Reduced expression and impaired kinase activity of a Chk2 mutant identified in human lung cancer

Cancer Research

Volumn 61, Issue 14, 2001, Pages 5362-5365

  Matsuoka, Shuhei ^a   Nakagawa, Taku ^b   Masuda, Akira ^b   Haruki, Nobuhiro ^b   Elledge, Stephen J ^a   Takahashi, Takashi ^b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b AICHI CANCER CENTER HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOTRANSFERASE;

ALLELE; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; DNA DAMAGE; GENE ACTIVATION; GENE ACTIVITY; GENE EXPRESSION; GENE INACTIVATION; GENE MUTATION; GENETIC STABILITY; HUMAN; HUMAN CELL; IONIZING RADIATION; LUNG CANCER; MUTANT; PHOSPHORYLATION; PRIORITY JOURNAL;

ANIMALS; BLOTTING, WESTERN; CELL LINE; COS CELLS; DNA DAMAGE; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUTATHIONE TRANSFERASE; HUMANS; LUNG NEOPLASMS; MUTATION; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT FUSION PROTEINS;

EID: 0035878816     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Cell cycle checkpoints: Preventing an identity crisis
2. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
3. A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
4. A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage
5. Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway
6. Role of human Cds1 (Chk2) kinase in DNA damage checkpoint and its regulation by p53
7. Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro
8. Caffeine abolishes the mammalian G2/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity
9. Threonine 68 is required for radiation-induced phosphorylation and activation of cds1
10. Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation
11. DNA damage-induced activation of p53 by the checkpoint kinase Chk2
12. Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53
13. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
14. Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome
15. Screening hCHK2 for mutations
16. p53: A frequent target for genetic abnormalities in lung cancer
17. Histological type-selective, tumor-predominant expression of a novel CHK1 isoform and infrequent in vivo somatic CHK2 mutation in small cell lung cancer
18. Protein kinase catalytic domain sequence database: Identification of conserved features of primary structure and classification of family members
19. Characterization of tumor-associated Chk2 mutants