Bile acid synthesis in primary cultures of rat and human hepatocytes

Hepatology

Volumn 27, Issue 2, 1998, Pages 615-620

  Ellis, Ewa ^a   Gooowin, Bryan ^b   Abrahamsson, Anna ^a   Lioole, Chris ^b   Mode, Agneta ^a   Rudling, Mats ^a   Bjorkhem, Ingemar ^a   Einarsson, Curt ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; CHENODEOXYCHOLIC ACID; CHOLESTEROL 7ALPHA MONOOXYGENASE; CHOLIC ACID; DEXAMETHASONE; LIOTHYRONINE;

ANIMAL CELL; ARTICLE; BILE ACID SYNTHESIS; CELL HYBRIDIZATION; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; LIVER CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM;

ADOLESCENT; ADULT; ANIMALS; BILE ACIDS AND SALTS; CELLS, CULTURED; CHENODEOXYCHOLIC ACID; CHOLESTEROL 7-ALPHA-HYDROXYLASE; CHOLIC ACID; CHOLIC ACIDS; DEXAMETHASONE; FEMALE; HUMANS; LIVER; MALE; MIDDLE AGED; RATS; RNA, MESSENGER; TRIIODOTHYRONINE;

EID: 0031889214     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510270241     Document Type: Article

References (9)

1. Bjōrkhem I. Mechanism of bile acid biosynthesis in mammalian liver. In: Danielsson H, Sjövall J, eds. New comprehensive biochemistry. Vol 12. Amsterdam: Elsevier, 1985:231-278.
2. Axelson M, Sjövall J. Potential bile acid precursors in plasma-possible indicators of biosynthetic pathways to cholic and chenodeoxycholic acids in man. J Steroid Biochem 1990;36:631-640.
3. Javitt N. Bile acid synthesis from cholesterol: regulatory and auxiliary pathways. FASEBJ 1994;8:1308-1311.
4. Björkhem I, Nyberg B, Einarsson K. 7α-hydroxylation of 27-hydroxycholesterol in human liver microsomes. Biochim Biophys Acta 1992;1128: 73-76.
5. Shoda J, Toll A, Axelson M, Pieper F, Wikvall K, Sjövall J. Formation of 7α- and 7β-hydroxylated precursors from 27-hydroxycholesterol in human liver microsomes and mitochondria. HEPATOLOGY 1993;17: 395-403.
6. Princen HMG, Meijer P, Wolthers BG, Vonk RJ, Kuipers E Cyclosporine A blocks bile acid synthesis in cultured hepatocytes by specific inhibition of chenodeoxycholic acid synthesis. Biochem J 1991;275:501-505.
7. 3 by cyclosporin A. Biochem J 1993;293:203-206.
8. Reihner E, Björkhem I, Angelin B, Ewerth S, Einarsson K. Bile acid synthesis in humans: regulation of hepatic microsomal cholesterol 7α-hydroxylase activity. Gastroenterology 1989;97:1498-1505.
9. Vlahcevic ZR, Heuman DM, Hylemon PB. Regulation of bile acid synthesis. HEPATOLOGY 1991;13:590-600.