The role of Aβ42 in Alzheimer's disease

Journal of Physiology Paris

Volumn 92, Issue 3-4, 1998, Pages 289-292

  Younkin, Steven G ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; CHOLINERGIC SYSTEM; CONFERENCE PAPER; FAMILIAL DISEASE; FOREBRAIN; HUMAN; MOUSE; MUTATION; NONHUMAN; PATHOGENESIS; SENILE PLAQUE;

EID: 0032105394     PISSN: 09284257     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-4257(98)80035-1     Document Type: Conference Paper

References (32)

1. [1] Borchelt D.R., Thinakaran G., Eckman C.B., Lee M.K., Davenport F., Ratovitsky T., Prada C.M., Kim G., Seekins S., Yager D., Slunt H.H., Wang R., Seeger M., Levey A.I., Gandy S.E., Copeland N.G., Jenkins N.A., Price D.L., Younkin S.G., Sisodia S.S., Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo, Neuron 17 (1996) 1005-1013.
2. [2] Cai, X.D., Golde, T.E., Younkin S.G., Release of excess amyloid beta protein from a mutant amyloid beta protein precursor [see comments], Science 259 (1993) 514-516.
3. [3] Chartier-Harlin M.C., Crawford F., Houlden, H., Warren A., Hughes D., Fidani L., Goate A., Rossor M., Roques P., Hardy J., Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene, Nature 353 (1991) 844-846.
4. [4] Citron M., Ottersdorf T., Haass C., McConlogue L., Hung A.Y., Seubert P., Vigo-Pelfrey C., Leiberburg I., Selkoe D.J., Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production. Nature 360 (1992) 672-674.
5. [5] Citron M., Vigo-Pelfrey C., Teplow D.B., Miller C., Schenk D., Johnston J., Winblad B., Venizelos N., Lannfelt L., Selkoe D.J., Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation, Proc. Natl. Acad. Sci. USA 91 (1994) 11993-11997.
6. [6] Citron M., Westaway D., Xia W., Carlson G., Diehl T., Levesque G., Johnson-Wood K., Lee M., Seubert P., Davis A., Kholodenko D., Motter R., Sherrington R., Perry B., Yao H., Strome R., Lieberburg I., Rommens J., Kim S., Schenk D., Fraser P., St George Hyslop P., Selkoe D.J., Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice [see comments], Nature Med. 91 (1997) 67-72.
7. [7] Dovey H.F., Suomensaari-Chrysler S., Lieberburg I., Sinha S., Keim P.S., Cells with a familial Alzheimer's disease mutation produce authentic beta-peptide, Neuroreport 4 (1993) 1039-1042.
8. [8] Duff K., Eckman C., Zehr C., Yu X., Prada C.M., Perez-Tur J., Hutton M., Buee L., Harigaya Y., Yager D., Morgan D., Gordon M.N., Holcomb L., Refolo L., Zenk B., Hardy J., Younkin S., Increased amyloid-beta42 (43) in brains of mice expressing mutant presenilin 1, Nature 383 (1996) 710-713.
9. [9] Dyrks T., Weidemann A., Multhaup G., Salbaum J.M., Lemaire H.G., Kang J., Muller-Hill B., Masters C.L., Beyreuther K., Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease, EMBO J. 7 (1988) 949-957.
10. [10] Glenner G.G. in: Katzman R. (Ed.), Banbury Report 15: Biological aspects of Alzheimer's disease, Cold Spring Harbor Laboratory, New York, 1983, pp. 137-144.
11. [11] Glenner G.G., Wong C.W., Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein, Biochem. Biophys. Res. Commun. 120 (1984) 885-890.
12. [12] Goate A., Chartier-Harlin M.C., Mullan M., Brown J., Crawford F., Fidani L., Giuffra L., Haynes A., Irving N., James L., Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease [see comments], Nature 349 (1991) 704-706.
13. [13] Haass C., Schlossmacher M.G., Hung A.Y., Vigo-Pelfrey C., Mellon A., Ostaszewski B.L., Lieberburg I., Koo E.H., Schenk D., Teplow D.B., Selkoe D.J., Amyloid B peptide is produced by cultured cells during normal metabolism, Nature 359 (1992) 322-325.
14. [14] Iwatsubo T., Mann D.M., Odaka A., Suzuki N., Ihara Y., Amyloid beta protein (A beta) deposition: A beta 42 (43) precedes A beta 40 in Down syndrome [see comments], Ann. Neurol. 37 (1995) 294-299.
15. [15] Iwatsubo T., Odaka A., Suzuki N., Mizusawa H., Nukina N., Ihara Y., Visualization of A beta 42 (43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42 (43), Neuron 13 (1994) 45-53.
16. [16] Jarrett J.T., Berger E.P., Lansbury P.T., Jr., The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease, Biochemistry 32 (1993) 4693-4697.
17. [17] Kang J., Lemaire H.G., Unterbeck A., Salbaum J.M., Masters C.L., Grzeschik K.H., Multhaup G., Beyreuther K., Muller-Hill B., The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor, Nature 325 (1987) 733-736.
18. [18] Levy-Lahad E., Wasco W., Poorkaj P., Romano D.M., Oshima J., Pettingell W.H., Yu C.E., Jondro P.D., Schmidt S.D., Wang K., Candidate gene for the chromosome 1 familial Alzheimer's disease locus [see comments], Science 269 (1995) 973-977.
19. [19] Masliah E., Terry R.D., Mallory M., Alford M., Hansen L.A., Diffuse plaques do not accentuate synapse loss in Alzheimer's disease, Am. J. Pathol. 137 (1990) 1293-1297.
20. [20] Masters C.L., Simms G., Weinman N.A., Multhaup G., McDonald B.L., Beyreuther K., Amyloid plaque core protein in Alzheimer disease and Down syndrome, Proc. Natl. Acad. Sci. USA 82 (1985) 4245-4249.
21. [21] Mori H., Tokio K., Ogawara M., Selkoe D.J., Mass spectrometry of purified amyloid beta protein in Alzheimer's disease, J. Biol. Chem. 267 (1992) 17082-17086.
22. [22] Mullan M., Crawford F, Axelman K., Houlden H., Lilius L., Winblad B., Lannfelt L., A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid, Nat. Genet. 1 (1992) 345-347.
23. [23] Prelli F., Castano E., Glenner G.G., Frangione B., Differences between vascular and plaque core amyloid in Alzheimer's disease, J. Neurochem. 51 (1988) 648-651.
24. [24] Rogaev E., Sherrington R., Levesque G., Ikeda M., St. George-Hyslop P., Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene, Nature 376 (1995) 775-778.
25. [25] Scheuner D., Eckman C., Jensen M., Song X., Citron M., Suzuki N., Bird T.D., Hardy J., Hutton M., Kukull W., Larson E., Levy-Lahad E., Viitanen M., Peskind E., Poorkaj P., Schellenberg G., Tanzi R., Wasco W., Lannfelt L., Selkoe D., Younkin S., Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease [see comments], Nat. Med. 2 (1996) 864-870.
26. [26] Seubert P., Vigo-Pelfrey C., Esch F., Lee M., Dovey H., Davis D., Sinha S., Schlossmacher M., Whaley J., Swindlehurst C., McCormack R., Wolfert R., Selkoe D., Lieberburg I., Schenk D., Isolation and quantitation of soluble Alzheimer's B peptide from biological fluids, Nature 359 (1992) 325-327.
27. [27] Sherrington R., Rogaev E.I., Liang Y., Rogaeva E.A., Levesque G., Ikeda M., Chi H., Lin C., Li G., Holman K., Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease [see comments], Nature 375 (1995) 754-760.
28. [28] Shoji M., Golde T.E., Ghiso J., Cheung T.T., Estus S., Shaffer L.M., Cai X.D., McKay D.M., Tintner R., Frangione B., Younkin S.G., Production of the Alzheimer amyloid beta protein by normal proteolytic processing, Science 258 (1992) 126-129.
29. [29] Suzuki N., Cheung T.T., Cai X.D., Odaka A., Otvos L., Jr., Eckman C., Golde T.E., Younkin S.G., An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants, Science 264 (1994) 1336-1340.
30. [30] Terry R.D., in: Davis R.L., Robertson D.M. (Eds.), Textbook of Neuropathology, Williams & Wilkins, Baltimore, 1985, pp. 824-841.
31. [31] Vigo-Pelfrey C., Lee D., Keim P., Lieberburg I., Schenk D.B., Characterization of beta-amyloid peptide from human cerebrospinal fluid, J. Neurochem. 61 (1993) 1965-1968.
32. [32] Yamaguchi H., Hirai S., Morimatsu M., Shoji M., Harigaya Y., Diffuse type of senile plaques in the brains of Alzheimer-type dementia, Acta Neuropathol. (Berl.) 77 (1988) 113-119.