The potential role of lycopene for human health

Journal of the American College of Nutrition

Volumn 16, Issue 2, 1997, Pages 109-126

  Gerster, Helga ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Body distribution; Cancer epidemiology: prostate; Dietary source; Hyperlipidemia; Inflammatory disease; Kinetics; Non provitamin A carotenoid lycopene; Pancreas; Stomach; HIV infection

Indexed keywords

ANTIOXIDANT; CAROTENOID; LYCOPENE; REACTIVE OXYGEN METABOLITE;

ADRENAL GLAND; ALCOHOL CONSUMPTION; ANTINEOPLASTIC ACTIVITY; BIOAVAILABILITY; CANCER PREVENTION; CANCER RISK; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; NUTRITIONAL VALUE; PANCREAS CANCER; PARKINSON DISEASE; PROSTATE; PROSTATE CANCER; RETINA MACULA AGE RELATED DEGENERATION; REVIEW; SEPSIS; STOMACH CANCER; TESTIS; TOMATO;

HUMAN IMMUNODEFICIENCY VIRUS; LYCOPERSICON ESCULENTUM;

EID: 0030970834     PISSN: 07315724     EISSN: 15411087     Source Type: Journal    
DOI: 10.1080/07315724.1997.10718661     Document Type: Review

References (116)

1. DrummondJC, WilbrahamA: ‘The Englishman’s Food. Five Centuries of English Diet." London: Pimlico, 1991.
2. BlockG, PattersonB, SubarA: Emit, vegetables, and cancer prevention: A review of the epidemiological evidence. Nutr Cancer18:1-29. 1992.
3. HocmanG: Prevention of cancer: vegetables and plants. Comp Biochem Physiol 93B:201-212, 1989.
4. BjclkeE: Dietary vitamin A and human lung cancer. Int J Cancer 15:561-565. 1975.
5. Ncwbeme PM, Rogers AE: Vitamin A, retinoids and cancer In Newell GR. Ellison NM (eds): "Nutrition and Cancer: Etiology and Treatment." New York: Raven Press, pp 217-232, 1981.
6. Peto R, Doll R, Buckley JD, Spom MB: Can bcta-carotene materially reduce human cancer rates? Nature 290:201-208. 1981.
7. van PoppelG: Carotenoids and cancer an update with emphasis on human intervention studies. Eur J Cancer29:1335-1344, 1993.
8. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group: The effect of vitamin E and beta carotene on the incidcncc of lung cancer and other cancers in male smokers. N Engl J Med330:1029-1035, 1994.
9. Omenn GS, Goodman GE, Thomquist MD, Balmes J, Cullen MR, Glass A, Keogh JP, Meyskens FL, Valanis B, Williams JH, Barnhart S and Hammar S: Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med 334:1150-1155. 1996.
10. KrinskyNJ: Micronutrients and their influence on mutagenicity and malignant transformation. Ann NY Acad Sei686:229-242, 1993.
11. Gerster H: β-Carotene, vitamin E and vitamin C in different stages of experimental carcinogenesis. Eur J Clin Nutr 49:155-168. 1995.
12. KhachikF, BecchcrGR, SmithJC: I.utein, lycopcnc, and their oxidative metabolites in chemoprevemion of cancer. J Cell Biochem Suppl22:236-246, 1995.
13. GersterH: Anticarcinogenic effect of common carotenoids. Int J Vitam Nutr Res63:93-121. 1993.
14. DiMascio P, Kaiser SP, Sics H: Lycopenc as the most efficient biological carotcnoid singlet oxygen quencher. Arch Biochem Biophys274:532-538, 1989.
15. RaumaAI., TörrönenR.HänninenO.VcrhagenH, MykkäncnH: Antioxidant status in long-term adherents to a strict uncooked vegan diet. Am J Clin Nutr62:1221-1227, 1995.
16. BlockG: Micronutrients and cancer: Time for action?J Natl Canccr Inst 85:846-848. 1993.
17. ScottKJ, HartDJ: Development and evaluation of an HPLC method for the analysis of carotenoids in foods, and the measurement of the carotcnoid contcnt of vegetables and fruits commonly consumed in the UK. Eood Chem54:101-111, 1995.
18. Mangels AR, Holden JM, Bccchcr GR, Forman MR, Ianza E: Carotenoid content of fruits and vegetables: An evaluation of analytical data. J Am Diet Assoc93:284-296. 1993.
19. Chug AhujaJK, HoldenJM, FormanMR. MangelsAR. BeechcrGR. LanzaE: The development and application of a carotenoid database for fruits, vegetables, and selected multicomponent foods. J Am Diet Assoc93:318-323, 1993.
20. OngASH.TeeES: Natural sources of carotenoids from plants and oils. Methods Enzymol213:142-167, 1992.
21. StahlW, SiesH: Uptake of lycopene and its geometrical isomers is greater from heat-processed than from unprocessed tomato juice in humans. J Nutr 122:2161-2166, 1992.
22. Bntton G: Structure and properties of carotenoids in relation to function. FASEB J9:1551-1558, 1995.
23. StahlW, SchwarzW, SundquistAR, Sics H: cit-trans Isomers of lycopenc and β-carotene in human scrum and tissues. Arch Bio-chem Biophys294:173-177, 1992.
24. Schicrle J, Bretzcl W, Biihlcr I, Faccin N, Hess D, Steiner K, Schucp W: Contcnt and isomcric ratio of lycopenc in food and human blood plasma. Food Chem 1997, in press.
25. SakamotoH, MoriH, OjimaF, IshiguroY, ArimotoS.ImacY.NanbaT.OgawaM.FukubaH: Elevation of serum carotenoids after continual ingestion of tomato juice (Abstract). Nippon Eiyo Shokuryo Gaggaishi47:93-99, 1994.
26. StahlW, SiesH: Separation of geometrical isomers of 0-carotene and lycopene. Methods Enzymol234:388-400, 1994.
27. Mathews-RothMM, KrinskyNI: Mammalian metabolism of carotenoids other than β-carotene. Methods Enzymol213:265272, 1992.
28. ComstockGW, NorkusEP, HoffmanSC, XuMW. Hel/lsoucr KJ: Stability of ascorbic acid, carotcnoids, retinol, and toco-pherols in plasma stored at —70° for 4 years Canccr Epidemiol Biomark Prcv4:505-507, 1995
29. RockCL.SwcndscidME.JacobRA.McKccRW.Plasma carot-enoid levels in human subjects fed a low carotenoid diet. J Nutr122:96-100. 1992.
30. CarughiA.Hooper FG-Plasma carotenoid concentrations before and after Supplementation with a caiotenoid mixture. Am J Chn Nutr59:896-899. 1994.
31. MicozziMS, BrownED, EdwardsBK, BienJG. TaylorPR. KhachikF, BeecherGR. SmithJC: Plasma carotenoid response to chronic intake of selected foods and β-carotene Supplements in men. Am J Clin Nutr55:1120-1125, 1992.
32. AschcrioA.StampfcrMJ, ColditzGA, RimmEB, Iitin I., Willett WC: Correlations of vitamin A and E intakes with the plasma concentrations of carotcnoids and tocopherols among American men and women. J Nutr122:1792-1801, 1992.
33. CampbellDR. GrossMD, MartiniMC. GranditsGA, SlavinJL, PotterJD.Plasma carotenoids as biomaikeTs of vegetable and fruit intake Canccr Epidemiol Biomarkers Prev3:493-500. 1994.
34. ItoY.MinoharaM.OgitsuN, KusuharaY, SasakiR.OtaniM, ItoM.AokiK: Serum concentrations of α-carotene, β-carotenc, lycopcnc and retinol-binding protein in human subjects. Jap J Clin Chem16:18-25, 1987.
35. OlmedillaB, GranadoF, BlancoI, Rojas-HidalgoE: Seasonal and sex related variations in six serum carotcnoids, retinol, and a-tocopherol. Am J Clin Nutr60:106-110. 1994.
36. BradyWE, Marcs-PcrlmanJA, BowenP, Staccwicz-SapuntzakisM: Human scrum carotenoid concentrations arc related to physiologic and lifestyle factors. J Nutr126:129-137, 1996.
37. ZarlingEJ, MobarhanS, BowenP, KamathS: Pulmonary pentanc cxcrction increases with age in healthy subjects. Mech Ageing Developm67:141-147, 1993.
38. ScottKJ, ThumhamDI, HartDJ, BinghamS: The correlation between intake of lutein, lycopcnc and β-carotene from vegetables and fruits and concentrations in blood plasma. Proc Nutr Soc53:138, 1994.
39. PamukER. ByersT, CoatesRJ, VannJW, SowellAL, GunterEW, GlassD: Effect of smoking on serum nutrient concentrations in African-American Women. Am J Clin Nutr59:891-895, 1994.
40. risoprostancs) in smokers, N Engl J Med 332:1198-1203, 1995.
41. RossMA, CrosleyLK, BrownKM, DuthieSJ. CollinsAC. ArthurJR, DuthieGG: Plasma concentrations of carotenoids and antioxidant vitamins in Scottish males: influences of smoking. Eur J Clin Nutr49:861-865, 1995.
42. PengYM, PengYS. LinY, MoonT, RocDJ, RitenbaughCH: Concentrations and plasma-tissuc-diet relationships of carotenoids, retinoids, and tocopherols in humans. Nutr Cancer23:233-246, 1995.
43. LeoMA, RosmanAS, LieberCS: Differential depletion of carotenoids and tocopherols in liver disease. Hepatology17:977-986, 1993.
44. FormanMR, BeecherGR. LanzaE.ReichmanME, GraubardBI, CampbellWS, MarrT, YongLC, JuddJT, TaylorPR: Effect of alcohol consumption on plasma carotenoid concentrations in premenopausal women: a controlled dietary study. Am J Clin Nutr62:131-135, 1995.
45. BlakelySR, BrownF.D, BabuU, GrundelE, MitchellGV: Bioavailability of carotenoids in tomato paste and dried spinach and their interactions with canthaxanthin. FASEB J8:192, 1994.
46. GazianoJM, JohnsonEJ, RussellRM, MansonJE, StampferMJ, RidkerPM, FreiB, HennekensCH, KrinskyNI: Discrimination in absorption or transport of β-carotene isomers after oral Supplementation with either all-trans or α-cis-β carotene. Am J Clin Nutr61:1248-1252, 1995.
47. GargV, Staccwicz-Sapuntzakis M, Bowen PE: Lycopcnc absorption kinetics after a single dose of tomato olcorcsin (Abstract). FASEB J8:A192, 1994
48. WahlqvistML, WattanapcnpaiboonN, MacraeFA, LambertJR, Macl-ennanR, Hsu-HageBH-H: Changes in serum carotcnoids in subjects with colorectal adenomas after 24 mo of α-carotene Supplementation. Am J Clin Nutr 60:936-943, 1994.
49. Johnson EJ, Krinsky NI, Russell RM: Serum response of all-trans β-carotcne and lycopcnc in humans after ingestion of individual and combined doses of β-carotene and lycopene (Abstract). FASEB J10:A239, 1996.
50. ErshovYV, DmitrovskiiA A, BykhovskiiVY: Characterization of ihe interaction of β-carotene-15, 15'-dioxygenase from rabbit small intestine with lycopene, 15, 15' dehydro α carotcne, lutein, and astaxanthine. Biochemistry-Russia58:483-487, 1993.
51. van VlictT, van SchaikF, SchrcursWHP, van den BergH: In vitro measurement of β-carotene cleavage activity: methodological considerations and the effect of other carotenoids on β-carotene cleavage. Int J Vitam Nutr Res66:77-85, 1996.
52. Kaplan LA, Lau JM, Stein EA: Carotcnoid composition, concentrations, and relationships in various human organs. Clin Physiol Biochcm 8:1-10, 1990.
53. SchmitzHH, PoorCL, WellmanRB, ErdmanJW: Concentration of sclcctcd carntcnoids and vitamin A in human liver, kidney and lung tissue. J Nutr121:1613-1621, 1991.
54. ClintonSK, WilliamsAW, BoileauTW, ZhouJR, NortheyD, TeicherB, ErdmanJW: Tissue distribution of lycopene isomers in nude mice bearing implants of human prostate adenocarcinoma (Abstract). FASEB J10:A242, 1996.
55. ParkerRS: Carotcnoid and tocopherol composition of human adipose tissue. Am J Clin Nutr47:33-36. 1988.
56. StahlW, SiesH: Physical quenching of singlet oxygen and c/j-trans isomerization of carotenoids. Ann NY Acad Sci691: 10-19, 1993.
57. Ukai N, Iju Y, Etoh H, Yagi A, Ina K, Oshima S, Ojima F, Sakamoto H, Ishiguro Y: Photosensitized oxygenation of lyco pene. Biosci Biotech Biochem 58:1718-1719, 1994.
58. ConnPF, SchalchW, TruscottTG: The singlet oxygen and carotcnoid interaction. J Photochcm Photobiol B: Biol11:41-47, 1991.
59. TinklerJH, BohmF, SchalchW.TruscottTG: Dietary carote-noids protect human cells from damage. J Photochcm Photobiol B: Biol26:283-285, 1994.
60. OjimaF, SakamotoH, IshiguroY, TeraoJ: Consumption of carotenoids in photosensitized oxidation of human plasma and plasma low-density lipoprotein. Free Rad Biol Med15:377-384, 1993.
61. LuY, EtohH, WatanabcN, InaK, UkaiN, OshimaS, OjimaF, SakamotoH, IshiguroY: A new carotcnoid, hydrogen peroxide oxidation products from lycopene Biosct Biotech Biochcm59: 2153-2155, 1995.
62. BohmF, TrinklerJH, TruscottTG: Carotenoids protect against ccll membrane damage by the nitrogen dioxide radical. Nature Med1:98-99, 1995.
63. TsuchiyaM, ScitaG, ThompsonDFT, PackerL, KaganVE, LivreaMA: Retinoids and carotenoids are peroxyl radical scavengers. In: Livrea MA, Packer L (eds): "Retinoids: Progress in Research and Clinical Applications." New York: Marcel Dckkcr Inc, pp 525-536, 1993.
64. BurtonGW, Ingoid KU: β-Carotene: an unusual type of lipid antioxidant. Science224:569-573, 1984.
65. LieblerDC: Antioxidant reactions of carotenoids. Ann NY Acad Sci691:20-31, 1993.
66. FrankeA A, HarwoodPJ, ShimamotoT, Iumeng S, Zhang I-X, Bertram JS, Wilkens LR, Le Marchand LL, Cooney RV: Effects of micronutrients and antioxidants on lipid peroxidation in human plasma and in ccll culture. Cancer Lett79:17-26, 1994.
67. 2-isoprostanes) in smokers. N Engl J Med 332:1198-1203, 1995.
68. KeaneyJF, FreiB: Antioxidant protection of low-density lipoprotein and its role in the prevention of atherosclerotic vascular disease. In Frei B (ed): "Natural Antioxidants in Human Health and Disease." San Diego: Academic Press, pp 303-351, 1994.
69. RousseauEJ, DavisonAJ, DunnB: Protection by β-carotene and related compounds against oxygen-mediated cytotoxicity and genotoxicity: Implications for carcinogenesis and anticarcinogenesis. Free Rad Biol Med13:407-533, 1992.
70. Kim H: Carotenoids protcct cultured rat hcpatocytcs from injury caused by carbon tetrachloride Int J Biochem Cell Biol 27:1303-1309, 1995.
71. Matsushima-NishiwakiR.ShidojiY, NishiwakiS, YamadaT, MoriwakiH, MutoY: Suppression by carotenoids of microcystin-induced morphological changcs in mouse hcpatocytcs. Lipids30:1029-1034, 1995.
72. TsushimaM, MaokaT, KatsuyamaM, KozukaM, MatsunoT, TokudaH.NishinoH, IwashimaA: Inhibitory effect of natural carotenoids on Epstein-Barr virus activation activity of a tumor promotor in Raji cells. A screening study for anti-tumor promoters. Biol Pharm Bull18:227-233, 1995.
73. KücükOE, PunkA, FrankeAA, CusterIJ, WilkensLR, Lc MarchandLL. HiguchiCM, CooneyRV, HsuTC: Correlations between mutagen sensitivity and plasma nutrient levels of healthy individuals. Cancer Epidemiol Biomark Prev4:217-221, 1995.
74. HeY.CampbellTC: Effects of carotenoids on aflatoxin B,-induced mutagenesis in S. typhimurium TA 100 and TA 98. Nutr Cancer13:243-253, 1990.
75. LevyJ, BosinE, FeldmanB, GiatY, MünsterA.DanilcnkoM, SharoniY: Lycopene is a more potent inhibitor of human cancer ccll proliferation than either a-carotcnc or β-carotcne. Nutr Cancer24:257-266. 1995.
76. CountrymanC, BanksonD, CollinsS, MarB, Iin W: Lycopene inhibits the growth of the HL-60 promyelocytic leukemia ccll line (Abstract). Clin Chem37:1056, 1991.
77. BanksonDD, CountrymanCJ, CollinsSJ: Potentiation of the rctinoic acid-induccd differentiation of HL-60 cells by lycopene (Abstract). Am J Clin Nutr 53 Suppl. P-13, 1991.
78. BertramJS, PungA, ChurleyM, KappockTJ, WilkinsSR, CooneyRV: Diverse carotenoids protcct against chemically induced neoplastic transformation. Carcinogenesis 12:671-678, 1991.
79. Zhang LX, Cooney RV, Bertram JS: Carotenoids up-regulate coruiexin43 gene expression independent of their provitamin A or antioxidant properties. Cancer Res 52:5707-5712, 1992.
80. Wang CJ, Chou MY, Lin JK: Inhibition of growth and develop ment of the transplantable C-6 glioma cells inoculated in rats by retinoids and carotenoids. Cancer Lett 48:135-142. 1989.
81. NagasawaH.MitamuraT.SakamotoS.YamamotoK: Effects of lycopene on spontaneous mammary tumour development in SHN virgin mice. Anticancer Res15:1173-1178. 1995.
82. ColditzGA, BranchLG, LipnickRJ: Increased green and yellow vegetable intake and lowered cancer deaths in an elderly population. Am J Clin Nutr41:32-36, 1985.
83. Cook-MozaffariPJ. AzordeganF, DayNE. RessicaudA, SabaiC, ArameshB: Oesophageal cancer studies in the Caspian Littoral of Iran: results of a ease control study. Br J Canccr39:293-309, 1979.
84. BuiattiE, PalliD, DccaxliA, Amadori G, Avcllini C, Bianchi S, Bisemi R, Cipriani F, Coceo P, Giacosa A, Marubini E, Puntoni R, Vindigni C, Fraumeni J, Blot W: A case-control study of gastric canccr and diet in Italy. Int J Cancer44:611-616, 1989.
85. TsugancS.TsudaM, GeyF, WatanabeS: Cross-sectional study with multiple measurements of biological markers for assessing stomach cancer risks at the population level. Environ Health Perspect98:207-210, 1992.
86. FranceschiS, BidoliE.la VecciaC, TalaminiR, D’AvanzoB, NegriE: Tomatoes and risk of digestivc-tract cancers. Int J Cancer59:181-184, 1994.
87. MillsPK, BeesonL, Phillips RI, Fraser GE: Cohort study of diet, lifestyle, and prostate canccr in adventist men. Canccr 64:598-604. 1989.
88. GiovannucciE, AscherioA, RimmEB, StampferMJ, ColditzGA, WillettWC: Intake of carotcnoids and retinol in relation to risk of prostate cancer. J Natl Canccr Inst87:1767-1776, 1995.
89. Hsing AW, Comstock GW, Abbey H, Polk BF: Serologic precursors of canccr. Retinol, carotcnoids. and tocopherol and risk of prostate canccr. J Natl Canccr Inst 82:941-946. 1990.
90. BurneyPGJ, ComstockGW, MorrisJS: Serologic precursors of canccr: scrum micronutrients and the subsequent risk of pancreatic cancer. Am J Clin Nutr49:895-900, 1989.
91. PotischmanN, HerreroR, BrintonLA. ReevesWC, Staccwicz-SapuntzakisM.JonesCJ, BrenesMM, TenorioF.de BrittonRC. GaitanE: A case-control study of nutrient status and invasive cervical canccr. Am J Epidemiol134:1347-1355, 1991.
92. PotischmanN, HooverRN, BrintonLA, SwansonCA, HerreroR, TenorioF, de BrittonRC, GaitanE, ReevesWC: The relations between cervical canccr and serological markers of nutritional status. Nutr Canccr21:193-201, 1994.
93. BatiehaAM, ArmenianHK, NorkusEP, MorrisJS, SpateVE, ComstockGW: Serum micronutricnts and the subsequent risk of cervical canccr in a population-based nested case control study. Cancer Epidemiol Biomark Prev2:335-339, 1993.
94. Van Kcwyck J, Davis FG, Bowen PE: Dietary and serum carotcnoids and cervical intraepilhelial neoplasia. Int J Cancer 48:34-1991.
95. Hclzlsouer KJ, Comstock GW, Morris JS: Selenium, lycopene. α-tocopherol, β-carotene, retinol, and subsequent bladder canccr. Canccr Res 49:6144-6148, 1989.
96. PotischmanN, McCulJochCE, ByersT, NcmotoT.StubbeN.MilchR, ParkerR, RasmussenKM. RootM, GrahamS, CampbellTC: Breast canccr and dietary and plasma concentrations of carotenoids and vitamin A. Am J Clin Nutr52:909-915, 1990
97. OndonSJ, SteinEA, HendersonIC, StampferMJ, WoodWC, RcmineS, DmochowskiJR. RobertNJ, WillettWC: Carotcnoids. retinol, and vitamin F. and risk of proliferative benign breast disease and breast cancer. Canccr Causes Control3:503-512, 1992.
98. Le MarchandL, HankinJH. KolonclI.N, BccchcrGR.Wilkens LR, Zhao IP: Inlake of specific carotenoids and lung cancer risk Cancer Epidemiol Biomark Prcv 2:183-187. 1993.
99. SteinmetzKA, PotterJD, FolsomAR: Vegetables, fruit, and lung canccr in Iowa Women’s Health Study. Cancer Res53:536-543, 1993.
100. Ribayo MercadoJD, GarmynM, GilchrcstBA, RussellRM: Skin lycopcnc is destroyed preferentially over β-carotene during ultraviolet irradiation in humans. J Nutr125:1854-1859, 1995.
101. GrolierP, DuszkaC.PostaireE, BijotM, QuestelE, CesariniJP: Skin response to UV radiations and oxidative stress after oral Supplementation with β-carotene and lycopene (Abstract). Int Conf Food Factors. Chemistry and Prevention. Hamatsu, Japan, October 1995
102. BaumMK, Shor-PosnerG, BonvchiP.CassettiI, LuY, Mantero-AtienzaE, BeachRS, SaubcrlichHE: Influence of HIV infection on vitamin status and requirements Ann NY Acad Sci669:165-174, 1992.
103. KartcrDL, KartcrAJ, YarrishR.PattersonC, KassPH. NordJ, KislakJW: Vitamin A deficiency in non-vitamin-supplcmcnted patients with AIDS: a cross-sectional study. J Aquir Immune Def Syndr8:199-203. 1995.
104. SembaRD, GrahamNMH, CaiaffaWT, MargolickJB, ClementL, VlahovD: Increased mortality associated with vitamin A deficiency during human immunodeficiency virus type 1 infection. Arch Intern Med153:2149-2154, 1993.
105. SappcyC, LeclercqP, CoudrayC, FaureP, MicoudM, FavierA: Vitamin, trace clement and peroxide status in HIV seropositive patients: asymptomatic patients present a severe 0-carotcnc deficiency. Clin Chim Acta230:34-42, 1994
106. Periquct BA, Jammcs NM, Lambert WE, Tricoirc J, Moussa MM, Garcia J, Ghisolfi J, Thouvcnot JP: Micronutrient levels in HIV 1-infectcd children. AIDS9:887-893, 1995.
107. SuamaC, DeanRT, MayJ.StockerR: Human atherosclerotic plaque contains both oxidized lipids and relatively large amounts of a-tocophcrol and ascorbatc. Artcrioscler Thromb Vase Biol 15:1616-1624, 1995
108. KardinaalAFM, KokFJ. RingstadJ, Gomez-AraccnaJ, Malacv VP, Kohlmcicr L, Martin BC, Aro A, Kark JD, Dclgado-Rodriguez M, Riemersma RA, van Veer P, Huttunen JK. Mar-tin-Moreno JM: Antioxidants in adipose tissue and risk of myocardial infarction: the EURAMIC study. lancet342:1379-1384, 1993.
109. StreetDA. ComstockGW, SalkeldRM, SchiiepW, KlagMJ: Serum antioxidants and myocardial infarction. Arc low levels of carotcnoids and α-tocophcrol risk factors for myocardial infarction? Circulation 90:1154-1161, 1994.
110. Schafer E, Jinder L, Hadcll K, MoJgaard J, Holme I, Olsson AG, Walldius G: Probucol treatment decreases scrum concentrations of dict-dcrived antioxidants. Artcrioscler Thromb Vase Biol15: 1057-1063, 1995.
111. Araujo FB, Barbosa DS, Hsin CY, Maranhao RC, Abdalla DSP: Evaluation of oxidative stress in patients with hypcrlipidcmia. Atherosclerosis117:61-71, 1995.
112. Marcs-PerlmanJA, BradyWE, KleinR, KleinBEK, BowenP.Staccwicz-SapuntzakisM, PaltaM: Scrum antioxidants and age-related macular degeneration in a population-based case control study. Arch Ophthalmol113:1518-1523, 1995.
113. Jimenez-JimenczFJ. MolinaJA. Fcmandcz-CallcP.VazquezA.Cabrera-ValdiviaF, CatalanMJ. Garcia-AlbcaE, BermejoF, CodoceoR: Serum levels of β-carotene and other carotenoids in Parkinson’s disease. Neuroscience letters157:103-106. 1993.
114. GoodeHP. CowleyHC. WalkerBE, HowdlePD, WebsterNR: Dccrc&scd antioxidant status and increased lipid peroxidation in patients with scptic shock and secondary organ dysfunction. Crit Care Med23:646-651, 1995.
115. HomnickDN, CoxJH, DeLoofMJ, RingerTV: Carotenoid levels in normal children and in children with cystic fibrosis. J Pcdiatr122:703707, 1993.
116. SnowdonDA, GrossMD, ButlerSM: Antioxidants and reduced functional capacity in the elderly: Findings from the Nun Study. J Gerontol MED SCI 51A:M10-M16, 1996.