Liver-enriched transcription factors and hepatocyte differentiation

FASEB Journal

Volumn 10, Issue 2, 1996, Pages 267-282

  Cereghini, Silvia ^a  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

liver development; regulatory networks; transcription factors

Indexed keywords

HOMEODOMAIN PROTEIN; TRANSCRIPTION FACTOR;

CELL DIFFERENTIATION; CELL LINEAGE; DNA BINDING; ENDODERM; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSCRIPTION; LIVER CELL; LIVER DEVELOPMENT; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; STRUCTURE ACTIVITY RELATION;

EID: 0029962261     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.10.2.8641560     Document Type: Review

References (103)

1. Derman, E., Krauter, K., Walling, L., Weinberger, C., Ray, M., and Darnell, J. E., Jr. (1981) Transcriptional control in the production of liver-specific mRNAs. Cell 23, 731-739
2. Makover, A., Soprano, D. R., Wyatt, M., and Goodman, D. S. (1989) An in situ-hybridization study of the localization of retinol-binding protein and transthyretin messenger RNAs during fetal development in the rat. Differentiation 40, 17-25
3. Cascio, S., and Zaret, K. S. (1991) Hepatocyte differentiation initiates during endodermal-mesenchymal interactions prior to liver formation. Development 113, 217-225
4. De Simone, V., and Coitese, R. (1991). Transcriptional regulation of liver-specific gene expression. Curr, Opin. Cell Biol. 3, 960-965
5. Courtois, G., Morgan, J. G., Campbell, L. A., Fourel, G., and Crabtree, G. R. (1987) Interaction of a liver-specific nuclear factor with the fibrinogen and α1-antitrypsin promoters. Science 238, 688-692
6. Cereghini, S., Blumenfeld, M., and Yaniv, M. (1988) A liver-specific factor essential for albumin transcription differs between differentiated and dedifferentiated rat hepatoma cells. Genes & Der. 2, 957-974
7. Hardon, E., Frain, M., Paonessa, G., and Cortese, R. (1988) Two distinct factors interact with the promoter regions of several liver specific genes. EMBO J. 7, 1711-1719
8. Tronche, F., and Yaniv, M. (1992) HNF1, a homeoprotein member of the hepatic transcription regulatory network. BioEssays 14, 579-586
9. Kelsey, G. (1994) Genetic analysis of liver-specific gene expression In Liver Gene Transcription (Tronche, F., Yaniv, M., eds) R. G. Landes Co., Austin, Texas
10. Baumhueter, S., Courtois, G., and Crabtree, G. R. (1988) A variant nuclear protein in dedifferentiated hepatoma cells binds to the same functional sequences in the β fibrinogen gene promoter as HNF-1. EMBO J. 7, 2485-2493
11. Cereghini, S., Yaniv, M., and Cortese, R. (1990). Hepatocyte dedifferentiation and extinction is accompanied by a block in the synthesis of mRNA coding for the transcription factor HNF1/LFB1. EMBO J. 9, 2257-2263
12. Kuo, C. J., Conley, P. B., Chen, L., Sladek, F. M., Darnell, J. E., Jr., and Crabtree, C. R. (1992) A transcriptional hierarchy involved in mammalian cell-type specification. Nature (London) 355, 457;-461
13. Frain, M., Swart, G., Monaci, P., Nicosia, A., Stampfli, S., Frank, R., and Cortese, R. (1989) The liver-specific transcriptin factor LF-B1 contains a highly diverged homeobox DNA binding domain. Cell 59, 145-157
14. Nicosia, A., Monaci, P., Tomei, L., De Francesco, R., Nuzzo, M., Stunnenberg, H., and Cortese, R. (1990) A myosin-like dimerization helix and an extra-large homeodomain are essential elements of a tripartite DNA binding structure of LFB1. Cell 61, 1225-1236
15. Chouard, T., Blumenfeld, M , Bach, I., Vandekerckhove, J., Cereghini, S., and Yaniv, M. (1990) A distal dimerization domain is essential for DNA-binding by the atypical HNK1 homeodomain. Nucleic Acid Res. 18, 5853-5863
16. Cereghini, S., Ott, M. O., Power, S., and Maury, M. (1992) Expression patterns of vHNF1 and HNF1 homeoproteins in eaily postimplantation embryos suggest distinct and sequential developmental roles. Development 116, 783-797
17. Toniatti, C., Monaci, P., Nicosia, A., Cortese, R., and Ciliberto, G. (1993) A bipartite activation domain is responsible for the activity of transcription factor HNF1/LFB1 in cells of hepatic and nonhepatic origin. DNA Cell Biol. 12, 199-212
18. Ceska, T. A., Lamers, M., Monaci, P., Nicosia, A., Cortese, R., and Suck, D. (1993) The X-ray structure of an atypical homeodomain present in the rat liver transcription factor LFB1/HNF1 and implications for DNA binding. EMBO. J. 12, 1805-1810
19. Rey-Campos, J., Chouard, T., Yaniv, M., and Cereghini, S. (1991) vHNF1 is a homeoprotein that activates transcription and forms heterodimers with HNF1. EMBO J. 10, 1445-1457
20. De Simone, V., De Magistris, L., Lazzaro, D., Gerstner, J., Monaci, P., Nicosia, A., and Cortese, R. (1991) LFB3, a heterodimer forming homeoprotein of the LFB1 family, is expressed in specialized epithelia. EMBO J. 10, 1435-1443
21. Mendel, D. B., Hansen, L. P., Craves, M. K., Conley P. B., and Crabtree, C. R. (1991) HNF-1α and HNF-1β (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro. Genes & Dev. 5, 1042-1056
22. Kadesch, T. (1992) Consequences of heteromeric interactions among helixloop-helix proteins. Cell Growth. Diff. 4, 49-55
23. Mendel, D. B., Khavari, P. A., Conley, P. B., Craves, M. K., Hansen, L. P., Admon, A., and Crabtree, G. R. (1991b). Characterization of a cofactor that regulates dimerization of a mammalian homeodomain protein. Science 254, 1762-1767
24. von Strandmann, P. E., and Ryffel, G. U. (1995) Developmental expression of the maternal protein XD CoH, the dimerization cofactor of the homcoprotein LFB1 (HNF1) Development 121, 1217-1226
25. Bach, I., and Yaniv, M. (1993) More potent transcriptional activators or a transdominant inhibitor of the HNF1 homeoprotein family are generated by alternative RNA processing. EMBO J. 12, 4229-4242
26. Bartowski, S., Zapp, D., Weber. H., Eberle, G., Zoidl, C., Senkel, S., Klein-Hitpass, L., and Ryffel, G. U. (1993) Developmental regulation and tissue distribution of the liver transcription factor LFB1 (HNF1) in Xenopus laevis. Mol. Cell. Biol. 13, 421-431
27. Demartis, A., Maffei, M., Vignali, R., Barsacchi, G., and DeSimone, V. (1994) Cloning and developmental expression of LFB3/HNF1β transcription factor in Xenopus laevis. Mech. Dev. 47, 19-28
28. Ott, M. O., Rey-Campos, J., Cereghini, S., and Yaniv, M. (1991) vHNF1 is expressed in epithelial cells of distinct embryonic origin during development and precedes HNF1 expression. Mech. Dev. 36, 47-58
29. Lazzaro, D., De Simone, V., De Magistris, L., Lehtonen, E., and Cortese, R. (1992) LFB1 and LFB3 homeoproteins are sequentially expressed during kidney development. Development 114, 469-479
30. Duncan, S. A., Manova, K., Chen, W. Hoodless, P., Weinstein, D. C., Baehvarova, R. F., and Damell, J. E., Jr. (1994) Expression of transcription factor HNF-4 in the extraembryonic cndoderm, gut and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst. Proc. Natl. Acad. Sci. USA 91, 7598-7602
31. Costa, R. H., Grayson, D. R., and Darnell, J. E., Jr (1989). Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and α1-antitrypsin genes. Mol. Cell. Biol. 9, 1415-1425
32. Lai, E., Prezioso, V. R., Tao W. F., Chen, W. S., and Darnell, J. E., Jr. (1991) Hepatocyte nuclear factor 3a belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head. Genes & Dev. 5, 416-427
33. Weigel, D., Jurgens, C., Kuttner, F., Seifert, E., and Jäckle, H. (1989) The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the drosophila embryo. Cell 57, 645-658
34. Costa, H.H. (1994) Hepatocyte nuclear factor 3/forkhead protein family: Mammalian transcription factors that possess divergent cellular expression patterns and binding specificities. In Liver Gene Transcription (Tranche, F., Yaniv, M., eds) pp. 183-206, R. G. Landes Co., Austin, Texas Cell, 57, 645-658.
35. Costa, H.H. (1994) Hepatocyte nuclear factor 3/forkhead protein family: Mammalian transcription factors that possess divergent cellular expression patterns and binding specificities. In Liver Gene Transcription (Tranche, F., Yaniv, M., eds) pp. 183-206, R. G. Landes Co., Austin, Texas Cell, 57, 645-658.
36. Lai, E., Clark, K. L., Burley, S. K., and Darnell, J. E., Jr. (1993) Hepatocyte nuclear factor 3/fork head or "winged helix" proteins: A family of transcription factor of diverse biological function. Proc. Natl Acad. Sci. USA 90, 10421-10423
37. McPherson, C. E., Shim, E. Y., Friedman, D. S., and Zarel, K. S, (1993) An active tissue specific enhancer and bound transcription factors existing in a precisely positioned nucleosomal array. Cell 75, 387-398
38. Overdier, D. C., Porcella, A., and Costa, R. H. (1994) The DNA dinding specificity of the HNF-3/fkh domain is influenced by amino acids residues adjacent to the recognition sequence. Mol Cell. Biol. 14, 2755-2766
39. Qian, X., and Costa, R. H. (1995) Analysis of hepatocyte nuclear factor-3β protein domains for transcriptional activation and nuclear targeting Nucleic Acids Res. 22, 1182-1191
40. Ang, S. L., Wierda, A., Wong, D., Stevens, K. A., Cascio, S., Rossant, J., and Zaret, K. S. (1993) The formation and maintenance of the definitive endo-derm lineage in the mouse: involvement of HNF3/forkhead proteins. Development 119, 1301-1315
41. Monaghan, A. P., Kaestner, K. H., Grau, E., and Schütz, G. (1993) Postimplantation expression patterns indicated a role for the mouse forkhead/HNF3 α, β and γ genes in determination of definitive endoderm, chordamesoderm and neuroectoderm. Development 119, 567-578
42. Ang, S. L., and Rossant, J. (1994) HNF3β is essential for node and notochord formation in mouse development. Cell 78, 561-574
43. Weinstein, D., Ruiz Altaba, A., Chen, W., Hoodless, P., Prezioso, V., Jessell, T., and Darnell, J., Jr. (1994) The winged-helix transcription factor HNF3β is required for notochord delopment in the mouse embryo. Cell 78, 575-588
44. Sasaki, H., and Hogan, B. L. M. (1994) HNF3β as a regulator of floorplate development Cell 76, 103-115
45. Roelink, H., Augsburger, A., Heemskcrk, J., Korzh, V., Norlin, S., Ruiz Altaba, A., Tanabe, Y., Placzek, M., Edlund, T., Jessell, T., and Dodd, J. (1994) Floorplate and motor neuron induction by vhh-1 a vertebrate homolog of hedgehog expressed by the notochord. Cell, 76, 761-765
46. O'Reilly, M. A. J., Smith, J. C., and Cunliffe, V. (1995) Patterning of the mesoderm in Xenopus: dose-dependent and synergistic effects of Brachury and Pinttvallis. Development 121, 1351-1359
47. Nehls, M., Pfiefer, D., Schorp, M., Hedrich, H., and Boehm, T. (1994) New member of the winged-helix protein family disrupted in mouse and rat nude mutations. Nature (London) 372, 103-106
48. Sladek, F. M., Zhong, W., Lai, E., and Darnell, J. E., Jr. (1990) Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes & Dev. 4, 2353-2365
49. Mietus-Snyder, M., Sladek, F. M., Ginsburg, G. S., Kuo, C. F., Ladias, J. A. A., Darnell, J.E., Jr., and Karathanasis, S. K. (1992). Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells. Mol. Cell. Biol. 12, 1708-1718
50. Sladek, F. M. (1994) Hepatocyte nuclear factor 4 (HNF4). In Liver Gene transcription (Tronche, F., Yaniv, M., eds) R. G. Landes Co., Austin, Texas
51. Zhong, W., Sladek, F. M., and Darnell, J. E., Jr. (1993) The expression pattern of a Drosophila homologue to the mouse transcription factor HNF4 suggests a determinative role in gut formation. EMBO J. 12, 537-544
52. Nakshatri, H., and Chambon, P. (1994) The directly repeated RG(G/T)TCA motifs of the rat and mouse cellular retinol-binding protein Ii genes are promiscuous binding sites for RAR, RXR, HNF4, and ARP-1 homo- and heterodimers. J. Biol. Chem. 269, 890-902
53. Ge, R., Rhee, M., Malik, S., and Karathanasis, S. K. (1994) Transcriptional repression of the apolipoprotein AI gene expression by the orphan receptor Arp-1. J. Biol. Chem. 269, 13185-13192
54. Cooney, A. J., Tsai, S. Y., O'Malley, B. W., and Tsai, M.-J. (1993) Multiple mechanisms of chicken ovalbumin upstream promoter transcription factor-dependent repression of transactivation by vitamin D, thyroid hormone and retinoic acid receptors. J. Biol. Chem. 268, 4152-4160
55. Malik, S., and Karathanasis, S. (1995) Transcriptional activation by the orphan receptor Arp-1. Nucleic Acids Res. 23, 1536-1543
56. Taraviras, S., Monaghan, A. P., Schütz, G., and Kelsey, G. (1994) Characterization of the mouse HNF4 gene and its expression during mouse embryo-genesis. Mech. Dev. 48, 67-79
57. Chen, W., Manova, K., Weinstein, D. C., Duncan, S. A., Plump, A. S., Prezioso, V. R., Bachvarova, R. F., and Darnell, J. E., Jr. (1994) Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. Genes & Dev. 8, 2466-2477
58. Hoshizaki, K. D., Blackburn, T., Price, C., Ghosh, M., Miles, K., Ragucci. M., and Sweis, R. (1994) Embryonic fat-cell lineage in Drosophila melanogaster. Development 120, 2489-2499
59. Qiu, Y., Cooney, A. J., Kuratani, S., DeMayo, F. J., Tsai, S. Y., and Tsai, M.-J. (1994) Spatiotemporal expression patterns of chicken ovalbumin upstream promoter-transcription factors in the developing mouse central nervous system: Evidence for a role in segmental patterning of the diencephalon Proc. Natl. Acad. Sci. USA 91, 4451-4455
60. Jonk, L. J. C., DeJonge, M. E. J., Vervaart, J. M. A., Wissink, S., and Kruijer, W. (1994) Cloning and expression during development of three murine members of the COUP family of nuclear receptors. Mech. Dev. 47, 81-97
61. Johnson, P. F., Landschulz, W. H., Graves, B. J., and McKnight, S. L. (1987) Identification of a rat liver nuclear protein that binds to the enhancer core element of three animal viruses. Genes & Dev. 1, 133-146
62. Umek, R. M., Friedman, A. D., and McKnight, S. L. (1991) CCAAT-enhancer binding protein: a component of a differentiation switch. Science 251, 288-292
63. Johnson, P. F., and Williams, S. C. (1994) CAAT/Enhancer binding (C/EBP) proteins In Liver Gene Transcription (Tronche, F., Yaniv, M., eds) R. G. Landes Co., Austin, Texas
64. Lavery, D. J., and Schibler, U. (1993) Circacdian transcription of the cholesterol 7α hydroxylase gene may involve the liver-enriched bZIP protein DBP. Genes & Dev. 7, 1871-1884
65. Drolet, D. W., Scully, K. M., Simmons, D. M., Wegner, M., Chu, K., Swanson, L. W., and Rosenfeld, M. G. (1991) TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins. Genes & Dev. 5, 1739-1753
66. Lin, F. T., and Lane, M. D. (1992) Antisense CCAAT/enhancer-binding protein RNA suppresses coordinate gene expression and triglyceride accumulation during differentiation of 3T3-L1 preadipocytes. Genes & Dev. 6, 533-542
67. Freytag, S. O., Paielli, D. L., and Geddes, T. M. (1994) Ectopic expression of the CCAAT/enhancer-binding piotein a promotes the adipogenic program in a variety of mouse fibroblastic cells Genes & Dev. 8, 1654-1663
68. Flodby, P., Antonsnn, P., Barlow, C., Blanck, A., Porsch-Hallstrom, I., and Xanthopoulos, K. (1993) Differential patterns of expression of three C/EBP isoforms, HNF-1 and HNF-4 after partial hepatectomy in rats Exp. Cell Res. 208, 248-255
69. Mischoulon, D., Rana, B., Bucher, N. L. R., and Farmer, S. R. (1992) Growth-dependent inhibition of CCAAT enhancer-binding protein (C/EBPα) gene expression during hepatocyte proliferation in the regenerating liver and in culture. Mol. Cell. Biol. 12, 2553-2560
70. Mueller, C. (1992) The down-regulation of albumin transcription during regeneration is due to the loss of HNF-1 and the D-site transcription factors. DNA Cell Biol. 11, 559-568
71. Descombes, P., and Schibler, U. (1991). A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA. Cell 67, 569-579
72. Kowenz-Leutz, E., Twamley, G., Ansieu, S., and Leutz, A. (1994) Novel mechanism of C/EBPβ transcriptional control: activation through derepression. Genes & Dev. 8, 2718-2791
73. Poli, V., Mancini, F. P., and Cortese, R. (1990) IL-6DBP a nuclear protein involved in interleukin-6 signal transduetion defines a new family of leucine zipper proteins related to C/EBP. Cell 63, 643-653
74. Akira, S., Isshiki, H., Sugita, T., Tanabe, O., Kishimoto, S., Nishio, Y., Nakajima T., Hirano, T., and Kishimoto, T. (1990) A nuclear factor for IL-6 expression (NF-IL6) is a member of the C/EBP family. EMBO J. 9, 1897-1906
75. Tanaka, T., et al. (1995) Targeted disruption of the NF-IL6 discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages. Cell 80, 353-361
76. Screpanti, I., et al. (1995) Lymphoprolifarative disorder and imbalances T-helper response in C/EBPβ deficient mice Embo J. 14, 1932-1941
77. Mueller, C. R., Maire, P., and Schibler, U. (1990). DBP, a liver-cnriched transcriptional activator, is expressed late in ontogeny and its tissue specificity is determined posttranscriptionally. Cell 61, 279-291
78. Inaba, T., Roberts, W. M. , Shapiro, L. H., Jolly, K. W., Raimondi, S. C, Smith, S. D., and Look, A. T. (1992) Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia-Science 257, 531-534
79. Hunger, S. P., Ohyashiki, K., Toyama, K., and Cleary, M. L. (1992) HIf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17,19) acute lymphoblastic leukemia. Genes & Dev. 6, 1608-1619
80. Iyer, S. V., Davis, D. L., Seal, S. N., and Burch, J. B. E.(1991) Chicken vitellogenin gene-binding protein, a leucine zipper transcription factor that binds to an important control element in the chicken vitellogenin II promoter, is related to rat DBP. Mol. Cell. Biol. 11, 4863-4875
81. Cuif, M.-H., Cognet, M., Boquet, D., Tremp, G., Kahn, A., and Vaulont, S. (1992).Elements responsible for hormonal control and tissue specificity of L-type pyruvate kinase gene expression in transgenic mice. Mol. Cel. Biol. 12, 4852-4861
82. Schmidt, E. E., and Schibler, U. (1995) Cell size regulation, a mechanism that controls cellular RNA accumulation: consequences on regulation of the ubiquitous transcription factors Octl and NFY, and the liver enriched transcription factor DBP. J. Cell Biol. 128, 467-483
83. Burch, J. B. E., and Davis, D. L. (1994) Alternative promoter usage and splicing options result in the differential expression of mRNAs encoding four isoforms of chicken VBP, a member of the PAR subfamily of hZip transcription factors. Nucleic Acids Res. 22, 4733-4741
84. Lawson, K. A, Meneses, J. J., and Pedersen, R. A. (1991) Clonal analysis of epiblast fate during germ layer formation in the mouse embryo. Development 113, 891-991
85. Le Douarin, N. M. (1975) An experimental analysis of liver development. Med. Biol. 53, 427-455
86. Houssaint, E. (1980) Differentiation of the mouse hepatic primordium.I. An analysis of tissue interactions in hepatocyte differentiation. Cell Differ. 9, 69-279
87. Wen-Chen, Y., Cao, Z., Classon, M., and McKnight, S. L. (1995) Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. Genes & Dev. 9, 168-181
88. Pani, L., Clevidence, D., Qian, X., and Costa, R. H. (1992) The restricted promoter activity of the liver transcription factor hepatocyte nuclear factor-3β involves a cell-specific factor and positive autoactivation. Mol. Cell. Biol. 12, 552-562
89. Sadani, U., Porcella, A., Pani, L., Johnson, P. F., Burch, J. B. E., Pine, R., and Costa, R. H. (1995) Cytokine regulation of the liver transcription factor HNF3β is mediated by C/EBP family and interferon regulatory factor 1. Cell Growth Diff. 6, 879-890
90. Tian, J.-M., and Schibler, U. (1991) Tissue-specific expression of the gene encoding hepatocyte nuclear factor 1 may involve hepatocyte nuclear factor 4. Genes & Dev. 5, 2225-2234
91. Zapp, D., Bartkowski, S., Holewa, B., Zoidl, C., Klein-Hitpass, L., and Ryffel, G. U. (1993) Elements and factors involved in tissue-specific and embryonic expression of the liver transcription factor LFB1 in Xenopus laevis. Mol. Cell. Biol. 13, 6416-6426
92. Zhong, W., Mirkovitch, J., and Darnell, J. E., Jr. (1994) Tissue-specific regulation of mouse hepatocyte nuclear factor 4 expression. Mol. Cell. Biol. 14, 7276-7284
93. Bulla, G. A., and Fournier, R. E. K. (1994) Genetic analysis of a transcriptional activation pathway by using hepatoma cell variants. Mol. Cell. Biol. 14, 7086-7094
94. Kritis, A. A., Ktistaki, E., Baida, D., Zannis, V. I., and Talianidis, I. (1993) An indirect negative autoregulatory mechanism involved in hepatocyte nuclear factor 1 gene expression. Nucleic Acids Res. 21, 5882-5889
95. Miura, N., and Tanaka, K. (1993) Analysis of the rat hepatocyte nuclear factor (HNF) 1 gene promoter: synergistic activation by HNF4 and HNF1 proteins. Nucleic Acids Res. 21, 3731-3736
96. Piaggio, G., Tomei, L.,Toniatti, C., De Francesco, R., and Cortese, R. (1994) LFB1/HNF1 acts as a reppressor of its own transcription. Nucleic Acids Res. 22, 4284-4290
97. 95a. Power, S.C. and Cereghini, S. (1996) Positive regulation of the vHNF1 promoter by the orphan receptors COUP-TFI/Ear3 and COUPTFII/Arp-1. Mol. Cell. Biol. In press
98. Legraverend, C., Antonson, P., Flodby, P., and Xanthopoulos, K. G. (1993) High level activity of the mouse CCAAT/enhancer binding protein (C/EBPα) gene promoter involves autoregulation and several ubiquitous transcription factors. Nucleic Acids Res. 21, 1735-1742
99. Timchenko, N., Wilson, D. R., Taylor, L. R., Abdelsayed, S., Wilde, M., Sawadogo, M., and Darlington, G. J. (1995) Autoregulation of the human C/EBPα gene by stimulation of upstream stimulatory factor binding. Mol. Cell. Biol. 15, 1192-1202
100. Eisenmann, D. M., and Kim, S. K. (1994) Signal transduction and cell fate specification during Caenorhabditis elegans vulval development. Curr. Opin. Gen. Dev. 4, 508-516
101. Jacob, A., Budhiraja, S., Qian, X., Clevidence, D., Costa, R. H., and Reichel, R. R. (1994) Retinoic acid mediated activation of HNF3α during EC stem cell diferentiation. Nucleic Acids Res. 22, 2126-2133
102. Hilberg, F., Aguzzi, A., Howells, N., and Wagner, E. F. (1993) c-Jun is essential for normal mouse development and hepatogenesis. Nature (London) 365 179-181
103. Schmidt, C., Bladt, F., Goedecke, S., Brinkmann, V., Zsciesche, W., Sharpe, M., Gherardl, E., and Birchmeier, C. (1995) Scatter factor/hepatocyte growth factor is essential for liver development. Nature (London) 373, 699-702