Imaging Aβ plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative

Journal of Neuropathology and Experimental Neurology

Volumn 61, Issue 9, 2002, Pages 797-805

  Klunk, William E ^a   Bacskai, Brian J ^a   Mathis, Chester A ^a   Kajdasz, Stephen T ^a   McLellan, Megan E ^a   Frosch, Matthew P ^a   Debnath, Manik L ^a   Holt, Daniel P ^a   Wang, Yanming ^a   Hyman, Bradley T ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Alzheimer disease; Amyloid; Chrysamine G; Imaging; Multiphoton microscopy; Positron emission tomography; Transgenic mice

Indexed keywords

1,4 BIS(4' HYDROXYSTYRYL) 2 METHOXYBENZENE; AMYLOID; ANTIAMYLOID AGENT; CHRYSAMINE G; CONGO RED; FLUORESCENT DYE; METHOXY X04; UNCLASSIFIED DRUG; 1,4-BIS(4'-HYDROXYSTYRYL)-2-METHOXYBENZENE; ALKENE; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; BENZENE; BENZENE DERIVATIVE; CARBON; COLORING AGENT; DIAGNOSTIC AGENT; DRUG DERIVATIVE; PEPTIDE FRAGMENT;

ALZHEIMER DISEASE; AMYLOID NEUROPATHY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CEREBROVASCULAR DISEASE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DIAGNOSTIC IMAGING; DRUG BINDING; DRUG SYNTHESIS; EARLY DIAGNOSIS; FLUORESCENCE; ISOTOPE LABELING; LIPOPHILICITY; MALE; MICROPHOTOGRAPHY; MICROSCOPIC ANATOMY; MULTIPHOTON MICROSCOPY; NEUROFIBRILLARY TANGLE; NONHUMAN; OPTICAL RESOLUTION; PATIENT MONITORING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; STAINING; ANIMAL; BINDING COMPETITION; BLOOD BRAIN BARRIER; CHEMISTRY; DISEASE MODEL; DRUG EFFECT; METABOLISM; METHODOLOGY; MICROSCOPY; MOUSE; PATHOLOGY; SENILE PLAQUE; SENSITIVITY AND SPECIFICITY; SPRAGUE DAWLEY RAT; THREE DIMENSIONAL IMAGING; TRANSGENIC MOUSE;

ALKENES; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; BENZENE; BENZENE DERIVATIVES; BINDING, COMPETITIVE; BLOOD-BRAIN BARRIER; CARBON RADIOISOTOPES; COLORING AGENTS; CONGO RED; DISEASE MODELS, ANIMAL; IMAGING, THREE-DIMENSIONAL; MALE; MICE; MICE, TRANSGENIC; MICROSCOPY; PEPTIDE FRAGMENTS; RATS; RATS, SPRAGUE-DAWLEY; SENILE PLAQUES; SENSITIVITY AND SPECIFICITY;

EID: 0036707494     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnen/61.9.797     Document Type: Article

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