Nuclear receptors: Coactivators, corepressors and chromatin remodeling in the control of transcription

Journal of Molecular Endocrinology

Volumn 23, Issue 3, 1999, Pages 255-275

  Collingwood, T N ^a   Urnov, F D ^a   Wolffe, A P ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; HORMONE RECEPTOR;

CHROMATIN; GENE ACTIVATION; GENE CONTROL; GENE REPRESSION; GENETIC TRANSCRIPTION; HORMONE ACTION; HUMAN; MOLECULAR GENETICS; PRIORITY JOURNAL; REVIEW; TRANSCRIPTION REGULATION;

EID: 0033400343     PISSN: 09525041     EISSN: None     Source Type: Journal    
DOI: 10.1677/jme.0.0230255     Document Type: Review

References (174)

1. Alland L, Muhle R, Hou H Jr, Potes J, Chin L, Schreiber-Agus N & De Pinho RA 1997 Role of NCoR and histone deacetylase in Sin3-mediated transcriptional and oncogenic repression. Nature 387 49-55.
2. Almouzni G & Wolffe AP 1993 Replication coupled chromatin assembly is required for the repression of basal transcription in vivo. Genes and Development 7 2033-2047.
3. Almouzni G, Mechali M & Wolffe AP 1991 Transcription complex disruption caused by a transition in chromatin structure. Molecular and Cellular Biology 11 655-665.
4. Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM & Meltzer PS 1997 AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science 277 965-968.
5. Archer TK, Cordingley MG, Marsaud V, Richard-Foy II & Hager GL 1989 Steroid transactivation at a promoter organized in a specifically positioned array of nucleosomes. In Proceedings: Second International CBT Symposium on the Steroid/Thyroid Receptor Family and Gene Regulation, pp 221-238. Berlin: Birkhauser & Verlag.
6. Archer TK, Cordingley MG, Wolford RG & Hager GL 1991 Transcription factor access is mediated by accurately positioned nucleosomes on the mouse mammary tumor virus promoter. Molecular and Cellular Biology 11 688-698.
7. Archer TK, Lefebvre P, Wolford RG & Hager GL 1992 Transcription factor loading on the MMTV promoter: a bimodal mechanism for promoter activation. Science 255 1573-1576.
8. Arents G, Burlingame RW, Wang BW, Love WE & Moudrianakis EN 1991 The nucleosomal core histone octamer at 3·1Å resolution: a tripartite protein assembly and a left-handed superhelix. Proceedings of the National Academy of Sciences of the USA 88 10148-10152.
9. Baniahmad A, Steiner C, Kohne AC & Renkawitz R 1990 Modular structure ot a chicken lysozyme silencer -involvement of an unusual thyroid-hormone receptor binding site. Cell 61 505-514.
10. Baniahmad A, Kohne AC & Renkawitz R 1992 A transferable silencing domain is present in the thyroid hormone receptor, in the v-erbA oncogene product and in the retinoic acid receptor. EMBO Journal 11 1015-1023.
11. Baniahmad A, Ha I, Reinberg D, Tsai SY, Tsai MJ & O'Malley BW 1993 Interaction of a receptor β with transcription factor TFIIB may mediate target gene activation and derepression by thyroid hormone. Proceedings of the National Academy of Sciences of the USA 90 8832-8836.
12. Baniahmad A, Leng X, Burris TP, Tsai SY, Tsai M-J & O'Malley BW 1995 The τ4 activation domain of the thyroid hormone receptor is required for release of a putative corepressor(s) necessary for transcriptional silencing. Molecular and Cellular Biology 15 76-86.
13. Bartsch J, Truss M, Bode J & Beato M 1996 Moderate increase in histone acetylation activates the mouse mammary tumor virus promoter and remodels its nucleosome structure. Proceedings of the National Academy of Sciences of the USA 93 10741-10746.
14. Bauer A, Mikulits W, Lagger G, Stengl G, Brosch G & Beug H 1998 The thyroid hormone receptor functions as a ligand-operated developmental switch between proliferation and differentiation of erythroid progenitors. EMBO Journal 17 4291-4303.
15. Bauer WR, Hayes JJ, White JH & Wolffe AP 1994 Nucleosome structural changes due to acetylation. Journal of Molecular Biology 236 685-690.
16. Blanco JC, Minucci S, Lu J, Yang XJ, Walker KK, Chen H, Evans RM, Nakatani Y & Ozato K 1998 The histone acetylase PCAF is a nuclear receptor coactivator. Genes and Development 12 1638-1651.
17. Blomquist P, Li Q & Wrange O 1996 The affinity of nuclear factor 1 for its DNA site is drastically reduced by nucleosome organization irrespective of its rotational and translational position. Journal of Biological Chemistry 271 154-159.
18. Bocquel MT, Kumar V, Stricker C, Chambon P & Gronemeyer H 1989 The contribution of the N-and C-terminal regions of steroid receptors to activation of transcription is both receptor and cell-specific. Nucleic Acids Research 17 2581-2595.
19. Bresnick EH, John S, Berard DS, Lefebvre P & Hager GL 1990 Glucocorticoid receptor-dependent disruption of a specific nucleosome on the mouse mammary tumor virus promoter is prevented by sodium butyrate. Proceedings of the National Academy of Sciences of the USA 87 3977-3981.
20. Bresnick EH, John S & Hager GL 1991 Histone hyperacetylation does not alter the positioning or stability of phased nucleosomes on the mouse mammary tumor virus long terminal repeat. Biochemistry 30 3490-3497.
21. Bresnick EH, Bustin M, Marsaud V, Richard-Foy H & Hager GL 1992 The transcriptionally-active MMTV promoter is depleted of H1. Nucleic Acids Research 20 273-278.
22. Brown DD, Wang Z, Kanamori A, Eliceiri B, Furlow JD &. Schwartzman R 1995 Amphibian metamorphosis: a complex program of gene expression changes controlled by the thyroid hormone. Recent Progress in Hormone Research 50 309-315.
23. Brown SA, Imbalzano AN & Kingston RE 1996 Activator-dependent regulation of transcriptional pausing on nucleosomal templates. Genes and Development 10 1479-1490.
24. Candau R, Chavez S & Beato M 1996 The hormone responsive region of mouse mammary tumor virus positions a nuclcosome and precludes access of nuclear factor 1 to the promoter. Journal of Steroid Biochemistry and Molecular Biology 57 19-31.
25. Chakravarti D, LaMorte VJ, Nelson MC, Nakajima T, Juguilon H, Montminy M & Evans RM 1996 Mediation of nuclear receptor signalling by CBP/p300. Nature 383 99-103.
26. Chavez S & Beato M 1997 Nucleosome-mediated synergism between transcription factors on the mouse mammary tumor virus promoter. Proceedings of the National Academy of Sciences of the USA 94 2885-2890.
27. Chen H, Lin RJ, Schiltz RL, Chakravarti D, Nash A, Nagy L, Privalsky ML, Nakatani Y & Evans RM 1997 Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell 90 569-580.
28. Chen JD & Evans RM 1995 A transcriptional co-repressor that interacts with nuclear hormone receptor. Nature 377 454-457.
29. Chiba H, Muramatsu M, Nomoto A & Kato H 1994 Two human homologs of Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor. Nucleic Acids Research 22 1815-1820.
30. Clark DJ, Hill CS, Martin SR & Thomas JO 1988 α-Helix in the carboxy-termmal domains of histones H1 and H5. EMBO Journal 7 69-75.
31. Collingwood TN, Rajanayagam O, Adams M, Wagner R, Cavailles V, Kalkhoven E, Matthews C, Nystrom E, Stenlof K, Lindstedt G, Tisell L, Fletterick RJ, Parker MG & Chatterjee VK 1997 A natural transactivation mutation in the thyroid hormone beta receptor: impaired interaction with putative transcriptional mediators. Proceedings of the National Academy of Sciences of the USA 94 248-253.
32. Collingwood TN, Wagner R, Matthews CH, Clifton-Bligh RJ, Gurnell M, Rajanayagam O, Agostini M, Fletterick RJ, Beck-Peccoz P, Reinhardt W, Binder G, Ranke MB, Hermus A, Hesch RD, Lazarus J, Newrick P, Parfitt V, Raggatt P, de Zegher F & Chatterjee VK 1998 A role for helix 3 of the TRβ ligand-binding domain in coactivator recruitment identified by characterization of a third cluster of mutations in resistance to thyroid hormone. EMBO Journal 17 4760-4770.
33. Cook PR 1994 RNA polymerase: structural determinant of the chromatin loop and the chromosome. BioEssays 16 425-430.
34. Cotè J, Quinn J, Workman JL & Peterson CL 1994 Stimulation of GAL4 derivative binding to nucleosomal DNA by the yeast SWI/SNF complex. Science 265 53-60.
35. Covault J & Chalkley R 1980 The identification of distinct populations of acetylated histone. Journal of Biological Chemistry 255 9110-9116.
36. Dallas PB, Cheney IW, Liao D-W, Bowrin V, Byam W, Pacchione S, Kobayashi R, Yaciuk P & Moran E 1998 p300/CREB binding protein-related p270 is a component of mammalian SWI/SNF complexes. Molecular and Cellular Biology 18 3596-3603.
37. Darimont BD, Wagner RL, Apriletti JW, Stallcup MR, Kushner PJ, Baxter JD, Flctterick RJ & Yamamoto KR 1998 Structure and specificity of nuclear receptor-coactivator interactions. Genes and Development 12 3343-3356.
38. Drabik CE, Nicita CA & Lutter LC 1997 Measurement of linker number change in transcribing chromatin. Journal of Molecular Biology 267 794-806.
39. Edmondson DG, Smith MM & Roth SY 1996 Repression domain of the yeast global repressor Tup1 interacts directly with histories H3 and H4. Genes and Development 10 1247-1259.
40. Elfring LK, Daniel C, Papoulas O, Deuring R, Sarte M, Moseley S, Beek SJ, Waldrip WR. Daubress G, DePace A, Kennison JA & Tamkun JW 1998 Genetic analysis of brahma: the Drosophila homolog of the yeast chromatin remodeling factor SWI2/SNF2. Genetics 148 251-265.
41. Feng W, Ribeiro RCJ, Wagner RL, Nguyen H, Apriletti JW, Fletterick RJ, Baxter JD, Kushner PJ & West BL 1998 Hormone-dependent coactivator binding to a hydrophobic cleft on nuclear receptors. Science 280 1747-1749.
42. Fondell JD, Roy AL & Roeder RG 1993 Unliganded thyroid hormone receptor inhibits formation of a functional preinitiation complex: implications for active repression. Genes and Development 7 1400-1410.
43. Fragoso G, John S, Robertis S & Hager GL 1995 Nucleosome positioning on the MMTV LTR from the frequently-biased occupancy of multiple frames. Genes and Development 9 1933-1947.
44. Fryer CJ & Archer TK 1998 Chromatin remodeling by the glucocorticoid receptor requires the BRG1 complex. Nature 393 88-91.
45. Gaudreau L, Schmid A, Blaschke D, Ptashne M & Horz W 1997 RNA polymerase II holoenzyme recruitment is sufficient to remodel chromatin at the yeast PHO5 promoter. Cell 89 55-62.
46. Germond JE, Hirt B, Oudet P, Gross-Bellard M & Chambon P 1975 Folding of the double helix in chromatin like structures from simian virus 40. Proceedings of the National Academy of Sciences of the USA 72 1843-1847.
47. Glass CK 1994 Differential recognition of target genes by nuclear receptor monomers, dimers, and heterodimers. Endocrine Reviews 15 391-407.
48. Godde JS, Nakatani Y & Wolffe AP 1995 The amino-terminal tails of the core histones and the translational position of the TATA box determine TBP/TFIIA association with nucleosomal DNA. Nucleic Acids Research 23 4557-4564.
49. Guschin D, Chandler S & Wolffe AP 1998 Asymmetric linker histone association directs the asymmetric rearrangement of core histone interactions in a positioned nucleosome containing a thyroid hormone response element. Biochemistry 37 8629-8636.
50. Hansen JC & Wolffe AP 1992 Chromatin folding inhibits both transcription initiation and elongation by RNA polymerase III. Biochemistry 31 7977-7988.
51. Hansen JC & Wolffe AP 1994 A role for histones H2A/H2B in chromatin folding and transcriptional repression. Proceedings of the National Academy of Sciences of the USA 91 2339-2343.
52. Hansen JC, van Holde KE & Lohr D 1991 The mechanism of nucleosome assembly onto ohgomers of the sea urchin 5S DNA positioning sequence. Journal of Biological Chemistry 266 4276-4282.
53. Hansen JC, Tse C & Wolffe AP 1998 Structure and function of the core histone N-termini: more than meets the eye. Biochemistry 37 17637-17641.
54. Hanstein B, Eckner R, DiRenzo J, Halachmi S, Liu H, Searoy B, Kurokawa R & Brown M 1996 p300 is a component of an estrogen receptor coactivator complex. Proceedings of the National Academy of Sciences of the USA 93 11540-11545.
55. Heery DM, Kalkhoven E, Hoare S & Parker MG 1997 A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature 387 733-736.
56. Heinzel T, Laviusky RM, Mullen TM, Soderstrom M, Laherty CD, Torchia JT, Yang W-M, Brard C, Ngo SG, Davie JR, Seto E, Eisenman RM, Rose DW, Glass CK & Rosenfeld MG 1997 N-CoR, mSIN3, and histone deacetylasc in a complex required for repression by nuclear receptors and Mad. Nature 387 43-48.
57. Hill CS, Rimmer JM, Green BN, Finch JT & Thomas JO 1991 Histone-DNA interactions and their modulation by phosphorylation of Ser-Pro-X-Lys/Arg-motifs. EMBO Journal 10 1939-1948.
58. Hirschhorn JN, Brown SA, Clark CD & Winston F 1992 Evidence that SNF2/SWI2 and SNF activate transcription in yeast by altering chromatin structure. Genes and Development 6 2288-2298.
59. Hong H, Kohli K, Trivedi A, Johnson DL & Stallcup MR 1996 GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors. Proceedings oj the National Academy of Sciences of the USA 93 4948-4952.
60. Hong L, Schroth GP, Matthews HR, Yau P & Bradbury EM 1993. Studies of the DNA binding properties of the histone H4 amino terminus. Journal of Biological Chemistry 268 305-314.
61. Horlein AJ, Naar AM, Heinzel T, Torchia J, Gloss B, Kurokawa R, Ryan A, Kamei Y, Soderstrom M, Glass CK & Rosenfeld MG 1995 Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature 377 397-404.
62. Imbalzano AM, Kwon H, Green MR & Kingston RE 1994 Facilitated binding of TATA-binding protein to nucleosomal DNA. Nature 370 481-485.
63. Imhof A, Yang XJ, Ogryzko VV, Nakatani Y, Wolffe AP & Ge H 1997 Acetylation of general transcription factors by histone acetyltransferases: identification of a major site of acetylation in TFIIEβ. Current Biology 7 689-692.
64. Jackson TA, Richer JK, Bain DL, Takimoto GS, Tung L & Horwitz KB 1997 The partial agonist activity of antagonist-occupied steroid receptors is controlled by a novel hinge domain-binding coactivator L7/SPA and the corepressors N-CoR or SMRT. Molecular Endocrinology 11 693-705.
65. Kadosh D & Struhl K 1997 Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters. Cell 89 365-371.
66. Kamei Y, Xu L, Heinzel T, Torchia J, Kurokama R, Gloss B, Lin S-C, Heyman RA, Rose DW, Glass CK & Rosenfeld MG 1996 A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85 403-414.
67. Kaufmann PD & Botchan MR 1994 Assembly of nucleosomes: do multiple assembly factors mean multiple mechanisms? Current Opinion in Genetics and Development 4 229-235.
68. Kennison JA & Tamkun JW 1988 Dosage-dependent modifiers of Polycomb and Antennapedia mutations in Drosophila. Proceedings of the National Academy of Sciences of the USA 85 8136-8140.
69. Korzus E, Torchia J, Rose DW, Xu L, Kurokawa R, McInerney E, Mullen R-M, Glass CK & Rosenfeld MG 1998 Transcription factor-specific requirements for coactivators and their acetyltransferase functions. Science 279 703-707.
70. Kruger W, Peterson CL, Sil A, Coburn C, Arents G, Moudrianakis EN & Herskowitz I 1995 Amino acid substitutions in the structured domains of histones H3 and H4 partially relieve the requirement of the yeast SWI/SNF complex for transcription. Genes and Development 9 2770-2779.
71. Kurokawa R, Soderstrom M, Horlein A, Halachmi S, Brown M, Rosenfeld MG & Glass CK 1995 Polarity-specific activities of retinoic acid receptors determined by a corepressor. Nature 377 451-454.
72. Kurumizaka H & Wolffe AP 1997 Sin mutations of histone H3: influence on nucleosome core structure and function. Molecular and Cellular Biology 17 6953-6969.
73. Laherty CD, Yang WM, Sun JM, Davie JR, Seto E & Eisenman RM 1997 Histone deacetylase associated with the mSin3 corepressor mediates Mad transcriptional repression. Cell 89 349-356.
74. Laherty CD, Billin AX, Lavinsky RM, Yochum GS, Bush AC, Sun JM, Mullen TM, Davie JR, Rose DW, Glass CK, Rosenfeld MG, Ayer DE & Eisenman RN 1998 Sap30, a component of the mSin3 corepressor complex involved in X-CoR-mediated repression by specific transcription factors. Molecular Cell 2 33-42.
75. Landsberger N & Wolffe AP 1995 The role of chromatin and Xenopus heat shock transcription factor (XHSF1) in the regulation of the Xenopus hsp70 promoter in vivo. Molecular and Cellular Biology 15 6013-6024.
76. Landsberger N, Ranjan M, Almouzni G, Stump D & Wolffe AP 1995 The heat shock response in Xenopus oocytes, embryos and somatic cells: a regulatory role for chromatin. Developmental Biology 170 62-74.
77. Lavinsky RM, Jepsen K, Heinzel T, Torchia J, Mullen TM, Schiff R, Del-Rio AL, Ricote M, Ngo S, Gemsch J, Hilsenbeck SG, Osborne CK, Glass CK, Rosenfeld MG & Rose DW 1998 Diverse signaling pathways modulate nuclear receptor recruitment of X-CoR and SMRT complexes. Proceedings of the National Academy of Sciences of the USA 95 2920-2925.
78. Le Douarin B, Zechel C, Garnier J-M, Lutz Y, Tora L, Pierrat B & Heery D 1995 The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18. EMBO Journal 14 2020-2033.
79. Le Douarin B, Nielsen AL, Garnier JM, Ichinose H, Jeanmougin F, Losson R & Chambon P 1996 A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors. EMBO Journal 15 6701-6715.
80. Le Douarin B, You J, Nielsen AL, Chambon P & Losson R 1998 TIF1α: a possible link between KRAB zinc finger proteins and nuclear receptors. Journal of Steroid Biochemistry and Molecular Biology 65 43-50.
81. Lee DY, Haves JJ, Pruss D & Wolffe AP 1993 A positive role for histone acetylation in transcription factor binding to nucleosomal DNA. Cell 72 73-84.
82. Lee HH & Archer TK 1994 Nucleosome-mediated disruption of transcription factor-chromatin initiation complexes at the mouse mammary tumor virus long terminal repeat in vivo. Molecular and Cellular Biology 14 32-41.
83. Lee HL & Archer TK 1998 Prolonged glucocorticoid exposure dephosphorylates histone H1 and inactivates the MMTV promoter. EMBO Journal 17 1454-1466.
84. Lee JW, Choi HS, Gyuris J, Brent R & Moore DD 1995 Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. Molecular Endocrinology 9 243-254.
85. Lefebvre D, Mouchon A, Lefebvre B & Formstecher P 1998 Binding of retinoic acid receptor heterodimers to DNA - role for histones NH2 termini. Journal of Biological Chemistry 273 12288-12295.
86. Li G, Chandler SP, Wolffe AP & Hall TC 1998 Architectural specificity in chromatin structure at the TATA box in vivo: nucleosome displacement upon β-phaseolin gene activation. Proceedings of the National Academy of Sciences of the USA 95 4772-4777.
87. Li H, Gomes PJ & Chen JD 1997 RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2. Proceedings of the National Academy of Sciences of the USA 94 8479-8484.
88. Li Q & Wrange O 1993 Translational positioning of a nucleosomal glucocorticoid response element modulates glucocorticoid receptor affinity. Genes and Developmental 7 2471-2482.
89. Li Q & Wrange O 1995 The accessibility of a glucocorticoid response element dependent on its rotational positioning. Molecular and Cellular Biology 15 4375-4384.
90. Li Q, Herrler M, Landsberger N, Kaludov N, Ogrzyko VV, Nakatani Y & Wolffe AP 1998 Xenopus NF-Y pre-sets chromatin and potentiates acetylation responsive transcription from the Xenopus hsp70 promoter in vivo. EMBO Journal 17 6300-6315.
91. Li Q, Imhof A, Collingwood TN, Urnov FD & Wolffe AP 1999 p300 stimulates transcription instigated by ligand-bound thyroid hormone receptor at a step subsequent to chromatin disruption. EMBO Journal (In Press).
92. Lin BC, Hong S-H, Krig S, Yoh SM & Privalsky ML 1997 A conformational switch in nuclear hormone receptors is involved in coupling hormone binding to corepressor release. Molecular and Cellular Biology 17 6131-6138.
93. Luger K, Mader AW, Richmond RK, Sargent DF & Richmond TJ 1997 X-ray structure of the nucleosome core particle at 2·8Å resolution. Nature 389 251-259.
94. Luisi BF, Xu WX, Otwinowski Z, Freedman LP, Yamamoto KR & Sigler P 1991 Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA. Nature 352 497-502.
95. Machuca I, Esslernont G, Fairclough L & Tata JR 1995 Analysis of structure and expression of the Xenopus thyroid hormone receptor β gene to explain its autoregulation. Molecular Endocrinology 9 96-107.
96. McInerney EM, Rose DW, Flynn SE, Westin S, Mullen TM, Krones A, Inostroza J, Torchia J, Nolte RT, Assa-Munt N, Milburn MV, Glass CK & Rosenfeld MG 1998 Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation. Genes and Development 12 3357-3368.
97. McKenna NJ, Nawaz Z, Tsai SY, Tsai M-Y & O'Malley BW 1998 Distinct steady-state nuclear receptor coregulators complexes exist in vivo. Proceedings of the National Academy of Sciences of the USA 95 11697-11702.
98. Marheineke K & Krude T 1998 Nucleosome assembly activity and intracellular localization of human CAF-1 changes during the cell division cycle. Journal of Biological Chemistry 273 15279-15286.
99. Meersseman G, Pennings S & Bradbury EM 1992 Mobile nucleosomes - a general behavior. EMBO Journal 11 2951-2959.
100. Meyer M-E, Gronemeyer H, Turcotte B, Bocquel M-T, Tasset D & Chambon P 1989 Steroid hormone receptors compete for factors that mediate their enhancer function. Cell 57 433-442.
101. Morse RH 1989 Nucleosomes inhibit both transcriptional initiation and elongation by RNA polymerase III in vitro. EMBO Journal 8 2343-2351.
102. Muchardt C & Yaniv M 1993 A human homolog of Saccharomyces cerevisiae SNF2/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor. EMBO Journal 12 4275-4290.
103. Nagy L, Kao HY, Chakravarti D, Lin RJ, Hassig CA, Ayer DE, Schreiber SL & Evans RM 1997 Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and historic deacetylase. Cell 89 373-380.
104. Neigeborn L & Carlson M 1984 Genes affecting the regulation of SUC2 gene repression in Saccharomyces cerevisiae. Genetics 108 845-858.
105. Nightingale KP, Wellinger RE, Sogo JM & Becker PB 1998 Histone acetylation facilitates RNA polymerase II transcription of the Drosophila hsp26 gene in chromatin. EMBO Journal 17 2865-2876.
106. Nolte RT, Wisely GB, Westin S, Cobbs JE, Lambert MH, Kurokawa R, Rosenfeld MG, Willson TM, Glass CK & Milburn MV 1998 Ligand binding and coactivator assembly of the peroxisome proliferator-activated receptor-γ. Nature 395 137-143.
107. Norton VG, Imai BS, Yau P & Bradbury EM 1989 Histone acetylation reduces nucleosome core particle linking number change. Cell 57 449-457.
108. Ogryzko VV, Schiltz RL, Russanova V, Howard BH & Nakatani Y 1996 The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 87 953-959.
109. Onate SA, Tsai SY, Tsai M-J & O'Malley BW 1995 Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science 270 1354-1357.
110. Ordentlich P, Downes M, Xie W, Genin A, Spinner NB & Evans RM 1999 Unique forms of human and mouse nuclear receptor corepressor SMRT. Proceedings of the National Academy of Sciences of the USA 96 2639-2644.
111. Ostlund Farrants AK, Blomquist P, Kwon H & Wrange O 1997 Glucocorticoid receptor-glucocorticoid response element binding stimulates nucleosome disruption by the SWI/SNF complex. Molecular and Cellular Biology 17 895-905.
112. Papoulas O, Beek SJ, Moseley SL, McCallum CM, Sarte M, Shearn A & Tamkun JW 1998 The Drosophila trithorax group proteins BRM, ASH1, and ASH2 are subunits of distinct protein complexes. Development 125 3955-3966.
113. Patterton HG & Simpson RT 1994 Nucleosomal location of the STE6 TATA box and Matα2p-mediated repression. Molecular and Cellular Biology 14 4002-4010.
114. Pederson DS & Morse RH 1990 Effect of transcription of yeast chromatin on DNA topology in vivo. EMBO Journal 9 1873-1881.
115. Perlmann T & Wrange O 1988 Specific glucocorticoid receptor binding to DNA reconstituted in a nucleosome. EMBO Journal 7 3073-3083
116. Perlmann T & Wrange O 1991 Inhibition of chromatin assembly in Xenopus oocytes correlates with derepression of the mouse mammary tumor virus promoter. Molecular and Cellular Biology 11 5259-5265.
117. Peterson CL, Dingwall A & Scott MP 1994 SWI/SNF gene products are components of a large multisubunit complex required for transcriptional enhancement. Proceedings of the National Academy of Sciences of the USA 91 2905-2908.
118. Pina B, Barettino D, Truss M & Beato M 1990a Structural features of a regulatory nucleosome. Journal of Molecular Biology 216 975-990.
119. Pina B, Bruggemeier U & Beato M 1990b Nucleosome positioning modulates accessibility of regulatory proteins to the mouse mammary tumor virus promoter. Cell 60 719-731.
120. Pruss D, Bartholomew B, Persinger J, Hayes J, Arents G, Moudrianakis EN & Wolffe AP 1996 An asymmetric model for the nucleosome: a binding site for linker histones inside the DNA gyres. Science 274 614-617.
121. Ranjan M, Wong J & Shi Y-B 1994 Transcriptional repression of Xenopus TRβ gene is mediated by a thyroid hormone response element located near the start site. Journal of Biological Chemistry 269 24699-24705.
122. Reeves R, Gorman CM & Howard B 1985 Minichromosome assembly of non-integrated plasmid DNA transfected into mammalian cells. Nucleic Acids Research 13 3599-3615.
123. Richard-Foy H & Hager GL 1987 Sequence-specific positioning of nucleosomes over the steroid-inducible MMTV promoter. EMBO Journal 6 2321-2328.
124. Roberts MS, Fragoso G & Hager GL 1995 The MMTV LTR B nucleosome adopts multiple translational and rotational positions during in vitro reconstitution. Biochemistry 34 12470-12480.
125. Roth SY, Dean A & Simpson RT 1990 Yeast α2 repressor positions nucleosomes in TRP1/ARS1 chromatin. Molecular and Cellular Biology 10 2247-2260.
126. Samuels HH, Perlman AJ, Raaka BM & Stanley F 1982 Organization of the thyroid hormone receptor in chromatin. Recent Progress in Hormone Research 38 557-599.
127. Schild C, Claret F-X, Wahli W & Wollfe AP 1993 A nucleosome-dependent static loop potentiates estrogen-regulated transcription from the Xenopus vitellogenin B1 promoter in vitro. EMBO Journal 12 423-433.
128. Schwarz PM & Hansen JC 1994 Formation and stability of higher order chromatin structures. Contributions of the histone octamer. Journal of Biological Chemistry 269 16284-16298.
129. Seale RL 1975 Assembly of DNA and protein during replication in HeLa cells. Nature 255 247-249.
130. Seale RL 1978 Nucleosomes associated with newly replicated DNA have an altered conformation. Proceedings of the National Academy of Sciences of the USA 75 2717-2721.
131. Shi Y-B, Yaoita Y & Brown DD 1992 The earliest changes in gene expression in tadpole intestine induced by thyroid hormone. Journal of Biological Chemistry 268 20312-20317.
132. Shibahar K & Stillman B 1999 Replication-dependent marking of DNA of PCNA facilitates CAF-1 coupled inheritance of chromatin. Cell 96 575-585.
133. Smith CL, Onate SA, Tsai M-J & O'Malley BW 1996 CREB-binding protein acts synergistically with steroid receptor coactivator-1 to enhance steroid receptor-dependent transcription. Proceedings of the National Academy of Sciences of the USA 93 8884-8888.
134. Smith CL, Nawaz Z & O'Malley BW 1997 Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen. Molecular Endocrinology 11 657-666.
135. Spencer TE, Jenster G, Burcin MM, Allis CD, Zhou J, Mizzen CA, Mizzen CA, McKenna NJ, Onate SA, Tsai SY, Tsai MJ & O'Malley BW 1997 Steroid receptor coactivator-1 is a histone acetyltransferase. Nature 389 194-198.
136. Stern MJ, Jensen RE & Herskowitz I 1984 Five SWI genes are required for expression of the HO gene in yeast. Journal of Molecular Biology 178 853-868.
137. Szilak L, Moitra J, Krylov D & Vinson C 1997 Phosphorylation destabilizes α-helices. Nature Structural Biology 4 112-114.
138. Takeshita A, Cardona GR, Koibuchi N, Suen CS & Chin WW 1997 TRAM-1, a novel 160 kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1. Journal of Biological Chemistry 272 27629-27634.
139. Tamkun JW, Deuring R, Scott MP, Kissinger M, Patlatucci AM, Kaufman TC & Kennison JA 1992 Brahma: a regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2/SWI2. Cell 68 561-572.
140. Tata JR 1996 Metamorphosis: an exquisite model for hormonal regulation of post-embryonic development. Biochemical Society Symposium 62 123-136.
141. Torchia J, Rose DW, Inostroza J, Kamei Y, Westin S, Glass CK & Rosenfeld MG 1997 The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature 387 677-684.
142. Torchia J, Glass C & Rosenfeld M 1998 Co-activators and co-repressors in the integration of transcriptional responses. Current Opinion in Cell Biologv 10 373-383.
143. Truss M, Bartsch J, Schelbert A, Haché RJG &Beato M 1995 Hormone induces binding of receptors and transcription factors to a rearranged nucleosome on the MMTV promoter in vivo. EMBO Journal 14 1737-1751.
144. Tse C, Sera T, Wolffe AP & Hansen JC 1998 Disruption of higher order folding by core histone acetylation dramatically enhances transcription of nucleosomal arrays by RNA polymerase III. Molecular and Cellular Biologv 18 4629-4638.
145. Tsukiyama T, Becker PB & Wu C 1994 ATP-dependent nucleosome disruption at a heat-shock promoter mediated by binding of GAGA transcription factor. Nature 367 525-532.
146. Ura K, Hayes JJ & Wolffe AP 1995 A positive role for nucleosome mobility in the transcriptional activity of chromatin templates: restriction by linker histones. EMBO Journal 14 3752-3765.
147. Ura K, Kurumizaka H, Dimitrov S, Almouzni G & Wolffe AP 1997 Histone acetylation: influence on transcription by RNA polymerase, nucleosome mobility and positioning, and linker histone dependent transcriptional repression. EMBO Journal 16 2096-2107.
148. Voegel JJ, Heine MJS, Zechel C, Chambon P & Gronemeyer H 1996 TIF2, a 160 kDa transcription mediator for the ligand-dependent activation function AF-2 of nuclear receptors. EMBO Journal 15 3667-3675.
149. Vom Baur E, Zechel C, Heery D, Heine MJ, Garnier JM, Vivat V, Le Douarin B, Gronemeyer H, Chambon P & Losson R 1996 Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1. EMBO Journal 15 110-124
150. Wade PA, Pruss D & Wolffe AP 1997 Histone acetylation: chromatin in action. Trends in Biochemical Sciences 22 128-132.
151. Wang W, Côté J, Xue Y, Zhou S, Khavara PA, Biggar SR, Muchardt C, Kalpana GV, Goff SP, Yaniv M, Workman JL & Crabtree GR 1996a Purification and biochemical heterogeneity of the mammalian SWI/SNF complex. EMBO Journal 15 5370-5382.
152. Wang W, Xue Y, Zhou S, Kuo A, Cairns BR & Crabtree GR 1996b Diversity and specialization of mammalian SWI/SXF complexes. Genes and Development 10 2117-2130.
153. Weintraub H 1985 Assembly and propagation of repressed and derepressed chromosomal states. Cell 42 705-711.
154. Weschser MA, Kladde MP, Alfieri JA & Peterson CL 1997 Effects ot Sin versions of histone H4 on yeast chromatin structure and function. EMBO Journal 16 2086-2095.
155. Westin S, Kurokawa R, Nolte RT, Wisely GB, McInerney EI, Rose DW, Milburn MV, Rosenfeld MG & Glass CK 1998 Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators. Nature 395 199-202.
156. Wilson CJ, Chao DM, Imbalzano AN, Schnitzer GR, Kingston R & Young RA 1996 RNA polymerase II holoenzyme contains SWI/SNF regulators involved in chromatin remodeling. Cell 84 235-244.
157. Wolffe AP 1997 Sinful repression. Nature 387 16-17.
158. Wolffe AP 1998 Chromatin Structure and Function, 3rd edn. London: Academic Press.
159. Wolffe AP & Pruss D 1996 Targeting chromatin disruption: transcription regulators that acetylate histories. Cell 84 817-819.
160. Wolffe AP, Khochbin S & Dimitrov S 1997 What do linker histones do in chromatin? BioEssays 19 249-255.
161. Wong C-W & Privalsky ML 1998 Transcriptional repression by the SMRT-mSin3 corepressor: multiple interactions, multiple mechanisms, and a potential role for TFIIB. Molecular and Cellular Biology 18 5500-5510.
162. Wong J & Shi Y-B 1995 Coordinated regulation of and transcriptional activation by Xenopus thyroid hormone and retinoid X receptors. Journal of Biological Chemistry 270 18479-18483.
163. Wong J, Shi Y-B & Wolffe AP 1995 A role for nucleosome assembly in both silencing and activation of the Xenopus TRβA gene by the thyroid hormone receptor. Genes and Development 9 2696-2711.
164. Wong J, Li Q, Levi B-Z, Shi Y-B & Wolffe AP 1997a Structural and functional features of a specific nucleosome containing a recognition element for the thyroid hormone receptor. EMBO Journal 16 7130-7145.
165. Wong J, Shi Y-B & Wolffe AP 1997b Determinants of chromatin disruption and transcriptional regulation instigated by the thyroid hormone receptor: hormone regulated chromatin disruption is not sufficient for transcriptional activation. EMBO Journal 16 3158-3171.
166. Wong J, Patterton D, Imhof A, Shi Y-B & Wolffe AP 1998 Distinct requirements for chromatin assembly in transcriptional repression by thyroid hormone receptor and histone deacetylase. EMBO Journal 17 520-534.
167. Yang X-J, Ogryzko VV, Nishikawa J-I, Howard B & Nakatani Y 1996 A p300/CBP-associatcd factor that competes with the adenoviral E1A oncoprotcin. Nature 32 319-324.
168. Yaoita Y & Brown DD 1990 A correlation of thyroid hormone receptor gene expression with amphibian metamorphosis. Genes and Development 4 1917-1924.
169. Yoshinaga SK, Peterson SL, Herskowitz I & Yamamoto KR 1992 Roles of SWI1, SWI2 and SWI3 proteins for transcriptional enhancement by steroid receptors. Science 258 1598-1604.
170. Zamir I, Dawson J, Lavinsky RM, Glass CK, Rosenfeld MG & Lazar MA 1997 Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex. Proceedings of the National Academy of Sciences of the USA 94 14400-14405.
171. Zaret KS & Yamamoto KR 1984 Reversible and persistent changes in chromatin structure accompany activation of a glucocorticoid dependent enhancer element. Cell 38 29-38.
172. Zhang D-E & Nelson DA 1988 Histone acetylation in chicken erythrocytes. Rates of acetylation and evidence that histones in both active and potentially active chromatin are rapidly modified. Biochemical Journal 250 233-240.
173. Zhang W, Bone JR, Edmondson DG, Turner BM & Roth SY 1998 Essential and redundant functions of histone acetylation revealed by mutation of target lysines and loss of the Gen5p acetyltransferase. EMBO Journal 17 3155-3167.
174. Zhao K, Wang W, Rando OJ, Xue Y, Swiderek K, Kuo A & Crabtree GR 1998 Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signalling. Cell 95 625-636.