2001;15:3263-3277.
-
(2001)
Genes Dev
, vol.15
, pp. 3263-3277
-
-
Tan, N.S.1
Michalik, L.2
Noy, N.3
Yasmin, R.4
Pacot, C.5
Heim, M.6
Fluhmann, B.7
Desvergne, B.8
Wahli, W.9
-
29
-
-
0006132932
-
Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ
-
Kliewer SA, Sundseth SS, Jones SA, Brown PJ, Wisely GB, Koble CS, Devchand P, Wahli W, Willson TM, Lenhard JM, Lehman JM. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ. Proc Natl Acad Sci U S A 1997;94:4318-4323.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 4318-4323
-
-
Kliewer, S.A.1
Sundseth, S.S.2
Jones, S.A.3
Brown, P.J.4
Wisely, G.B.5
Koble, C.S.6
Devchand, P.7
Wahli, W.8
Willson, T.M.9
Lenhard, J.M.10
Lehman, J.M.11
-
30
-
-
0030985318
-
Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay
-
Krey G, Braissant O, L'Horset F, Kalkhoven E, Perroud M, Parker MG, Wahli W. Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay. Mol Endocrinol. 1997;11:779-791.
-
(1997)
Mol Endocrinol
, vol.11
, pp. 779-791
-
-
Krey, G.1
Braissant, O.2
L'Horset, F.3
Kalkhoven, E.4
Perroud, M.5
Parker, M.G.6
Wahli, W.7
-
31
-
-
0030952937
-
Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ
-
Forman BM, Chen J, Evans RM. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ. Proc Natl Acad Sci USA 1997;94:4312-4317.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 4312-4317
-
-
Forman, B.M.1
Chen, J.2
Evans, R.M.3
-
32
-
-
0032505096
-
Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ
-
Nolte RT, Wisely GB, Westin S, Cobb JE, Lambert MH, Kurokawa R, Rosenfeld MG, Willson TM, Glass CK, Milburn MV. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ. Nature 1998;395:137-143.
-
(1998)
Nature
, vol.395
, pp. 137-143
-
-
Nolte, R.T.1
Wisely, G.B.2
Westin, S.3
Cobb, J.E.4
Lambert, M.H.5
Kurokawa, R.6
Rosenfeld, M.G.7
Willson, T.M.8
Glass, C.K.9
Milburn, M.V.10
-
33
-
-
0034721937
-
Ligand type-specific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators
-
Kodera Y, Takeyama K, Murayama A, Suzawa M, Mashiro Y, Kato S. Ligand type-specific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators. J Biol Chem. 2000;275:33201-33204.
-
(2000)
J Biol Chem
, vol.275
, pp. 33201-33204
-
-
Kodera, Y.1
Takeyama, K.2
Murayama, A.3
Suzawa, M.4
Mashiro, Y.5
Kato, S.6
-
34
-
-
0038813860
-
Differential recruitment of the coactivator proteins CREB-binding protein and steroid receptor coactivator-1 to peroxisome proliferator-activaled receptor gamma/9-cis-retinoic acid receptor heterodimers by ligands present in oxidized low-density lipoprotein
-
Wigren J, Surapureddi S, Olsson AG, Glass CK, Hammarstrom S, Soderstrom M. Differential recruitment of the coactivator proteins CREB-binding protein and steroid receptor coactivator-1 to peroxisome proliferator-activaled receptor gamma/9-cis-retinoic acid receptor heterodimers by ligands present in oxidized low-density lipoprotein. J Endocrinol. 2003;177:207-214.
-
(2003)
J Endocrinol
, vol.177
, pp. 207-214
-
-
Wigren, J.1
Surapureddi, S.2
Olsson, A.G.3
Glass, C.K.4
Hammarstrom, S.5
Soderstrom, M.6
-
35
-
-
0029035278
-
LXR, a nuclear receptor that defines a distinct retinoid response pathway
-
Willy PJ, Umesono K, Ong ES, Evans RM, Heyman RA, Mangelsdorf DJ. LXR, a nuclear receptor that defines a distinct retinoid response pathway. Genes Dev. 1995;9:1033-1045.
-
(1995)
Genes Dev
, vol.9
, pp. 1033-1045
-
-
Willy, P.J.1
Umesono, K.2
Ong, E.S.3
Evans, R.M.4
Heyman, R.A.5
Mangelsdorf, D.J.6
-
36
-
-
0034518420
-
The role of orphan nuclear receptors in the regulation of cholesterol homeostasis
-
Repa JJ, Mangelsdorf DJ, The role of orphan nuclear receptors in the regulation of cholesterol homeostasis. Annu Rev Cell Dev Biol. 2000;16:459-481.
-
(2000)
Annu Rev Cell Dev Biol
, vol.16
, pp. 459-481
-
-
Repa, J.J.1
Mangelsdorf, D.J.2
-
37
-
-
0033524420
-
Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta
-
Janowski BA, Grogan MJ, Jones SA, Wisely GB, Kliewer SA, Corey EJ, Mangelsdorf DJ. Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta. Proc Natl Acad Sci USA 1999;96:266-271.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 266-271
-
-
Janowski, B.A.1
Grogan, M.J.2
Jones, S.A.3
Wisely, G.B.4
Kliewer, S.A.5
Corey, E.J.6
Mangelsdorf, D.J.7
-
38
-
-
0013199471
-
Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα
-
Peet DJ, Turley SD, Ma W, Janowski BA, Lobaccaro J-MA, Hammer RE, Mangelsdorf DJ. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα. Cell 1998;93:693-704.
-
(1998)
Cell
, vol.93
, pp. 693-704
-
-
Peet, D.J.1
Turley, S.D.2
Ma, W.3
Janowski, B.A.4
Lobaccaro, J.-M.A.5
Hammer, R.E.6
Mangelsdorf, D.J.7
-
39
-
-
0035101931
-
Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice
-
Alberti S, Schuster G, Parini P, Feltkamp D, Diczfalusy U, Rudling M, Angelin B, Bjorkhem I, Pettersson S, Gustafsson JA. Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice. J Clin Invest. 2001;107:565-573.
-
(2001)
J Clin Invest
, vol.107
, pp. 565-573
-
-
Alberti, S.1
Schuster, G.2
Parini, P.3
Feltkamp, D.4
Diczfalusy, U.5
Rudling, M.6
Angelin, B.7
Bjorkhem, I.8
Pettersson, S.9
Gustafsson, J.A.10
-
40
-
-
0037036417
-
Dietary cholesterol fails to stimulate the human cholesterol 7alpha-hydroxylase gene (CYP7A1) in transgenic mice
-
Agellon LB, Drover VA, Cheema SK, Gbaguidi GF, Walsh A. Dietary cholesterol fails to stimulate the human cholesterol 7alpha-hydroxylase gene (CYP7A1) in transgenic mice. J Biol Chem. 2002;277:20131-20134.
-
(2002)
J Biol Chem
, vol.277
, pp. 20131-20134
-
-
Agellon, L.B.1
Drover, V.A.2
Cheema, S.K.3
Gbaguidi, G.F.4
Walsh, A.5
-
41
-
-
0037044830
-
Mice expressing the human CYP7A1 gene in the mouse CYP7A1 knock-out background lack induction of CYP7A1 expression by cholesterol feeding and have increased hypercholesterolemia when fed a high fat diet
-
Chen JY, Levy-Wilson B, Goodart S, Cooper AD. Mice expressing the human CYP7A1 gene in the mouse CYP7A1 knock-out background lack induction of CYP7A1 expression by cholesterol feeding and have increased hypercholesterolemia when fed a high fat diet. J Biol Chem. 2002;277:42588-42595.
-
(2002)
J Biol Chem
, vol.277
, pp. 42588-42595
-
-
Chen, J.Y.1
Levy-Wilson, B.2
Goodart, S.3
Cooper, A.D.4
-
42
-
-
0034284918
-
Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers
-
Repa JJ, Turley SD, Lobaccaro JA, Medina J, Li L, Lustig K, Shan B, Heyman RA, Dietschy JM, Mangelsdorf DJ. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science 2000;289:1524-1529.
-
(2000)
Science
, vol.289
, pp. 1524-1529
-
-
Repa, J.J.1
Turley, S.D.2
Lobaccaro, J.A.3
Medina, J.4
Li, L.5
Lustig, K.6
Shan, B.7
Heyman, R.A.8
Dietschy, J.M.9
Mangelsdorf, D.J.10
-
43
-
-
0038614979
-
Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8
-
Yu L, York J, von Bergmann K, Lutjohann D, Cohen JC, Hobbs HH. Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8. J Biol Chem. 2003;278:15565-15570.
-
(2003)
J Biol Chem
, vol.278
, pp. 15565-15570
-
-
Yu, L.1
York, J.2
Von Bergmann, K.3
Lutjohann, D.4
Cohen, J.C.5
Hobbs, H.H.6
-
44
-
-
0035158733
-
Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption
-
Lee MH, Lu K, Hazard S, Yu H, Shulenin S, Hidaka H, Kojima H, Allikmets R, Sakuma N, Pegoraro R, Srivastava AK, Salen G, Dean M, Patel SB. Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption. Nat Genet. 2001;27:79-83.
-
(2001)
Nat Genet
, vol.27
, pp. 79-83
-
-
Lee, M.H.1
Lu, K.2
Hazard, S.3
Yu, H.4
Shulenin, S.5
Hidaka, H.6
Kojima, H.7
Allikmets, R.8
Sakuma, N.9
Pegoraro, R.10
Srivastava, A.K.11
Salen, G.12
Dean, M.13
Patel, S.B.14
-
45
-
-
0034915332
-
Two genes that map to the STSL locus cause sitosterolemia: Genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively
-
Lu K, Lee MH, Hazard S, Brooks-Wilson A, Hidaka H, Kojima H, Ose L, Stalenhoef AF, Mietinnen T, Bjorkhem I, Bruckert E, Pandya A, Brewer HB, Jr., Salen G, Dean M, Srivastava A, Patel SB. Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively. Am J Hum Genet. 2001;69:278-290.
-
(2001)
Am J Hum Genet
, vol.69
, pp. 278-290
-
-
Lu, K.1
Lee, M.H.2
Hazard, S.3
Brooks-Wilson, A.4
Hidaka, H.5
Kojima, H.6
Ose, L.7
Stalenhoef, A.F.8
Mietinnen, T.9
Bjorkhem, I.10
Bruckert, E.11
Pandya, A.12
Brewer Jr., H.B.13
Salen, G.14
Dean, M.15
Srivastava, A.16
Patel, S.B.17
-
46
-
-
0034669025
-
Regulation of mouse sterol regulatory element-binding protein-1c (SREBP-1c) by oxysterol receptors LXRα and LXRβ
-
Repa JJ, Liang G, Ou J, Bashmakov Y, Lobaccaro J-MA, Shimomura I, Shan B, Brown MS, Goldstein JL, Mangelsdorf DJ. Regulation of mouse sterol regulatory element-binding protein-1c (SREBP-1c) by oxysterol receptors LXRα and LXRβ. Genes Dev. 2000;14:2819-2830.
-
(2000)
Genes Dev
, vol.14
, pp. 2819-2830
-
-
Repa, J.J.1
Liang, G.2
Ou, J.3
Bashmakov, Y.4
Lobaccaro, J.-M.A.5
Shimomura, I.6
Shan, B.7
Brown, M.S.8
Goldstein, J.L.9
Mangelsdorf, D.J.10
-
47
-
-
0035852770
-
Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands
-
DeBose-Boyd RA, Ou J, Goldstein JL, Brown MS. Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands. Proc Natl Acad Sci U S A 2001;98:1477-1482.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 1477-1482
-
-
DeBose-Boyd, R.A.1
Ou, J.2
Goldstein, J.L.3
Brown, M.S.4
-
48
-
-
0035047709
-
Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter
-
Yoshikawa T, Shimano H, Amemiya-Kudo M, Yahagi N, Hasty AH, Matsuzaka T, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Kimura S, Ishibashi S, Yamada N. Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter. Mol Cell Biol. 2001;21:2991-3000.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 2991-3000
-
-
Yoshikawa, T.1
Shimano, H.2
Amemiya-Kudo, M.3
Yahagi, N.4
Hasty, A.H.5
Matsuzaka, T.6
Okazaki, H.7
Tamura, Y.8
Iizuka, Y.9
Ohashi, K.10
Osuga, J.11
Harada, K.12
Gotoda, T.13
Kimura, S.14
Ishibashi, S.15
Yamada, N.16
-
49
-
-
0037184995
-
Pattern recognition receptors: Doubling up for the innate immune response
-
Gordon S. Pattern recognition receptors: doubling up for the innate immune response. Cell 2002;111:927-930.
-
(2002)
Cell
, vol.111
, pp. 927-930
-
-
Gordon, S.1
-
50
-
-
0035936802
-
Atherosclerosis; the road ahead
-
Glass C, Witztum J. Atherosclerosis; the road ahead. Cell 2001;104:503-516.
-
(2001)
Cell
, vol.104
, pp. 503-516
-
-
Glass, C.1
Witztum, J.2
-
51
-
-
0036852744
-
The macrophage foam cell as a target for therapeutic intervention
-
Li AC, Glass CK. The macrophage foam cell as a target for therapeutic intervention. Nat Med. 2002;8:1235-1242.
-
(2002)
Nat Med
, vol.8
, pp. 1235-1242
-
-
Li, A.C.1
Glass, C.K.2
-
52
-
-
0032540325
-
Oxidized LDL regulates macrophage gene expression through ligand activation of PPAR-gamma
-
Nagy L, Tontonoz P, Alvarez JGA, Chen H, Evans RM. Oxidized LDL regulates macrophage gene expression through ligand activation of PPAR-gamma. Cell 1998;93:229-240.
-
(1998)
Cell
, vol.93
, pp. 229-240
-
-
Nagy, L.1
Tontonoz, P.2
Alvarez, J.G.A.3
Chen, H.4
Evans, R.M.5
-
53
-
-
0032540012
-
PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL
-
Tontonoz P, Nagy L, Alvarez JGA, Thomazy VA, Evans RM. PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 1998;93:241-252.
-
(1998)
Cell
, vol.93
, pp. 241-252
-
-
Tontonoz, P.1
Nagy, L.2
Alvarez, J.G.A.3
Thomazy, V.A.4
Evans, R.M.5
-
54
-
-
0035132330
-
PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation
-
Chawla A, Barak Y, Nagy L, Liao D, Tontonoz P, Evans RM. PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. Nat Med. 2001;7:48-52.
-
(2001)
Nat Med
, vol.7
, pp. 48-52
-
-
Chawla, A.1
Barak, Y.2
Nagy, L.3
Liao, D.4
Tontonoz, P.5
Evans, R.M.6
-
55
-
-
0035139016
-
The role of PPAR-gamma in macrophage differentiation and cholesterol uptake
-
Moore KJ, Rosen ED, Fitzgerald ML, Randow F, Andersson LP, Altshuler D, Milstone DS, Mortensen RM, Spiegelman BM, Freeman MW. The role of PPAR-gamma in macrophage differentiation and cholesterol uptake. Nat Med. 2001;7:41-47.
-
(2001)
Nat Med
, vol.7
, pp. 41-47
-
-
Moore, K.J.1
Rosen, E.D.2
Fitzgerald, M.L.3
Randow, F.4
Andersson, L.P.5
Altshuler, D.6
Milstone, D.S.7
Mortensen, R.M.8
Spiegelman, B.M.9
Freeman, M.W.10
-
56
-
-
0036205326
-
Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux
-
Akiyama TE, Sakai S, Lambert G, Nicol CJ, Matsusue K, Pimprale S, Lee YH, Ricote M, Glass CK, Brewer HB, Jr., Gonzalez FJ. Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux. Mol Cell Biol. 2002;22:2607-2619.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 2607-2619
-
-
Akiyama, T.E.1
Sakai, S.2
Lambert, G.3
Nicol, C.J.4
Matsusue, K.5
Pimprale, S.6
Lee, Y.H.7
Ricote, M.8
Glass, C.K.9
Brewer Jr., H.B.10
Gonzalez, F.J.11
-
57
-
-
0035138625
-
PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway
-
Chinetti G, Lestavel S, Bocher V, Remaley AT, Neve B, Torra IP, Teissier E, Minnich A, Jaye M, Duverger N, Brewer HB, Fruchart JC, Clavey V, Staels B. PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway. Nat Med. 2001;7:53-58.
-
(2001)
Nat Med
, vol.7
, pp. 53-58
-
-
Chinetti, G.1
Lestavel, S.2
Bocher, V.3
Remaley, A.T.4
Neve, B.5
Torra, I.P.6
Teissier, E.7
Minnich, A.8
Jaye, M.9
Duverger, N.10
Brewer, H.B.11
Fruchart, J.C.12
Clavey, V.13
Staels, B.14
-
58
-
-
0033864582
-
Peroxisome proliferator-activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor-deficient mice
-
Li A, Brown K, Silvestre M, Willson T, Palinski W, Glass C. Peroxisome proliferator-activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor-deficient mice. J. Clin. Invest. 2000;106:523-531.
-
(2000)
J Clin Invest
, vol.106
, pp. 523-531
-
-
Li, A.1
Brown, K.2
Silvestre, M.3
Willson, T.4
Palinski, W.5
Glass, C.6
-
59
-
-
0035093258
-
Troglitazone inhibits formation of early atherosclerotic lesions in diabetic and nondiabetic low density lipoprotein receptor-deficient mice
-
Collins AR, Meehan WP, Kintscher U, Jackson S, Wakino S, Noh G, Palinski W, Hsueh WA, Law RE. Troglitazone inhibits formation of early atherosclerotic lesions in diabetic and nondiabetic low density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol. 2001;21:365-371.
-
(2001)
Arterioscler Thromb Vasc Biol
, vol.21
, pp. 365-371
-
-
Collins, A.R.1
Meehan, W.P.2
Kintscher, U.3
Jackson, S.4
Wakino, S.5
Noh, G.6
Palinski, W.7
Hsueh, W.A.8
Law, R.E.9
-
60
-
-
0035097590
-
Troglitazone inhibits atherosclerosis in apolipoprotein E-knockout mice: Pleiotropic effects on CD36 expression and HDL
-
Chen Z, Ishibashi S, Perrey S, Osuga J, Gotoda T, Kitamine T, Tamura Y, Okazaki H, Yahagi N, Iizuka Y, Shionoiri F, Ohashi K, Harada K, Shimano H, Nagai R, Yamada N. Troglitazone inhibits atherosclerosis in apolipoprotein E-knockout mice: pleiotropic effects on CD36 expression and HDL. Arterioscler Thromb Vasc Biol. 2001;21:372-377.
-
(2001)
Arterioscler Thromb Vasc Biol
, vol.21
, pp. 372-377
-
-
Chen, Z.1
Ishibashi, S.2
Perrey, S.3
Osuga, J.4
Gotoda, T.5
Kitamine, T.6
Tamura, Y.7
Okazaki, H.8
Yahagi, N.9
Iizuka, Y.10
Shionoiri, F.11
Ohashi, K.12
Harada, K.13
Shimano, H.14
Nagai, R.15
Yamada, N.16
-
61
-
-
0035957006
-
Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor
-
Claudel T, Leibowitz MD, Fievet C, Tailleux A, Wagner B, Repa JJ, Torpier G, Lobaccaro JM, Patemiti JR, Mangelsdorf DJ, Heyman RA, Auwerx J. Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor. Proc Natl Acad Sci U S A 2001;98:2610-2615.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 2610-2615
-
-
Claudel, T.1
Leibowitz, M.D.2
Fievet, C.3
Tailleux, A.4
Wagner, B.5
Repa, J.J.6
Torpier, G.7
Lobaccaro, J.M.8
Patemiti, J.R.9
Mangelsdorf, D.J.10
Heyman, R.A.11
Auwerx, J.12
-
62
-
-
17744376173
-
A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis
-
Chawla A, Boisvert WA, Lee CH, Laffitte BA, Barak Y, Joseph SB, Liao D, Nagy L, Edwards PA, Curtiss LK, Evans RM, Tontonoz P. A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis. Mol Cell. 2001;7:161-171.
-
(2001)
Mol Cell
, vol.7
, pp. 161-171
-
-
Chawla, A.1
Boisvert, W.A.2
Lee, C.H.3
Laffitte, B.A.4
Barak, Y.5
Joseph, S.B.6
Liao, D.7
Nagy, L.8
Edwards, P.A.9
Curtiss, L.K.10
Evans, R.M.11
Tontonoz, P.12
-
63
-
-
0034920087
-
Rapid communication: Inhibitory effect of pioglitazone on carotid arterial wall thickness in type 2 diabetes
-
Koshiyama H, Shimono D, Kuwamura N, Minamikawa J, Nakamura Y. Rapid communication: inhibitory effect of pioglitazone on carotid arterial wall thickness in type 2 diabetes. J Clin Endocrinol Metab. 2001;86:3452-3456.
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 3452-3456
-
-
Koshiyama, H.1
Shimono, D.2
Kuwamura, N.3
Minamikawa, J.4
Nakamura, Y.5
-
64
-
-
0031724132
-
Potent inhibitory effect of troglitazone on carotid arterial wall thickness in type 2 diabetes
-
Minamikawa J, Tanaka S, Yamauchi M, Inoue D, Koshiyama H. Potent inhibitory effect of troglitazone on carotid arterial wall thickness in type 2 diabetes. J Clin Endocrinol Metab. 1998;83:1818-1820.
-
(1998)
J Clin Endocrinol Metab
, vol.83
, pp. 1818-1820
-
-
Minamikawa, J.1
Tanaka, S.2
Yamauchi, M.3
Inoue, D.4
Koshiyama, H.5
-
65
-
-
0035962077
-
Relation of gemfibrozil treatment and lipid levels with major coronary events: VA-HIT: A randomized controlled trial
-
Robins SJ, Collins D, Wittes JT, Papademetriou V, Deedwania PC, Schaefer EJ, McNamara JR, Kashyap ML, Hershman JM, Wexler LF, Rubins HB. Relation of gemfibrozil treatment and lipid levels with major coronary events: VA-HIT: a randomized controlled trial. Jama. 2001;285:1585-1591.
-
(2001)
Jama
, vol.285
, pp. 1585-1591
-
-
Robins, S.J.1
Collins, D.2
Wittes, J.T.3
Papademetriou, V.4
Deedwania, P.C.5
Schaefer, E.J.6
McNamara, J.R.7
Kashyap, M.L.8
Hershman, J.M.9
Wexler, L.F.10
Rubins, H.B.11
-
66
-
-
0042669791
-
Insulin resistance and cardiovascular events with low HDL cholesterol: The Veterans Affairs HDL Intervention Trial (VA-HIT)
-
Robins SJ, Rubins HB, Faas FH, Schaefer EJ, Elam MB, Anderson JW, Collins D. Insulin resistance and cardiovascular events with low HDL cholesterol: the Veterans Affairs HDL Intervention Trial (VA-HIT). Diabetes Care 2003;26:1513-1517.
-
(2003)
Diabetes Care
, vol.26
, pp. 1513-1517
-
-
Robins, S.J.1
Rubins, H.B.2
Faas, F.H.3
Schaefer, E.J.4
Elam, M.B.5
Anderson, J.W.6
Collins, D.7
-
67
-
-
0032813660
-
Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1
-
Rust S, Rosier M, Funke H, Real J, Amoura Z, Piette JC, Deleuze JF, Brewer HB, Duverger N, Denefle P, Assmann G. Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1. Nat Genet. 1999;22:352-355.
-
(1999)
Nat Genet
, vol.22
, pp. 352-355
-
-
Rust, S.1
Rosier, M.2
Funke, H.3
Real, J.4
Amoura, Z.5
Piette, J.C.6
Deleuze, J.F.7
Brewer, H.B.8
Duverger, N.9
Denefle, P.10
Assmann, G.11
-
68
-
-
0032725185
-
The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway
-
Lawn RM, Wade DP, Garvin MR, Wang X, Schwartz K, Porter JG, Seilhamer JJ, Vaughan AM, Oram JF. The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway. J Clin Invest. 1999;104:R25-R31.
-
(1999)
J Clin Invest
, vol.104
-
-
Lawn, R.M.1
Wade, D.P.2
Garvin, M.R.3
Wang, X.4
Schwartz, K.5
Porter, J.G.6
Seilhamer, J.J.7
Vaughan, A.M.8
Oram, J.F.9
-
69
-
-
0032813808
-
Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency
-
Brooks-Wilson A, Marcil M, Clee SM, Zhang LH, Roomp K, van Dam M, Yu L, Brewer C, Collins JA, Molhuizen HO, Loubser O, Ouelette BF, Fichter K, Ashbourne-Excoffon KJ, Sensen CW, Scherer S, Mott S, Denis M, Martindale D, Frohlich J, Morgan K, Koop B, Pimstone S, Kastelein JJ, Hayden MR. Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency. Nat Genet. 1999;22:336-345.
-
(1999)
Nat Genet
, vol.22
, pp. 336-345
-
-
Brooks-Wilson, A.1
Marcil, M.2
Clee, S.M.3
Zhang, L.H.4
Roomp, K.5
Van Dam, M.6
Yu, L.7
Brewer, C.8
Collins, J.A.9
Molhuizen, H.O.10
Loubser, O.11
Ouelette, B.F.12
Fichter, K.13
Ashbourne-Excoffon, K.J.14
Sensen, C.W.15
Scherer, S.16
Mott, S.17
Denis, M.18
Martindale, D.19
Frohlich, J.20
Morgan, K.21
Koop, B.22
Pimstone, S.23
Kastelein, J.J.24
Hayden, M.R.25
more..
-
70
-
-
0032813809
-
The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease
-
Bodzioch M, Orso E, Klucken J, Langmann T, Bottcher A, Diederich W, Drobnik W, Barlage S, Buchler C, Porsch-Ozcurumez M, Kaminski WE, Hahmann HW, Oette K, Rothe G, Aslanidis C, Lackner KJ, Schmitz G. The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease. Nat Genet. 1999;22:347-351.
-
(1999)
Nat Genet
, vol.22
, pp. 347-351
-
-
Bodzioch, M.1
Orso, E.2
Klucken, J.3
Langmann, T.4
Bottcher, A.5
Diederich, W.6
Drobnik, W.7
Barlage, S.8
Buchler, C.9
Porsch-Ozcurumez, M.10
Kaminski, W.E.11
Hahmann, H.W.12
Oette, K.13
Rothe, G.14
Aslanidis, C.15
Lackner, K.J.16
Schmitz, G.17
-
71
-
-
0034115889
-
ABCA1-mediated transport of cellular cholesterol and phospholipids to HDL apolipoproteins
-
Oram JF, Vaughan AM. ABCA1-mediated transport of cellular cholesterol and phospholipids to HDL apolipoproteins. Curr Opin Lipidol. 2000;11:253-260.
-
(2000)
Curr Opin Lipidol
, vol.11
, pp. 253-260
-
-
Oram, J.F.1
Vaughan, A.M.2
-
72
-
-
0034710965
-
Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha
-
Venkateswaran A, Laffitte BA, Joseph SB, Mak PA, Wilpitz DC, Edwards PA, Tontonoz P. Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha. Proc Natl Acad Sci U S A 2000;97:12097-12102.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 12097-12102
-
-
Venkateswaran, A.1
Laffitte, B.A.2
Joseph, S.B.3
Mak, P.A.4
Wilpitz, D.C.5
Edwards, P.A.6
Tontonoz, P.7
-
73
-
-
0034623288
-
Sterol-dependent transactivation of the ABC1 promoter by the liver X Receptor/Retinoid X receptor
-
Costet P, Luo Y, Wang N, Tall AR. Sterol-dependent transactivation of the ABC1 promoter by the liver X Receptor/Retinoid X receptor. J. Biol. Chem. 2000;275:28240-28245.
-
(2000)
J Biol Chem
, vol.275
, pp. 28240-28245
-
-
Costet, P.1
Luo, Y.2
Wang, N.3
Tall, A.R.4
-
74
-
-
0034637128
-
ABC1 gene expression and ApoA-I-mediated cholesterol efflux are regulated by LXR
-
Schwartz K, Lawn RM, Wade DP. ABC1 gene expression and ApoA-I-mediated cholesterol efflux are regulated by LXR. Biochem Biophys Res Commun. 2000;274:794-802.
-
(2000)
Biochem Biophys Res Commun
, vol.274
, pp. 794-802
-
-
Schwartz, K.1
Lawn, R.M.2
Wade, D.P.3
-
75
-
-
0037188553
-
Synthetic LXR ligand inhibits the development of atherosclerosis in mice
-
Joseph SB, McKilligin E, Pei L, Watson MA, Collins AR, Laffitte BA, Chen M, Noh G, Goodman J, Hagger GN, Tran J, Tippin TK, Wang X, Lusis AJ, Hsueh WA, Law RE, Collins JL, Willson TM, Tontonoz P. Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc Natl Acad Sci USA 2002;99:7604-7609.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 7604-7609
-
-
Joseph, S.B.1
McKilligin, E.2
Pei, L.3
Watson, M.A.4
Collins, A.R.5
Laffitte, B.A.6
Chen, M.7
Noh, G.8
Goodman, J.9
Hagger, G.N.10
Tran, J.11
Tippin, T.K.12
Wang, X.13
Lusis, A.J.14
Hsueh, W.A.15
Law, R.E.16
Collins, J.L.17
Willson, T.M.18
Tontonoz, P.19
-
76
-
-
0037432165
-
T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice
-
Terasaka N, Hiroshima A, Koieyama T, Ubukata N, Morikawa Y, Nakai D, Inaba T. T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice. FEBS Lett. 2003;536:6-11.
-
(2003)
FEBS Lett
, vol.536
, pp. 6-11
-
-
Terasaka, N.1
Hiroshima, A.2
Koieyama, T.3
Ubukata, N.4
Morikawa, Y.5
Nakai, D.6
Inaba, T.7
-
77
-
-
0037015013
-
Identification of macrophage liver X receptors as inhibitors of atherosclerosis
-
Tangirala RK, Bischoff ED, Joseph SB, Wagner BL, Walczak R, Laffitte BA, Daige CL, Thomas D, Heyman RA, Mangelsdorf DJ, Wang X, Lusis AJ, Tontonoz P, Schulman IG. Identification of macrophage liver X receptors as inhibitors of atherosclerosis. Proc Natl Acad Sci USA 2002;99:11896-11901.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 11896-11901
-
-
Tangirala, R.K.1
Bischoff, E.D.2
Joseph, S.B.3
Wagner, B.L.4
Walczak, R.5
Laffitte, B.A.6
Daige, C.L.7
Thomas, D.8
Heyman, R.A.9
Mangelsdorf, D.J.10
Wang, X.11
Lusis, A.J.12
Tontonoz, P.13
Schulman, I.G.14
-
78
-
-
0034640288
-
Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols
-
Venkateswaran A, Repa JJ, Lobaccaro JM, Bronson A, Mangelsdorf DJ, Edwards PA. Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols. J Biol Chem. 2000;275:14700-14707.
-
(2000)
J Biol Chem
, vol.275
, pp. 14700-14707
-
-
Venkateswaran, A.1
Repa, J.J.2
Lobaccaro, J.M.3
Bronson, A.4
Mangelsdorf, D.J.5
Edwards, P.A.6
-
79
-
-
0037423555
-
Peroxisome proliferator-activated receptor alpha reduces cholesterol esterification in macrophages
-
Chinetti G, Lestavel S, Fruchart JC, Clavey V, Staels B. Peroxisome proliferator-activated receptor alpha reduces cholesterol esterification in macrophages. Circ Res. 2003;92:212-217.
-
(2003)
Circ Res
, vol.92
, pp. 212-217
-
-
Chinetti, G.1
Lestavel, S.2
Fruchart, J.C.3
Clavey, V.4
Staels, B.5
-
80
-
-
0034705071
-
CLA-I/SR-BI is expressed in atherosclerotic lesion macrophages and regulated by activators of peroxisome proliferator-activated receptors
-
Chinetti G, Gbaguidi FG, Griglio S, Mallat Z, Antonucci M, Poulain P, Chapman J, Fruchart JC, Tedgui A, Najib-Fruchart J, Staels B. CLA-I/SR-BI is expressed in atherosclerotic lesion macrophages and regulated by activators of peroxisome proliferator-activated receptors. Circulation 2000;101:2411-2417.
-
(2000)
Circulation
, vol.101
, pp. 2411-2417
-
-
Chinetti, G.1
Gbaguidi, F.G.2
Griglio, S.3
Mallat, Z.4
Antonucci, M.5
Poulain, P.6
Chapman, J.7
Fruchart, J.C.8
Tedgui, A.9
Najib-Fruchart, J.10
Staels, B.11
-
81
-
-
0034817390
-
Cloning of the human cholesteryl ester hydrolase promoter: Identification of functional peroxisomal proliferator-activated receptor responsive elements
-
Ghosh S, Natarajan R. Cloning of the human cholesteryl ester hydrolase promoter: identification of functional peroxisomal proliferator-activated receptor responsive elements. Biochem Biophys Res Commun. 2001;284:1065-1070.
-
(2001)
Biochem Biophys Res Commun
, vol.284
, pp. 1065-1070
-
-
Ghosh, S.1
Natarajan, R.2
-
82
-
-
0035941270
-
The peroxisome proliferator-activated receptor delta promotes lipid accumulation in human macrophages
-
Vosper H, Patel L, Graham TL, Khoudoli GA, Hill A, Macphee CH, Pinto I, Smith SA, Suckling KE, Wolf CR, Palmer CN. The peroxisome proliferator-activated receptor delta promotes lipid accumulation in human macrophages. J Biol Chem. 2001;276:44258-44265.
-
(2001)
J Biol Chem
, vol.276
, pp. 44258-44265
-
-
Vosper, H.1
Patel, L.2
Graham, T.L.3
Khoudoli, G.A.4
Hill, A.5
Macphee, C.H.6
Pinto, I.7
Smith, S.A.8
Suckling, K.E.9
Wolf, C.R.10
Palmer, C.N.11
-
83
-
-
0037417726
-
PPARdelta is a very low-density lipoprotein sensor in macrophages
-
Chawla A, Lee CH, Barak Y, He W, Rosenfeld J, Liao D, Han J, Kang H, Evans RM. PPARdelta is a very low-density lipoprotein sensor in macrophages. Proc Natl Acad Sci U S A 2003;100:1268-1273.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 1268-1273
-
-
Chawla, A.1
Lee, C.H.2
Barak, Y.3
He, W.4
Rosenfeld, J.5
Liao, D.6
Han, J.7
Kang, H.8
Evans, R.M.9
-
84
-
-
0037418303
-
Lipolysis of triglyceride-rich lipoproteins generates PPAR ligands: Evidence for an antiinflammatory role for lipoprotein lipase
-
Ziouzenkova O, Perrey S, Asatryan L, Hwang J, MacNaul KL, Moller DE, Rader DJ, Sevanian A, Zechner R, Hoefler G, Plutzky J. Lipolysis of triglyceride-rich lipoproteins generates PPAR ligands: evidence for an antiinflammatory role for lipoprotein lipase. Proc Natl Acad Sci USA 2003;100:2730-2735.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 2730-2735
-
-
Ziouzenkova, O.1
Perrey, S.2
Asatryan, L.3
Hwang, J.4
MacNaul, K.L.5
Moller, D.E.6
Rader, D.J.7
Sevanian, A.8
Zechner, R.9
Hoefler, G.10
Plutzky, J.11
-
85
-
-
0038460253
-
PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages
-
Welch JS, Ricote M, Akiyama TE, Gonzalez FJ, Glass CK. PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages. Proc Natl Acad Sci USA. 2003;100:6712-6717.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 6712-6717
-
-
Welch, J.S.1
Ricote, M.2
Akiyama, T.E.3
Gonzalez, F.J.4
Glass, C.K.5
-
86
-
-
0035895202
-
LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes
-
Laffitte BA, Repa JJ, Joseph SB, Wilpitz DC, Kast HR, Mangelsdorf DJ, Tontonoz P. LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. Proc Natl Acad Sci U S A. 2001;98:507-512.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 507-512
-
-
Laffitte, B.A.1
Repa, J.J.2
Joseph, S.B.3
Wilpitz, D.C.4
Kast, H.R.5
Mangelsdorf, D.J.6
Tontonoz, P.7
-
87
-
-
0037199994
-
Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta
-
Mak PA, Laffitte BA, Desrumaux C, Joseph SB, Curtiss LK, Mangelsdorf DJ, Tontonoz P, Edwards PA. Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta. J Biol Chem. 2002;277:31900-31908.
-
(2002)
J Biol Chem
, vol.277
, pp. 31900-31908
-
-
Mak, P.A.1
Laffitte, B.A.2
Desrumaux, C.3
Joseph, S.B.4
Curtiss, L.K.5
Mangelsdorf, D.J.6
Tontonoz, P.7
Edwards, P.A.8
-
89
-
-
0026725757
-
Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
-
Plump AS, Smith JD, Hayek T, Breslow J. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell 1992;71:343-353.
-
(1992)
Cell
, vol.71
, pp. 343-353
-
-
Plump, A.S.1
Smith, J.D.2
Hayek, T.3
Breslow, J.4
-
90
-
-
0026592806
-
Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E
-
Zhang SH, Reddick RL, Piedrahita JA, Maeda N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science 1992;258:468-471.
-
(1992)
Science
, vol.258
, pp. 468-471
-
-
Zhang, S.H.1
Reddick, R.L.2
Piedrahita, J.A.3
Maeda, N.4
-
91
-
-
0030945298
-
Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages
-
Fazio S, Babaev VR, Murray AB, Hasty AH, Carter KJ, Gleaves LA, Atkinson JB, Linton MF. Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages. Proc Natl Acad Sci USA 1997;94:4647-4652.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 4647-4652
-
-
Fazio, S.1
Babaev, V.R.2
Murray, A.B.3
Hasty, A.H.4
Carter, K.J.5
Gleaves, L.A.6
Atkinson, J.B.7
Linton, M.F.8
-
92
-
-
0032895706
-
Elimination of macrophage-specific apolipoprotein E reduces diet-induced atherosclerosis in C57BL/6J male mice
-
Boisvert WA, Curtiss LK. Elimination of macrophage-specific apolipoprotein E reduces diet-induced atherosclerosis in C57BL/6J male mice. J Lipid Res. 1999;40:806-813.
-
(1999)
J Lipid Res
, vol.40
, pp. 806-813
-
-
Boisvert, W.A.1
Curtiss, L.K.2
-
93
-
-
0032821194
-
Apolipoprotein E-dependent cholesterol efflux from macrophages: Kinetic study and divergent mechanisms for endogenous versus exogenous apolipoprotein E
-
Lin CY, Duan H, Mazzone T. Apolipoprotein E-dependent cholesterol efflux from macrophages: kinetic study and divergent mechanisms for endogenous versus exogenous apolipoprotein E. J Lipid Res. 1999;40:1618-1627.
-
(1999)
J Lipid Res
, vol.40
, pp. 1618-1627
-
-
Lin, C.Y.1
Duan, H.2
Mazzone, T.3
-
94
-
-
0026647688
-
Hypertriglyceridaemia due to genetic defects in lipoprotein lipase and apolipoprotein C-II
-
Fojo SS, Brewer HB. Hypertriglyceridaemia due to genetic defects in lipoprotein lipase and apolipoprotein C-II. J Intern Med. 1992;231:669-677.
-
(1992)
J Intern Med
, vol.231
, pp. 669-677
-
-
Fojo, S.S.1
Brewer, H.B.2
-
96
-
-
0028331148
-
Overexpression of apolipoprotein CII causes hypertriglyceridemia in transgenic mice
-
Shachter NS, Hayek T, Leff T, Smith JD, Rosenberg DW, Walsh A, Ramakrishnan R, Goldberg IJ, Ginsberg HN, Breslow JL. Overexpression of apolipoprotein CII causes hypertriglyceridemia in transgenic mice. J Clin Invest. 1994;93:1683-1690.
-
(1994)
J Clin Invest
, vol.93
, pp. 1683-1690
-
-
Shachter, N.S.1
Hayek, T.2
Leff, T.3
Smith, J.D.4
Rosenberg, D.W.5
Walsh, A.6
Ramakrishnan, R.7
Goldberg, I.J.8
Ginsberg, H.N.9
Breslow, J.L.10
-
97
-
-
0031985353
-
Hyperlipidemia and cutaneous abnormalities in transgenic mice overexpressing human apolipoprotein CI
-
Jong MC, Gijbels MJ, Dahlmans VE, Gorp PJ, Koopman SJ, Ponec M, Hofker MH, Havekes LM. Hyperlipidemia and cutaneous abnormalities in transgenic mice overexpressing human apolipoprotein CI. J Clin Invest. 1998;101:145-152.
-
(1998)
J Clin Invest
, vol.101
, pp. 145-152
-
-
Jong, M.C.1
Gijbels, M.J.2
Dahlmans, V.E.3
Gorp, P.J.4
Koopman, S.J.5
Ponec, M.6
Hofker, M.H.7
Havekes, L.M.8
-
98
-
-
0034983440
-
Apolipoproteins C-I and C-III as important modulators of lipoprotein metabolism
-
Shachter NS. Apolipoproteins C-I and C-III as important modulators of lipoprotein metabolism. Curr Opin Lipidol. 2001;12:297-304.
-
(2001)
Curr Opin Lipidol
, vol.12
, pp. 297-304
-
-
Shachter, N.S.1
-
99
-
-
0029891752
-
Expression of a novel human apolipoprotein (apoC-IV) causes hypertriglyceridemia in transgenic mice
-
Allan CM, Taylor JM. Expression of a novel human apolipoprotein (apoC-IV) causes hypertriglyceridemia in transgenic mice. J Lipid Res. 1996;37:1510-1518.
-
(1996)
J Lipid Res
, vol.37
, pp. 1510-1518
-
-
Allan, C.M.1
Taylor, J.M.2
-
100
-
-
0035900749
-
Regulation of lipoprotein lipase by the oxysterol receptors, LXRalpha and LXRbeta
-
Zhang Y, Repa JJ, Gauthier K, Mangelsdorf DJ. Regulation of lipoprotein lipase by the oxysterol receptors, LXRalpha and LXRbeta. J Biol Chem. 2001;276:43018-43024.
-
(2001)
J Biol Chem
, vol.276
, pp. 43018-43024
-
-
Zhang, Y.1
Repa, J.J.2
Gauthier, K.3
Mangelsdorf, D.J.4
-
101
-
-
18244381063
-
Peroxisome proliferator-activated receptor (PPAR) agonists decrease lipoprotein lipase secretion and glycated LDL uptake by human macrophages
-
Gbaguidi FG, Chinetti G, Milosavljevic D, Teissier E, Chapman J, Olivecrona G, Fruchart JC, Griglio S, Fruchart-Najib J, Staels B. Peroxisome proliferator-activated receptor (PPAR) agonists decrease lipoprotein lipase secretion and glycated LDL uptake by human macrophages. FEBS Lett. 2002;512:85-90.
-
(2002)
FEBS Lett
, vol.512
, pp. 85-90
-
-
Gbaguidi, F.G.1
Chinetti, G.2
Milosavljevic, D.3
Teissier, E.4
Chapman, J.5
Olivecrona, G.6
Fruchart, J.C.7
Griglio, S.8
Fruchart-Najib, J.9
Staels, B.10
-
102
-
-
0029920693
-
Lipoprotein lipase and lipolysis: Central roles in lipoprotein metabolism and atherogenesis
-
Goldberg IJ. Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis. J Lipid Res. 1996;37:693-707.
-
(1996)
J Lipid Res
, vol.37
, pp. 693-707
-
-
Goldberg, I.J.1
-
103
-
-
0034714215
-
Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in low density lipoprotein receptor-deficient mice
-
Babaev VR, Patel MB, Semenkovich CF, Fazio S, Linton MF. Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in low density lipoprotein receptor-deficient mice. J Biol Chem. 2000;275:26293-26299.
-
(2000)
J Biol Chem
, vol.275
, pp. 26293-26299
-
-
Babaev, V.R.1
Patel, M.B.2
Semenkovich, C.F.3
Fazio, S.4
Linton, M.F.5
-
104
-
-
0035571614
-
Macrophage-specific expression of human lipoprotein lipase accelerates atherosclerosis in transgenic apolipoprotein e knockout mice but not in C57BL/6 mice
-
Wilson K, Fry GL, Chappell DA, Sigmund CD, Medh JD. Macrophage-specific expression of human lipoprotein lipase accelerates atherosclerosis in transgenic apolipoprotein e knockout mice but not in C57BL/6 mice. Arterioscler Thromb Vasc Biol. 2001;21:1809-1815.
-
(2001)
Arterioscler Thromb Vasc Biol
, vol.21
, pp. 1809-1815
-
-
Wilson, K.1
Fry, G.L.2
Chappell, D.A.3
Sigmund, C.D.4
Medh, J.D.5
-
105
-
-
0030002205
-
Suppression of diet-induced atherosclerosis in low density lipoprotein receptor knockout mice overexpressing lipoprotein lipase
-
Shimada M, Ishibashi S, Inaba T, Yagyu H, Harada K, Osuga JI, Ohashi K, Yazaki Y, Yamada N. Suppression of diet-induced atherosclerosis in low density lipoprotein receptor knockout mice overexpressing lipoprotein lipase. Proc Natl Acad Sci U S A 1996;93:7242-7246.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 7242-7246
-
-
Shimada, M.1
Ishibashi, S.2
Inaba, T.3
Yagyu, H.4
Harada, K.5
Osuga, J.I.6
Ohashi, K.7
Yazaki, Y.8
Yamada, N.9
-
106
-
-
0032847139
-
Overexpressed lipoprotein lipase protects against atherosclerosis in apolipoprotein E knockout mice
-
Yagyu H, Ishibashi S, Chen Z, Osunga J, Okazaki K, Perrey S, Kitamine T, Shimada M, Ohashi K, Harada K, Shionoiri F, Yahagi N, Gotoda T, Yazaki Y, Yamada N. Overexpressed lipoprotein lipase protects against atherosclerosis in apolipoprotein E knockout mice. J Lipid Res 1999;40:1677-1685.
-
(1999)
J Lipid Res
, vol.40
, pp. 1677-1685
-
-
Yagyu, H.1
Ishibashi, S.2
Chen, Z.3
Osunga, J.4
Okazaki, K.5
Perrey, S.6
Kitamine, T.7
Shimada, M.8
Ohashi, K.9
Harada, K.10
Shionoiri, F.11
Yahagi, N.12
Gotoda, T.13
Yazaki, Y.14
Yamada, N.15
-
107
-
-
0035965240
-
Adenovirus-mediated rescue of lipoprotein lipase-deficient mice. Lipolysis of triglyceride-rich lipoproteins is essential for high density lipoprotein maturation in mice
-
Strauss JG, Frank S, Kratky D, Hammerle G, Hrzenjak A, Knipping G, von Eckardstein A, Kostner GM, Zechner R. Adenovirus-mediated rescue of lipoprotein lipase-deficient mice. Lipolysis of triglyceride-rich lipoproteins is essential for high density lipoprotein maturation in mice. J Biol Chem. 2001;276:36083-36090.
-
(2001)
J Biol Chem
, vol.276
, pp. 36083-36090
-
-
Strauss, J.G.1
Frank, S.2
Kratky, D.3
Hammerle, G.4
Hrzenjak, A.5
Knipping, G.6
Von Eckardstein, A.7
Kostner, G.M.8
Zechner, R.9
-
108
-
-
0036217558
-
Phospholipid transfer protein
-
van Tol A. Phospholipid transfer protein. Curr Opin Lipidol. 2002;13:135-139.
-
(2002)
Curr Opin Lipidol
, vol.13
, pp. 135-139
-
-
Van Tol, A.1
-
109
-
-
0037372065
-
The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions
-
Laffitte BA, Joseph SB, Chen M, Castrillo A, Repa J, Wilpitz D, Mangelsdorf D, Tontonoz P. The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions. Mol Cell Biol. 2003;23:2182-2191.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 2182-2191
-
-
Laffitte, B.A.1
Joseph, S.B.2
Chen, M.3
Castrillo, A.4
Repa, J.5
Wilpitz, D.6
Mangelsdorf, D.7
Tontonoz, P.8
-
110
-
-
0037131347
-
Phospholipid transfer protein is regulated by liver X receptors in vivo
-
Cao G, Beyer TP, Yang XP, Schmidt RJ, Zhang Y, Bensch WR, Kauffman RF, Gao H, Ryan TP, Liang Y, Eacho PI, Jiang XC. Phospholipid transfer protein is regulated by liver X receptors in vivo. J Biol Chem. 2002;277:39561-39565.
-
(2002)
J Biol Chem
, vol.277
, pp. 39561-39565
-
-
Cao, G.1
Beyer, T.P.2
Yang, X.P.3
Schmidt, R.J.4
Zhang, Y.5
Bensch, W.R.6
Kauffman, R.F.7
Gao, H.8
Ryan, T.P.9
Liang, Y.10
Eacho, P.I.11
Jiang, X.C.12
-
111
-
-
0036915379
-
Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors
-
Mak PA, Kast-Woelbern HR, Anisfeld AM, Edwards PA. Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors. J Lipid Res. 2002;43:2037-2041.
-
(2002)
J Lipid Res
, vol.43
, pp. 2037-2041
-
-
Mak, P.A.1
Kast-Woelbern, H.R.2
Anisfeld, A.M.3
Edwards, P.A.4
-
112
-
-
0037577517
-
Plasma phospholipid transfer protein. Adenovirus-mediated overexpression in mice leads to decreased plasma high density lipoprotein (HDL) and enhanced hepatic uptake of phospholipids and cholesteryl esters from HDL
-
Foger B, Santamarina-Fojo S, Shamburek RD, Parrot CL, Talley GD, Brewer HB, Jr. Plasma phospholipid transfer protein. Adenovirus-mediated overexpression in mice leads to decreased plasma high density lipoprotein (HDL) and enhanced hepatic uptake of phospholipids and cholesteryl esters from HDL. J Biol Chem. 1997;272:27393-27400.
-
(1997)
J Biol Chem
, vol.272
, pp. 27393-27400
-
-
Foger, B.1
Santamarina-Fojo, S.2
Shamburek, R.D.3
Parrot, C.L.4
Talley, G.D.5
Brewer Jr., H.B.6
-
113
-
-
0035065417
-
Dynamic changes in mouse lipoproteins induced by transiently expressed human phospholipid transfer protein (PLTP): Importance of PLTP in prebeta-HDL generation
-
Jaari S, van Dijk KW, Olkkonen VM, van der Zee A, Metso J, Havekes L, Jauhiainen M, Ehnholm C. Dynamic changes in mouse lipoproteins induced by transiently expressed human phospholipid transfer protein (PLTP): importance of PLTP in prebeta-HDL generation. Comp Biochem Physiol B Biochem Mol Biol. 2001;128:781-792.
-
(2001)
Comp Biochem Physiol B Biochem Mol Biol
, vol.128
, pp. 781-792
-
-
Jaari, S.1
Van Dijk, K.W.2
Olkkonen, V.M.3
Van Der Zee, A.4
Metso, J.5
Havekes, L.6
Jauhiainen, M.7
Ehnholm, C.8
-
114
-
-
0037192797
-
Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors
-
Joseph SB, Laffitte BA, Patel PH, Watson MA, Matsukuma KE, Walczak R, Collins JL, Osborne TF, Tontonoz P. Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors. J Biol Chem. 2002;277:11019-11025.
-
(2002)
J Biol Chem
, vol.277
, pp. 11019-11025
-
-
Joseph, S.B.1
Laffitte, B.A.2
Patel, P.H.3
Watson, M.A.4
Matsukuma, K.E.5
Walczak, R.6
Collins, J.L.7
Osborne, T.F.8
Tontonoz, P.9
-
115
-
-
0036790413
-
Consequences of cellular cholesterol accumulation: Basic concepts and physiological implications
-
Tabas I. Consequences of cellular cholesterol accumulation: basic concepts and physiological implications. J Clin Invest. 2002;110:905-911.
-
(2002)
J Clin Invest
, vol.110
, pp. 905-911
-
-
Tabas, I.1
-
117
-
-
0043133791
-
Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression
-
Wagner BL, Valledor AF, Shao G, Daige CL, Bischoff ED, Petrowski M, Jepsen K, Baek SH, Heyman RA, Rosenfeld MG, Schulman IG, Glass CK. Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression. Mol Cell Biol. 2003;23:5780-5789.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 5780-5789
-
-
Wagner, B.L.1
Valledor, A.F.2
Shao, G.3
Daige, C.L.4
Bischoff, E.D.5
Petrowski, M.6
Jepsen, K.7
Baek, S.H.8
Heyman, R.A.9
Rosenfeld, M.G.10
Schulman, I.G.11
Glass, C.K.12
-
120
-
-
0033595261
-
Interleukin-4-dependent production of PPAR-γ ligands in macrophages by 12/15-lipoxygenase
-
Huang JT, Welch JS, Ricote M, Binder CJ, Willson TM, Kelly C, Witztum JL, Funk CD, Conrad D, Glass CK. Interleukin-4-dependent production of PPAR-γ ligands in macrophages by 12/15-lipoxygenase. Nature 1999;400:378-382.
-
(1999)
Nature
, vol.400
, pp. 378-382
-
-
Huang, J.T.1
Welch, J.S.2
Ricote, M.3
Binder, C.J.4
Willson, T.M.5
Kelly, C.6
Witztum, J.L.7
Funk, C.D.8
Conrad, D.9
Glass, C.K.10
-
121
-
-
0037087324
-
Regulation of cytokine expression by ligands of peroxisome proliferator activated receptors
-
Cunard R, Ricote M, DiCampli D, Archer DC, Kahn DA, Glass CK, Kelly CJ. Regulation of cytokine expression by ligands of peroxisome proliferator activated receptors. J Immunol. 2002;168:2795-2802.
-
(2002)
J Immunol
, vol.168
, pp. 2795-2802
-
-
Cunard, R.1
Ricote, M.2
DiCampli, D.3
Archer, D.C.4
Kahn, D.A.5
Glass, C.K.6
Kelly, C.J.7
-
123
-
-
0033007231
-
Effect of peroxisome proliferator-activated receptor alpha activators on tumor necrosis factor expression in mice during endotoxemia
-
Hill MR, Clarke S, Rodgers K, Thornhill B, Peters JM, Gonzalez FJ, Gimble JM. Effect of peroxisome proliferator-activated receptor alpha activators on tumor necrosis factor expression in mice during endotoxemia. Infect Immun. 1999;67:3488-3493.
-
(1999)
Infect Immun
, vol.67
, pp. 3488-3493
-
-
Hill, M.R.1
Clarke, S.2
Rodgers, K.3
Thornhill, B.4
Peters, J.M.5
Gonzalez, F.J.6
Gimble, J.M.7
-
124
-
-
0034665060
-
Role for peroxisome proliferator-activated receptor alpha in oxidized phospholipid-induced synthesis of monocyte chemotactic protein-1 and interleukin-8 by endothelial cells
-
Lee H, Shi W, Tontonoz P, Wang S, Subbanagounder G, Hedrick CC, Hama S, Borromeo C, Evans RM, Berliner JA, Nagy L. Role for peroxisome proliferator-activated receptor alpha in oxidized phospholipid-induced synthesis of monocyte chemotactic protein-1 and interleukin-8 by endothelial cells. Circ Res. 2000;87:516-521.
-
(2000)
Circ Res
, vol.87
, pp. 516-521
-
-
Lee, H.1
Shi, W.2
Tontonoz, P.3
Wang, S.4
Subbanagounder, G.5
Hedrick, C.C.6
Hama, S.7
Borromeo, C.8
Evans, R.M.9
Berliner, J.A.10
Nagy, L.11
-
125
-
-
0031888958
-
PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines
-
Jiang C, Ting AT, Seed B. PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature 1998;391:82-86.
-
(1998)
Nature
, vol.391
, pp. 82-86
-
-
Jiang, C.1
Ting, A.T.2
Seed, B.3
-
126
-
-
0034610759
-
Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase
-
Rossi A, Kapahi P, Natoli G, Takahashi T, Chen Y, Karin M, Santoro MG. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase. Nature 2000;403:103-108.
-
(2000)
Nature
, vol.403
, pp. 103-108
-
-
Rossi, A.1
Kapahi, P.2
Natoli, G.3
Takahashi, T.4
Chen, Y.5
Karin, M.6
Santoro, M.G.7
-
127
-
-
0034712933
-
2 inhibits multiple steps in the NF-κB signaling pathway
-
2 inhibits multiple steps in the NF-κB signaling pathway. Proc Natl Acad Sci U S A 2000;97:4844-4849.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 4844-4849
-
-
Straus, D.S.1
Pascual, G.2
Li, M.3
Welch, J.4
Ricote, M.5
Hsiang, C.H.6
Sengchanthalansgsy, L.L.7
Ghosh, G.8
Glass, C.K.9
-
128
-
-
0035210586
-
Peroxisome proliferator-activated receptor-gamma haploinsufficiency enhances B cell proliferative responses and exacerbates experimentally induced arthritis
-
Setoguchi K, Misaki Y, Terauchi Y, Yamauchi T, Kawahata K, Kadowaki T, Yamamoto K. Peroxisome proliferator-activated receptor-gamma haploinsufficiency enhances B cell proliferative responses and exacerbates experimentally induced arthritis. J Clin Invest. 2001;108:1667-1675.
-
(2001)
J Clin Invest
, vol.108
, pp. 1667-1675
-
-
Setoguchi, K.1
Misaki, Y.2
Terauchi, Y.3
Yamauchi, T.4
Kawahata, K.5
Kadowaki, T.6
Yamamoto, K.7
-
129
-
-
0037031267
-
Effect of rosiglitazone treatment on nontraditional markers of cardiovascular disease in patients with type 2 diabetes mellitus
-
Haffner SM, Greenberg AS, Weston WM, Chen H, Williams K, Freed MI. Effect of rosiglitazone treatment on nontraditional markers of cardiovascular disease in patients with type 2 diabetes mellitus. Circulation 2002;106:679-684.
-
(2002)
Circulation
, vol.106
, pp. 679-684
-
-
Haffner, S.M.1
Greenberg, A.S.2
Weston, W.M.3
Chen, H.4
Williams, K.5
Freed, M.I.6
-
130
-
-
0038193542
-
Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages
-
Castrillo A, Joseph SB, Marathe C, Mangelsdorf DJ, Tontonoz P. Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages. J Biol Chem. 2003;278:10443-10449.
-
(2003)
J Biol Chem
, vol.278
, pp. 10443-10449
-
-
Castrillo, A.1
Joseph, S.B.2
Marathe, C.3
Mangelsdorf, D.J.4
Tontonoz, P.5
-
131
-
-
0037503924
-
Liver x receptor signaling pathways in cardiovascular disease
-
Tontonoz P, Mangelsdorf DJ. Liver x receptor signaling pathways in cardiovascular disease. Mol Endocrinol. 2003;17:985-993.
-
(2003)
Mol Endocrinol
, vol.17
, pp. 985-993
-
-
Tontonoz, P.1
Mangelsdorf, D.J.2
-
132
-
-
2242436246
-
Reduction of atherosclerosis by the peroxisome proliferator-activated receptor alpha agonist fenofibrate in mice
-
Duez H, Chao YS, Hernandez M, Torpier G, Poulain P, Mundt S, Mallat Z, Teissier E, Burton CA, Tedgui A, Fruchart JC, Fievet C, Wright SD, Staels B. Reduction of atherosclerosis by the peroxisome proliferator-activated receptor alpha agonist fenofibrate in mice. J Biol Chem. 2002;277:48051-48057.
-
(2002)
J Biol Chem
, vol.277
, pp. 48051-48057
-
-
Duez, H.1
Chao, Y.S.2
Hernandez, M.3
Torpier, G.4
Poulain, P.5
Mundt, S.6
Mallat, Z.7
Teissier, E.8
Burton, C.A.9
Tedgui, A.10
Fruchart, J.C.11
Fievet, C.12
Wright, S.D.13
Staels, B.14
-
133
-
-
0032746173
-
A novel therapy for colitis utilizing PPAR-γ ligands to inhibit the epithelial inflammatory response
-
Su CG, Wen X, Bailey ST, Jiang W, Rangwala SM, Keilbaugh SA, Flanigan A, Murthy S, Lazar MA, Wu GD. A novel therapy for colitis utilizing PPAR-γ ligands to inhibit the epithelial inflammatory response. J Clin Invest. 1999;104:383-389.
-
(1999)
J Clin Invest
, vol.104
, pp. 383-389
-
-
Su, C.G.1
Wen, X.2
Bailey, S.T.3
Jiang, W.4
Rangwala, S.M.5
Keilbaugh, S.A.6
Flanigan, A.7
Murthy, S.8
Lazar, M.A.9
Wu, G.D.10
-
134
-
-
0035794293
-
Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimer. A basis for new therapeutic strategies
-
Desreumaux P, Dubuquoy L, Nutten S, Peuchmaur M, Englaro W, Schoonjans K, Derijard B, Desvergne B, Wahli W, Chambon P, Leibowitz MD, Colombel JF, Auwerx J. Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimer. A basis for new therapeutic strategies. J Exp Med. 2001;193:827-838.
-
(2001)
J Exp Med
, vol.193
, pp. 827-838
-
-
Desreumaux, P.1
Dubuquoy, L.2
Nutten, S.3
Peuchmaur, M.4
Englaro, W.5
Schoonjans, K.6
Derijard, B.7
Desvergne, B.8
Wahli, W.9
Chambon, P.10
Leibowitz, M.D.11
Colombel, J.F.12
Auwerx, J.13
-
135
-
-
0035341427
-
Amelioration of experimental autoimmune encephalomyelitis in C57BL/6 mice by an agonist of peroxisome proliferator-activated receptor-gamma
-
Niino M, Iwabuchi K, Kikuchi S, Ato M, Morohashi T, Ogata A, Tashiro K, Onoe K. Amelioration of experimental autoimmune encephalomyelitis in C57BL/6 mice by an agonist of peroxisome proliferator-activated receptor-gamma. J Neuroimmunol. 2001;116:40-48.
-
(2001)
J Neuroimmunol
, vol.116
, pp. 40-48
-
-
Niino, M.1
Iwabuchi, K.2
Kikuchi, S.3
Ato, M.4
Morohashi, T.5
Ogata, A.6
Tashiro, K.7
Onoe, K.8
-
136
-
-
0036499074
-
Peroxisome proliferator-activated receptor-gamma agonist 15-deoxy-Delta(12, 14)-prostaglandin J(2) ameliorates experimental autoimmune encephalomyelitis
-
Diab A, Deng C, Smith JD, Hussain RZ, Phanavanh B, Lovett-Racke AE, Drew PD, Racke MK. Peroxisome proliferator-activated receptor-gamma agonist 15-deoxy-Delta(12, 14)-prostaglandin J(2) ameliorates experimental autoimmune encephalomyelitis. J Immunol. 2002;168:2508-2515.
-
(2002)
J Immunol
, vol.168
, pp. 2508-2515
-
-
Diab, A.1
Deng, C.2
Smith, J.D.3
Hussain, R.Z.4
Phanavanh, B.5
Lovett-Racke, A.E.6
Drew, P.D.7
Racke, M.K.8
-
137
-
-
0036260784
-
Peroxisome proliferator-activated receptor-gamma agonists prevent experimental autoimmune encephalomyelitis
-
Feinstein DL, Galea E, Gavrilyuk V, Brosnan CF, Whitacre CC, Dumitrescu-Ozimek L, Landreth GE, Pershadsingh HA, Weinberg G, Heneka MT. Peroxisome proliferator-activated receptor-gamma agonists prevent experimental autoimmune encephalomyelitis. Ann Neurol. 2002;51:694-702.
-
(2002)
Ann Neurol
, vol.51
, pp. 694-702
-
-
Feinstein, D.L.1
Galea, E.2
Gavrilyuk, V.3
Brosnan, C.F.4
Whitacre, C.C.5
Dumitrescu-Ozimek, L.6
Landreth, G.E.7
Pershadsingh, H.A.8
Weinberg, G.9
Heneka, M.T.10
-
138
-
-
0036546185
-
Peroxisome proliferator-activated receptor-gamma agonists inhibit experimental allergic encephalomyelitis by blocking IL-12 production, IL-12 signaling and Th1 differentiation
-
Natarajan C, Bright JJ. Peroxisome proliferator-activated receptor-gamma agonists inhibit experimental allergic encephalomyelitis by blocking IL-12 production, IL-12 signaling and Th1 differentiation. Genes Immun. 2002;3:59-70.
-
(2002)
Genes Immun
, vol.3
, pp. 59-70
-
-
Natarajan, C.1
Bright, J.J.2
-
139
-
-
0034030527
-
Troglitazone improves psoriasis and normalizes models of proliferative skin disease: Ligands for peroxisome proliferator-activated receptor-gamma inhibit keratinocyte proliferation
-
Ellis CN, Varani J, Fisher GJ, Zeigler ME, Pershadsingh HA, Benson SC, Chi Y, Kurtz TW. Troglitazone improves psoriasis and normalizes models of proliferative skin disease: ligands for peroxisome proliferator-activated receptor-gamma inhibit keratinocyte proliferation. Arch Dermatol. 2000;136:609-616.
-
(2000)
Arch Dermatol
, vol.136
, pp. 609-616
-
-
Ellis, C.N.1
Varani, J.2
Fisher, G.J.3
Zeigler, M.E.4
Pershadsingh, H.A.5
Benson, S.C.6
Chi, Y.7
Kurtz, T.W.8
-
140
-
-
0037250963
-
Effect of topical PPARbeta/delta and PPARgamma agonists on plaque psoriasis, a pilot study
-
Kuenzli S, Saurat JH. Effect of topical PPARbeta/delta and PPARgamma agonists on plaque psoriasis, a pilot study. Dermatology 2003;206:252-256.
-
(2003)
Dermatology
, vol.206
, pp. 252-256
-
-
Kuenzli, S.1
Saurat, J.H.2
|