Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin.

The FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Volumn 15, Issue 1, 2001, Pages 16-18

  Haugabook, S J ^a   Le, T ^a   Yager, D ^a   Zenk, B ^a   Healy, B M ^a   Eckman, E A ^a   Prada, C ^a   Younkin, L ^a   Murphy, P ^a   Pinnix, I ^a   Onstead, L ^a   Sambamurti, K ^a   Golde, T E ^a   Dickson, D ^a   Younkin, S G ^a   Eckman, C B ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ANDROSTANE DERIVATIVE; PEPTIDE FRAGMENT; PHOSPHATIDYLINOSITOL 3 KINASE; WORTMANNIN;

AGING; ALZHEIMER DISEASE; ANIMAL; ARTICLE; BIOLOGICAL MODEL; BRAIN; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; MOUSE; ORAL DRUG ADMINISTRATION; PATHOLOGY; PHYSIOLOGY; SENILE PLAQUE; SOLUBILITY; TRANSGENIC MOUSE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADMINISTRATION, ORAL; AGING; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANDROSTADIENES; ANIMALS; BRAIN; MICE; MICE, TRANSGENIC; MODELS, BIOLOGICAL; PEPTIDE FRAGMENTS; SENILE PLAQUES; SOLUBILITY;

MLCS; MLOWN;

EID: 0035221587     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.00-0528fje     Document Type: Article

References (0)