UCN-01 abrogates G2 arrest through a Cdc2-dependent pathway that is associated with inactivation of the Wee1Hu kinase and activation of the Cdc25C phosphatase

Journal of Biological Chemistry

Volumn 273, Issue 50, 1998, Pages 33455-33464

  Yu, Lijia ^a   Orlandi, Linda ^b   Wang, Pei ^a   Orr, Michael S ^a   Senderowicz, Adrian M ^a   Sausville, Edward A ^a   Silvestrini, Rosella ^b   Watanabe, Nobumoto ^c   Piwnica Worms, Helen ^d   O'Connor, Patrick M ^a,e  

^a NATIONAL CANCER INSTITUTE   (United States)

^b Ist Nazionale Studio Cura Tumori   (Italy)

^c RIKEN TSUKUBA INSTITUTE   (Japan)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e AGOURON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 HYDROXYSTAUROSPORINE; ANTINEOPLASTIC AGENT; FOSTRIECIN; GENE PRODUCT; PHOSPHATASE; PROTEIN KINASE; PROTEIN KINASE INHIBITOR;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CYCLE G2 PHASE; DNA DAMAGE; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME INHIBITION; FLOW CYTOMETRY; MITOSIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TEMPERATURE SENSITIVITY;

ALKALOIDS; ALKENES; AMINO ACID SEQUENCE; ANIMALS; CDC2 PROTEIN KINASE; CDC25 PHOSPHATASE; CELL CYCLE PROTEINS; ENZYME ACTIVATION; ENZYME INHIBITORS; G2 PHASE; MICE; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PROTEIN-TYROSINE KINASES; PYRONES; STAUROSPORINE; TUMOR CELLS, CULTURED;

ANIMALIA; MURINAE;

EID: 0032509403     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.50.33455     Document Type: Article

References (12)

1. Akinaga, S., Gomi, K., Morimoto, M., Tamaoki, T., and Okabe, M. (1991) Cancer Res. 51, 4888-4892
2. Akinaga, S., Nomura, K., Gomi, K., and Okabe, M. (1993) Cancer Chemother. Pharmacol. 32, 183-189
3. Akinaga, S., Nomura, K., Gomi, K., and Okabe, M. (1994) Cancer Chemother. Pharmacol. 33, 273-280
4. Wang, Q., Worland, P. J., Clark, J. L., Carlson, B. A., and Sausville, E. A. (1995) Cell Growth Differ. 6, 927-936
5. Wang, Q., Fan, S., Eastman, A., Worland, P. J., Sausville, E. A., and O'Connor, P. M. (1996) J. Natl. Cancer Inst. 88, 956-965
6. Tsuchida, E., and Urano, M. (1997) Int. J. Radiat. Oncol. Biol. Phys. 39, 1153-1161
7. Shao, R. G., Cao, C. X., Shimizu, T., O'Connor, P. M., Kohn, K. W., and Pommier, Y. (1997) Cancer Res. 57, 4029-4035
8. O'Connor, P. M. (1997) Cancer Surv. 29, 151-182
9. Fan, S., Smith, M. L., Rivet, D. J. N., Duba, D., Zhan, Q., Kohn, K. W., Fornace, A. J., Jr., and O'Connor, P. M. (1995) Cancer Res. 55, 1649-1654
10. Demarcq, C., Bunch, R. T., Creswell, D., and Eastman, A. (1994) Cell Growth Differ. 5, 983-993
11. Sorenson, C. M., Barry, M. A., and Eastman, A. (1990) J. Natl. Cancer Inst. 82, 749-755
12. Lee, H., Lamer, J. M., and Hamlin, J. L. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 526-531