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Volumn 26, Issue SUPPL.2, 1997, Pages 26-36

Hepatotoxicity in drug development: Detection, significance antf solutions

Author keywords

Drug development; Hepatotoxicity

Indexed keywords

ANTILIPEMIC AGENT; CHOLINESTERASE INHIBITOR; CYPROTERONE ACETATE; ENOXACIN; ETHINYLESTRADIOL; LEUKOTRIENE RECEPTOR BLOCKING AGENT; MEVINOLIN; PHENOBARBITAL; SEX HORMONE;

EID: 0030993661     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0168-8278(97)80494-1     Document Type: Article
Times cited : (128)

References (67)
  • 2
    • 0020678834 scopus 로고
    • New applications of microbial products
    • Demain AL. New applications of microbial products. Science 1983; 219: 709-14.
    • (1983) Science , vol.219 , pp. 709-714
    • Demain, A.L.1
  • 3
    • 0022420493 scopus 로고
    • Natural plant chemicals: Sources of industrial and medicinal materials
    • Balandrin MF, Klocke JA, Wurtele ES, Bollinger WH. Natural plant chemicals: sources of industrial and medicinal materials. Science 1985; 228: 1154-60.
    • (1985) Science , vol.228 , pp. 1154-1160
    • Balandrin, M.F.1    Klocke, J.A.2    Wurtele, E.S.3    Bollinger, W.H.4
  • 4
    • 0026419319 scopus 로고
    • Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery
    • Houghten RA, Pinilla C, Blondelle SE, Appel JR, Cooley CT, Cuervo JH. Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery. Nature 1991; 354: 84-6.
    • (1991) Nature , vol.354 , pp. 84-86
    • Houghten, R.A.1    Pinilla, C.2    Blondelle, S.E.3    Appel, J.R.4    Cooley, C.T.5    Cuervo, J.H.6
  • 5
    • 0026730489 scopus 로고
    • Structure-based strategies for drug design and discovery
    • Kuntz ID. Structure-based strategies for drug design and discovery. Science 1992; 257: 1078-82.
    • (1992) Science , vol.257 , pp. 1078-1082
    • Kuntz, I.D.1
  • 6
    • 0028128244 scopus 로고
    • Safety assessment program for US regulatory agencies: A perspective of requirements and compliance
    • Bendele RA. Safety assessment program for US regulatory agencies: a perspective of requirements and compliance. Toxicol Pathol 1994; 22: 95-104.
    • (1994) Toxicol Pathol , vol.22 , pp. 95-104
    • Bendele, R.A.1
  • 7
    • 0028349719 scopus 로고
    • An examination of the drug review process within the United States
    • Johns PA. An examination of the drug review process within the United States. J Am Coll Toxicol 1994; 13: 121-42.
    • (1994) J Am Coll Toxicol , vol.13 , pp. 121-142
    • Johns, P.A.1
  • 8
    • 0028213640 scopus 로고
    • Risks, regulation and rewards in new drug development in the United States
    • Di Masi JA. Risks, regulation and rewards in new drug development in the United States. Regul Toxicol Pharmacol 1994; 19: 228-35.
    • (1994) Regul Toxicol Pharmacol , vol.19 , pp. 228-235
    • Di Masi, J.A.1
  • 10
    • 0001936586 scopus 로고
    • Clinical toxicity: Could it have been predicted? Premarketing experience
    • Lumley CE, Walker SR, eds. Lancaster: Quay Publishing
    • Lumley C. Clinical toxicity: could it have been predicted? Premarketing experience. In: Lumley CE, Walker SR, eds. Animal Toxicity Studies. Their Relevance for Man. Lancaster: Quay Publishing, 1990; 49-57.
    • (1990) Animal Toxicity Studies. Their Relevance for Man , pp. 49-57
    • Lumley, C.1
  • 11
    • 0023064477 scopus 로고
    • Predicting the safety of medicines from animal toxicity tests. I. Rodents alone
    • Lumley CE, Walker SR. Predicting the safety of medicines from animal toxicity tests. I. Rodents alone. Arch Toxicol 1987; Suppl 11:295-9.
    • (1987) Arch Toxicol , Issue.11 SUPPL. , pp. 295-299
    • Lumley, C.E.1    Walker, S.R.2
  • 12
    • 0023222862 scopus 로고
    • Predicting the safety of medicines from animal toxicity tests. II. Rodents and non-rodents
    • Lumley CE, Walker SR. Predicting the safety of medicines from animal toxicity tests. II. Rodents and non-rodents. Arch Toxicol 1987; Suppl 11: 300-4.
    • (1987) Arch Toxicol , Issue.11 SUPPL. , pp. 300-304
    • Lumley, C.E.1    Walker, S.R.2
  • 14
    • 0025946166 scopus 로고
    • Predictive value of animal studies in toxicology
    • Zbinden G. Predictive value of animal studies in toxicology. Regul Toxicol Pharmacol 1991; 14: 167-77.
    • (1991) Regul Toxicol Pharmacol , vol.14 , pp. 167-177
    • Zbinden, G.1
  • 15
    • 0027521852 scopus 로고
    • Application of animal toxicology data to clinical study of experimental drugs
    • Tomaszewski KE. Application of animal toxicology data to clinical study of experimental drugs. Comp Haematol Int 1993; 3: 67-70.
    • (1993) Comp Haematol Int , vol.3 , pp. 67-70
    • Tomaszewski, K.E.1
  • 16
    • 4043117056 scopus 로고
    • Design of first-administration studies in healthy man
    • O'Grady J, Linet OI, eds. London: Macmillan Press
    • Broom C. Design of first-administration studies in healthy man. In: O'Grady J, Linet OI, eds. Early Phase Drug Evaluation in Man. London: Macmillan Press, 1990; 206-13.
    • (1990) Early Phase Drug Evaluation in Man , pp. 206-213
    • Broom, C.1
  • 17
    • 0027506349 scopus 로고
    • The use of the dog in toxicity tests on pharmaceutical compounds
    • Parkinson C, Grasso P. The use of the dog in toxicity tests on pharmaceutical compounds. Human Exp Toxicol 1993; 12: 99-109.
    • (1993) Human Exp Toxicol , vol.12 , pp. 99-109
    • Parkinson, C.1    Grasso, P.2
  • 18
    • 0027400083 scopus 로고
    • The concept of multispecies testing in industrial toxicology
    • Zbinden G. The concept of multispecies testing in industrial toxicology. Regul Toxicol Pharmacol 1993; 17: 85-94.
    • (1993) Regul Toxicol Pharmacol , vol.17 , pp. 85-94
    • Zbinden, G.1
  • 20
    • 0001726653 scopus 로고
    • Precision-cut liver slices: An in vitro system for profiling potential hepatotoxicants
    • Azri S, Gandolfi AJ, Brendel K. Precision-cut liver slices: an in vitro system for profiling potential hepatotoxicants. In Vitro Toxicol 1990; 3: 309-25.
    • (1990) In Vitro Toxicol , vol.3 , pp. 309-325
    • Azri, S.1    Gandolfi, A.J.2    Brendel, K.3
  • 21
    • 0027227702 scopus 로고
    • Correlation of metabolism, covalent binding and toxicity for a series of bromobenzene derivatives using rat liver slices in vitro
    • Fisher R, Brendel K, Hanzlik RP. Correlation of metabolism, covalent binding and toxicity for a series of bromobenzene derivatives using rat liver slices in vitro. Chem Biol Interact 1993; 88: 191-208.
    • (1993) Chem Biol Interact , vol.88 , pp. 191-208
    • Fisher, R.1    Brendel, K.2    Hanzlik, R.P.3
  • 22
    • 0027193313 scopus 로고
    • The integration of investigative toxicology in the drug discovery process
    • Dean JH, Olson HM. The integration of investigative toxicology in the drug discovery process. Biol Cell 1993; 77: 3-8.
    • (1993) Biol Cell , vol.77 , pp. 3-8
    • Dean, J.H.1    Olson, H.M.2
  • 23
    • 0025319361 scopus 로고
    • The role of experimental toxicology in safety evaluation: Challenges facing the pharmaceutical industry
    • Kapeghian JC, Traina VM. The role of experimental toxicology in safety evaluation: challenges facing the pharmaceutical industry. Med Res Rev 1990; 10: 271-80.
    • (1990) Med Res Rev , vol.10 , pp. 271-280
    • Kapeghian, J.C.1    Traina, V.M.2
  • 24
    • 0027398769 scopus 로고
    • Effect of bile acids on intra-cellular calcium in isolated rat hepatocyte couplets
    • Thibault N, Ballet F. Effect of bile acids on intra-cellular calcium in isolated rat hepatocyte couplets. Biochem Pharmacol 1993; 45: 289-93.
    • (1993) Biochem Pharmacol , vol.45 , pp. 289-293
    • Thibault, N.1    Ballet, F.2
  • 25
    • 0027788161 scopus 로고
    • Effect of tauroursodeoxycholate on actin filament alteration induced by cholestatic agents: A study in isolated rat hepatocytes couplets
    • Thibault N, Maurice M, Maratrat M, Cordier A, Feldmann G, Ballet F. Effect of tauroursodeoxycholate on actin filament alteration induced by cholestatic agents: a study in isolated rat hepatocytes couplets. J Hepatol 1993; 19: 367-76.
    • (1993) J Hepatol , vol.19 , pp. 367-376
    • Thibault, N.1    Maurice, M.2    Maratrat, M.3    Cordier, A.4    Feldmann, G.5    Ballet, F.6
  • 26
    • 0026719622 scopus 로고
    • Actin filament alteration as a potential marker for cholestasis: A study in isolated rat hepatocyte couplets
    • Thibault N, Claude JR, Ballet F. Actin filament alteration as a potential marker for cholestasis: a study in isolated rat hepatocyte couplets. Toxicology 1992; 73: 269-79.
    • (1992) Toxicology , vol.73 , pp. 269-279
    • Thibault, N.1    Claude, J.R.2    Ballet, F.3
  • 27
    • 0023723401 scopus 로고
    • Reactive intermediates and their toxicological significance
    • Monks TJ, Lau SS. Reactive intermediates and their toxicological significance. Toxicology 1988; 52: 1-53.
    • (1988) Toxicology , vol.52 , pp. 1-53
    • Monks, T.J.1    Lau, S.S.2
  • 28
    • 0026643209 scopus 로고
    • Role of covalent and non covalent interactions in cell toxicity: Effect on proteins
    • Hinson JA, Roberts DW. Role of covalent and non covalent interactions in cell toxicity: effect on proteins. Annu Rev Pharmacol Toxicol 1992; 32: 471-510.
    • (1992) Annu Rev Pharmacol Toxicol , vol.32 , pp. 471-510
    • Hinson, J.A.1    Roberts, D.W.2
  • 29
    • 0025274623 scopus 로고
    • Covalent and non covalent interactions in acute lethal cell injury caused by chemicals
    • Nelson SD, Pearson PG. Covalent and non covalent interactions in acute lethal cell injury caused by chemicals. Annu Rev Pharmacol Toxicol 1990; 30: 169-95.
    • (1990) Annu Rev Pharmacol Toxicol , vol.30 , pp. 169-195
    • Nelson, S.D.1    Pearson, P.G.2
  • 30
    • 0027715770 scopus 로고
    • Specific targets of covalent drug-protein interactions in hepatocytes and their toxicological significance in drug-induced liver injury
    • Boelsterli UA. Specific targets of covalent drug-protein interactions in hepatocytes and their toxicological significance in drug-induced liver injury. Drug Metab Rev 1993; 25: 395-451.
    • (1993) Drug Metab Rev , vol.25 , pp. 395-451
    • Boelsterli, U.A.1
  • 31
    • 0027477180 scopus 로고
    • Immunochemical detection of liver protein adducts of the non-steroidal antiinflammatory drug diclofenac
    • Pumford NR, Myers TG, Davila JC, Highet RJ, Pohl LR. Immunochemical detection of liver protein adducts of the non-steroidal antiinflammatory drug diclofenac. Chem Res Toxicol 1993; 6: 147-50.
    • (1993) Chem Res Toxicol , vol.6 , pp. 147-150
    • Pumford, N.R.1    Myers, T.G.2    Davila, J.C.3    Highet, R.J.4    Pohl, L.R.5
  • 33
    • 0024202767 scopus 로고
    • Immunochemical analysis of acetaminophen covalent binding to proteins. Partial characterization of the major acetaminophen-binding liver proteins
    • Bartolone JB, Birge RB, Sparks K, Cohen SD, Khairallah EA. Immunochemical analysis of acetaminophen covalent binding to proteins. Partial characterization of the major acetaminophen-binding liver proteins. Biochem Pharmacol 1988; 37: 4763.
    • (1988) Biochem Pharmacol , vol.37 , pp. 4763
    • Bartolone, J.B.1    Birge, R.B.2    Sparks, K.3    Cohen, S.D.4    Khairallah, E.A.5
  • 34
    • 0028298121 scopus 로고
    • Specificity of in vitro covalent binding of tienilic acid metabolites to human liver microsomes in relationship to the type of hepatotoxicity: Comparison with two directly hepatotoxic drugs
    • Lecoeur S, Bonierbale E, Challine D, Gautier JC, Valadon P, Dansette PM, et al. Specificity of in vitro covalent binding of tienilic acid metabolites to human liver microsomes in relationship to the type of hepatotoxicity: comparison with two directly hepatotoxic drugs. Chem Res Toxicol 1994; 7: 434-42.
    • (1994) Chem Res Toxicol , vol.7 , pp. 434-442
    • Lecoeur, S.1    Bonierbale, E.2    Challine, D.3    Gautier, J.C.4    Valadon, P.5    Dansette, P.M.6
  • 35
    • 0242668517 scopus 로고
    • Human antiendoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome that hydroxylates the drug
    • Beaune PH, Dansette PM, Mansuy D, Kiffel L, Finck M, Amar C, et al. Human antiendoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome that hydroxylates the drug. Proc Natl Acad Sci USA 1987; 84: 551-5.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 551-555
    • Beaune, P.H.1    Dansette, P.M.2    Mansuy, D.3    Kiffel, L.4    Finck, M.5    Amar, C.6
  • 36
    • 0001847944 scopus 로고
    • Mechanisms of drug-induced hepatic injury
    • Stricker BHCH, ed. Amsterdam: Elsevier
    • Pessayre D. Mechanisms of drug-induced hepatic injury. In: Stricker BHCH, ed. Drug-induced Hepatic Injury, 2nd edn. Amsterdam: Elsevier, 1992; 23-51.
    • (1992) Drug-induced Hepatic Injury, 2nd Edn. , pp. 23-51
    • Pessayre, D.1
  • 37
    • 0027444834 scopus 로고
    • Bioactivation and irreversible binding of the cognition activator tacrine using human and rat liver microsomal preparations. Species differences
    • Woolf TF, Pool WF, Bjorge SM, Chang T, Goel OP, Purchase CF, et al. Bioactivation and irreversible binding of the cognition activator tacrine using human and rat liver microsomal preparations. Species differences. Drug Metab Dispos 1993; 21: 874-82.
    • (1993) Drug Metab Dispos , vol.21 , pp. 874-882
    • Woolf, T.F.1    Pool, W.F.2    Bjorge, S.M.3    Chang, T.4    Goel, O.P.5    Purchase, C.F.6
  • 38
    • 0027326685 scopus 로고
    • An investigation into the formation of stable protein-reactive and cytotoxic metabolites from tacrine in vitro. Studies with human and rat liver microsomes
    • Madden S, Woolf TF, Pool WF, Park BK. An investigation into the formation of stable protein-reactive and cytotoxic metabolites from tacrine in vitro. Studies with human and rat liver microsomes. Biochem Pharmacol 1993; 46: 13-20.
    • (1993) Biochem Pharmacol , vol.46 , pp. 13-20
    • Madden, S.1    Woolf, T.F.2    Pool, W.F.3    Park, B.K.4
  • 41
    • 0016108703 scopus 로고
    • Induction of liver growth by xenobiotic compounds and other stimuli
    • Schulte-Hermann R. Induction of liver growth by xenobiotic compounds and other stimuli. CRC Crit Rev Toxicol 1974; 3: 97-158.
    • (1974) CRC Crit Rev Toxicol , vol.3 , pp. 97-158
    • Schulte-Hermann, R.1
  • 42
    • 0021248961 scopus 로고
    • Controlled death (apoptosis) of normal and putative preneoplastic cells in rat liver following withdrawal of tumor promoters
    • Bursch W, Lauer B, Timmermann-Trosiener I, Barthel G, Schuppler J, Schulte-Hermann R. Controlled death (apoptosis) of normal and putative preneoplastic cells in rat liver following withdrawal of tumor promoters. Carcinogenesis 1984; 5: 453-8.
    • (1984) Carcinogenesis , vol.5 , pp. 453-458
    • Bursch, W.1    Lauer, B.2    Timmermann-Trosiener, I.3    Barthel, G.4    Schuppler, J.5    Schulte-Hermann, R.6
  • 43
    • 0026578966 scopus 로고
    • Nuclear receptors and chemical carcinogenesis
    • Green S. Nuclear receptors and chemical carcinogenesis. Trends Pharmacol Sci 1992; 13: 251-5.
    • (1992) Trends Pharmacol Sci , vol.13 , pp. 251-255
    • Green, S.1
  • 44
    • 0026522195 scopus 로고
    • The dioxin and peroxisome proliferator-activated receptors: Nuclear receptors in search of endogenous ligands
    • Poellinger L, Gottlicher M, Gustafsson JA. The dioxin and peroxisome proliferator-activated receptors: nuclear receptors in search of endogenous ligands. Trends Pharmacol Sci 1992; 13: 241-4.
    • (1992) Trends Pharmacol Sci , vol.13 , pp. 241-244
    • Poellinger, L.1    Gottlicher, M.2    Gustafsson, J.A.3
  • 45
    • 0028174982 scopus 로고
    • Carcinogenicity of TCDD. Experimental, mechanistic and epidemiological evidence
    • Huff J, Lucier G, Tritscher A. Carcinogenicity of TCDD. Experimental, mechanistic and epidemiological evidence. Annu Rev Pharmacol Toxicol 1994; 34: 343-72.
    • (1994) Annu Rev Pharmacol Toxicol , vol.34 , pp. 343-372
    • Huff, J.1    Lucier, G.2    Tritscher, A.3
  • 47
    • 0021051308 scopus 로고
    • Carcinogenesis by hepatic peroxisome proliferators: Evaluation of the risk of hypolipidemic drugs and industrial plasticizers to humans
    • Reddy JK, Lalwai ND. Carcinogenesis by hepatic peroxisome proliferators: evaluation of the risk of hypolipidemic drugs and industrial plasticizers to humans. CRC Crit Rev Toxicol 1983; 12: 1-58.
    • (1983) CRC Crit Rev Toxicol , vol.12 , pp. 1-58
    • Reddy, J.K.1    Lalwai, N.D.2
  • 48
    • 0025930566 scopus 로고
    • Stimulation of hepatocyte DNA synthesis by ethinyl estradiol
    • Butterworth BE, Slaga TJ, Farland W, McClain M, eds. New York: Wiley-Liss
    • Yager JD, Shi YE. Stimulation of hepatocyte DNA synthesis by ethinyl estradiol. In: Butterworth BE, Slaga TJ, Farland W, McClain M, eds. Chemically Induced Cell Proliferation. Implication for Risk Assessment. New York: Wiley-Liss, 1991; 53-65.
    • (1991) Chemically Induced Cell Proliferation. Implication for Risk Assessment , pp. 53-65
    • Yager, J.D.1    Shi, Y.E.2
  • 49
    • 0027996471 scopus 로고
    • Growth stimulation followed by growth inhibition in liver of female rats treated with ethinyl estradiol
    • Yager JD, Zurlo J, Sewall C, Lucier GW, He H. Growth stimulation followed by growth inhibition in liver of female rats treated with ethinyl estradiol. Carcinogenesis 1994; 15: 2117-23.
    • (1994) Carcinogenesis , vol.15 , pp. 2117-2123
    • Yager, J.D.1    Zurlo, J.2    Sewall, C.3    Lucier, G.W.4    He, H.5
  • 50
    • 0026512675 scopus 로고
    • Phenobarbital induction of cytochrome P-450 gene expression
    • Waxman DJ, Azaroff L. Phenobarbital induction of cytochrome P-450 gene expression. Biochem J 1992; 281: 577-92.
    • (1992) Biochem J , vol.281 , pp. 577-592
    • Waxman, D.J.1    Azaroff, L.2
  • 51
    • 0028231149 scopus 로고
    • Mechanisms of non-genotoxic carcinogenesis
    • Shaw IC, Jones HB. Mechanisms of non-genotoxic carcinogenesis. Trends Pharmacol Sci 1994; 15: 89-93.
    • (1994) Trends Pharmacol Sci , vol.15 , pp. 89-93
    • Shaw, I.C.1    Jones, H.B.2
  • 52
    • 0027979565 scopus 로고
    • Current knowledge of mechanisms of carcinogenicity: Genotoxins versus non-genotoxins
    • Purchase IFH. Current knowledge of mechanisms of carcinogenicity: genotoxins versus non-genotoxins. Hum Exp Toxicol 1994; 13: 17-28.
    • (1994) Hum Exp Toxicol , vol.13 , pp. 17-28
    • Purchase, I.F.H.1
  • 53
    • 0028208243 scopus 로고
    • Suppression of liver cell apoptosis in vitro by the non-genotoxic hepatocarcinogen and peroxisome proliferator nafenopine
    • Bayly AC, Roberts RA, Dive C. Suppression of liver cell apoptosis in vitro by the non-genotoxic hepatocarcinogen and peroxisome proliferator nafenopine. J Biol Cell 1994; 125: 197-203.
    • (1994) J Biol Cell , vol.125 , pp. 197-203
    • Bayly, A.C.1    Roberts, R.A.2    Dive, C.3
  • 54
  • 55
    • 0027857943 scopus 로고
    • Concepts, labelling procedures and design of cell proliferation studies relating to carcinogenesis
    • Goldsworthy TL, Butterworth BE, Maronpot RR. Concepts, labelling procedures and design of cell proliferation studies relating to carcinogenesis. Environ Health Perspect 1993; 101, suppl 5: 59-66.
    • (1993) Environ Health Perspect , vol.101 , Issue.5 SUPPL. , pp. 59-66
    • Goldsworthy, T.L.1    Butterworth, B.E.2    Maronpot, R.R.3
  • 56
    • 0025368026 scopus 로고
    • The gastric antisecretory drug omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P450
    • Diaz D, Fahre I, Daujat M, Fahre G, Joyeux H, Bories P, Michel H, Maurel P. The gastric antisecretory drug omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P450. Gastroenterology 1990; 99: 737-47.
    • (1990) Gastroenterology , vol.99 , pp. 737-747
    • Diaz, D.1    Fahre, I.2    Daujat, M.3    Fahre, G.4    Joyeux, H.5    Bories, P.6    Michel, H.7    Maurel, P.8
  • 57
    • 0026621357 scopus 로고
    • Chemical structure-activity relationships: Peroxisome proliferation and lipid regulation in rats
    • Mc Guire EJ, Gray RH, De La Iglesia FA. Chemical structure-activity relationships: peroxisome proliferation and lipid regulation in rats. J Am Coll Toxicol 1992; 11: 353-61.
    • (1992) J Am Coll Toxicol , vol.11 , pp. 353-361
    • Mc Guire, E.J.1    Gray, R.H.2    De La Iglesia, F.A.3
  • 58
    • 0026100678 scopus 로고
    • Peroxisome proliferation and non genotoxic carcinogenesis: Commentary on a symposium
    • Moody DE, Reddy JK, Lake BG, Popp JA, Reese DH. Peroxisome proliferation and non genotoxic carcinogenesis: commentary on a symposium. Fundam Appl Toxicol 1991; 16: 233-48.
    • (1991) Fundam Appl Toxicol , vol.16 , pp. 233-248
    • Moody, D.E.1    Reddy, J.K.2    Lake, B.G.3    Popp, J.A.4    Reese, D.H.5
  • 59
    • 0024509605 scopus 로고
    • Biochemical mechanisms of induction of hepatic peroxisome proliferation
    • Lock EA, Mitchell AE, Elcombe CR. Biochemical mechanisms of induction of hepatic peroxisome proliferation. Annu Rev Pharmacol Toxicol 1989; 29: 145-63.
    • (1989) Annu Rev Pharmacol Toxicol , vol.29 , pp. 145-163
    • Lock, E.A.1    Mitchell, A.E.2    Elcombe, C.R.3
  • 60
    • 0024460524 scopus 로고
    • The significance of hepatic microsomal enzyme induction and altered thyroid function in rats: Implications for thyroid gland neoplasia
    • McClain RM. The significance of hepatic microsomal enzyme induction and altered thyroid function in rats: implications for thyroid gland neoplasia. Toxicol Path 1989; 17: 294-306.
    • (1989) Toxicol Path , vol.17 , pp. 294-306
    • McClain, R.M.1
  • 61
    • 0026554628 scopus 로고
    • UDP-glucuronyltransferase inducers reduce thyroid hormone levels in rats by an extrathyroidal mechanism
    • Barter RA, Klaassen CD. UDP-glucuronyltransferase inducers reduce thyroid hormone levels in rats by an extrathyroidal mechanism. Toxicol Appl Pharmacol 1992; 113: 36-42.
    • (1992) Toxicol Appl Pharmacol , vol.113 , pp. 36-42
    • Barter, R.A.1    Klaassen, C.D.2
  • 62
    • 0025606337 scopus 로고
    • Species variation in the response of the cytochrome P450 dependent monooxygenase system to inducers and inhibitors
    • Boobis AR, Sesardic D, Murray BP, Edwards RJ, Singleton AM, Rich KJ, et al. Species variation in the response of the cytochrome P450 dependent monooxygenase system to inducers and inhibitors. Xenobiotica 1990; 20: 1139-61.
    • (1990) Xenobiotica , vol.20 , pp. 1139-1161
    • Boobis, A.R.1    Sesardic, D.2    Murray, B.P.3    Edwards, R.J.4    Singleton, A.M.5    Rich, K.J.6
  • 63
    • 0027881693 scopus 로고
    • Comparison of proliferating cell nuclear antigen to tritiated thymidine as a marker of proliferating hepatocytes in rats
    • Foley J, Ton T, Maronpot RR, Butterworth B, Goldworthy TL. Comparison of proliferating cell nuclear antigen to tritiated thymidine as a marker of proliferating hepatocytes in rats. Environ Health Perspect 1993; 101, suppl 5: 199-206.
    • (1993) Environ Health Perspect , vol.101 , Issue.5 SUPPL. , pp. 199-206
    • Foley, J.1    Ton, T.2    Maronpot, R.R.3    Butterworth, B.4    Goldworthy, T.L.5
  • 65
    • 0028277010 scopus 로고
    • Image analysis of bromodeoxyuridine (BrdU) stain-ing for measurement of S-phase in rat and mouse liver
    • Soames AR, Lavender D, Foster JR, Williams SM, Wheeldon EB. Image analysis of bromodeoxyuridine (BrdU) stain-ing for measurement of S-phase in rat and mouse liver. J Histochem Cytochem 1994; 42: 939-44.
    • (1994) J Histochem Cytochem , vol.42 , pp. 939-944
    • Soames, A.R.1    Lavender, D.2    Foster, J.R.3    Williams, S.M.4    Wheeldon, E.B.5
  • 66
    • 0025985195 scopus 로고
    • Guidelines for measuring chemically induced cell proliferation in specific rodent target organs
    • Butterworth BE, Slaga TJ, Farland N, McClain M, eds. New York: Wiley-Liss
    • Goldworthy TL, Morgan KT, Popp JA, Butterworth BE. Guidelines for measuring chemically induced cell proliferation in specific rodent target organs. In: Butterworth BE, Slaga TJ, Farland N, McClain M, eds. Chemically Induced Cell Proliferation. Implication for Risk Assessment. New York: Wiley-Liss, 1991; 253-4.
    • (1991) Chemically Induced Cell Proliferation. Implication for Risk Assessment , pp. 253-254
    • Goldworthy, T.L.1    Morgan, K.T.2    Popp, J.A.3    Butterworth, B.E.4
  • 67
    • 0027817149 scopus 로고
    • Use of cell proliferation data in cancer risk assessment: FDA view
    • Scheuplein RJ. Use of cell proliferation data in cancer risk assessment: FDA view. Environ Health Perspect 1993; 101, suppl 5: 139-42.
    • (1993) Environ Health Perspect , vol.101 , Issue.5 SUPPL. , pp. 139-142
    • Scheuplein, R.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.