-
1
-
-
0030801772
-
Diagnosis and treatment of Alzheimer disease and related disorders. Consensus statement of the American Association for Geriatric Psychiatry, the Alzheimer's Association, and the American Geriatrics Society
-
Small, G.W., et al. 1997. Diagnosis and treatment of Alzheimer disease and related disorders. Consensus statement of the American Association for Geriatric Psychiatry, the Alzheimer's Association, and the American Geriatrics Society. JAMA. 278:1363-1371.
-
(1997)
JAMA
, vol.278
, pp. 1363-1371
-
-
Small, G.W.1
-
2
-
-
0034861814
-
Prevalence, costs, and treatment of Alzheimer's disease and related dementia: A managed care perspective
-
Rice, D.P., et al. 2001. Prevalence, costs, and treatment of Alzheimer's disease and related dementia: a managed care perspective. Am. J. Manag. Care. 7:809-818.
-
(2001)
Am. J. Manag. Care
, vol.7
, pp. 809-818
-
-
Rice, D.P.1
-
3
-
-
0035990321
-
Health care utilization and costs of Alzheimer's disease: The role of co-morbid conditions, disease stage, and pharmacotherapy
-
Fillit, H., Hill, J.W., and Fufferman, R. 2002. Health care utilization and costs of Alzheimer's disease: the role of co-morbid conditions, disease stage, and pharmacotherapy. Fam. Med. 34:528-535.
-
(2002)
Fam. Med.
, vol.34
, pp. 528-535
-
-
Fillit, H.1
Hill, J.W.2
Fufferman, R.3
-
4
-
-
0031949628
-
A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion ofexon 9 of presenilin 1
-
Crook, R., et al. 1998. A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion ofexon 9 of presenilin 1. Nat. Med. 4:452-455.
-
(1998)
Nat. Med.
, vol.4
, pp. 452-455
-
-
Crook, R.1
-
5
-
-
8244260610
-
Two novel (M233T and R278T) presenilin-1 mutations in early-onset Alzheimer's disease pedigrees and preliminary evidence for association of presenilin-1 mutations with a novel phenotype
-
Kwok, J.B., et al. 1997. Two novel (M233T and R278T) presenilin-1 mutations in early-onset Alzheimer's disease pedigrees and preliminary evidence for association of presenilin-1 mutations with a novel phenotype. Neuroreport. 8:1537-1542.
-
(1997)
Neuroreport
, vol.8
, pp. 1537-1542
-
-
Kwok, J.B.1
-
6
-
-
0034718027
-
Biochemical detection of Aβ isoforms: Implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease
-
Golde, T.E., Eckman, C.B., and Younkin, S.G. 2000. Biochemical detection of Aβ isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease. Biochim. Biophys. Acta. 1502:172-187.
-
(2000)
Biochim. Biophys. Acta
, vol.1502
, pp. 172-187
-
-
Golde, T.E.1
Eckman, C.B.2
Younkin, S.G.3
-
7
-
-
0034966874
-
Presenilins as therapeutic targets for the treatment of Alzheimer's disease
-
Golde, T.E., and Younkin, S.G. 2001. Presenilins as therapeutic targets for the treatment of Alzheimer's disease. Trends Mol. Med. 7:264-269.
-
(2001)
Trends Mol. Med
, vol.7
, pp. 264-269
-
-
Golde, T.E.1
Younkin, S.G.2
-
8
-
-
0031052381
-
Amyloid, the presenilins and Alzheimer's disease
-
Hardy, J. 1997. Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci. 20:154-159.
-
(1997)
Trends Neurosci.
, vol.20
, pp. 154-159
-
-
Hardy, J.1
-
9
-
-
0032105394
-
The role of A beta 42 in Alzheimer's disease
-
Younkin, S.G. 1998. The role of A beta 42 in Alzheimer's disease. J. Physiol. Paris. 92:289-292.
-
(1998)
J. Physiol. Paris
, vol.92
, pp. 289-292
-
-
Younkin, S.G.1
-
10
-
-
0035066332
-
Alzheimer's disease: Genes, proteins, and therapy
-
Selkoe, DJ. 2001. Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 81:741-766.
-
(2001)
Physiol. Rev.
, vol.81
, pp. 741-766
-
-
Selkoe, D.J.1
-
11
-
-
17944368176
-
The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation
-
Nilsberth, C., et al. 2001. The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation. Nat. Neurosci. 4:887-893.
-
(2001)
Nat. Neurosci.
, vol.4
, pp. 887-893
-
-
Nilsberth, C.1
-
12
-
-
16044373524
-
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's discase
-
Scheuner, D., et al. 1996. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's discase. Nat. Med. 2:864-870.
-
(1996)
Nat. Med.
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
-
13
-
-
0034123538
-
Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model
-
Holtzman, D.M., et al. 2000. Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model. Ann. Neurol. 47:739-747.
-
(2000)
Ann. Neurol.
, vol.47
, pp. 739-747
-
-
Holtzman, D.M.1
-
14
-
-
0027258525
-
The carboxy terminus of β amyloid protein is critical for the seeding of amyloid formation: Implications for pathogenesis of Alzheimer's disease
-
Jarrett, J.T., Berger, E.P., and Lansbury, P.T., Jr. 1993. The carboxy terminus of β amyloid protein is critical for the seeding of amyloid formation: implications for pathogenesis of Alzheimer's disease. Biochemistry. 32:4693-4697.
-
(1993)
Biochemistry
, vol.32
, pp. 4693-4697
-
-
Jarrett, J.T.1
Berger, E.P.2
Lansbury P.T., Jr.3
-
15
-
-
0031921466
-
Mutant genes in familial Alzheimer's disease and transgenic models
-
Price, D.L., and Sisodia, S.S. 1998. Mutant genes in familial Alzheimer's disease and transgenic models. Annu. Rev. Neurosci. 21:479-505.
-
(1998)
Annu. Rev. Neurosci.
, vol.21
, pp. 479-505
-
-
Price, D.L.1
Sisodia, S.S.2
-
16
-
-
0029896354
-
Mechanisms of neuronal degeneration in Alzheimer's disease
-
Yankner, B.A. 1996. Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron. 16:921-932.
-
(1996)
Neuron
, vol.16
, pp. 921-932
-
-
Yankner, B.A.1
-
17
-
-
0033600228
-
A stop-codon mutation in the BRI gene associated with familial British dementia
-
Vidal, R., et al. 1999. A stop-codon mutation in the BRI gene associated with familial British dementia. Nature. 399:776-781.
-
(1999)
Nature
, vol.399
, pp. 776-781
-
-
Vidal, R.1
-
18
-
-
0034712749
-
A decamer duplication in the 3′ region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred
-
Vidal, R., et al. 2000. A decamer duplication in the 3′ region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred. Proc. Natl. Acad. Sci. USA. 97:4920-4925.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 4920-4925
-
-
Vidal, R.1
-
19
-
-
0026597063
-
Alzheimer's disease: The amyloid cascade hypothesis
-
Hardy, J.A., and Higgins, G.A. 1992. Alzheimer's disease: the amyloid cascade hypothesis. Science. 256:184-185.
-
(1992)
Science
, vol.256
, pp. 184-185
-
-
Hardy, J.A.1
Higgins, G.A.2
-
20
-
-
11544279355
-
Diffusible, nonfibrillar ligands derived from Abeta 1-42 are potent central nervous system neurotoxins
-
Lambert, M.P., et al. 1998. Diffusible, nonfibrillar ligands derived from Abeta 1-42 are potent central nervous system neurotoxins. Proc. Natl. Acad. Sci. USA. 95:6448-6453.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 6448-6453
-
-
Lambert, M.P.1
-
21
-
-
0030799122
-
Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate
-
Walsh, D.M., Lomakin, A., Benedek, G.B., Condron, M.M., and Teplow, D.B. 1997. Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate. J. Biol. Chem. 272:22364-22372.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 22364-22372
-
-
Walsh, D.M.1
Lomakin, A.2
Benedek, G.B.3
Condron, M.M.4
Teplow, D.B.5
-
22
-
-
0037130174
-
Neurodegenerative disease: Amyloid pores from pathogenic mutations
-
Lashuel, H.A., Hartley, D., Petre, B.M., Walz, T., and Lansbury, P.T., Jr. 2002. Neurodegenerative disease: amyloid pores from pathogenic mutations. Nature. 418:291.
-
(2002)
Nature
, vol.418
, pp. 291
-
-
Lashuel, H.A.1
Hartley, D.2
Petre, B.M.3
Walz, T.4
Lansbury P.T., Jr.5
-
23
-
-
0028981717
-
The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice
-
LaFerla, F.M., Tinkle, B.T., Bieberich, C.J., Haudenschild, C.C., and Jay, G. 1995. The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice. Nat. Genet. 9:21-30.
-
(1995)
Nat. Genet.
, vol.9
, pp. 21-30
-
-
LaFerla, F.M.1
Tinkle, B.T.2
Bieberich, C.J.3
Haudenschild, C.C.4
Jay, G.5
-
24
-
-
0033622324
-
Intraneuronal Abeta42 accumulation in human brain
-
Gouras, G.K., et al. 2000. Intraneuronal Abeta42 accumulation in human brain. Am. J. Pathol. 156:15-20.
-
(2000)
Am. J. Pathol.
, vol.156
, pp. 15-20
-
-
Gouras, G.K.1
-
25
-
-
0032413192
-
Alzheimer's disease: Generic studies and transgenic models
-
Price, D.L., Tanzi, R.E., Borchelt, D.R., and Sisodia, S.S. 1998. Alzheimer's disease: generic studies and transgenic models. Annu. Rev. Genet. 32:461-493.
-
(1998)
Annu. Rev. Genet.
, vol.32
, pp. 461-493
-
-
Price, D.L.1
Tanzi, R.E.2
Borchelt, D.R.3
Sisodia, S.S.4
-
26
-
-
0035433962
-
Alzheimer's disease and Abeta toxicity: From top to bottom
-
Small, D.H., Mok, S.S., and Bornstein, J.C. 2001. Alzheimer's disease and Abeta toxicity: from top to bottom. Nat. Rev. Neurosci. 2:595-598.
-
(2001)
Nat. Rev. Neurosci.
, vol.2
, pp. 595-598
-
-
Small, D.H.1
Mok, S.S.2
Bornstein, J.C.3
-
27
-
-
0034612175
-
Inflammation and Alzheimer's disease
-
Akiyama, H., et al. 2000. Inflammation and Alzheimer's disease. Neurobiol. Aging. 21:383-421.
-
(2000)
Neurobiol. Aging
, vol.21
, pp. 383-421
-
-
Akiyama, H.1
-
28
-
-
0033860372
-
Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity
-
Varadarajan, S., Yatin, S., Aksenova, M., and Butterfield, D.A. 2000. Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity. J. Struct. Biol. 130:184-208.
-
(2000)
J. Struct. Biol.
, vol.130
, pp. 184-208
-
-
Varadarajan, S.1
Yatin, S.2
Aksenova, M.3
Butterfield, D.A.4
-
29
-
-
0026941497
-
The disordered neuronal cytoskeleton in Alzheimer's disease
-
Lee, V.M.-Y., and Trojanowski, J.Q. 1992. The disordered neuronal cytoskeleton in Alzheimer's disease. Curr. Opin. Neurobiol. 2:653-656.
-
(1992)
Curr. Opin. Neurobiol.
, vol.2
, pp. 653-656
-
-
Lee, V.M.-Y.1
Trojanowski, J.Q.2
-
30
-
-
0032543684
-
Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
-
Hutton, M., et al. 1998. Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17. Nature. 393:702-705.
-
(1998)
Nature
, vol.393
, pp. 702-705
-
-
Hutton, M.1
-
31
-
-
0032560487
-
Mutation in the tau gene in familial multiple system tauopathy with presenile dementia
-
Spillantini, M.G., et al. 1998. Mutation in the tau gene in familial multiple system tauopathy with presenile dementia. Proc. Natl. Acad. Sci. USA. 95:7737-7741.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 7737-7741
-
-
Spillantini, M.G.1
-
32
-
-
0034426011
-
Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein
-
Lewis, J., et al. 2000. Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nat. Genet. 25:402-405.
-
(2000)
Nat. Genet.
, vol.25
, pp. 402-405
-
-
Lewis, J.1
-
33
-
-
0035943436
-
Formation of neurofibrillary tangles in P3011 tau transgenic mice induced by Abeta 42 fibrils
-
Gotz, J., Chen, F., van Dorpe, J., and Nitsch, R.M. 2001. Formation of neurofibrillary tangles in P3011 tau transgenic mice induced by Abeta 42 fibrils. Science. 293:1491-1495.
-
(2001)
Science
, vol.293
, pp. 1491-1495
-
-
Gotz, J.1
Chen, F.2
Van Dorpe, J.3
Nitsch, R.M.4
-
34
-
-
17944382037
-
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP
-
Lewis, J., et al. 2001. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science. 293:1487-1491.
-
(2001)
Science
, vol.293
, pp. 1487-1491
-
-
Lewis, J.1
-
35
-
-
0035902436
-
Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease
-
Evin, G., et al. 2001. Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease. Biochemistry. 40:8359-8368.
-
(2001)
Biochemistry
, vol.40
, pp. 8359-8368
-
-
Evin, G.1
-
36
-
-
0034621824
-
Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1
-
Li, Y.M., et al. 2000. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1. Nature. 405:689-694.
-
(2000)
Nature
, vol.405
, pp. 689-694
-
-
Li, Y.M.1
-
37
-
-
0033780472
-
Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1
-
Esler, W.P., et al. 2000. Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1. Nat. Cell Biol. 2:428-434.
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 428-434
-
-
Esler, W.P.1
-
38
-
-
0034602419
-
Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors
-
Seiffert, D., et al. 2000. Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors. J. Biol. Chem. 275:34086-34091.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 34086-34091
-
-
Seiffert, D.1
-
39
-
-
0012816771
-
Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in the brain
-
Dovey, H., Varghese, J., and Anderson, J.P. 2000. Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in the brain. J. Neurochem. 76:1-10.
-
(2000)
J. Neurochem.
, vol.76
, pp. 1-10
-
-
Dovey, H.1
Varghese, J.2
Anderson, J.P.3
-
40
-
-
0033535504
-
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
-
De Strooper, B., et al. 1999. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature. 398:518-522.
-
(1999)
Nature
, vol.398
, pp. 518-522
-
-
De Strooper, B.1
-
41
-
-
0035912829
-
Gamma-secretase inhibitors repress thymocyte development
-
Hadland, B.K., et al. 2001. Gamma-secretase inhibitors repress thymocyte development. Proc. Natl. Acad. Sci. USA. 98:7487-7491.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 7487-7491
-
-
Hadland, B.K.1
-
42
-
-
0035824391
-
γ-Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase
-
Ni, C.Y., Murphy, M.P., Golde, T.E., and Carpenter, G. 2001. γ-Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science. 294:2179-2181.
-
(2001)
Science
, vol.294
, pp. 2179-2181
-
-
Ni, C.Y.1
Murphy, M.P.2
Golde, T.E.3
Carpenter, G.4
-
43
-
-
0026443727
-
Deposition of β/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain
-
Kammesheidt, A., et al. 1992. Deposition of β/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain. Proc. Natl. Acad. Sci. USA. 89:10857-10861.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 10857-10861
-
-
Kammesheidt, A.1
-
44
-
-
0024472693
-
Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease
-
Yankner, B.A., et al. 1989. Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. Science. 245:417-420.
-
(1989)
Science
, vol.245
, pp. 417-420
-
-
Yankner, B.A.1
-
45
-
-
0035112647
-
BACE1 is the major beta-secretase for generation of Abeta peptides by neurons
-
Cai, H., et al. 2001. BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nat. Neurosci. 4:233-234.
-
(2001)
Nat. Neurosci.
, vol.4
, pp. 233-234
-
-
Cai, H.1
-
46
-
-
0035116273
-
Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation
-
Luo, Y., et al. 2001. Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation. Nat. Neurosci. 4:231-232.
-
(2001)
Nat. Neurosci.
, vol.4
, pp. 231-232
-
-
Luo, Y.1
-
47
-
-
0036714840
-
Crystal structure of memapsin 2 (beta-secretase) in complex with an inhibitor O00M-3
-
Hong, L., et al. 2002. Crystal structure of memapsin 2 (beta-secretase) in complex with an inhibitor OM00-3. Biochemistry. 41:10963-10967.
-
(2002)
Biochemistry
, vol.41
, pp. 10963-10967
-
-
Hong, L.1
-
48
-
-
0034613320
-
Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor
-
Hong, L., et al. 2000. Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor. Science. 290:150-153.
-
(2000)
Science
, vol.290
, pp. 150-153
-
-
Hong, L.1
-
49
-
-
0035829592
-
A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity
-
Weggen, S., et al. 2001. A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature. 414:212-216.
-
(2001)
Nature
, vol.414
, pp. 212-216
-
-
Weggen, S.1
-
50
-
-
0034254924
-
Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease
-
Lim, G.P., et al. 2000. Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease. J. Neurosci. 20:5709-5714.
-
(2000)
J. Neurosci.
, vol.20
, pp. 5709-5714
-
-
Lim, G.P.1
-
51
-
-
0033772113
-
Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors
-
Wolozin, B., Kellman, W., Ruosseau, P., Celesia, G.G., and Siegel, G. 2000. Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Arch. Neurol. 57:1439-1443.
-
(2000)
Arch. Neurol.
, vol.57
, pp. 1439-1443
-
-
Wolozin, B.1
Kellman, W.2
Ruosseau, P.3
Celesia, G.G.4
Siegel, G.5
-
52
-
-
0034638746
-
Statins and the risk of dementia
-
Jick, H., Zornberg, G.L., Jick, S.S., Seshadri, S., and Drachman, D.A. 2000. Statins and the risk of dementia. Lancet. 356:1627-1631.
-
(2000)
Lancet
, vol.356
, pp. 1627-1631
-
-
Jick, H.1
Zornberg, G.L.2
Jick, S.S.3
Seshadri, S.4
Drachman, D.A.5
-
53
-
-
0029072551
-
Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: A case-control study
-
Jarvik, G.P., et al. 1995. Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: a case-control study. Neurology. 45:1092-1096.
-
(1995)
Neurology
, vol.45
, pp. 1092-1096
-
-
Jarvik, G.P.1
-
54
-
-
0031976318
-
Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease
-
Notkola, I.L., et al. 1998. Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease. Neuroepidemiology. 17:14-20.
-
(1998)
Neuroepidemiology
, vol.17
, pp. 14-20
-
-
Notkola, I.L.1
-
55
-
-
0031026879
-
Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study
-
Hofman, A., et al. 1997. Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study. Lancet. 349:151-154.
-
(1997)
Lancet
, vol.349
, pp. 151-154
-
-
Hofman, A.1
-
56
-
-
0035897938
-
Midlife vascular risk factors and Alzheimer's disease in later life: Longitudinal, population based study
-
Kivipelto, M., et al. 2001. Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study. BMJ. 322:1447-1451.
-
(2001)
BMJ
, vol.322
, pp. 1447-1451
-
-
Kivipelto, M.1
-
57
-
-
0032568552
-
Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons
-
Simons, M., et al. 1998. Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. Proc. Natl. Acad. Sci. USA. 95:6460-6464.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 6460-6464
-
-
Simons, M.1
-
58
-
-
0035160066
-
A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease
-
Refolo, L.M., et al. 2001. A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease. Neurobiol. Dis. 8:890-899.
-
(2001)
Neurobiol. Dis.
, vol.8
, pp. 890-899
-
-
Refolo, L.M.1
-
59
-
-
0001504829
-
Simvastarin strongly reduces levels of Alzheimer's disease beta-amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo
-
Fassbender, K., et al. 2001. Simvastarin strongly reduces levels of Alzheimer's disease beta-amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo. Proc. Natl. Acad. Sci. USA. 98:5856-5861.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 5856-5861
-
-
Fassbender, K.1
-
60
-
-
0033833354
-
Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model
-
Refolo, L.M., et al. 2000. Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model. Neurobiol. Dis. 7:321-331.
-
(2000)
Neurobiol. Dis.
, vol.7
, pp. 321-331
-
-
Refolo, L.M.1
-
61
-
-
0034795651
-
Acyl-coenzyme A: Cholesterol acyltransferase modulates the generation of the amyloid beta-peptide
-
Puglielli, L., et al. 2001. Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide. Nat. Cell Biol. 3:905-912.
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 905-912
-
-
Puglielli, L.1
-
62
-
-
0035888328
-
Cholesterol modulation as an emerging strategy for the treatment of Alzheimer's disease
-
Golde, T.E., and Eckman, C.B. 2001. Cholesterol modulation as an emerging strategy for the treatment of Alzheimer's disease. Drug Discov. Today. 6:1049-1055.
-
(2001)
Drug Discov. Today
, vol.6
, pp. 1049-1055
-
-
Golde, T.E.1
Eckman, C.B.2
-
63
-
-
0035826795
-
A fluid connection: Cholesterol and Abeta
-
Wolozin, B. 2001. A fluid connection: cholesterol and Abeta. Proc. Natl. Acad. Sci. USA. 98:5371-5373.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 5371-5373
-
-
Wolozin, B.1
-
64
-
-
0031054674
-
Brain infarction and the clinical expression of Alzheimer disease. The Nun Study
-
Snowdon, D.A., et al. 1997. Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. JAMA. 277:813-817.
-
(1997)
JAMA
, vol.277
, pp. 813-817
-
-
Snowdon, D.A.1
-
65
-
-
0035221587
-
Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin
-
Haugabook, S.J., et al. 2001. Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin. FASEB J. 15:16-18.
-
(2001)
FASEB J.
, vol.15
, pp. 16-18
-
-
Haugabook, S.J.1
-
66
-
-
0032839878
-
Plaque busters: Strategies to inhibit amyloid formation in Alzheimer's disease
-
Soto, C. 1999. Plaque busters: strategies to inhibit amyloid formation in Alzheimer's disease. Mol. Med. Today. 5:343-350.
-
(1999)
Mol. Med. Today
, vol.5
, pp. 343-350
-
-
Soto, C.1
-
67
-
-
0036615884
-
Reduction ofamyloid load and cerebral damage in a transgenic mouse model of Alzheimer's disease by treatment with a beta-sheet breaker peptide
-
Permanne, B., et al. 2002. Reduction ofamyloid load and cerebral damage in a transgenic mouse model of Alzheimer's disease by treatment with a beta-sheet breaker peptide. FASEB J. 16:860-862.
-
(2002)
FASEB J.
, vol.16
, pp. 860-862
-
-
Permanne, B.1
-
68
-
-
0033973529
-
In vivo reversal of amyloid-beta lesions in rat brain
-
Sigurdsson, E.M., Permanne, B., Soto, C., Wisniewski, T., and Frangione, B. 2000. In vivo reversal of amyloid-beta lesions in rat brain. J. Neuropathol. Exp. Neurol. 59:11-17.
-
(2000)
J. Neuropathol. Exp. Neurol.
, vol.59
, pp. 11-17
-
-
Sigurdsson, E.M.1
Permanne, B.2
Soto, C.3
Wisniewski, T.4
Frangione, B.5
-
69
-
-
0034964390
-
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice
-
Cherny, R.A., et al. 2001. Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron. 30:665-676.
-
(2001)
Neuron
, vol.30
, pp. 665-676
-
-
Cherny, R.A.1
-
70
-
-
0035827681
-
Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits
-
Curtain, C.C., et al. 2001. Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits. J. Biol. Chem. 276:20466-20473.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 20466-20473
-
-
Curtain, C.C.1
-
71
-
-
0033536163
-
Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
-
Schenk, D., et al. 1999. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature. 400:173-177.
-
(1999)
Nature
, vol.400
, pp. 173-177
-
-
Schenk, D.1
-
72
-
-
0034530636
-
Nasal A beta treatment induces anti-A beta antibody production and decreases cerebral amyloid burden in PD-APP mice
-
Lemere, C.A., et al. 2000. Nasal A beta treatment induces anti-A beta antibody production and decreases cerebral amyloid burden in PD-APP mice. Ann. NY Acad. Sci. 920:328-331.
-
(2000)
Ann. NY Acad. Sci.
, vol.920
, pp. 328-331
-
-
Lemere, C.A.1
-
73
-
-
0035902619
-
Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease
-
DeMattos, R.B., et al. 2001. Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. USA. 98:8850-8855.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 8850-8855
-
-
DeMattos, R.B.1
-
74
-
-
0034700471
-
A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
-
Janus, C., et al. 2000. A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature. 408:979-982.
-
(2000)
Nature
, vol.408
, pp. 979-982
-
-
Janus, C.1
-
75
-
-
0033835996
-
Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
-
Bard, F., et al. 2000. Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat. Med. 6:916-919.
-
(2000)
Nat. Med.
, vol.6
, pp. 916-919
-
-
Bard, F.1
-
76
-
-
0034746897
-
Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition
-
Das, P., Murphy, M.P., Younkin, L.H., Younkin, S.G., and Golde, T.E. 2001. Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition. Neurobiol. Aging. 22:721-727.
-
(2001)
Neurobiol. Aging
, vol.22
, pp. 721-727
-
-
Das, P.1
Murphy, M.P.2
Younkin, L.H.3
Younkin, S.G.4
Golde, T.E.5
-
77
-
-
84984755327
-
A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
-
Morgan, D., et al. 2000. A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature. 408:982-985.
-
(2000)
Nature
, vol.408
, pp. 982-985
-
-
Morgan, D.1
-
78
-
-
0035106780
-
Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy
-
Bacskai, B.J., et al. 2001. Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy. Nat. Med. 7:369-372.
-
(2001)
Nat. Med.
, vol.7
, pp. 369-372
-
-
Bacskai, B.J.1
-
79
-
-
0036752545
-
Open peer commentary regarding Abeta immunization and CNS inflammation by Pasinetti et al
-
Das, P., and Golde, T.E. 2002. Open peer commentary regarding Abeta immunization and CNS inflammation by Pasinetti et al. Neurobiol. Aging. 23:671-674.
-
(2002)
Neurobiol. Aging
, vol.23
, pp. 671-674
-
-
Das, P.1
Golde, T.E.2
-
80
-
-
0036853548
-
Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease
-
Hock, C., et al. 2002. Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease. Nat. Med. 8:1270-1275.
-
(2002)
Nat. Med.
, vol.8
, pp. 1270-1275
-
-
Hock, C.1
-
81
-
-
0036780877
-
Opinion. Amyloid-beta immunotherapy for Alzheimer's disease: The end of the beginning
-
Schenk, D. 2002. Opinion. Amyloid-beta immunotherapy for Alzheimer's disease: the end of the beginning. Nat. Rev. Neurosci. 3:824-828.
-
(2002)
Nat. Rev. Neurosci.
, vol.3
, pp. 824-828
-
-
Schenk, D.1
-
82
-
-
0030007964
-
Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: Implications for initial events in amyloid plaque formation
-
Lemere, C.A., et al. 1996. Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation. Neurobiol. Dis. 3:16-32.
-
(1996)
Neurobiol. Dis.
, vol.3
, pp. 16-32
-
-
Lemere, C.A.1
-
83
-
-
0035960646
-
Rates of global and regional cerebral atrophy in AD and frontotemporal dementia
-
Chan, D., et al. 2001. Rates of global and regional cerebral atrophy in AD and frontotemporal dementia. Neurology. 57:1756-1763.
-
(2001)
Neurology
, vol.57
, pp. 1756-1763
-
-
Chan, D.1
-
84
-
-
0035928402
-
Imaging of onset and progression of Alzheimer's disease with voxel-compression mapping of serial magnetic resonance images
-
Fox, N.C., et al. 2001. Imaging of onset and progression of Alzheimer's disease with voxel-compression mapping of serial magnetic resonance images. Lancet. 358:201-205.
-
(2001)
Lancet
, vol.358
, pp. 201-205
-
-
Fox, N.C.1
-
85
-
-
0028324521
-
Alzheimer's disease in the NAS-NRC registry of aging twin veterans. II. Longitudinal findings in a pilot series
-
National Academy of Sciences. National Research Council Registry
-
Breitner, J.C., et al. 1994. Alzheimer's disease in the NAS-NRC registry of aging twin veterans. II. Longitudinal findings in a pilot series. National Academy of Sciences. National Research Council Registry. Dementia. 5:99-105.
-
(1994)
Dementia
, vol.5
, pp. 99-105
-
-
Breitner, J.C.1
-
86
-
-
0030774535
-
The genetics of Alzheimer's disease
-
Rubinsztein, D.C. 1997. The genetics of Alzheimer's disease. Prog. Neurobiol. 52:447-454.
-
(1997)
Prog. Neurobiol.
, vol.52
, pp. 447-454
-
-
Rubinsztein, D.C.1
-
87
-
-
0030696944
-
Apolipoprotein E, a gene with complex biological interactions in the aging brain
-
Roses, A.D. 1997. Apolipoprotein E, a gene with complex biological interactions in the aging brain. Neurobiol. Dis. 4:170-185.
-
(1997)
Neurobiol. Dis.
, vol.4
, pp. 170-185
-
-
Roses, A.D.1
-
88
-
-
0032899712
-
A full genome scan for late onset Alzheimer's disease
-
Kehoe, P., et al. 1999. A full genome scan for late onset Alzheimer's disease. Hum. Mol. Genet. 8:237-245.
-
(1999)
Hum. Mol. Genet.
, vol.8
, pp. 237-245
-
-
Kehoe, P.1
-
89
-
-
0034704197
-
Susceptibility locus for Alzheimer's disease on chromosome 10
-
Myers, A., et al. 2000. Susceptibility locus for Alzheimer's disease on chromosome 10. Science. 290:2304-2305.
-
(2000)
Science
, vol.290
, pp. 2304-2305
-
-
Myers, A.1
-
90
-
-
0034703979
-
Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees
-
Errekin-Taner, N., et al. 2000. Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Science. 290:2303-2304.
-
(2000)
Science
, vol.290
, pp. 2303-2304
-
-
Errekin-Taner, N.1
-
91
-
-
0034704198
-
Evidence for genetic linkage of Alzheimer's disease to chromosome 10q
-
Bertram, L., et al. 2000. Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. Science. 290:2302-2303.
-
(2000)
Science
, vol.290
, pp. 2302-2303
-
-
Bertram, L.1
-
92
-
-
0035159744
-
Biological markers and the treatment of Alzheimer's disease
-
Galasko, D. 2001. Biological markers and the treatment of Alzheimer's disease. J. Mol. Neurosci. 17:119-125.
-
(2001)
J. Mol. Neurosci.
, vol.17
, pp. 119-125
-
-
Galasko, D.1
-
93
-
-
0034718210
-
Diagnostic approaches to Alzheimer's disease
-
Boss, M.A. 2000. Diagnostic approaches to Alzheimer's disease. Biochim. Biophys. Acta. 1502:188-200.
-
(2000)
Biochim. Biophys. Acta
, vol.1502
, pp. 188-200
-
-
Boss, M.A.1
-
94
-
-
0033762711
-
Increased 8,12-iso-iPF2alpha-VI in Alzheimer's disease: Correlation of a noninvasive index of lipid peroxidation with disease severity
-
Pratico, D., et al. 2000. Increased 8,12-iso-iPF2alpha-VI in Alzheimer's disease: correlation of a noninvasive index of lipid peroxidation with disease severity. Ann. Neurol. 48:809-812.
-
(2000)
Ann. Neurol.
, vol.48
, pp. 809-812
-
-
Pratico, D.1
-
95
-
-
0034745018
-
Cerebrospinal fluid abeta42, tau, and f2-isoprostane concentrations in patients with Alzheimer disease, other dementias, and in age-matched controls
-
Montine, T.J., et al. 2001. Cerebrospinal fluid abeta42, tau, and f2-isoprostane concentrations in patients with Alzheimer disease, other dementias, and in age-matched controls. Arch. Pathol. Lab. Med. 125:510-512.
-
(2001)
Arch. Pathol. Lab. Med.
, vol.125
, pp. 510-512
-
-
Montine, T.J.1
-
96
-
-
0034936365
-
Heritability of plasma amyloid beta in typical late-onset Alzheimer's disease pedigrees
-
Ertekin-Taner, N., et al. 2001. Heritability of plasma amyloid beta in typical late-onset Alzheimer's disease pedigrees. Genet. Epidemiol. 21:19-30.
-
(2001)
Genet. Epidemiol.
, vol.21
, pp. 19-30
-
-
Ertekin-Taner, N.1
-
97
-
-
0032869023
-
Plasma amyloid beta-peptide 1-42 and incipient Alzheimer's disease
-
Mayeux, R., et al. 1999. Plasma amyloid beta-peptide 1-42 and incipient Alzheimer's disease. Ann. Neurol. 46:412-416.
-
(1999)
Ann. Neurol.
, vol.46
, pp. 412-416
-
-
Mayeux, R.1
-
98
-
-
0035815573
-
Elevated plasma amyloid beta-pepride 1-42 and onset of dementia in adults with Down syndrome
-
Schupf, N., et al. 2001. Elevated plasma amyloid beta-pepride 1-42 and onset of dementia in adults with Down syndrome. Neurosci. Lett. 301:199-203.
-
(2001)
Neurosci. Lett.
, vol.301
, pp. 199-203
-
-
Schupf, N.1
-
99
-
-
0034691124
-
In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease
-
Skovronsky, D.M., et al. 2000. In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. USA. 97:7609-7614.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 7609-7614
-
-
Skovronsky, D.M.1
-
100
-
-
0036707494
-
Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative
-
Klunk, W.E., et al. 2002. Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. J. Neuropathol. Exp. Neurol. 61:797-805.
-
(2002)
J. Neuropathol. Exp. Neurol.
, vol.61
, pp. 797-805
-
-
Klunk, W.E.1
-
101
-
-
0037066123
-
Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia
-
Jack, C.R., Jr., et al. 2002. Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia. Neurology. 58:750-757.
-
(2002)
Neurology
, vol.58
, pp. 750-757
-
-
Jack C.R., Jr.1
-
102
-
-
0036711817
-
Imaging amyloid-beta deposits in vivo
-
Bacskai, B.J., Klunk, W.E., Mathis, C.A., and Hyman, B.T. 2002. Imaging amyloid-beta deposits in vivo. J. Cereb. Blood Flow Metab. 22: 1035-1041.
-
(2002)
J. Cereb. Blood Flow Metab.
, vol.22
, pp. 1035-1041
-
-
Bacskai, B.J.1
Klunk, W.E.2
Mathis, C.A.3
Hyman, B.T.4
|