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Volumn 6, Issue 7, 2001, Pages 357-366

Screening for human ADME/Tox drug properties in drug discovery

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; KETOCONAZOLE; PHENYLPROPANOLAMINE; TERFENADINE;

EID: 0035313896     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(01)01712-3     Document Type: Review
Times cited : (490)

References (25)
  • 3
    • 0030512057 scopus 로고    scopus 로고
    • Strategic proposals for predicting drug-drug interactions during new drug development: based on sixteen deaths caused by interactions of the new antiviral sorivudine with 5-fluorouracil prodrugs
    • (1996) J. Toxicol. Sci. , vol.21 , pp. 299-300
    • Watabe, T.1
  • 4
    • 0027118223 scopus 로고
    • Warnings based on non-sedating antihistamines terfenadine and astemizole
    • (1992) J. Am. Med. Assoc. , vol.268 , pp. 705
  • 5
    • 0005778662 scopus 로고
    • Pharmaceutical applications of cell culture: an overview
    • Wilson G., et al. (Eds.), Pharmaceutical Applications of Cell and Tissue Culture to Drug Transport, Plenum Press
    • (1991) , pp. 1-14
    • Borchardt, R.T.1
  • 6
    • 0024593744 scopus 로고
    • Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability
    • (1989) Gastroenterology , vol.96 , pp. 736-749
    • Hildago, I.J.1
  • 8
    • 0005819530 scopus 로고    scopus 로고
    • Li, A.P.S. et al. (2001) Caco-2 Cell Screening Assay for Intestinal Absorption. In High Throughput Screening: Supplement to Biomedical Products. (January), pp. 6-9, Cahners
  • 11
    • 0024551516 scopus 로고
    • Optimization of cryopreservation procedures for rat and human hepatocytes
    • (1989) Xenobiotica , vol.19 , pp. 489-498
    • Loretz, L.J.1
  • 12
    • 0032968777 scopus 로고    scopus 로고
    • Cryopreserved human hepatocytes: characterization of DME activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential
    • (1999) Chem. Biol. Interact. , vol.121 , pp. 17-35
    • Li, A.P.1
  • 14
    • 0032733974 scopus 로고    scopus 로고
    • Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: an examination of in vitro half-life approach and non-specific binding to microsomes
    • (1999) Drug Metab. Dispos. , vol.27 , pp. 1350-1359
    • Obach, R.S.1
  • 15
    • 0005821402 scopus 로고    scopus 로고
    • Li, A.P., ed. (1997) Advances in Pharmacology: Pharmacokinetic Drug-Drug Interactions (Vol. 43), Academic Press
  • 18
    • 0032169485 scopus 로고    scopus 로고
    • The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
    • (1998) J. Clin. Invest. , vol.102 , pp. 1016-1023
    • Lehmann, J.M.1
  • 21
    • 0032727340 scopus 로고    scopus 로고
    • Effects of cytochrome P450 inducers on 17-alpha-ethinylestradiol (EE2) conjugation by primary human heptocytes
    • (1999) Br. J. Clin. Pharmacol. , vol.48 , pp. 733-742
    • Li, A.P.1
  • 22
    • 0001714139 scopus 로고
    • Primary hepatocytes as an in vitro toxicological system
    • Gad S. (Ed.), In Vitro Toxicology, Raven Press
    • (1994) , pp. 195-220
    • Li, A.P.1
  • 23
    • 0005863469 scopus 로고    scopus 로고
    • A high-throughput screening assay for hepatotoxicity using cryopreserved animal and human hepatocytes
    • (2000) The Toxicologist , vol.54 , pp. 206
    • Lu, C.1
  • 24
    • 0031712302 scopus 로고    scopus 로고
    • Ethionine toxicity in vitro: the correlation of data from rat hepatocyte suspensions and monolayers with in vivo observations
    • (1998) Arch. Toxicol. , vol.72 , pp. 588-596
    • Waterfield, C.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.