Consumption of vegetables reduces genetic damage in humans: First results of a human intervention trial with carotenoid-rich foods

Carcinogenesis

Volumn 18, Issue 9, 1997, Pages 1847-1850

  Pool Zobel, B L ^a   Bub, A ^a   Muller H ^a   Wollowski, I ^a   Rechkemmer, G ^a  

^a FEDERAL RESEARCH INSTITUTE OF NUTRITION AND FOOD   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CAROTENOID; ENDONUCLEASE; LYCOPENE; WATER;

ADULT; ARTICLE; ASSAY; CARROT; CHEMOPROPHYLAXIS; DNA DAMAGE; DNA STRAND BREAKAGE; FRUIT JUICE; GENETIC DAMAGE; HUMAN; HUMAN EXPERIMENT; MALE; MILK; NORMAL HUMAN; NUTRITION; OXIDATION; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; SPINACH; TOMATO; VEGETABLE;

ADULT; ANTIMUTAGENIC AGENTS; ANTIOXIDANTS; CAROTENOIDS; DIET; DNA DAMAGE; ELECTROPHORESIS; HUMANS; OXIDATIVE STRESS; VEGETABLES;

EID: 0031418203     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/18.9.1847     Document Type: Article

References (31)

1. Block, G., Patterson, B. and Subar, A. (1992) Fruit vegetables, and cancer prevention: a review of the epidemiological evidence. Nutr. Canc., 18, 1-29.
2. Willett, W.C. (1994) Diet and health: what should we eat? Science, 264, 532-537.
3. Ames, B.N., Gold, L.S. and Willett, W.C. (1995) The causes and prevention of cancer. Proc. Natl Acad. Sci. USA, 92, 5258-5265.
4. Aruoma, O.I. (1994) Nutrition and health aspects of free radicals and antioxidants. Fd Chem Toxicol., 32, 671-683.
5. Bonorden, W.R. and Pariza, M.W. (1994) Antioxidant nutrients and protection from free radicals. In Kotsonis, F.N., Mackey, M. and Hielle, J. (eds.) Nutritional Toxicology, Raven Press Ltd, New York, pp. 19-48.
6. Isler, O. (1981) Foreword. In Bauernfeind, J.C. (ed.) Carotenoids as Colorants and Vitamin A Precursors, Academic Press, New York.
7. Krinsky, N.I. (1993) Actions of carotenoids in biological systems. Ann. Rev. Nutr., 13, 561-587.
8. The Alpha Tocopherol, Beta-Carotene Cancer Prevention Study group. (1994) The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N. Engl. J. Med., 330, 1029-1035.
9. Omenn, G.S., Goodman, G.E., Thornquist, M., Grizzle, J., Rosenstock, L., Barnhart, S. et al. (1996) Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N. Engl. J. Med., 334, 1150-1155.
10. Mayne, S.T. (1996) Beta-carotene, carotenoids, and disease prevention in humans. FASEB J., 10, 690-701.
11. Byers, T. and Guerrero, N. (1995) Epidemiological evidence for vitamin C and vitamin E in cancer prevention. Am. J. Clin. Nutr., 62 (suppl), 1385S-1392S.
12. Mayne, S.T., Hanelman, G.J. and Beecher, G. (1996) Beta-Carotene and lung cancer promotion in heavy smokers - a plausible relationship? J. Natl. Cancer Inst., 88, 1513-1515.
13. Omenn, G.S., Goodman, G.E., Thornquist, M.D., Balmes, J., Cullen, M.R., Glass, A., Keogh, J.P., Meyskens, F.L., Valanis, B., Williams, J.H., Barnhart, S., Cherniak, M.G., Brodkin, C.A. and Hammar, S. (1996) Risk factors for lung cancer and for intervention effects in CARET, the beta-carotene and retinol efficacy trial. J. Natl. Cancer Inst., 88, 1550-1559.
14. Albanes, D., Heinonen, O.P., Taylor, P.R., Virtamo, J., Edwards, B.K., Rautalahti, M., Hartman, A.M. Palmgren, J., Freedman, L.S., Haapakoski, J., Barrett, M.J., Pietinen, P., Malila, N., Tala, E., Liippo, K., Salomaa, E.R., Tangrea, J.A., Teppo, L., Askin, F.B., Taskinen, E., Erozan, Y., Greenwald, P. and Huttunen, J.K. (1996) α-Tocopherol and β-carotene supplements and lung cancer incidence in the alpha-tocopherol, beta-carotene cancer prevention study: effects of base-line characteristics and study compliance. J. Natl. Cancer Inst., 88, 1560-1570.
15. Machlin, L.J. (1995) Critical assessment of the epidemiological data concerning the impact of antioxidant nutrients on cancer and cardiovascular disease. Crit. Rev. Food Sci. Nutr., 35, 41-50.
16. Szarka, C.E., Grana, G. and Engstrom, P. (1994) Chemoprevention of cancer. Current Problems in Cancer, 1, 3-79.
17. Collins, A.R., Dusinská, M., Gedik, C.M. and Stetina, R. (1996) Oxidative damage to DNA: Do we have a reliable biomarker? Environ. Hlth. Perspect., 104, 465-469.
18. Duthie, S., Ma, A., Ross, M.A. and Collins, A.R. (1996) Antioxidant supplementation decreases oxidative DNA damage in human lymphocytes. Cancer Res., 56, 1291-1295.
19. Collins, A.R., Duthie, S.J. and Dobson, V.L. (1995) Direct enzymic detection of endogenous oxidative base damage in human lymphocyted DNA. Carcinogenesis, 14, 1733-1735.
20. Fearon, E.R. and Vogelstein, B. (1990) A genetic model for colorectal tumorigenesis. Cell, 61, 759-767.
21. Wattenberg, L.W. (1992) Inhibition of carcinogenesis by minor dietary constituents. Cancer Res., 52 (Suppl.), 2085s-2091s.
22. Rowland, I.R., Bearne, C.A., Fischer, R. and Pool-Zobel, B.L. (1996) The effect of lactulose on DNA damage induced by 1,2-dimethylhydrazine in the colon of human-flora-associated rats. Nutr. Canc., 26, 38-47.
23. . Pool-Zobel, B.L., Neudecker, C., Domizlaff, I., Ji, S., Schillinger, U., Rumney, C.J., Moretti, M., Villarini, M., Scassellatti-Sforzolini, G. and Rowland, I.R. (1996) Lactobacillus-and Bifidobacterium-mediated antigenotoxicity in colon cells of rats: prevention of carcinogen-induced damage in vivo and elucidation of involved mechanisms. Nutr. Canc., 26, 365-380.
24. Singh, N.P., McCoy, M.T., Tice, R.R. and Schneider, E.L. (1988) A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res., 175, 184-191.
25. McKelvey, V.J., Green, M., Schmezer, P., Pool-Zobel, B.L., De Me',M.P. and Collins, A.R. (1993) The single cell gelelectrophoresis (SCGE) assay (Comet assay): a European review. Mutat. Res., 288, 47-63.
26. Dusinská, M. and Collins, A.R. (1996) Detection of oxidised purines and UV-induced photoproducts in DNA of single cells, by inclusion of lesion-specific enzymes in the comet assay. ATLA, 24, 405-411.
27. Pool-Zobel, B.L., Lotzmann, N., Knoll, M., Kuchenmeister, F., Lambertz, R., Leucht, U., Schröder, H.G. and Schmezer, P. (1994) Detection of genotoxic effects in human gastric and nasal mucosa cells isolated from biopsy samples. Environ. Mol. Mutag., 24, 23-45.
28. Holz, O., Jörres, R., Kästner, A., Krause, T. and Magnussen, H. (1995) Reproducibility of basal and induced DNA single-strand breaks detected by the single-cell gel electrophoresis assay in human peripheral mononuclear leukocytes. Int. Arch. Occup. Environm. Hlth., 67, 305-310.
29. Anderson, D., Yu, T.W., Phillips, B.J. and Schmezer, P. (1994) The effect of various antioxidants and other modifying agents on oxygen-radical-generated DNA damage in human lymphocytes in the COMET assay. Mutat. Res., 307, 261-271.
30. Pool-Zobel, B.L. and Leucht, U. (1997) Induction of DNA damage by risk factors of colon cancer in human colon cells derived from biopsies. Mutat. Res., 375, 105-115.
31. Pool-Zobel, B.L., Collins, A.R. and Rechkemmer, G. (1997) Levels of endogenous DNA damage and oxidised DNA bases in colon cells derived from biopsies of 50 non-colon cancer patients. AACR, 38, 299 (Abstract).