Biochemical basis of hepatocellular injury

Toxicologic Pathology

Volumn 24, Issue 1, 1996, Pages 77-83

  Kedderis, Gregory L ^a  

^a CIIT CENTERS FOR HEALTH RESEARCH   (United States)

Author keywords

apoptosis; biotransformation; calcium homeostasis; cytolethality; DNA; hepatocyte; Hepatotoxicity; mitochondria; necrosis

Indexed keywords

APOPTOSIS; BIOTRANSFORMATION; CONFERENCE PAPER; DNA DAMAGE; HUMAN; LIVER CELL DAMAGE; LIVER MITOCHONDRION; LIVER NECROSIS; LIVER TOXICITY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SPECIES DIFFERENCE;

EID: 0030026975     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1177/019262339602400111     Document Type: Conference Paper

References (60)

1. Alison MR and Sarraf CE (1995). Apoptosis: Regulation and relevance to toxicology. Human Exp. Toxicol. 14: 234-247.
2. Anders MW, Lash L, Dekant W, Elfarra AA, and Dohn DR (1988) Biosynthesis and biotransformation of glutathione S-conjugates to toxic metabolites. CnV. Rev. Toxicol. 18: 311-341.
3. Billings RE, McMahon RE, Ashmore J, and Wagle SR (1977). The metabolism of drugs in isolated rat hewpatocytes: A comparison with in vivo drug metabolism and drug metabolism in subcellular fractions. Drug Metab. Dispos. 5: 518-526.
4. Bradley MO, Taylor VI, Armstrong, MJ, and Galloway SM (1987). Relationships among cytotoxicity, lysosomal breakdown, chromosome aberrations, and DNA double-strand breaks. Mutat. Res. 189: 69-79.
5. Cook JA and Mitchell JB (1989). Viability measurements in mammalian cell systems. Anal. Biochem. 179: 1-7.
6. Corcoran GB and Ray SD (1992). The role of the nucleus and other compartments in toxic cell death produced by alkylating hepatotoxicants. Toxicol. Appl. Pharmacol. 113: 167-183.
7. Eastman A (1993). Apoptosis: A product of programmed and unprogrammed cell death. Toxicol. Appl. Pharmacol. 121: 160-164.
8. Elia MC, Storer RD, Harmon LS, Kraynak AR, McKelvey TW, Hertzog PR, Keenan KP, DeLuca JG, and Nichols WW (1993). Cytotoxicity as measured by trypan blue as a potentially confounding variable in the in vitro alkaline elution/rat hepatocyte assay. Mutat. Res. 291: 193-205.
9. Elia MC, Storer RD, McKelvey TW, Kraynak AR, Barnum JE, Harmon LS, DeLuca JG, and Nichols WW (1994). Rapid DNA degradation in primary rat hepatocytes treated with diverse cytotoxic chemicals: Analysis by pulsed field gel electrophoresis and implications for alkaline elution assays. Environ. Mol. Mutagen. 24: 181-191.
10. Evans WH (1981). Membrane traffic at the hepatocyte's sinusoidal and canalicular surface domains. Hepatology 1: 452-451.
11. Gores GJ, Herman B, and Lemasters JJ (1990). Plasma membrane bleb formation and rupture: A common feature of hepatocellular injury. Hepatology 11: 690-698.
12. Guengerich FP (1990). Enzymatic oxidation of xenobiotic chemicals. Crit. Rev. Biochem. Mol. Biol. 25: 97-153.
13. Guengerich FP (1991). Reactions and significance of cytochrome P-450 enzymes. J. Biol. Chem. 266: 10019-10022.
14. Guengerich FP, Kim D-H, and Iwasaki M (1991). Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects. Chem. Res. Toxicol. 4: 168-179.
15. Herman B, Gores GJ, Nieminen A-L, Kawanishi T, Harman A, and Lemasters JJ (1990). Calcium and pH in anoxic and toxic injury. Cril. Rev. Toxicol. 21: 127-148.
16. Hinson JA and Roberts DW (1992). Role of covalent and noncovalent interactions in cell toxicity: Effects on proteins. Annu. Rev. Pharmacol. Toxicol. 32: 471-510.
17. Hong J, Pan J, Gonzalez FJ, Gelboin HV, and Yang CS (1987) The induction of a specific form of cytochrome P-450 (P-450j) by fasting. Biochem. Biophys. Res. Commun. 142: 1077-1083.
18. Houston JB (1994). Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance. Biochem. Pharmacol. 47: 1469-1479.
19. Jaeger RJ, Conolly RJB, and Murphy SD (1974). Effect of 18 hr fast and glutathione depletion on 1,1-dichloroethylene-induced hepatotoxicity and lethality in rats. Exp. Mol Pathol. 20: 187-198.
20. Jakoby WB (ed) (1980) Enzymatic Basis of Detoxication, Vols. 1 and 2. Academic Press, New York.
21. Jungermann K and Katz N (1989). Functional specialization of different hepatocyte populations. Physiol. Rev. 69: 708-764.
22. Kamendulis LM and Corcoran GB (1994). DNA as a critical target in toxic cell death: Enhancement of dimethylnitrosamine cytotoxicity by DNA repair inhibitors J. Pharmacol. Exp. Ther. 271: 1695-1698.
23. Kedderis GL (1990). The role of the mixed-function oxidase system in the toxication and detoxication of chemicals: Relationship to chemical interactions. In: Toxic Interactions, RS Goldstein, WR Hewitt, and JB Hook (eds). Academic Press, San Diego, pp. 31-60.
24. Kedderis GL, Carfagna MA, Held SD, Murphy JE, and Gargas ML (1993). Kinetic analysis of furan biotransformation by F-344 rats in vivo and in vitro. Toxicol. Appl. Pharmacol. 123: 274-282.
25. McConkey DJ, Hartzell P, Nicotera P, Wyllie AH, and Orrenius S (1988). Stimulation of endogenous endonuclease activity in hepatocytes exposed to oxidative stress. Toxicol. Lett. 42: 123-130.
26. Meister A (1988). Glutathione metabolism and its selective modification. J. Biol. Chem. 263: 17205-17208.
27. Meister A and Anderson ME (1983). Glutathione. Annu. Rev. Biochem. 52: 711-760.
28. Meyers LL, Beierschmitt WP, Khairallah EA, and Cohen SD (1988). Acetaminophen-induced inhibition of hepatic mitochondrial respiration in mice. Toxicol. Appl. Pharmacol. 93: 378-387.
29. Monks TJ and Lau SS (1988). Reactive intermediates and their lexicological significance. Toxicology 52: 1-53.
30. 2+. J Biol. Chem. 260: 13035-13040.
31. 2+ in cell killing. Chem. Res. Toxicol. 3: 484-494.
32. 2+ and the stimulation of a nonlysosomal proteolytic system. J. Biol. Chem. 261: 14628-14635.
33. 2+ is mediated by the activation of a non-lysosomal proteolytic system. FEBS Lett. 209: 139-144.
34. Pessayre D, Dolder A, Artigou J-Y, Wandscheer J-C, Descatoire V, Degott C, and Benhamou J-P (1979). Effect of fasting on metabolite-mediated hepatotoxicity in the rat. Gastroenterology 77: 264-271.
35. Porter TD and Coon MJ (1991). Cytochrome P-450: Multiplicity of isoforms, substrates, and catalytic and regulatory mechanisms. J. Biol. Chem. 266: 13469-13472.
36. 2+-mediated cell processes as critical targets for toxicant action: Conceptual and methodological pitfalls. Toxicol. Appl. Pharmacol. 94: 331-341.
37. Rappaport AM (1979). Physioanatomical basis to toxic liver injury. In: Toxic Injury of the Liver, Pt. A, E Farber and MM Fisher (eds). Marcel Dekker, New York, pp. 1-57.
38. 2+ antagonists inhibit DNA fragmentaion and toxic cell death induced by acetaminophen. FASEB J. 7: 453-463.
39. ++-endonuclease and poly(ADP-ribose) polymerase inhibitors in mice. J. Pharmacol. Exp. Ther. 263: 387-394.
40. 2+ in the nucleus during acetaminophen-induced liver injury. Toxicol. Appl. Pharmacol. 106: 346-351.
41. 2+ homeostasis, cell death, proliferation, and differentiation. Chem.-Biol. Interact 77: 1-23.
42. Rush GF, Gorski JR, Ripple MG, Sowinski J, Bugelski P, and Hewitt WR (1985). Organic hydroperoxide-induced lipid peroxidation and cell death in isolated hepatocytes. Toxicol. Appl. Pharmacol. 78: 473-483.
43. Seeman P (1972). The membrane actions of anesthetics and tranquilizers. Pharmacol. Rev. 24: 583-655.
44. Seglen PO (1976). Preparation of isolated rat liver cells. Meth. Cell Biol. 13: 29-83.
45. 2+-endonuclease, DNA repair, and glutathione depletion inhibitors on DNA fragmentation and cell death. Toxicol. Appl. Pharmacol. 112: 32-40.
46. Sies H (ed) (1985). Oxidative Stress. Academic Press, New York.
47. Sirica AE and Pilot HC (1980). Drug metabolism and effects of carcinogens in cultured hepatic cells. Pharmacol. Rev. 31: 205-228.
48. Smith PF, Gandolfi AJ, Krumdieck CL, Putnam CW, Zukoski CF, Davis WM, and Brendel K (1985). Dynamic organ culture of precision liver slices for in vitro toxicology. Life Sci. 36: 1367-1375.
49. Stewert AR, Dannan GA, Guzelian PS, and Guengerich FP (1985). Changes in the concentration of seven forms of cytochrome P-450 in primary cultures of adult rat hepatocytes. Mol. Pharmacol. 27: 125-132.
50. Stogniew M and Fenselau C (1982). Electrophilic reactions of acyl-linked glucuronides: Formation of clofibrate mcrcapturate in humans. Drug Metab. Dispos. 10: 609-613.
51. Tee LBG, Davies DS, Seddon CE, and Boobis AR (1987). Species differences in the hepatotoxicity of paracetamol are due to differences in the rate of conversion to its cytotoxic metabolite. Biochem. Pharmacol. 36: 1041-1052.
52. Thurman RG and Kauffman FC (1980). Factors regulating drug metabolism in intact hepatocytes. Pharmacol. Rev. 31: 229-251.
53. Thurman RG and Kauffman FC (1985). Sublobular compartmentation of pharmacologic events (SCOPE): Metabolic fluxes in periportal and pericentral regions of the liver lobule. Hepatology 5: 144-151.
54. Tribble DL, Aw TY, and Jones DP (1987). The pathophysiological significance of lipid peroxidation in oxidative cell injury. Hepatology 7: 377-386.
55. Uhlig S and Wendel A (1992). The physiological consequences of glutathione variations. Life Sci. 51: 1083-1094.
56. Wieland T and Faulstich H (1978). Amatoxins, phallotoxins, phallolysin, and antamanide: The biologically active components of poisonous Amanita mushrooms. Crit. Rev. Biochem. 13: 185-260.
57. Williams DE, Reed RL, Kedzierski B, Dannan GA, Guengerich FP, and Buhler DE (1989). Bioactivation and detoxication of the pyrrolizidine alkaloid senecionine by cytochrome P-450 enzymes in rat liver. Drug Metab. Dispos. 17: 387-392.
58. Williamson JM, Boettcher B, and Meister A (1982). Intracellular cysteine delivery system that protects against toxicity by promoting glutathione synthesis. Proc. Natl Acad. Sci. USA 79: 6246-6249.
59. Wolkoff AW, Johansen KL, and Goeser T (1987). The isolated perfused rat liver: Preparation and application. Anal. Biochem. 167: 1-14.
60. Wyllie AH, Kerr JFR, and Currie AR (1980). Cell death: The significance of apoptosis. Int. Rev. Cytol. 68, 251-306.