Are chemically reactive metabolites responsible for adverse reactions to drugs?

Current Drug Metabolism

Volumn 3, Issue 4, 2002, Pages 351-366

  Williams, D P ^a   Kitteringham, N R ^a   Naisbitt, D J ^a   Pirmohamed, M ^a   Smith, D A ^a   Park, B K ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ANTICOAGULANT AGENT; ASCORBIC ACID; BENZO[A]PYRENE DERIVATIVE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA CAROTENE; CAPTOPRIL; CARBON TETRACHLORIDE; CEPHALOSPORIN DERIVATIVE; CLOZAPINE; CYTOCHROME P450; DICLOFENAC; DRUG METABOLITE; FREE RADICAL; GLUCURONIDE; GLUTATHIONE; HALOTHANE; LAMOTRIGINE; NITROGEN DERIVATIVE; ORGANIC COMPOUND; PARACETAMOL; PENICILLIN DERIVATIVE; PHENYTOIN; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PYRENE DERIVATIVE; QUINONE DERIVATIVE; RIBOFLAVIN; SULFAMETHOXAZOLE; TAURINE; UNINDEXED DRUG; DRUG;

APOPTOSIS; BLEEDING; BLOOD DYSCRASIA; CARCINOGENICITY; CHEMICAL REACTION; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVATION; DRUG ACTIVITY; DRUG METABOLISM; DRUG STRUCTURE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LIVER TOXICITY; MACROMOLECULE; MOLECULAR WEIGHT; MUTAGENESIS; REVIEW; SKIN MANIFESTATION; TISSUE NECROSIS; ANIMAL; BIOTRANSFORMATION; CHEMICAL STRUCTURE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; HEMATOLOGIC DISEASE; LIVER DISEASE; METABOLISM; SKIN DISEASE;

ANIMAL; BIOTRANSFORMATION; HEMATOLOGIC DISEASES; HUMAN; LIVER DISEASES; MOLECULAR STRUCTURE; PHARMACEUTICAL PREPARATIONS; SKIN DISEASES; SUPPORT, NON-U.S. GOV'T; ANIMALS; HUMANS;

EID: 0035996569     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/1389200023337423     Document Type: Review

References (157)