DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology

Cancer Research

Volumn 61, Issue 13, 2001, Pages 4990-4993

  Lukas, Claudia ^a   Bartkova, Jirina ^a   Latella, Lucia ^a   Falck, Jacob ^a,b   Mailand, Niels ^a   Schroeder, Tine ^a   Lukas, Jiri ^a   Bartek, Jiri ^a   Sehested, Maxwell ^b  

^a DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^b Mental Health Center Glostrup   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CHK1 PROTEIN KINASE; CHK2 PROTEIN KINASE; PROTEIN KINASE; UNCLASSIFIED DRUG;

ARTICLE; BRAIN TISSUE; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; DNA DAMAGE; ENZYME ACTIVATION; EPIDERMIS CELL; GAMMA RADIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; INTESTINE CELL; MUSCLE TISSUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINOBLASTOMA;

ANTIBODIES, MONOCLONAL; CELL CYCLE; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; DNA DAMAGE; ENZYME ACTIVATION; FIBROBLASTS; G1 PHASE; HUMANS; OSTEOSARCOMA; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; S PHASE; TUMOR CELLS, CULTURED;

EID: 0035393594     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. The DNA damage response: Putting checkpoints in perspective
2. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
3. Caffeine inhibits the checkpoint kinase ATM
4. A human Cds 1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage
5. Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway
6. Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53
7. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
8. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
9. DNA damage-induced activation of p53 by the checkpoint kinase Chk2
10. hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response
11. Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro
12. Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1
13. Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome
14. Histological type-selective, tumor-predominant expression of a novel CHK1 isoforin and infrequent in vivo somatic CHK2 mutation in small cell lung cancer
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16. Involvement of Myc activity in a G(1)/S-promoting mechanism parallel to the pRb/E2F pathway
17. Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex
18. Plasticity of the differentiated state
19. Cell-cycle-dependent, and ATM-independent expression of human Chk1 kinase
20. p53 Down-regulates CHK1 through p21 and the retinoblastoma protein