Antioxidants in fruits and vegetables - The millennium's health

International Journal of Food Science and Technology

Volumn 36, Issue 7, 2001, Pages 703-725

  Kaur, Charanjit ^a   Kapoor, Harish C ^b  

^a Div of Fruits and Hort Technology   (India)

^b INDIAN AGRICULTURAL RESEARCH INSTITUTE   (India)

Author keywords

Antioxidant activity; Carotenoids; Flavonoids; Free radicals; Phenols; Processing methods; Vitamins

Indexed keywords

EID: 0035538409     PISSN: 09505423     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2621.2001.00513.x     Document Type: Review

References (225)

1. Acheson, R.M. & Williams, D.R.R. (1983). Does consumption of fruits and vegetables protect against stroke. Lancer, 1, 1191-1193.
2. Alpha tocopherol, Beta carotene Cancer Prevention Study Group (ATBC) (1994). The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in the male smokers. New England Journal of Medicine, 330, 1029-1035.
3. Al-Saikhon, M.S., Howard, L.R. & Miller, J.C. (1995). Antioxidant activity and total phenolics in different genotypes of potato (Solanum tuberosum). Journal of Food Science, 60, 341-343.
4. Amakura, Y., Umino, Y., Tsuji, S. & Tonogai, Y. (2000). Influence of jam processing on the radical scavenging activity and phenolic content in berries. Journal of Agricultural Food Chemistry, 48, 6292-6297.
5. American Institute of Cancer Research. (1997). Food Nutrition, and the Prevention of Cancer: A Global Perspective. Washington, DC: American Institute of Cancer Research.
6. Ames, B.N. (1983). Dietary carcinogens and anticarcinogens oxygen radicals and degenerative diseases. Science, 221, 1256-1262.
7. Ames, B.N., Shigenga, M.K. & Hagen, T.M. (1993). Oxidants, antioxidants and degenerative diseases of ageing. Proceedings of National Academy of Sciences USA, 90, 7915-7922.
8. Ancos de, B., Gonzalez, E.M. & Cano, M.P. (2000b). Ellagic acid, vitamin C and total phenolic contents and radical scavenging capacity affected by freezing and frozen storage in raspberry fruit. Journal of Agricultural Food Chemistry, 48, 4565-4570.
9. Ancos de, B., Ibanez, E., Reglero, G. & Cano, M.P. (2000a). Frozen storage effects on anthocyanins and volatile compounds of raspberry fruit. Journal of Agricultural Food Chemistry, 48, 873-879.
10. Andlauer, W. & Furst, P. (1998). Antioxidative power of phytochemicals with special reference to cereals. Cereal Foods World, 43, 356-360.
11. Anese, M., Manzocco, L., Nicoli, M.C. & Lerci, C.R. (1999). Antioxidant properties of tomato juice as affected by heating. Journal of the Science of Food and Agriculture, 79, 750-754.
12. Anese, M., Pittia, P. & Nicoli, M.C. (1993). Oxygen consuming properties of heated glucose-glycine aqueous solutions. Italian Journal of Food Science, 5, 75-79.
13. Appel, M.J. & Woutersen, R.A. (1996). Effects of dietary β-carotene and selenium on initiation and promotion of pancreatic carcinogenesis in azaserine treated rats. Carcinogenesis, 17, 1411-1416.
14. Arnaeo, M.B., Cano, A., Hernandez-Ruiz, J., Gracia Canovas, F. & Acosta, M. (1996). Inhibition by L-ascorbic acid and other antioxidants of the 2-2′-azinobis (3-ethyl-benzthiazoline-6-sulfonic acid) oxidation catalyzed by peroxidase: a new approach for determining total antioxidant status of foods. Analytical Biochemistry, 236, 255-261.
15. Ascherio, A., Rimm, E.B., Giovannicci, E.L. et al. (1992). A prospective study of nutritional factors and hypertension among US men. Circulation, 86, 1475-1484.
16. Baranowitz, S.A., Starrett, B. & Brookner, A.R. (1996). Carotene deficiency in HIV patients. AIDS, 10, 115-118.
17. Benzie, I.E.F. & Strain, J.J. (1996). The ferric reducing ability of plasma (FRAP) as a measure of antioxidant power: the FRAP assay. Analytical Biochemistry, 239, 70-76.
18. Bidlack, W.R. (1998). Phytochemicals: a potential new health paradigm. Food Technology, 52, 168-172.
19. Block, G., Patterson, B. & Subar, A. (1992). Fruits, vegetables and cancer prevention: a review of the epidemiological evidence. Nutrition and Cancer, 18, 1 29.
20. Bocco, A., Cuvelier, M.E., Richard, H. & Berset, C. (1998). Antioxidant activity and phenolic composition of citrus peel and seed extracts. Journal of Agricultural Food Chemistry, 46, 2123-2129.
21. Boileau, T.W.M., Moore, A.C. & Erdman, J.W. Jr. (1999). Carotenoids and vitamin A. In: Antioxidant Status, Diet, Nutrition and Health (edited by A.M. Papas). Pp. 133-158. Boca Raton, FL: CRC Press.
22. Bonnely, S., Peyrat-Maillard, M.N., Rondini, L., Masy, D. & Berset, C. (2000). Antioxidant activity of malt rootlet extracts. Journal of Agricultural Food Chemistry, 48, 2785-2792.
23. Bouic, P.J. & Lamprecht, J.H. (1999). Plant sterols and sterolins: a review of their immune-modulating properties. Altern Medical Review, 4, 170-179.
24. Bramley, P.M. (2000). Is lycopene beneficial to human health? Phytochemistry, 54, 233-236.
25. Brand-Williams, W., Cuvelier, M.E. & Berset, C. (1995). Use of a free radical method to evaluate antioxidant activity. Lehensm-Wiss Technology, 28, 25-30.
26. Bravo, I. (1998). Polyphenols: chemistry, dietary source, metabolism, and nutritional significance. Nutritional Review, 56, 317-333.
27. Bresnick, E., Birt, D.F., Woltuman, K., Wheeler, M.M. & Markin, R.S. (1990). Reduction in mammary tumoro-genesis in the rat by cabbage and cabbage residue. Carcinogenesis, 11, 1159-1163.
28. Bressa, F., Tesson, N., Dalla Rosa, M., Sensidoni, A. & Yubaro, F. (1996). Antioxidant effect of Maillard reaction products: application to butter cookie of a competition kinetic analysis. Journal of Agricultural Food Chemistry, 44, 692-695.
29. Britton, G.W. (1995). Structure and properties of carotenoids in relation to function. FASB Journal, 9, 1551-1558.
30. Burning, J.E. & Hennekens, C.H. (1997). Antioxidant vitamin and cardiovascular diseases. Nutrition Review, 55, 553-560.
31. Calixeto, F.S. (1998). Antioxidant dietary fiber product: a new concept and a potential food ingredient. Journal of Agricultural Food Chemistry, 46, 4303-4306.
32. Cano, A., Hernandez-Ruiz, J., Garcia-Canovas, F., Acosta, M. & Arnao, M.B. (1998). An end point method for estimation of the total antioxidant activity in plant material. Phytochemical Analysis, 9, 196-202.
33. Cao, G., Booth, S.L., Sadowski, J.A. & Prior, R.L. (1998). Increase in human plasma antioxidant capacity after consumption of controlled diets high in fruits and vegetables. American Journal of Clinical Nutrition, 68, 1081-1087.
34. Cao, G., Srfie, E. & Prior, R.L. (1996). Antioxidant capacity of tea and common vegetables. Journal of Agricultural Food Chemistry, 44, 3425-3431.
35. Cao, G., Verdon, C.P., Wu, A.H.B., Wang, H. & Prior, R.L. (1995). Automated oxygen radical absorbance capacity assay using COBAS FARA II. Clinical Chemistry, 41, 1735-1737.
36. Chandler, L.A. & Schwanz, S.J. (1987). HPLC separation of cis-trans carotene isomers in fresh and processed fruits and vegetables. Journal of Food Science, 52, 669-672.
37. Chu, Y.H., Chang, C.L. & Hsu, H.F. (2000). Flavonoid content of several vegetables and their antioxidant activity. Journal of the Science of Food and Agriculture, 80, 561-566.
38. Clarke, M.P. (1999). Can food forestall ageing. Agriculture Research USDA, February, 15-17.
39. Clinton, S.K. (1998). Lycopene chemistry, biology and implications for human health diseases. Nutrition Review. 56, 35-51.
40. Constantino, L., Albasino, A., Rastelli, G. & Benvenuti, S. (1992). Activity of phenolic crude extract as scavenging of superoxide radicals and inhibitors of xanthine oxidase. Planta Medica, 58, 342-344.
41. Crowell, P.L. (1997). Monoterpenes in breast cancer chemoprevention. Breast Cancer Research Treatments. 46, 191-197.
42. Crazier, A., Lean. M.E.J., McDonald, M.S. & Black, C. (1997). Quantitative analysis of the flavonoid content of commercial tomatoes, onions, lettuce, and celery. Journal of Agricultural Food Chemistry, 45, 590-595.
43. Day, A.P. (1998). Effects of concentrated red grape juice consumption on serum antioxidant capacity and low density lipoprotein oxidation. Annals of Nutrition and Metabolism, 41, 353-355.
44. Deighton, N., Brennan, R., Finn, C. & Davies, H.V. (2000). Antioxidant properties of domesticated and wild Rubus species. Journal of the Science of Food and Agriculture, 80, 107-1313.
45. Diaz, M.N., Frei, B., Vita, J.A. & Keaney, J.F. (1997). Antioxidants and atherosclerotic heart disease. New England Journal of Medicine, 337, 408-416.
46. Dillard, C.J. & German, J.B. (2000). Phytochemicals: nutraceuticals and human health. Journal of the Science of Food and Agriculture, 80, 1744-1756.
47. DiMasico, P., Kaiser, S. & Sies, H. (1989). Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Archives of Biochemistry and Biophysics, 274, 532-538.
48. Djilas, S.M. & Milic, B.L. (1994). Naturally occurring phenolic compounds as inhibitors of free radical formation in the Maillard Reaction. In: Maillard Reaction in Chemistry, Food and health (edited by T.P. Lakuja, G.A. Reineccius, V.M. Monnier, J. O'Brien & J.W. Beynes). Pp. 75-80. Cambridge: The Royal Society of Chemistry.
49. Doll, R. (1990). An overview of the epidemiological evidence linking diet and cancer. Proceedings of Nutrition Society, 49, 119-131.
50. Donovan, L.J., Meyer, A.S. & Waterhouse, A.L. (1998). Phenolics composition and antioxidative activity of Prune and Prune Juice (Prunus domestica). Journal of Agricultural Food Chemistry, 46, 1247-1252.
51. Dragsted, C.O., Strube, M. & Larsen, L.C. (1993). Cancer protective factors in fruits and vegetables. Biochemical and biological background. Pharmacology and Toxicology, 72(Suppl.), 116-135.
52. Duh, P.D., Yen, D.B. & Yen, G.C. (1992). Extraction and identification of an antioxidative component from edible oils. Food Chemistry, 14, 45-51.
53. Dziezak, J.D. (1986). Preservaives., Antioxidants. The ultimate answer to oxidation. Food Technology, September, 94-102.
54. Eichner, K. (1981). Antioxidative effect of Maillard Reaction Intermediates. Progressive Food Nutrition Science, 5, 441-451.
55. Elliot, J.G. (1999). Application of antioxidant vitamins in foods and beverages. Food Technology, 53, 46-48.
56. Fahey, J.W. & Stephenson, K.K. (1999). Cancer chemo-protective effects of cruciferous vegetables. Horticulture Science, 34, 1159-1163.
57. Fogliano, V., Verde, V., Randazzo, G. & Ritieni, A. (1999). Method of measuring antioxidant activity and its application to monitoring the antioxidants capacity of wines. Journal of Agricultural Food Chemistry, 47, 1035-1040.
58. Franceschi, S., Bicdoli, E., Veechia, C., Talamini, R., D'Avanzo, B. & Negii, E. (1994). Tomatoes and risk of digestive tract cancers. International Journal of Cancer, 59, 181-184.
59. Frankel, E.N., Kanner, J., Germen, J.B., Perks, E. & Kinsella, J.E. (1993). Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet, 341, 454-457.
60. Frankel, E.N., Waterhouse, A.L. & Teissedre, P. (1995). Principal phenolic phytochemicals in selected California wines and their antioxidant activity in inhibiting oxidation of human low density lipoproteins. Journal of Agricultural Food Chemistry, 43, 890-894.
61. Fuhrman, B., Lavy, A. & Aviram, M. (1995). Consumption of red wines with meals reduces the susceptibility of human plasma and low density lipoproteins to lipid peroxidation. American Journal of Chemical Nutrition, 61, 549-554.
62. Garcia-Closas, R., Gonzalez, C.A., Agudo, A. & Riboli, E. (1999). Intake of specific carotenoids and flavonoids and the risk of gastric cancer in Spain. Cancer Causes and Control, 10, 71-75.
63. Gaulejac, N., Glories, Y. & Vivas, N. (1999b). Free radical scavenging effect of anthocyanins in red wines. Food Research International, 32, 37-333.
64. Gaulejac, N., Vivas, N. & Borgeois, G. (1999a). The influence of various phenolics compounds on scavenging activity assessed by an enzymatic method. Journal of the Science of Food and Agriculture, 79, 1081-1090.
65. Gazzani, G., Papetti, A., Massolini, G. & Daglia, M. (1998). Antioxidative and pro-oxidant activity of water soluble components of some common diet vegetables and the effect of thermal treatment. Journal of Food Chemistry, 6, 4118-4122.
66. Gerster, H. (1997). The potential role of lycopene for human health. Journal of American Clinical Nutrition, 16, 109-126.
67. Gey, K.F., Puska, P., Jordan, P. & Moser, V.K. (1991). Inverse correlation between plasma vitamin E and mortality for ischemic heart disease in cross-cultured epidemiology. American Journal of Clinical Nutrition, 53, 326C-334S.
68. Gil, M.I., Ferreres, F. & Tomas-Barheran, F.A. (1999). Effect of post harvest storage and processing on the antioxidant constituents (flavonoids and vitamin C) of fresh cut spinach. Journal of Agricultural Food Chemistry, 47, 2213-2217.
69. Gil, M.I., Tomas-Barberan, F.A., Hess-Pierce, B., Holeroft, D.M. & Kader, A.A. (2000). Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. Journal of Agricultural Food Chemistry, 48, 4581-4589.
70. Giovannucci, E. (1999). Tomatoes, tomato-based products, lycopene and cancer: Review of epidemiolgic literature. Journal of National Cancer Institute, 91, 317-331.
71. Giovanucci, E., Asherio, A. & Willett, W. C. (1995). Intake of carotenoids and retinol in relation to the risk of prostate cancer. Journal of National Cancer Institute, 87, 1767-1776.
72. Glazer, A.N. (1990). Phycoerythrin fluorescence-based assay of reactive oxygen species. Methods in Enzymology, 186, 167-168.
73. Gould, M.N. (1997). Cancer chemoprevention and therapy by monoterpenes. Environment Health Perspective, 105, 977-979.
74. Greefield, H. &Southgate, D.A.T. (1992). Food Composition Data Production, Management and Use. Elsevier Applied Science.
75. Greenberg, E.R., Baron, J.A., Tosteson, T.D. et al. (1994). A clinical trial of antioxidant vitamin to prevent colorectal cancer. New England Journal of Medicine, 331, 141-147.
76. Guo, C., Cao, G., Sofic, E. & Prior, R.L. (1997). High performance liquid chromatography coupled with colorometric array detection of electroactive components on fruits and vegetables: relationship to oxygen radical absorbance capacity. Journal of Agricultural Food Chenistry, 45, 1787-1796.
77. Hagerman, A.E., Riedl, K.M., Jones, G.A. et al. (1998). High molecular weight plant polyphenolics (tannins) as biological antioxidants. Journal of Agricultural Food Chemistry, 46, 1887-1892.
78. Hakkinen, S.H., Karenlampi, S.O., Mykkanen, H.M. & Torronen, A.R. (2000). Influence of domestic processing and storage on flavonol contents in berries. Journal of Agricultural Food Chemistry, 48, 2960-2965.
79. Halliwell, B., Gutteridge, J.M.C. & Aruoma, O.I. (1987). The deoxy ribose method: a simple test tube assay for determination of rate constants for reaction of hydroxyl radicals. Analytical Biochemistry, 165, 215-219.
80. Halliwell, B., Murcia, M.A., Chirico, S. & Auroma, O.I. (1995). Free radicals and antioxidants in food and in vivo: what they do and how they work?. Critical Review in Food Science and Nutrition, 35, 7-20.
81. Hammerschmidt, P.A. & Pratt, D.E. (1978). Phenolic antioxidants of dried soybeans. Journal of Food Science, 43, 556-559.
82. Hara, H., Haga, S., Aoyama, Y. & Kiriyama, S. (1999). Short chain fatty acids supress cholestrol synthesis in rat liver and intestine. Journal of Nutrition, 129, 942-948.
83. Heinonen, M., Lehtonen, P.J. & Hopia, A. (1998a). Antioxidative activity of berry and fruit wines and liquor. Journal of Agricultural Food Chemistry, 46, 25-31.
84. Heinonen, I.M., Meyer, A.S. & Frankel, E.N. (1998b). Antioxidant activity of berry phenolics on human low-density lipoprotein and liposome oxidation. Journal of Agricultural Food Chemistry, 46, 4107-1122.
85. Hennekens, C.H., Buring, J.E. & Peto, R. (1994). Antioxidant vitamins: Benefits not yet proved. New England Journal of Medicine, 330, 1080-1081.
86. Hennekens, C.H., Buring, J.E., Manson, M. et al. (1996). Lack of effect of long term supplementation with β-carotene on the incidence of malignant neoplasms and cardiovascular disease. New England Journal of Medicine, 334, 1145-1149.
87. Hertog, M.G.L., Feskens, E.J.M., Hollman, P.C.H., Katan, J.B. & Kromhout, D. (1993). Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet, 342, 1007-1011.
88. Hertog, M.G.L., Hollman, P.C.H. &Katan, M.B. (1992). Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in The Netherlands. Journal of Agricultural Food Chemistry, 40, 2379-2383.
89. Hirasa, K. & Takemasa, M. (1998). Spice Science Tecnology. New York: Marcel Dekker.
90. Hirayama, O., Nakamina, K., Hamada, S. & Koliayashi, Y. (1994). Singlet oxygen quenching ability of naturally occurring carotenoids. Lipids, 29, 149-150.
91. Hirota, S., Shimoda, T. & Takahama, U. (1998). Tissue and spatial distribution of flavonol and peroxidase in onion bulbs and stability of flavanolglucosides during boiling of the scales. Journal of Agricultural Food Chemistry, 46, 3497-3502.
92. Hopia, A., Huang, S.W., German, B.J. & Frankel, E.N. (1996). Effect of different lipid systems on antioxidant activity of rosemary constituent camasol and carnosic acid with and without alpha-tocopherol. Journal of Agricultural Food Chemistry, 44, 2030-2036.
93. Hopia, A.I. & Heinonen, M. (1999). Comparison of antioxidant activity of flavonoid aglycons and their glycosides in methyl linoleate. Journal of American Oil Chemist Society, 76, 139-144.
94. Howard, E.A., Wong, A.D., Perry, A.K. & Klein, B.P. (1999). β-Carotene and ascorbic acid in fresh and processed vegetables. Journal of Food Science, 64, 929-936.
95. Huang, M.T. & Ferraro, T. (1991). Phenolic compounds in food and cancer prevention. In: Phenolic Compounds in Food and Their Effects on Health: Antioxidants and Cancer Prevention (edited by M.T. Huang, C.-T. Ho & C.Y. Lee). Pp. 220-238. ACS Symposium Series 5078. Washington, DC: American Chemical Society.
96. Iwai, K., Abe, K. & Matsue, H. (2000). Establishment of XYZ-dish method for a new antioxidative activity assay using photon detection. Nippon Shokuhin Kagaku Kogaku Kaishi, 41, 181-190.
97. Jones, P.H.J., Nitanios, F.Y., Raeini-Saraz, M. & Vanstone, C.A. (1999). Cholestrol lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in a hyperlipidemic men. American Journal of Clinical Nutrition, 69, 1144-1150.
98. Jonsson, I. (1991). Thermal degradation of carotenoids and influence of their physiological functions. In: Nutrition and Toxicologycal Consequences of Food Processing (edited by M. Friedman). Pp. 75-82. New York, NY, USA: Plenum Press.
99. Joseph, J.A., Shukit-Hale, B., Denisova, N.A. et al. (1999). Reversal of age-related declines in neuronal signal transduction, cognitive, and motor behavioural deficits with blue berry, spinach, or strawberry dietary supplementation. Journal of Neuroscience, 19, 8114-8812.
100. Justesen, U., Knuthsen, P. & Leth, T. (1998). Quantitative analysis of flavanols, flavones, and flavanones in fruits, vegetables and beverages by high performance liquid chromatography with photodiode array and mass spectrometric detection. Journal of Chromatography, 799, 101-110.
101. Kaanane, A., Kane, D. & Labuza, T.P. (1988). Time and temperature effect on stability of Moroccan processed orange juice during storage. Journal of Food Science, 53, 1470-1489.
102. Kahkonen, M.P., Hopia, A.I., Vuorela, H.J. et al. (1999). Antioxidant activity of plant extracts containing phenolic compounds. Journal of Agricultural Food Chemistry, 47, 3954-3962.
103. Kanner, J., Frankel, E., Granit, R. et al. (1994). Natural antioxidants in grapes and wines. Journal of Agricultural Food Chemistry, 42, 64-69.
104. Karakaya, S. & Kavas, A. (1999). Antimutagenic activities of some foods. Journal of Agricultural Food Chemistry, 79, 237-242.
105. Khachik, F., Beecher, G.R. & Smith, J.C. Jr (1995). Lutein, lycopene and their oxidative metabolites in chemoprevention of cancer. Journal of Cell Biochemistry, Suppl., 22, 236-246.
106. Khachik, F., Goli, M.B., Beecher, G.R. et al. (1992). Effect of food preparation on qualitative and quantitative distribution of major carotenoids constituents of tomatoes and several green vegetables. Journal of Agricultural Food Chemistry, 40, 390-398.
107. Kikugava, K., Kunugi, A. & Kurechi, T. (1990). Natural antioxidants exploited commercially. In: Food Antioxidants (edited by BJ.F. Hudson). Pp. 65-98. Essex: Elsevier Applied Science.
108. Kikuzaki, H. & Nakatani, N. (1993). Antioxidant effects of some ginger constituents. Journal of Food Science, 58, 1407-1410.
109. Kinsella, J.E., Frankel, E., German, B. & Kanner, J. (1993). Possible mechanism and protective role of antioxidants in wine and plant foods. Food Technology, 47, 85-89.
110. Klein, B.P. & Kurilich, A.C. (2000). Processing effects on dietary antioxidants from plant foods. Horticulture Science, 35, 580-584.
111. Knekt, P., Jarvinen, R., Seppanen, R., Heliovaara, M., Teppo, L. & Aroma, A. (1997). Dietary flavonoids and the risk of lung cancer and other malignant neoplasms. American Journal of Epidemiology, 146, 223-230.
112. Kohlmeier, L. & Hastings, S.B. (1995). Epidemiologic evidence of a role of curotenoid in cardiovascular disease prevention. American Journal of Clinical Nutrition, 62, S1370-S1376.
113. Kohlmeier, L., Clark, J.D., Gomez-Gracia, E. et al. (1997). Lycopene and myocardial infection risk in the EURAMIC study. American Journal of Epidemiology, 146, 618-626.
114. Lansky, E., Shubert, S. & Neeman, I. (1998). Pharmacological and therapeutical properties of pomegranate. In: Proceedings 1st International Symposium on Pomegranate (edited by P. Megarazo, J.J. Martinez & J. Martinez.). pp. Pr-07. Orihuela, Spam: CIHEAM.
115. Larrauri, J.A., Ruperez, P. & Saura-Calixeto, F. (1997). Effect of drying temperature on the stability of polyphenols and antioxidant activity of red grape pomace peels. Journal of Agricultural Food Chemistry, 45, 1890-1893.
116. Lathrop, P.J. & Leung, H.K. (1980). Rate of ascorbic acid degradation during thermal processing of canned peas. Journal of Food Science, 45, 152-153.
117. Lavelli, V., Peri, C. & Rizzolo, A. (2000). Antioxidant activity of tomato products as studied by model reactions using xanthine oxidase, myeloperoxidase, and copper-induced lipid peroxidation. Journal of Agricultural Food Chemistry, 48, 1442-1448.
118. Lee, H.S. (1992). Antioxidant activity of browning reaction products isolated from storage aged orange juice. Journal of Agricultural Food Chemistry, 40, 550-552.
119. Lee, I.M., Cook, C., Rosner, N.R., Manson, M., Buring, J.E. & Hennekens, C.H. (1999). Beta-carotene supplementation and incidence of cancer and cardiovascular disease: The women's health study. Journal of the National Cancer Institute, 91, 2102-2106.
120. Levy, J., Bosin, E., Fieldman, B. et al. (1995). Lycopene is a more potent inhibitor of human cancer cell proliferation than either α-carotene or β-carotene. Nutritional Cancer, 24, 257-266.
121. Lietty, A., Cristoni, A. & Picci, M. (1976). Studies on Vaccinium myrtillus anthocyanosides: Vasoprotective and antiinflammatory activity. Arzneim-Forch, 26, 829-832.
122. Liu, R.H. (2000). Cancer-An apple a day helps keep cancer away. Nature, 405, 903-904.
123. Lund, D.B. (1979). Effects of commercial processing on nutrients. Food Technology, 33, 28-34.
124. Macheix, J.J., Fleuriet, A. & Billot, J. (1990). Fruit Phenolics. Boca Raton, FL: CRC Press.
125. Maeda, H., Katsuki, T., Akaiki, T. & Yasutake, R. (1992). High correlation between lipid peroxide radical and tumor promotor effect: supression of the tumor production in the Epstein-Barr virus/B-lymphocytes system and scavenging of alkyl peroxide radicals by various vegetable extracts. Japanese Journal of Cancer Research, 83, 923-928.
126. Matasufuji, H., Nakamuro, H., Chino, M. & Mitsuharo, T. (1998). Antioxidant activity of capasanthin and the fatty acid esters in paprika (Capsicum annum). Journal of Agricultural Food Chemistry, 46, 3468-3472.
127. Matasushima-Nishikawa, R., Shidoji, Y., Nishiwaki, S., Yamada, T., Moriwaki, H. & Muto, Y. (1995). Supression by carotenoids of microcystin-induced morphological changes in mouse hepatocytes. Lipids, 30, 1029-1034.
128. McCarthy, M.A. & Mattehus, R.H. (1994). Nutritional quality of fruits and vegetables subjected to minimal processes. In: Minimally Processed Refrigerated Fruits and Vegetables (edited by R.C. Wiley). Pp. 313-326. New York: Chapman & Hall.
129. Meltzer, H.M. & Malterud, K.E. (1997). Can dietary flavonoids influence the development of coronary heart disease?. Scandavian Journal of Nutrition, 41, 50-57.
130. Meyer, A.S., Donovan, J.L., Pearson, D.A., Waterhouse, A.I. & Frankel, E.N. (1998b). Fruit hydroxycinnamic acids inhibit human low-density lipoproteins oxidation in vitro. Journal of Agricultural Food Chemistry, 46, 1783-1787.
131. Meyer, A.S., Jepsen, S.M. & Nina, S.S. (1998a). Enzymatic release of antioxidants for human low density lipoprotein from grape pomace. Journal of Agricultural Food Chemistry, 46, 2439-2446.
132. Meyer, A.S., Yi, O.-S., Pearson, D.A., Waterhouw, A.I. & Frankel, E.N. (1997). Inhibition of human low-density lipoprotein oxidation in relation to composition of phenolic antioxidants in grapes. Journal of Agricultural Food Chemistry, 45, 1638-1643.
133. Miki, N. & Akatsu, K. (1971). Stability in tomato juice of lycopene from inner and outer part of the flesh. Nippon Journal of Food Science and Technology, 18, 309-312.
134. Miki, W. (1991). Biological functions and activities of animal carotenoids. Pure Applied Chemistry, 63, 141-146.
135. Miller, N.J., Diplock, A.T. & Rice Evans, C.A. (1995). Evaluation of the total antioxidant activity as a marker of apple juice on storage. Journal of Agricultural Food Chemistry, 43, 1794-1801.
136. Miller, N.J., Rice-Evans, C.A., Davies, M.J., Gopinathan, V. & Milner, A. (1993). A novel method of measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates. Clinical Science, 84, 407-412.
137. Mimaki, Y., Kuroda, M., Kameyama, A., Yokosuka, A. & Sahida, Y. (1998). Steriodal saponins from the underground parts of Ruscus aculeatus and their cytostatic activity on HL60 cells. Phytochemistry, 48, 485-493.
138. Mitimura, T., Tsundo, S. & Nagasawa, H. (1996). Lycopene, a carotenoid, supresses TGF alpha mRNA expression in spontaneous mammary tumors of SHN mice. Bulletin Faculty of Agriculture, Meiji University, 105, 45-48.
139. Mitsuda, H., Yasumoto, K. & Iwami, K. (1966). Antioxidant action of indole compounds during the auto-oxidation of linoleic acid. Eiyo to Shekyuryou, 19, 210-214.
140. Miyake, T. & Shibamoto, T. (1997). Antioxidative activities of Natural compounds found in plants. Journal of Agricultural Food Chemistry, 45, 1819-1822.
141. Moriguchi, S., Okshima, N., Sumida, S., Okamura, K. & Kishino, Y. (1996). β-Carotene supplementation enhances lymphocyte proliferation with mutagens in human peripheral blood lymphocytes. Nutrition Research, 16, 211-212.
142. Mortensen, A. & Skibsted, L.H. (1997). Importance of carotenoid structure in radical scavenging reactions. Journal of Agricultural Food Chemistry, 45, 2970-2977.
143. Nagasawa, H., Mitamura, T., Sakamoto, S. & Yamamoto, K. (1995). Effect of lycopene on spontaneous mammary tumor development in SHN virgin mice. Anticancer Research, 15, 1173-1178.
144. Nakatani, N. (1997). Antioxidants from spices and herbs. In: Natural Antioxidants: Chemistry, Health, Effects and Applications (edited by F. Shahidi). Pp. 64-75. Champaign, IL: AOAC Press.
145. Namiki, M. (1990). Antioxidants, antimutagens in food. Critical Review in Food Science and Nutrition, 29, 273-300.
146. Narisawa, T., Fukaura, Y., Hasebe, M. et al. (1996). Inhibtory effects of natural carotenoids, α-carotene, lycopene and lutein, on colonic aberrant crypt foci formation in rats. Cancer Letters, 107, 137-142.
147. Newmark, H., Mergens, W. & Newmark, H.L. (1984). A hypothesis for dietary components as blocking agents of chemical carcinogenesis: Plant phenolics and pyrrole pigments. Nutrition and Cancer, 6, 58-70.
148. Nicoli, M.C., Anese, M. & Parpinel, M. (1999). Influence of processing on the antioxidant properties of fruits and vegetables. Trends in Food Science Technology, 10, 94-100.
149. Nicoli, M.C., Anese, M., Parpinel, M.T., Franceschi, S. & Lerici, C.R. (1997). Study on loss and formation of antioxidants during processing and storage. Cancer Letters, 114, 71-74.
150. Nishina, A., Kuboto, K., Kameoka, H. & Osawa, T. (1991). Anti Oxidizing Component, Musizin, in Rumex japonicus. Houtt. Journal American Oil Chemists Society, 68, 735-739.
151. Ojima, F., Sakamoto, H., Ishiguro, Y. & Terao, J. (1993). Consumption of carotenoids in photosensitized oxidation of human plasma and plasma low density lipoproteins. Free Radicals in Biology and Medicine, 15, 377-384.
152. Okuda, T., Yoshida, T. & Hatano, T. (1992). Antioxidant effects of tannins and related phenols. In: Phenolic Compounds in foods and their effect on health (edited by M.T. Huang, C.T. Ho & C.Y. Lee). Pp. 87-97. Washington, DC: American Chemical Society.
153. Omenn, G.S., Goodman, G.E., Thornquist, M.D. et al. (1996). Effects of combination of beta-carotene and vitamin A on lung cancer and cardiovascular diseases. New England Journal of Medicine, 334, 1150-1155.
154. Oomah, B.D. & Mazza, G. (2000). Functional Foods. In: The Wiley Encyclopedia of Science & Technology, 2nd edition, V2 (edited by F.J. Francis). Pp. 1176-1182. New York, NY: Wiley.
155. Papas, A.M. (1999). Vitamin E: tocopherols and tocotrienols. In: Antioxidant Status, Diet, Nutrition and Health (edited by A.M. Papas). Pp. 189-210. Boca Raton, FL: CRC Press.
156. Parfitt, V.J., Rubba, P., Bolton, C., Marotta, G., Hartog, M. & Mancini, M. (1994). A comparison of antioxidant status and free radical peroxidation of plasma lipoprpteins in the healthy young persons from Naples and Bristol. European Heart Journal, 15, 871-876.
157. Piironen, G.W., Price, K.R., Rhodes, M.J.C. & Williamsons, G. (1986). Tocopherols and tocotrienols in Finnish foods: Vegetables, fruits and berries. Journal of Agricultural Food Chemistry, 34, 742-746.
158. Pool-Zobel, B.L., Buh, A., Muller, H., Wollowski, I. & Hochkemmet, G. (1997). Consumption of vegetables reduces genetic damage in humans: First result of a human intervention trial with carotenoid-rich foods. Carcinogenesis, 18, 1847-1850.
159. Porter, L.W., Levasseur, L.A. & Henick, A.S. (1977). Evaluation of some natural and synthetic antioxidants in linoleic acid monolayer on silica. Journal of Food Science, 42, 1533-1535.
160. Potischman, N., Hoover, R.N., Brinton, L.A. et al. (1994). The relation between cervical cancer and serological markers of nutritional status. Nutrition and Cancer, 21, 193-201.
161. Price, K.R., Bacon, J.R. & Rhodes, M.J.C. (1997). Effect of storage and domestic processing on the content and composition of flavanol glucosides in onion (Allium). Journal of Agricultural Food Chemistry, 45, 938-942.
162. Price, K.R., Casuscelli, F., Colquhoun, I.J. & Rhodes, M.J.C. (1998a). Composition and content of flavonolglycosides in broccoli florets (Brassica olearacea) and their fate during cooking. Journal of Science of Food and Agriculture, 77, 468-472.
163. Price, K.R., Colquhoun, I.J., Barnes, K.A. & Rhodes, M.J.C. (1998b). Composition and content of flavonol glycosides in green beans and their fate during processing. Journal of Agricultural Food Chemistry, 46, 4898-4903.
164. Price, K.R., Presser, T., Richetin, A.M.F. & Rhodes, M.J.C. (1999). A comparison of the flavonol content and composition in desert, cooking, and cider making apples: distribution within the fruit and effect of juicing. Food Chemistry, 66, 489-494.
165. Prieme, H., Loft, S., Nyyssonen, K., Salonen, J.T. & Poulsen, H. E. (1997). No effect of supplementation with vit. E, ascorbic acid or coenzyme Q10 on oxidative damage estimated by 8-oxo-7,8-dihydro-2′-deoxyguanosine excretion in smokers. American Jounal of Clinical Nutrition, 65, 503-507.
166. Prior, R.L. & Cao, G. (2000). Antioxidant phytochemicals in fruits and vegetables: diet and health implications. Horticulture Science, 35, 588-592.
167. Prior, R.L., Cao, G., Martin, A. et al. (1998). Antioxidant capacity as influenced by total phenolics and anthocyanin content, maturity and variety of Vaccinium species. Journal of Agricultural Food Chemistry, 46, 2686-2693.
168. Ramon, J.M., Serra, L., Cerdo, C. & Oromi, J. (1993). Dietary factors and gastric cancer risk. Cancer, 71, 1731-1735.
169. Rapola, J.M., Virtamo, J., Rippati, S. et al. (1997). Randomised trial of alpha-tocopherol and beta-carotene supplements on incidence of major coronary events in men with previous myocardial infection. Lancet, 349, 1715-1720.
170. Rechner, A. (2000). Einfluss der Verarbeitungstechnik auf die antioxidative kapazitat von wertgebenden apfel-und beerensaftkomponenten. Dissertation, Universitat Gie Ben.
171. Renaud, S. & de Lorgeril, M. (1992). Wine, alcohol, platelets and the French Paradox for coronary heart disease. Lancet, 339, 1523-1526.
172. Rice-Evans, C.A. & Miller, N.T. (1994). Total antioxidant status in plasma and blood fluids. Methods in Enzymology, 234, 279-293.
173. Rice-Evans, C.A., Miller, N.T. & Paganga, G. (1997). Antioxidant properties of phenolic compounds. Trends in Plant Science, 4, 304-309.
174. Salah, N., Miller, N.J., Paganga, G., Tijburg, L., Bolwell, P. & Rice-Evans, C. (1995). Polyphenolic flavonoids as scavengers of aqueous phase radicals and as chain breaking antioxidants. Archives in Biochemistry and Biophysics, 322, 339-346.
175. Salvini, S., Parpinel, M., Gnagnarella, P., Maisonneuve, P. & Turrini, A. (1998). Banco Dati Di Composizione Degil Alimenti Per Studi Epidemiologici in Italia. Milano: Institute Europeo di Oncologia.
176. Scalfi, L., Fogliano, V., Pentangelo, A., Graziani, G., Giordano, I. & Ritieni, A. (2000). Antioxidant activity and general fruit characteristics in different ecotypes of Corbarini small tomatoes. Journal of Agricultural Food Chemistry, 48, 1363-1366.
177. Schmidt, D.R. & Sobota, A.E. (1998). An examination of the antiadherence activity of cranberry and low-density lipoprotein oxidation. Annals of Nutrition Metabolism, 41, 353-357.
178. Schubert, S.Y., Lansky, E.P. & Neeman, I. (1999). Antioxidant and eicosanoid enzyme inhibition properties of pomegranate seed oil and fermented juice flavonoids. Journal of Ethnopharmacology, 66, 11-17.
179. Severini, C., Pittia, P. et al. (1994). Interaction between Maillard reaction products and lipid oxidation during the roasting process and storage of hazel nuts. In: Development in Food Engineering (edited by T. Yano, R. Matsuno & K. Nakamura). Pp. 289-291. Glasgow, UK: Blackie Academic and Professional Press.
180. Shahidi, F. & Wanasundam, P.K.J. (1992). Phenolic antioxidants. Critical Review in Food Science and Nutrition, 32, 67-103.
181. Singleton, V.L. (1982). Grape and wine phenolics: Background and prospectus. In: Proceedings University California, Davis, Wine Grape Centennial Symposium (edited by A.D. Webb). Davis: Department Viticulture and Enology, University of California.
182. Smith, W., Mitchell, P., Webb, K. & Leider, S.R. (1999). Dietary oxidants and age-related maculopathy: The blue mountain study. Opthamology, 106, 761-767.
183. Smith, J.G., Yokoyama, W.H. & German, G.B. (1998). Butyric acid from diet: actions at the levels of gene expression. Critical Review of Food Science, 38, 259-267.
184. Southern, S. (1998). Increased consumption of fruits and vegetables in the prevention of cancer of the colon, rectum and breast. Epidemiology, 9, 338-341.
185. Southon, S. (2000). Increased fruit and vegetable consumption within the EU: Potential health benefits. Food Research International, 33, 211-217.
186. Stahelin, H.B., Gey, K.F, Eichholzer, M. & Ludin, E. (1991). β-carotene and cancer prevention: The basal study. American Journal of Clinical Nutrition, 53, 265S-269S.
187. Stampfer, M.J., Hennekens, C.H., Manson, J.E., Colditz, G.A., Rosner, B. & Willett, W.C. (1993). Vitamin consumption and the risk of coronary disease in women. New England Journal of Medicine, 328, 1444-1449.
188. Steinberg, D. (1991). Antioxidants and atherosclerosis. A current assessment. Circulation, 84, 1420-1425.
189. Steinmetz, K.A. & Potter, J.D. (1996). Vegetable, fruit and cancer epidemiology. Cancer Causes and Control, 2, 325-351.
190. Strube, M., Haenen, G.R.M., van den Berg, H. & Bast, A. (1997). Pitfalls in a method for assessment of total antioxidant capacity. Free Radical Research, 26, 515-521.
191. Sun, H.J., Lee, J.M., Cho, J.S., Kim, Y.S. & Chung, S.H. (1999). Radical scavenging compounds in onion skin. Food Research International, 32, 659-664.
192. Taga, M.S., Miller, E.E. & Pratt, E. (1984). Chia seed natural antioxidants. Journal of Association of Oil Chemists Society, 61, 928-931.
193. Talalay, P. (1992). The role of enzyme induction in protection against carcinogenesis. In: Cancer Chemoprevention (edited by L. Wattenberg, M. Lipkin, G.W. Boone & G.J. Kelloff). Pp. 469-478. Boca Raton, FL: CRC Press.
194. Talcott, S.T., Howard, L.R. & Brenes, C.H. (2000). Antioxidant changes and sensory properties of carrot puree processed with and without periderm tissues. Journal of Agricultural Food Chemistry, 48, 1315-1321.
195. Teel, R.W. & Castonguay, A. (1992). Antimutagenic effects of polyphenolic compounds. Cancer Letters, 66, 107-113.
196. Teissedre, P.L., Frankel, E.N., Waterhouse, A.L., Peleg, E. & Germen, J. B. (1996). Inhibition of in vitro human LDL oxidase by phenolic antioxidants from grapes and wines. Journal of the Science of Food and Agriculture, 70, 55-61.
197. Torronen, R. (2000). Flavonols and ellagic acid in berries. Recent Advances in Agricultural and Food Chemistry, 1, 31-37.
198. Tribble, D.L. (1999). Antioxidant consumption and risk of coronary heart diseases. Emphasis on vitamin C, vitamin E and beta carotene. Circulation, 99, 591-595.
199. Tubaro, F. & Ursini, F. (1996). Misura Dell' Attivita Antiossidante Tramite L'analisi Di Una Cineticadi Competizione in Antiossidanti Naturali Negli Alimenti Aspetti Technologici E Qualitativi (edited by I. Conte, M. Dalla, Rosa & A. Zamarani). Pp. 45-53. Padova: CLEUP.
200. Uedo, N., Tatasuta, M., Iushi, H. et al. (1999). Inhibition by D-limonene of gastric carcinogenesis induced by N-methyl-N-nitro-N-nitrosoguanidine in Wistar rats. Cancer Letters, 137, 131-136.
201. Unno, T., Sugimoto, A. & Kakuda, T. (2000). Scavenging effect of tea catichins and their epimers on superoxide anion radicals generated by hypoxanthine-xanthine oxidase system. Journal of the Science of Food and Agriculture, 80, 601-606.
202. Usman, A. & Hosono, A. (1997). Antimutagenic activity of Maillard reaction Products against mutagenic heated Tauco. Italian Journal of Food Science, 9, 267-276.
203. van den Berg, R.V., Haenen, G.R.M.M., van den Berg, H. & Bast, A. (1999). Applicability of an improved Trolox equivalent antioxidant capacity (TEAC) assay for evaluation of antioxidant capacity measurements of mixtures. Food Chemistry, 66, 511-517.
204. Van den Broeck, L., Ludikhuyeze, L., Weemaes, C. & Van Loey, M. (1998). Kinetics for isobaric-isothermal degradation of L-ascorbic acid. Journal of Agricultural Food Chemistry, 46, 2001-2006.
205. Van Poppel, G. (1993). Carotenoids and cancer: An update with emphasis on human intervention studies. European Journal of Cancer, 29A, 1335-1344.
206. Van Poppel, G., Poulson, H.E. & Loft, S. (1995). No influence of β-carotene on oxidative damage in male smokers. Journal of National Cancer Institute, 87, 310-311.
207. Velioglu, Y.S., Mazza, G., Gao, L. & Oomah, B.D. (1998). Antioxidative activity and total phenolics in selected fruits, vegetables and grain products. Journal of Agricultural Food Chemistry, 46, 4113-4117.
208. Verlangieri, A.J., Kapeghian, J.C., el-Dean, S. & Bush, M. (1985). Fruit and vegetable consumption and cardiovascular mortality. Medical Hypothesis, 16, 7-15.
209. Vinson, J.A., Hao, Y., Su, K. & Zubic, L. (1998). Food antioxidant quantity and quality in foods: Vegetables. Journal of Agricultural Food Chemistry, 46, 3630-3634.
210. Wanasundara, U., Amarowicz, R. & Sahidi, E. (1994). Isolation and identification of an antioxidative component in canola meal. Journal of Agricultural Food Chemistry, 42, 1285-1290.
211. Wang, H., Cao. G. & Prior. R.L. (1997). Oxygen radical absorbing capacity of anthocyanin. Journal of Agricultural Food Chemistry, 45, 304-309.
212. Wang, H., Cao, G.H. & Prior, R.L. (1996). Total antioxidant capacity of fruits. Journal of Agricultural Food Chemistry, 44, 701-705.
213. Wargovich, M.J. (2000). Anticancer properties of fruits and vegetables. Horticulture Science, 35, 573-575.
214. Wattenberg, L.W. & Coccin, J.B. (1991). Inhibition of 4-methylnitrosoamine-1-(3-pyridyl)-1-butanone carcinogenesis in mice by D-limonene and citrus fruit oils. Carcinogenesis, 12, 115-117.
215. Wayner, D.D.M., Burton, G.W., Ingold, K.U., Barelay, L.R.C. & Locke, S.J. (1987). The relative contribution of vitamin E. urate, ascorbate, and protein to the total peroxyl radical-trapping antioxidant activity of human blood plasma. Biochimica et Biophysica Acta, 924, 408-419.
216. Weisburger, J.H. (1998). Evaluation of the evidence on the role of tomato products in disease prevention. Proceedings of Society fur Experimental Biology and Medicine, 218, 140-143.
217. West, C. & Castenmiller, J. (1998). Food processing and bioavailability of food antioxidants. In: Proceedings. FAIR CT95-0158 Symposium Natul. Antioxidants in Processed Foods-Effects on storage characteristics and nutritional value. Denmark: Agril. University of Federiksberg.
218. Wijewickreme, A.N. & Kitts, D.D. (1998). Oxidative reactions of model Maillard reaction products and α-tocopherol in a flour-lipid mixture. Journal of Food Science, 63, 466-471.
219. Wijewickreme, A.N., Krejpcio, Z. & Kitts, D.D. (1999). Hydroxyl scavenging activity of glucose, fructose, and ribose-lysine model Maillard products. Journal of Food Science, 64, 457-461.
220. Willet, C.W. (1994). Diet and health: What should we eat? Science, 264, 512-537.
221. Williamson, G., Faulkner, K. & Plumb, G.W. (1998). Glucosinolates and phenolics as antioxidants from plant foods. European Journal of Cancer Prevention, 7, 17-21.
222. Yen, G.C. & Tsai, L.C. (1993). Antimutagenecity of partially fractionated Maillard Reaction Product. Food Chemistry, 47, 11-15.
223. Yen, G.C., Chen, H.W. & Dun, P.D. (1998). Extraction and identificaion of an antioxidative component from Jue Ming Zi (Cassia tora L.). Journal of Agricultural Food Chemistry, 46, 820-824.
224. Yen, G.C., Wu. S.C. & Duh, P.D. (1996). Extraction and identification of antioxidant components from the leaves of mulberry. Journal of Agricultural Food Chemistry, 44, 1687-1690.
225. Zhang, Y., Kenski, T.W., Cho, C.G., Posner, G.S. & Talalay, P. (1994a). Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates. Proceeding of National Academy of Sciences, USA, 91, 2147-2150.