A significant role of human cytochrome P450 2C8 in amiodarone N-deethylation: An approach to predict the contribution with relative activity factor

Drug Metabolism and Disposition

Volumn 28, Issue 11, 2000, Pages 1303-1310

  Ohyama, Katsuhiro ^a   Nakajima, Miki ^a   Nakamura, Sumika ^a   Shimada, Noriaki ^b   Yamazaki, Hiroshi ^a   Yokoi, Tsuyoshi ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b DAIICHI PURE CHEMICALS CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMIODARONE; ANTIBODY; CHLORZOXAZONE; COUMARIN; CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 3A4; CYTOCHROME P450 INHIBITOR; CYTOCHROME P450 ISOENZYME; DEBRISOQUINE 4 HYDROXYLASE; DEETHYLAMIODARONE; ERYTHROMYCIN; ETHOXYRESORUFIN DEETHYLASE; FLUVOXAMINE; FURAFYLLINE; KETOCONAZOLE; MEPHENYTOIN; PACLITAXEL; PHENACETIN O DEETHYLASE; QUERCETIN; QUINIDINE; SULFAPHENAZOLE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; HUMAN; HUMAN TISSUE; LIVER MICROSOME; MICHAELIS CONSTANT; PRIORITY JOURNAL; PROTEIN CONTENT;

ALKYLATION; AMIODARONE; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; MICROSOMES, LIVER; RECOMBINANT PROTEINS; STEROID 16-ALPHA-HYDROXYLASE; STEROID HYDROXYLASES;

EID: 0033783019     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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