Human hepatocyte cell lines proliferating as cohesive spheroid colonies in alginate markedly upregulate both synthetic and detoxificatory liver function

Journal of Hepatology

Volumn 34, Issue 1, 2001, Pages 68-77

  Khalil, Marianne ^a   Shariat Panahi, Ali ^a   Tootle, Rosemary ^a   Ryder, Tim ^a   McCloskey, Paschal ^a   Roberts, Eve ^b   Hodgson, Humphrey ^a   Selden, Clare ^a,c  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

3 Dimensional; Alginate; Bio artificial liver; Detoxification; Human hepatocyte; Liver specific protein

Indexed keywords

ALBUMIN; ALGINIC ACID; ALPHA 1 ANTITRYPSIN; ANDROSTENEDIONE; CYTOCHROME P450; ETHOXYRESORUFIN DEETHYLASE; FIBRINOGEN; OROSOMUCOID; PROTHROMBIN; UREA;

ARTICLE; ARTIFICIAL LIVER; CELL CONTACT; CELL POLARITY; CELL PROLIFERATION; CRYOPRESERVATION; DETOXIFICATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LIVER CELL; LIVER CELL CULTURE; LIVER FAILURE; LIVER FUNCTION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; STEROID METABOLISM; UREA CYCLE;

ALGINATES; ANDROSTENEDIONE; CELL DIVISION; CELL LINE; CRYOPRESERVATION; CYTOCHROME P-450 ENZYME SYSTEM; GLUCURONIC ACID; HEPATOCYTES; HEXURONIC ACIDS; HUMANS; LIVER; LIVER, ARTIFICIAL; METABOLIC DETOXICATION, DRUG; SPHEROIDS, CELLULAR; UP-REGULATION; UREA;

EID: 0035137478     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(00)00080-5     Document Type: Article

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