Human hepatocytes as a tool for studying toxicity and drug metabolism

Current Drug Metabolism

Volumn 4, Issue 4, 2003, Pages 292-312

  Gomez Lechon M J ^a   Donato, M T ^a   Castell, J V ^a   Jover, R ^a  

^a HOSPITAL UNIVERSITARIO LA FE   (Spain)

Author keywords

Cryopreservation; CYP engineered cells; Cytochrome P450; Drug induction; Drug metabolism; Drug drug interaction; Hepatocytes; Hepatotoxicity

Indexed keywords

3 METHYLCHOLANTHRENE; ACETONE; ALCOHOL; ANTICONVULSIVE AGENT; APOPROTEIN; BENZENE; BILE ACID; CLOFIBRATE; COUMARIN; CYTOCHROME P450; DEXAMETHASONE; DEXTROMETHORPHAN; DICLOFENAC; DRUG; FIBRIC ACID DERIVATIVE; GLUCOCORTICOID; ISONIAZID; LIPID; LIPOPROTEIN; MACROLIDE; MEVINOLIN; OMEPRAZOLE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PESTICIDE; PHENOBARBITAL; PLASMA PROTEIN; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PYRIDINE; SIMVASTATIN; UNINDEXED DRUG; XENOBIOTIC AGENT;

ADENOVIRUS; BILE ACID SYNTHESIS; BIOLOGICAL MODEL; CARBOHYDRATE METABOLISM; CELL CULTURE; CELL ISOLATION; CELL SURVIVAL; CRYOPRESERVATION; CYTOLOGY; DRUG ACTIVATION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFECT; DRUG EFFICACY; DRUG ELIMINATION; DRUG INHIBITION; DRUG INTERACTION; DRUG MECHANISM; DRUG METABOLISM; DRUG SAFETY; DRUG SCREENING; DRUG TRANSFORMATION; ENZYME ACTIVATION; ENZYME INHIBITION; GENETIC ENGINEERING; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIPID METABOLISM; LIVER; LIVER CELL; LIVER TOXICITY; METABOLISM; NONHUMAN; PROTEIN SYNTHESIS; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; REVIEW; RISK ASSESSMENT; TIME; TRANSCRIPTION INITIATION; VIRUS RECOMBINANT;

CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; DRUG INTERACTIONS; HEPATOCYTES; HUMANS; LIVER; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; TIME FACTORS;

EID: 0043092060     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/1389200033489424     Document Type: Review

References (179)

1. Donato, M.T.; Castell, J. V. and Gómez-Lechón, MJ. (1995) Drug Metab. Dispos., 23 (5), 553-558.
2. Gonzalez, F.J. (1990) Pharmacol. Ther., 45(1), 1-38.
3. Meyer, U.A. and Zanger, U.M. (1997) Ann. Rev. Pharmaco. Toxicol., 37(3), 269-296.
4. Pelkonen, O. and Raunio, H. (1997) Environ. Health Perspt., 105(Suppl. 4), 767-774.
5. Lu, A.Y.H. (1998) Drug Metab. Disp., 26(12), 1217-1222.
6. Kennedy, T. (1997) Drug Discovery Today, 2(2), 436-444.
7. Rodrigues, A.D.; Wong, S.L. (1997) Adv. Pharmacol., 43, 65-101.
8. Chen, Q.; Galleano, M. And Cederbaum, A.I. (1998b) Alcohol. Clin. Exp. Res., 22(4), 782-784.
9. Crespi, C.L.; Gonzalez, F.J.; Steimel, D.T., Turner, T.R.; Gelboin, H.V..; Penman, B.W. and Langenbach, R. (1991) Chem. Res Toxicol., 4(5), 566-572.
10. Macé, K.; Offord, E.A. and Pfeifer, A.M.A. (1997) in In vitro Methods in Pharmaceutical Research, (Castell, J.V. and Gómez-Lechón, M.J. Eds.), Academic Press, London, pp. 433-456.
11. Maurel, P. (1996) Adv. Drug Deliv. Rev., 22(3), 105-132.
12. Gómez-Lechón, M.J.; Donato, T.; Ponsoda, X.; Fabra, R. Trullenque, R. and Castell, J.V. (1997) in Isolation, culture ad use of human hepatocytes in drug research, In Vitro Methods in Pharmaceutical Research, (Castell, J.V. and Gómez-Lechón, M.J. Eds.), Academic Press, London, pp. 129-153.
13. Donato, M.T.; Gómez-Lechón, M.J. and Castel], J.V. (1990) Biochem. Pharmacol., 39(8), 1321-1326.
14. Gómez-Lechón, M.J.; Donato, T.; Jover, R.; Rodriguez, C.; Ponsoda, X.; Glaise, D.; Castell, J.V. and Guguen-Guillouzo, C. (2001) Eur. J. Biochem., 268(5), 1448-1459.
15. Rodríguez-Antona, C.; Donato, M.T.; Boobis, A., Edwards, R.J.; Watts, P.S.; Castell, J.V. and Gómez-Lechón, M.J- (2002) Xenobiotica, 32 (6), 505-520.
16. Cereghini, S. (1996) FASEB J., 10(2), 267-282.
17. Ourlin, J.E.; Jounaïdi, Y.; Maurel, P. and Vilarém, M.J. (1997) J. Hepatol., 26(Suppl. 2), 54-62.
18. Jover, R.; Bort, R.; Gómez-Lechón, M.J. and Castell, J.V. (2000) in Progress in the Reduction, Refinement and Replacement of Animal Experimentation. (Balls, M.; van Zeller, A.M.; Halder, M.E. Eds.) pp. 127-137.
19. Jover, R.; Bort, R.; Gomez-Lechón, M.J. and Castell, J.V. (1998) FEBS Lett., 431(2), 227-230.
20. Jover, R.; Bort, R.; Gomez-Lechón, M.J. and Castell, J.V. (2001) Hepatology, 33(3), 668-675.
21. Jover, R.; Bort, R.; Gomez-Lechón, M.J. and Castell, J.V. (2002) FASEB J., 10.1096/fj.02-0195fje.
22. Chapman, D.E.; Christensen, T.A.; Michener, S.R. and Powis, G. (1993) in Human drug metabolism from molecular biology to man, (Jeffrey, E.H. Ed.), CRC Press, London, pp. 53-63.
23. Mitry, R.R.; Hughes, R.D. and Dhawan, A. (2002) Semin. Cell Dev. Biol., 13(6), 463-467.
24. Olinga, P.; Merema, M.; Hof, I.H.; de Jong, K.P.; Slooff, M.J.H.; Meijer, D.K.F., Groothuis, G.M.M. (1998) Drug Metab. Dispos., 26(1), 5-11.
25. Olinga, P.; Merema, M.T.; Hof, I.H.; De Jager, M.H.; De Jong, K.P.; Slooff, M.J.H.; Meijer, D.K.F. and Groothuis, G.M.M. (1998) Xenobiotica, 28(4), 349-360.
26. Serralta, A.; Donato, M.T.; Orbis, F.; Castell, J.V.; Mir, J. and Gómez-Lechón, M.J. (2003) Toxicol. in vitro, (in press ).
27. Schmucker, D.L. (2001) Drugs Aging, 18(11), 837-851.
28. Reese, J.A.; Byard, J.L. (1981) In Vitro, 17(11), 935-940.
29. Vons, C.; Pegorier, J.P.; Ivanov, M.A.; Girard, J.; Melcion, C.; Cordier, A. and Franco, D. (1990) Toxicol. in vitro, 4(3), 432-436.
30. David, P.; Viollon, C.; Alexandre, E; Azimzadeh, A.; Nicod, L.; Wolf, P.; Jaeck, D.; Boudjema, K. and Richert, L. (1998) Hum. Exp. Toxicol., 17(10), 544-553.
31. Guillouzo, A.; Guyomard, C.; Fautrel, A. and Chesné, F. (2000) in The Hepatocyte Review (Berry, M.N. and Edwards, A. M., Eds.) Kluwer Academic Press London, pp. 125-145.
32. Caraceni, P.; Gasbarrini, A.; Nussler, A.; Di Silvio, M.; Bartoli, F.; Borle, A.B. and Van Thiel, D.H. (1994) Hepatology, 20(5), 1247-1254.
33. Spinelli, S.V.; Rodriguez, J.V,; Quintana, A.B.; Mediavilla, M.G. and Guibert, E.E. (2002) Cell Transplant, 11(2), 161-168.
34. Guguen-Guillouzo, C.; Bourel, M.; Guillouzo, A. (1986) Prog. Liver Dis., 8(8), 33-50.
35. Li, A.P. (2000) in The hepatocyte review (Berry, M.N. and Edwards, A. Eds), Kluwer Academic Publishers, Dordrecht, The Netherlands, pp. 391-410.
36. Donini, A.; Baccarani, U.; Lavaroni, S.; Dialti, V.; Adami, V.; Risaliti, A, Cautero, N.; Degrassi, A. and Bresadola, F. (2001) Transplant. Proc., 33(1-2), 1972-1973.
37. Gómez-Lechón, M.J.; López, P.; Donato, T.; Montoya, A.; Larrauri, A.; Giménez, P.; Trullenque, R.; Fabra, R. and Castell, J.V. (1990) In Vitro Cell. Biol. Dev., 26(1), 67-74.
38. Ryan, C.M.; Carter, E.A.; Jenkins, R.L.; Sterling, L.M.; Yarmush, M.L.; Malt, R.A. and Tompkins, R.G. (1993) Surgery, 113(1), 48-54.
39. Kim, H.M.; Han, S.B.; Hyun, B.H.; Ahn, C.J.; Cha, Y.N.; Jeong, K.S.; Oh, G.T. (1995) J. Toxicol. Sci., 20(5), 565-578.
40. Miyazaki, K.; Takaki, R.; Nakayama, F.; Yamauchi, S.; Koga, A.; Todo, S. (1981) Cell Tissue Res., 218(1), 13-21.
41. Skett, P.; Bayliss, M. (1996) Xenobiotica, 26(1), 1-7.
42. Ferrini, J.B., Pichard, L.; Domerge, J. and Maurel, P. (1997) Chem. Biol. Interact., 107(1-2), 31-45.
43. Hino, H.; Tateno, C.; Sato, H.; Yamasaki, C.; Katayama, S.; Kohashi, T.; Aratani, A.; Asahara, T.; Dohi, K.; Yoshizato, K. (1999) Biochem. Biophys. Res. Commun., 256(1), 184-191.
44. Runge, D.; Runge, D.M.; Jager, D.; Lubecki, K.A.; Beer Stolz, D.; Karathanasis, S.; Kietzmann, T.; Strom, S.C.; Jungermann, K., Fleig, W.E.; Michalopoulos, G.K. (2000) Biochem. Biophys. Res. Commun., 269(1), 46-53.
45. Katsura, N.; Ikai, I.; Mitaka, T.; Shiotani, T.; Yamanokuchi, S.; Sugimoto, S.; Kanazawa, A.; Terajima, H.; Mochizuki, Y. and Yamaoka, Y. (2002) J. Surg. Res., 106(1), 115-123.
46. Washizu, J.; Chan, C.; Berthiaune, F.; Tompkins, R.G.; Toner, M. and Yarmush, M. L. (2000) Tissue Eng., 6(5), 497-504.
47. Donato, M.T.; Ponsoda, X.; O'Connor, E.; Castell, J.V. and Gómez-Lechón, M.J. (2001) Xenobiotica, 31(5), 249-264.
48. Chen, H.L.; Wu, H.L.; Fon, C.C.; Chen, P.J.; Lai, M.Y. and Chen, D.S. (1998) J. Biomed. Sci., 5(6), 435-440.
49. Dunn, J.C.; Yarmush, M.L.; Koebe, H.G. and Tompkins, R.G. (1989) FASEB J., 3(2), 174-177.
50. Reid, L.M.; Fiorino, A.S.; Sigal, S.H.; Brill, S.; Holst, P.A. (1992) Hepatology, 15(6), 1198-1203.
51. Koebe, H. G.; Pahernik, S.; Eyer, P. and Schildberg, F.W. (1994) Xenobiotica, 24(2), 95-107.
52. Kono, Y.; Yang, S. and Roberts, D. (1997) In vitro Cell. Dev. Biol., 33(5), 467-472.
53. Bader, A.; Knop, E. and Haverich, A. (2000) in The Hepatocyte Review, (Berry, M.N. and Edwards, A.M. Eds.), Kluwer Academic Publuishers, London, pp. 97-116.
54. Zeilinger, K.; Sauer, I.M.; Pless, G.; Strobel, C.; Rudzitis, J.; Wang, A.; Nussler, A.K.; Grebe, A.; Mao, L.; Auth, S.H.; Unger, J.; Neuhaus, P.; Gerlach, J.C. (2002) Altern. Lab. Anim., 30(5), 525-538.
55. Auth, M.K.; Joplin, R.E.; Okamoto, M.; Ishida, Y.; McMaster, P.; Neuberger, J.M.; Blaheta, R.A.; Voit, T. and Strain, A.J. (2001) Hepatology, 33(3), 519-529.
56. Selden, C.; Shariat, A.; McCloskey, P.; Ryder, T.; Roberts, E.; Hodgson, H. (1999) Ann. N. Y. Acad. Sci., 875, 353-363.
57. Clement, B.; Guguen-Guillouzo, C.; Campion, J.P., Glaise, D., Bourel, M. and Guillouzo, A. (1984) Hepatology, 4(3), 373-380.
58. Bhatia, S.N.; Balis, U.J.; Yarmush, M.L. and Toner M. (1999) FASEB J., 13(14), 1883-1890.
59. Tong, J.Z.; Sarrazin, S.; Cassio, D., Gauthier, F., Alvarez, F. (1994) Biol. Cell., 81(1), 77-81.
60. Khalil, M.; Shariat-Panahi, A.; Tootle, R.; Ryder, T.; McCloskey, P.; Roberts, E.; Hodgson, H.; Selden, C. (2001) J. Hepatol., 34 (3), 68-77.
61. Ijima, H.; Nakazawa, K.; Mizumoto, H.; Matsushita, T.; Funatsu, K. (1998) J. Biomater. Sci. Polym. Ed., 9(7), 765-778.
62. Padgham, C.R.W.; Boyle, C.C.; Wang, X.J.; Raleigh, S.M.; Wright, M.C. and Paine, A.J. (1993) Biochem. Biophys. Res. Commun., 197 (2), 599-605.
63. Nagaki, M.; Shidoji, Y.; Yamada, Y.; Sugiyama, A.; Tanaka, M.; Akaike, T.; Ohnishi, H.; Moriwaki, H.; Muto, Y. (1995) Biochem. Biophys. Re.s Commun., 210(1),38-43.
64. Gómez-Lechón, M.J.; Jover, R.; Donato, T.; Ponsoda, X.; Rodriguez, C.; Stenzel, K.G.; Klocke, R.; Paul, D., Guillen, I.; Bort, R.; Castel], J.V. (1998) J. Cell. Physiol., 177(4), 553-562.
65. López, M. P.; Gómez-Lechón, M.J. and Castell, J. V. (1991) Diabetes, 40 (2), 263-268.
66. Lopez, M. P.; Gómez-Lechón, M.J. and Castel], J. V. (1991) Biophys. Acta, 1094 (2), 200-206.
67. Keppens, S.; Vandekerckhove, A.; Moshage, H.; Yap, S.H.; Aerts, R.; De Wulf, H. (1993) Hepatology, 17(4), 610-614.
68. Braun, L.; Puskas, F.; Csala, M.; Meszaros, G.; Mandl, J. and Banhegyi, G. (1997) Free Radic. Biol. Med., 23(5), 804-808.
69. An, J.; Li, Y.; van De Werve, G. and Newgard, C.B. (2001) J. Biol. Chem., 276(14), 107221-107229.
70. Iynedjian, P.B.; Marie, S.; Gjinovci, A.; Genin, B., Deng, S.P.; Buhler, L.; Morel, P.; Mentha, G. (1995) J. Clin. Invest., 95(5), 1966-1973.
71. Schippers, I.J.; Moshage, H.; Roelofsen, H.; Muller, M.; Heymans, H.S.; Ruiters, M.; Kuipers, F. (1997) Cell. Biol. Toxicol., 13(4-5), 375-386.
72. Castell, J.V.; Gómez-Lechón, M.J.; David, M.; Fabra R.; Trullenque, R. and Heinrich P. C. (1990) Hepatology, 12(5), 1179-1186.
73. Chan, C.; Berthiaume, F.; Washizu, J.; Toner, M. and Yarmush, M.L. (2002) Biotechnol. Bioeng., 78(7), 753-760.
74. Kaibori, M.; Kwon, A.H.; Oda, M.; Kamiyama, Y.; Kitamura, N.; Okumura, T. (1998) Hepatology, 27(5), 1354-1361.
75. Snyder, M.L.; Hay, R.V.; Whitington, P.F.; Scanu, A.M.; Fless, G.M. (1994) Arterioscler. Thromb., 14(5),770-779.
76. Ellis, E.; Goodwin, B.; Abrahamsson, A.; Liddle, C.; Mode, A.; Rudling, M.; Bjorkhem, I. and Einarsson, C. (1998) Hepatology, 27(2), 615-620.
77. Axelson, M.; Ellis, E.; Mork, B.; Garmark, K.; Abrahamsson, A.; Bjorkhem, I.; Ericzon, B.G. and Einarsson, C. (2000) Hepatology, 31(6), 1305-1312.
78. Olinga, P.; Merema, M.; Sandker, G.W.; Slooff, M.J.; Meijer, D.K.; Groothuis, G.M. (1998) J. Pediatr. Gastroenterol. Nutr., 27(3), 366-368.
79. Hillaire, S.; Ballet, F.; Franco, D.; Setchell, K.D.; Poupon, R. (1995) Hepatology, 22(1), 82-87.
80. Fardel, O.; Morel, F. and Guillouzo, A. (1993) Carcinogenesis, 14(4), 781-783.
81. Capuani. G.; Miccheli, A.; Tomassini, A.; Falasca, L.; Aureli, T. and Conti, F. (2000) Artif. Cells Blood Substit. Immobil. Biotechnol., 28(4), 293-305.
82. Lian, W.N.; Tsai, J.W.; Yu, P.M.; Wu, T.W.; Yang, S.C.; Chau, Y.P.; Lin, C.H. (1999) Hepatology, 30(3), 748-760.
83. Shimada, T.; Yamazaki, H.; Mimura, M.; Inui, Y. and Guengerich, F.P. (1994) J. Pharmacol. Exp. Ther., 270 (1), 414-423.
84. LeCluyse, E.L. (2001) Eur. J. Pharmac. Sci., 13 (4), 343-368.
85. Waxman, D.J.; Lapenson, D.P.; Aoyama, T.; Gelboin, H.V.; Gonzalez, F.J. and Korzekwa, K. (1991) Arch. Biochem. Biophys., 290(1), 160-166.
86. Yamazaki, H.; Inoue, K.; Shaw, P.M.; Checovich, W.J., Guengerich, F.P.; Shimada, T. (1997) J. Pharmacol. Exp. Ther., 283(2), 434-442.
87. Donato, M.T.; Castell, J.V. and Gómez-Lechón, M.J. (1999) J. Hepatol., 31(1), 542-549.
88. Guillouzo, A. and Chesné, C. (1996) in Cell culture models of epithelial tissues: a practical approach (Shaw, A.J. Eds.), Oxford University Press, Oxford, UK. pp. 67-85.
89. Woodcroft, K.J.; Novak, R.F. (1998) Drug Metab. Dispos., 26 (4), 372-378.
90. Morel, F.; Beaune, Ph.; Ratanasavanh, D.; Flinois, J.P.; Yang, C.S.; Guengerich, F.P- and Guillouzo, A. (1990) Eur. J. Biochem., 191(2), 437-444.
91. Guillouzo, A.; Morel, F.; Fardel, O. and Meunier, B. (1993) Toxicology, 82(1-5), 209-219.
92. Li, A.P. Maurel, P.; Gomez-Lechon, M.J.; Cheng, L.C.; Jurima-Romet, M. (1997) Chem. Biol. Interact., 107(1-2), 5-16.
93. Paine, A.J. (2000) in The hepatocyte review, (Berry, M.N. and Edwards, A. Eds.) Kluwer Academic Publishers, Dordrecht, The Netherlands, pp. 411-420.
94. Gómez-Lechón, M.J.; Donato, M.T. and Castel], J.V. (1997) In Vitro Toxicol, 10(1/2), 63-70.
95. Kistler, A.; Liechti, H.; Pichard, L.; Wolz, E.; Oesterhelt, G., Hayes, A.; Maurel, P. (2002) Arch. Toxicol., 75(11-12), 665-675.
96. Rodrigues, A.D. (1999) Biochem. Pharmacol., 57(5), 465-480.
97. Ohyama, K.; Nakajima, M.; Nakamura, S.; Shimada, N.; Yamazaki, H.; Yokoi, T. (2000) Drug Metab. Dispos., 28(11), 1303-1310.
98. Hewitt, N.J.; Buhring, K.U.; Dasenbrock, J.; Haunschild, J.; Ladstetter, B., Utesch, D. (2001) Drug Metab. Dispos., 29(7), 1042-1050.
99. McGuinnity, D.F. and Riley, R.J. (2001) Biochem. Soc. Trans., 29(11), 135-139.
100. Houston, J.B. (1994) Biochem. Pharmacol., 47(9), 1469-79.
101. Lave, T.; Coassolo, P.; Reigner, B. (1999) Clin. Pharmacokinet., 36(3), 211-231.
102. Ponsoda, X.; Pareja, E.; Gómez-Lechón, M.J.; Fabra, R.; Carrasco, E.; Trullenque, R. and Castell, J.V. (2001) J. Hepatol., 34 (1), 19-25.
103. Remmel, R.P.; Burchell, B. (1993) Biochem. Pharmacol., 46(4), 559-566.
104. McGinnity, D.F.; Parker, A.J.; Soars, M.; Riley, R.J. (2000) D rug Metab. Dispos., 8(11), 1327-1334.
105. Komatsu, K.; Ito, K.; Nakajima, Y.; Kanamitsu, S.; Imaoka, S.; Funae, Y.; Green, C.E.; Tyson, C.A.; Shimada, N. and Sugiyama, Y. (2000) Drug Metab. Dispos., 28(4), 475-481.
106. Bort, R.; Macé, K.; Boobis, A.; Gomez-Lechon, M.J.; Pfeifer, A. and Castell, J. (1999) Biochem. Pharmacol., 58(5), 787-796.
107. Skett, P.; Tyson, C.; Guillouzo, A.; Maier, P. (1995) Biochem. Pharmacol., 50(2), 280-285.
108. Li, A.P.; Gorycki, P.D.; Hengstler, J.G.; Kedderis, G.L.; Koebe, H.G.; Rahmani, R.; de Sousas, G.; Silva, J.M.; Skett, P. (1999) Chem. Biol. Interact., 121(1), 117-123.
109. de Sousa, G.; Langouet, S.; Nicolas, F.; Lorenzon, G.; Placidi, M.; Rahmani, R. and Guillouzo, A. (1996) Cell. Biol. Toxicol., 12(4-6), 351-358.
110. Silva, J.M.; Day, S.H.; Nicoll-Griffith, D.A. (1999) Chem. Biol. Interact., 121(1), 49-63.
111. Alexandre, E.; Viollon-Abadie, C.; David, P.; Gandillet, A.; Coassolo, P.; Heyd, B.; Mantion, G.; Wolf, P.; Bachellier, P.; Jaeck, D. and Richert, L. (2002) Cryobiology, 44(2), 103-113.
112. Dou, M.; de Sousa, G.; Lacarellem, B.; Placidi, M.; Lechene De La Porte P.; Domingo, M.; Lafont, H. and R. Rahmani. (1992) Cryobilogy, 29(4), 454-469.
113. Adams, R.M.; Wang, M.; Crane, A.M.; Brown, B.; Darlington, G.J. and Ledley, F.D. (1995) Cell Transplant., 4(6), 579-586.
114. Ruegg, C. E.; Silber, P.M.; Mughal, R.A.; Ismail, J.; Lu, C.; Bode, D.C. and Li, A.P. (1997) In vitro Toxicol., 10(3), 217-222.
115. Loretz, L.J.; Li, A.P.; Flye, M.W. and Wilson, A.G.E. (1989) Xenobiotica, 19(4), 489-498.
116. Coundouris, J. A.; Grant, M. H.; Engest J.; Petrie, J. C. and Hawksworth, G.M. (1993) Xenobiotica, 23(12), 1399-1409.
117. Li, A.P.; Lu, C.; Brent, J.A.; Pham, C.; Fackett, A.; Ruegg, C.E.; Silber, P.M. (1999) Chem. Biol. Interact., 121(1), 17-35.
118. De Loecker, W.; Koptelov, V.A.; Grischenko, V.I. and De Loecker, P. (1998) Cryobiology, 37(2), 103-109.
119. Guillouzo, A.; Rialland, L.; Fautrel, A.; Guyomard, C. (1999) Chem. Biol. Interact., 121(1), 7-16.
120. Strom, S. C.; Dorko, K.; Thompson, M. T.; Pisarov, L. A. and Nussler, A. K. (1998) in Large scale isolation and culture of human hepatocytes. (Fraco, D.; Boudejema, K. and Vater, B. Eds.) Les Editions INSERM, Paris, pp. 196-205.
121. Rialland, L.; Guyomard, C.; Scotte, M.; Chesne, C.; Guillouzo, A. (2000) Cell. Biol. Toxicol., 16(2), 105-116.
122. Hengstler, J.G.; Utesch, D.; Steinberg, P.; Platt, K.L.; Diener, B.; Ringel, M.; Swales, N.; Fischer, T.; Biefang, K.; Gerl, M.; Bottger, T.; Oesch, F. (2000) Drug Metab. Rev., 32(1), 81-118.
123. Schehrer, L.; Regan, J.D.; Westendorf, J. (2000) Toxicology, 147(3), 177-191.
124. Skett, P.; Roberts, P., Khan, S. (1999) Chem. Biol. Interact., 121(1), 65-76.
125. Fu, T.; Guo, D.; Huang, X.; O'Gorman, MR.; Huang, L.; Crawford, SE.; Soriano, HE. (2001) Cell. Transplant., 10(1), 59-66.
126. Reinach, B.; de Sousa, G.; Dostert, P.; Ings, R.; Gugenheim, J.; Rahmani, R. (1999) Chem. Biol. Interact., 121(1), 37-48.
127. Pichard, L.; Fabre, I.; Fabre, G.; Domergue, J.; Saint Aubert, B.; Mourad, G. and Maurel, P. (1990) Drug Metab. Dispos., 18 (5), 595-606.
128. Li, A.P. and Jurima-Romet, M. (1997) Chem. Biol. Toxicol., 13 (4-5), 365-374.
129. Cohen, L.H.; van Leeuwen, R.E.; van Thiel, G.C.; van Pelt, J.F. and Yap, S.H. (2000) Biopharm. Drug Dispos., 21(9), 353-364.
130. Pelkonen, O.; Maenpaa, J.; Taavitsainen, P.; Rautio, A., Raunio, H. (1998) Xenobiotica, 28(12), 1203-1253.
131. Ronis, M.J.J.; Ingelman-Sundberg, M. (1999) in Handbook of drug metabolism (Woolf, T.F. Eds.) Marcel Dekker, Inc, New York, pp. 239-262.
132. Guzelian, P.S. (1994) in Cytochrome P450 8th International Conference, (Lechner, M.C.; Libbey, J. Eds.), Eurotext, Paris, pp. 109-113.
133. Kocarek, T.A.; Schuetz, E.G.; Strom, S.C.; Fisher, R.A.; Guzelian, P.S. (1995) Drug Metab. Dispos., 23(3), 415-421.
134. Lu, C. and Li, A.P. (2001) Chem. Biol. Interact., 134(3), 271-291.
135. Meunier, V.; Bourrie, M.; Julian, B.; Marti, E.; Guillou, F., Berger, Y. and Fabre, G. (2000) Xenobiotica, 30(6), 589-607.
136. Runge, D.; Kohler, C.; Kostrubsky, V.E.; Jager, D.; Lehmann, T.; Runge, D.M.; May, U.; Stolz, D.B.; Strom, S.C.; Fleig, W.E.; Michalopoulos, G.K. (2000) Biochem. Biophys. Res. Commun., 273(1), 333-341.
137. Chang, T.K.H.; Yu, L.; Maurel, P. and Waxman, D.J. (1997) Cancer Res., 57(10), 1946-1954.
138. Donato, M.T.; Viitala, P.; Rodríguez-Antona, C.; Lindfors, A.; Castell, J.V.; Raunio, H.; Gómez-Lechón, M.J. and Pelkonen O. (2000) J. Pharmacol. Exp. Ther., 11(28), 1321-1326.
139. Gerbal-Chaloin, S.; Pascussi, JM.; Pichard-Garcia, L.; Daujat, M.; Waechte, F.; Fabre, J.M.; Carrere, N. and Maurel, P. (2001) Drug Metab. Dispos., 29(3), 242-251.
140. Bowen, W.P.; Carey, J.E.; Miah, A.; McMurray, H.F.; Munday, P.W.; James, R.S.; Coleman, R.A. and Brown, A.M. (2000) Drug Metab. Dispos., 28(7), 781-788.
141. Raucy, J.L., Mueller, L.; Duan, K.; Allen, S.W.; Strom, S.; Lasker, J.M. (2002) J. Pharmacol. Exp. Ther., 302(2), 475-482.
142. Sumida, A.; Kinoshita, K.; Fukuda, T.; Matsuda, H.; Yamamoto, I.; Inaba, T.; Azuma, J. (1999) Biochem. Biophys. Res. Común., 262(2), 499-503.
143. Rodríguez-Antona, C.; Donato, M.T.; Pareja, E.; Gómez-Lechón, M.J. and Castell, J.V. (2001) Arch. Biochem. Biophys., 393 (2), 308-315.
144. Donato, M.T.; Gómez-Lechón, M.J. and Castell, J.V. (1993) Anal. Biochem., 213(1), 29-33.
145. Rodríguez-Antona, C.; Jover, R.; Gómez-Lechón, M.J. and Castell, J.V. (2000) Arch. Biochem. Biophys., 376(1), 109-116.
146. Curi-Pedrosa, R.; Daujat, M.; Pichard, L.; Ourlin, L.C.; Clair, P.; Gervot, L.; Lesca, P.; Domergue, J.; Joyeux, H.; Fourtanier, G. and Maurel, P. (1994) J. Pharmacol. Exp. Ther., 269(1), 384-392.
147. Masubuchi, N.; Li, A.P. and Okazaki, O. (1998) Chem. Biol. Interact., 114(1-2), 1-13.
148. Pelkonen, O.; Hukkanen, J.; Honkakoski, P.; Hakkola, J.; Viitala, P. and Raunio, H. (2002) in Ernst Schering Res Found Workshop 37, (Pelkonen, O. and Baumann, A. Eds) pp. 105-137.
149. Waxman, D.J. (1999) Arch. Biochem. Biophys., 369(1), 11-23.
150. Ronis, M.J.J.; Huang, J.; Crouch, J.; Mercado, C.; Irby, D.; Valentine, C.R.; Lumpkin, C.K.; Ingelman-Sundberg, M.; Badger, T.M. (1993) J. Pharmacol. Exp. Ther., 264(2), 944-950.
151. Whitlock, J.P. (1999) Ann. Rev. Pharmacol. Toxicol., 39, 103-125.
152. McGehee, R.E.; Ronis, M.J.J.; Cowherd, R.M.; Ingelman-Sundberg, M.; Badger, T.M. (1994) Biochem. Pharmacol., 48(9), 1823-1833.
153. Jones, S.A.; Moore, L.B.; Shenk, J.L.; Wisely, G.B.; Hamilton, G.A.; McKee, D.D.; Tomkinson, N.C.; LeCluyse, E.L.; Lambert, M.H.; Willson, T.M.; Kliewer, S.A. and Moore, J.T. (2000) Mol. Endocrinol., 14 (1), 27-39.
154. Castell, J.V.; Gómez-Lechón, M.J.; Ponsoda, X. and Bort, R. (1997) in In Vitro Methods in Pharmaceutical Research. (Catell, J.V. Gómez-Lechón, M.J. Eds.), Academic Press, London, UK, pp.375-410.
155. Li, A. P. (2001) Drug Discov. Today, 6(7), 357-366.
156. Jaeschke, H., Gores, G.J.; Cederbaum, A.I.; Hinson, J.A.; Pessayre, D.; Lemasters, J.J. (2002) Toxicol. Sci., 65(2), 166-176.
157. Williams, D.P., Kitteringham, N.R.; Naisbitt, D.J.; Pirmohamed, M.; Smith, D.A.; Park, B.K. (2002) Curr. Drug Metab., 3(4), 351-366.
158. Kedderis, G.L. (1996) Toxicol. Pathol., 24(1), 77-83.
159. Nieminen, A. L.; Saylor, A. K.; Tesfai, S. A.; Herman, B. and Lemasters, J.J. (1995) Biochem. J., 307(Pt 1), 99-106.
160. Ross, D. (1989 J. Pharm. Pharmacol., 41(8), 505-511.
161. Chapman, D.E. (1995) Cell, 80(3), 259-268.
162. Sies, H. (1971) in Oxidative Stress. Oxidants and Antioxidants. (Sies, H. Eds.) Academic Press. London.
163. Boelsterli, U.A. (1993) Drug Met. Rev., 25(4), 395-451.
164. Ballet, F. (1997) J. Hepatol., 26(Suppl. 2), 26-36.
165. Guillouzo, A. (1998) Environ. Health Perspect., 106(Suppl. 2), 511-532.
166. Davila, J.C.; Rodriguez, R.J.; Melchert, R.B. and Acosta, D. (1998) Annu. Rev. Pharmacol. Toxicol., 38, 63-96.
167. Krishnan, K. and Andersen, M.E. (1994) in Principles and Methods of Toxicology, (Hayes, A.W. Eds.) Raven Press, New York, pp. 149-188.
168. Harries, H.M,; Fletcher, S.T.; Duggan, C.M.; Baker, V.A. (2001) Toxicol. In Vitro, 15(4-5), 399-405.
169. Waring, J.F.; Ciurlionis, R.; Jolly, R.A.; Heindel, M.; Ulrich, R.G. (2001) Toxicol. Lett., 120(1-3), 359-368.
170. Schuppe-Koistinen, I.; Frisk, A.L.; Janzon, L. (2002) Toxicology, 179(3), 197-219.
171. Castell, J.; Hernandez, D.; Gomez, A.M.; Guillen, I.; Donato, T. and Gomez-L, M.J. (1997) Gene Ther., 4(5), 455-464.
172. Rodriguez-Antona, C.; Bort, R.; Jover, R.; Tindberg, N.; Ingelman-Sundberg, M.; Gómez-Lechón, M.J. and Castell, J.V. (2003) Mol. Pharmacol., 63(5), 1180-1189.
173. Hadzopoulou-Cladaras, M.; Kistanova, E.; Evagelopoulou, C.; Zeng, S.; Cladaras, C. and Ladias, J. (1997) J. Biol. Chem., 1(3), 539-550.
174. Torres-Padilla, M.; Fougere-Deschatrette, C. and Weiss, M. (2001) Mech. Dev., 2(2), 183-193.
175. Descombes, P. and Schibler, U. (1991) Cell 67(3), 569-579.
176. Ossipow, V.; Descombes, P. and Ychibler, U. (1993) Proc. Natl. Acad. Sci. USA, 90(17), 8219-8223
177. Jones, P.; Veenstra, G., Wade. P, Vermaak, D., Kass, S., Landsberger, N., Strouboulis, J. and Wolffe, A. (1998) Nat. Genet., 19(1), 187-191.
178. Collingwood, T.; Urnov, F and Wolffe, A. (1999) J. Mol. Endocrinol., 23(3), 255-275.
179. Brown, C.; Lechner, T.; Howe, L. and Workman, J. (2000) Trends Biochem. Sci., 25(1), 15-19.