Potential biologic agents for treating rheumatoid arthritis

Rheumatic Disease Clinics of North America

Volumn 27, Issue 2, 2001, Pages 445-491

  Moreland, Larry W ^b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; BIOLOGICAL RESPONSE MODIFIER; CD4 ANTIGEN; CD40 ANTIGEN; COMPLEMENT INHIBITOR; CYTOKINE; CYTOKINE RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1 ANTIBODY; INTERFERON BETA SERINE; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 13; INTERLEUKIN 15; INTERLEUKIN 16; INTERLEUKIN 17; MAJOR HISTOCOMPATIBILITY ANTIGEN; MINOCYCLINE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; RECOMBINANT INTERLEUKIN 10; RECOMBINANT INTERLEUKIN 11; RECOMBINANT INTERLEUKIN 12; RECOMBINANT INTERLEUKIN 4; RECOMBINANT INTERLEUKIN 6; T LYMPHOCYTE RECEPTOR; TETRACYCLINE; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

ANGIOGENESIS; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; B LYMPHOCYTE; CHRONIC INFLAMMATION; CLINICAL TRIAL; GENE THERAPY; HUMAN; IMMUNE RESPONSE; JOINT DESTRUCTION; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; REVIEW; RHEUMATOID ARTHRITIS; SYNOVITIS; T LYMPHOCYTE;

EID: 0035001555     PISSN: 0889857X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0889-857X(05)70212-X     Document Type: Article

References (520)

1. J.R. Abrams M.G. Lebwohl C.A. Guzzo CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris J Clin Invest 103 1999 1243 1252
2. 1 disease with anti-I-A monoclonal antibodies J Exp Med 158 1983 1350 1355
3. D. Aderka J. Le J. Vilcek IL-6 inhibits lipopolysaccharide induced tumor necrosis factor production in cultured human monocytes, U937 cells, and in mice J Immunol 143 1989 3517 3523
4. L. Adorini A. Sette S. Buus Interaction of an immunodominant epitope with Ia molecules in T-cell activation Proc Natl Acad Sci USA 5 1988 5181 5185
5. S. Akira T. Taga T. Kishimoto Interleukin-6 in biology and medicine Adv Immunol 54 1993 1 78
6. J.B. Allen H.L. Wong G.L. Costa Suppression of monocyte function and differential regulation of IL-1 and IL-1ra by IL-4 contribute to resolution of experimental arthritis J Immunol 151 1993 4344 4351
7. T. Alonzi E. Fattori D. Lazzaro Interleukin 6 is required for the development of collagen-induced arthritis J Exp Med 187 1998 461 468
8. H.J. Andrews T.A. Plumpton G.P. Harper A synthetic peptide metalloproteinases inhibitor, but not TIMP, prevents the breakdown of proteoglycan within articular cartilage in vitro Agents Actions 37 1992 147 154
9. H.J. Andrews T.A. Edwards T.E. Cawston Transforming growth factor-beta causes partial inhibition of interleukin 1-stimulated cartilage degradation in vitro Biochem Biophys Res Commun 162 1989 144 150
10. W.P. Arend Interleukin-1 receptor antagonist. A new member of the interleukin family J Clin Invest 88 1991 1445 1451
11. W.P. Arend M. Malyak Smith M.F. Jr Binding of the IL-1α, IL-1β, and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors by synovial fluids J Immunol 153 1994 4766 4774
12. W.P. Arend F.G. Joslin R.C. Thompson An IL-1 inhibitor from human monocytes: Production and characterization of biologic properties J Immunol 43 1989 1851 1858
13. A.L. Arsenault S. Lhotak W.L. Hunter Taxol involution of collagen-induced arthritis: Ultrastructural correlation with the inhibition of synovitis and neovascularization Clin Immunol Immunopathol 86 1998 280 289
14. A. Aruffo CD44: One ligand, two functions J Clin Invest 98 1996 2191 2192
15. N.G. Arvidson B. Gudbjörnsson L. Elfman Circadian rhythm of serum interleukin-6 in rheumatoid arthritis Ann Rheum Dis 53 1994 521 524
16. M.G. Attur R.N. Patel S.B. Abramson Interleukin-17 up-regulation of nitric oxide production in human osteoarthritis cartilage Arthritis Rheum 40 1997 1050 1053
17. P. Bacha D.P. Williams C. Waters Interleukin-2 receptor-targeted cytotoxicity: Interleukin-2 receptor-mediated action of a diphtheria toxin-related interleukin-2 fusion protein J Exp Med 167 1988 612 622
18. A.M. Badger D.E. Griswold R. Kapadia Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritis Arthritis Rheum 43 2000 175 183
19. A.M. Badger J.N. Bradbeer B. Botta Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function J Pharmacol Exp Ther 279 1996 1453 1461
20. A.M. Badger M.N. Cook M.W. Lark SB 203580 inhibits p38 mitogen-activated protein kinase, nitric oxide production, and inducible nitric oxide synthase in bovine cartilage-derived chondrocytes J Immunol 161 1998 467 473
21. M. Baggiolini B. Dewald B. Moser Human chemokines: An update Annu Rev Immunol 15 1997 675 705
22. J. Bajorath N.J. Chalupny J.S. Marken Identification of residues on CD40 and its ligand which are critical for the receptor-ligand interaction Biochemistry 34 1995 1833 1844
23. A.C. Bakker L.A.B. Joosten O.J. Arntz Prevention of murine collagen-induced arthritis in the knee and ipsilateral paw by local expression of human interleukin-1 receptor antagonist protein in the knee Arthritis Rheum 40 1997 893 900
24. B. Balasa T. Krahl G. Patstone CD40 ligand-CD40 interactions are necessary for the initiation of insulitis and diabetes in nonobese diabetic mice J Immunol 159 1997 4620 4627
25. G. Bandara G.M. Mueller J. Galea-Lauri Intraarticular expression of biologically active interleukin-1 receptor antagonist protein by ex vivo gene transfer Proc Natl Acad Sci USA 90 1993 10764 10768
26. S. Banerjee T.M. Haqqi H.S. Luthra Possible role of Vβ T cell receptor genes in susceptibility to collagen-induced arthritis in mice J Exp Med 167 1988 532 539
27. R.E. Banks P.M. Patel P.J. Selby Interleukin 12: A new clinical player in cytokine therapy Br J Cancer 71 1995 655 659
28. D.A. Barnes J. Tse M. Kaufhold Polyclonal antibody directed against human RANTES ameliorates disease in the Lewis rat adjuvant-induced arthritis model J Clin Invest 101 1998 2910 2919
29. J.L. Baron E.P. Reich I. Visintin The pathogenesis of adoptive murine autoimmune diabetes requires an interaction between α4-integrins and vascular cell adhesion molecule-1 J Clin Invest 93 1994 1700 1708
30. B.E. Barton J.V. Jackson Protective role of interleukin 6 in the lipopolysaccharide-galactosamine septic shock model Infect Immun 61 1993 1496 1499
31. A.A. Beg D. Baltimore An essential role for NF-κB in preventing TNF-α-induced cell death Science 274 1996 782 784
32. A. Bendele G. Sennello T. McAbee Effects of interleukin 1 receptor antagonist alone and in combination with methotrexate in adjuvant arthritis rats J Rheumatol 26 1999 1225 1229
33. A. Bendele T. McAbee G. Sennello Efficacy of sustained blood levels of interleukin-1 receptor antagonist in animal models of arthritis. Comparison of efficacy in animal models with human clinical data Arthritis Rheum 42 1999 498 506
34. A. Bendrups A. Hilton A. Meager Reduction of tumor necrosis factor α and interleukin-1β levels in human synovial tissue by interleukin-4 and glucocorticoid Rheumatol Int 12 1993 217 220
35. C.F. Bennett T.P. Condon S. Grimm Inhibition of endothelial cell adhesion molecule expression with antisense oligonucleotides J Immunol 152 1995 3530 3540
36. + T-cells as a marker of disease activity in rheumatoid arthritis Ann Rheum Dis 59 2000 190 195
37. N. Bertazzolo L. Punzi M.P. Stefani Interrelationships between interleukin (IL)-1, IL-6, and IL-8 in synovial fluid of various arthropathies Agents Actions 41 1994 90 92
38. Bessis N. Boissier N.-C. P. Ferrara Attenuation of collagen-induced arthritis in mice by treatment with vector cells engineered to secrete interleukin-13 Eur J Immunol 26 1996 2399 2403
39. B. Beutler F. Bazzoni TNF, apoptosis and autoimmunity: A common thread? Blood Cells Mol Dis 24 1998 216 230
40. N. Bhardwaj U. Santhanam L.L. Lau IL-6/IFN-beta 2 in synovial effusions of patients with rheumatoid arthritis and other arthritides: Identification of several isoforms and studies of cellular sources J Immunol 143 1989 2153 2159
41. L. Bjermer R. Lundgren R. Hallgren Hyaluronan and type III procollagen peptide concentrations in bronchoalveolar lavage fluid in idiopathic pulmonary fibrosis Thorax 44 1989 126 131
42. A. Boe M. Baiocchi M. Carbonatto Interleukin 6 knock-out mice are resistant to antigen-induced experimental arthritis Cytokine 11 1999 1057 1064
43. C. Bogdan Y. Vodovotz C. Nathan Macrophage deactivation by interleukin-10 J Exp Med 174 1991 1549 1555
44. S.S. Boggs K.D. Patrene G.M. Mueller Prolonged systemic expression of human IL-1 receptor antagonist (hIL-1ra) in mice reconstituted with hematopoietic cells transduced with a retrovirus carrying the hIL-1ra cDNA Gene Ther 2 1995 632 638
45. L.J. Bonassar E.H. Frank J.C. Murray Changes in cartilage composition and physical properties due to stromelysin degradation Arthritis Rheum 38 1995 173 183
46. D.N. Bourdette R.H. Whitham Y.K. Chou Immunity to TCR peptides in multiple sclerosis. I. Successful immunization of patients with synthetic Vβ5.2 and Vβ6.1 CDR2 peptides J Immunol 152 1994 2510 2519
47. F.M. Brennan S. Allard M. Londei Heterogeneity of T cell receptor idiotypes in rheumatoid arthritis Clin Exp Immunol 73 1988 417 423
48. B. Bresnihan G. Cunnane Interleukin-1 receptor antagonist Rheum Dis Clin North Am 24 1998 615 628
49. B. Bresnihan J.M. Alvaro-Gracia M. Cobby Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist Arthritis Rheum 41 1998 2196 2204
50. C.E. Brinckerhoff Joint destruction in arthritis: Metalloproteinases in the spotlight Arthritis Rheum 34 1991 1073 1075
51. J. Briolay J. Dechanet D. Blanchard Interleukin 4 inhibits polyclonal immunoglobulin secretion and cytokine production by peripheral blood mononuclear cells from rheumatoid arthritis patients J Clin Immunol 12 1992 36 44
52. B.M. Bröker U. Korthäuer P. Heppt Biased T cell receptor V gene usage in rheumatoid arthritis: Oligoclonal expansion of T-cells expressing Vα2 genes in synovial fluid but not in peripheral blood Arthritis Rheum 36 1993 1234 1243
53. M. Brozik I. Rosztoczy K. Meretey Interleukin-6 levels in synovial fluids of patients with different arthritides: Correlation with local IgM rheumatoid factor and systemic acute phase protein production J Rheumatol 19 1992 63 68
54. A. Bucht J.R. Oksenberg S. Lindblad Characterization of T-cell receptor αβ repertoire in synovial tissue from different temporal phases of rheumatoid arthritis Scand J Immunol 35 1992 159 165
55. J.E. Buhlmann R.J. Noelle Therapeutic potential for blockade of the CD40 ligand gp39 J Clin Immunol 16 1996 83 89
56. F. Burns M.S. Stack M.S. Gray Inhibition of purified collagenase from alkaline-burned rabbit corneas Invest Ophthalmol Vis Sci 30 1989 1569 1575
57. D.M. Butler A.M. Malfait R.N. Maini Anti-IL-12 and anti-TNF antibodies synergistically suppress the progression of murine collagen-induced arthritis Eur J Immunol 29 1999 2205 2212
58. S. Buus O. Werdelin Oligopeptide antigens of the angiotensin lineage compete for presentation by paraformaldehyde-treated accessory cells to T-cells J Immunol 136 1986 459 465
59. S. Buus A. Sette S.M. Colon The relation between major histocompatibility complex (MHC) restriction and the capacity of Ia to bind immunogenic peptides Science 235 1987 1353 1358
60. R.L. Camp A. Scheynius C. Johansson CD44 is necessary for optimal contact allergic responses but is not required for normal leukocyte extravasation J Exp Med 178 1993 497 507
61. G.V. Campion M.E. Lebsack J. Lookabaugh Dose-range and dose-frequency study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis Arthritis Rheum 39 1996 1092 1101
62. G.W. Cannon S.H. Pincus R.D. Emkey Double-blind trial of recombinant gamma-interferon versus placebo in the treatment of rheumatoid arthritis Arthritis Rheum 32 1989 964 973
63. G.W. Cannon D.A. Marble M.M. Griffiths Immunologic assessment during treatment of rheumatoid arthritis with anti-CD5 immunoconjugate J Rheumatol 22 1995 207 213
64. G.W. Cannon R.D. Emkey A. Denes Prospective 5-year follow-up of recombinant interferon gamma in rheumatoid arthritis J Rheumatol 20 1993 1867 1873
65. M.J. Cantwell T. Hua N.J. Zvaifeler Deficient Fas ligand expression by synovial lymphocytes from patients with rheumatoid arthritis Arthritis Rheum 40 1997 1644 1652
66. D.F. Carmichael G.P. Stricklin J.M. Stuart Systemic administration of TIMP in the treatment of collagen-induced arthritis in mice Agents Actions 27 1989 378 379
67. W.M. Carr S.J. Roth E. Luther Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant Proc Natl Acad Sci USA 91 1994 3652 3656
68. D.A. Carson Unconventional T-cell activation by IL-15 in rheumatoid arthritis Nat Med 3 1997 148 149
69. D.B. Carter M.R. Deibel C.J. Dunn Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein Nature 344 1990 633 638
70. + cells J Immunol 140 1988 713 716
71. N.L. Carteron C.L. Schimenti D. Wofsy Treatment of murine lupus with F(ab')2 fragments of monoclonal antibody to L3T4: Suppression of autoimmunity does not depend on T helper cell depletion J Immunol 142 1989 1470 1475
72. M.A. Cassatella L. Meda S. Bonora Interleukin (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role of tumor necrosis factor and IL-1 beta in mediating the production of IL-8 triggered by lipopolysaccharide J Exp Med 178 1993 2207 2211
73. M.A. Cassatella L. Meda S. Gasperini Interleukin 10 (IL-10) upregulates IL-1 receptor antagonist production from lipopolysaccharide-stimulated human polymorphonuclear leukocytes by delaying mRNA degradation J Exp Med 179 1994 1695 1699
74. T. Cawston Proteinases and inhibitors Br Med Bull 51 1995 385 401
75. D.M. Center J. Kornfeld W.W. Cruikshank Interleukin 16 and its function as a CD4 ligand Immunol Today 17 1996 476 481
76. M. Chabaud J.M. Durand N. Buchs Human interleukin-17. A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium Arthritis Rheum 42 1999 963 970
77. M. Chabaud F. Fossiez Taupin J.-L. Enhancing effect of IL-17 on IL-1-induced IL-6 and leukemia inhibitory factor production by rheumatoid arthritis synoviocytes and its regulation by Th2 cytokines J Immunol 161 1998 409 414
78. K.M. Chang N.S. Ramamurthy T.F. McNamara Tetracyclines inhibit Porphyromonas gingivalis induced alveolar bone loss in rats by a non-antimicrobial mechanism J Periodontal Res 29 1994 242 249
79. W.F. Chen A. Zlotnick IL-10—a novel cytotoxic T-cell differentiation J Immunol 147 1991 528 534
80. Y. Chernajovsky G. Adams O.L. Podhajcer Inhibition of transfer of collagen-induced arthritis into SCID mice by ex vivo infection of spleen cells with retroviruses expressing soluble tumor necrosis factor receptor Gene Ther 2 1995 731 735
81. G. Chiocchia M.C. Boissier C. Fournier Therapy against murine collagen-induced arthritis with T-cell receptor Vβ specific antibodies Eur J Immunol 21 1991 2899 2905
82. P. Chomarat J. Banchereau P. Miossec Differential effects of interleukins 10 and 4 on the production of interleukin-6 by blood and synovium monocytes in rheumatoid arthritis Arthritis Rheum 38 1995 1046 1054
83. P. Chomarat E. Vannier J. Dechanet Balance of IL-1 receptor antagonist/IL-1β in rheumatoid synovium and its regulation by IL-4 and IL-10 J Immunol 154 1995 1432 1439
84. S.D. Clark D.K. Kobayashi H.G. Welgus Regulation of the expression of tissue inhibitor of metalloproteinases and collagenase by retinoids and glucocorticoids in human fibroblasts J Clin Invest 80 1987 1280 1288
85. S. Cohen E. Hurd J.J. Cush Treatment of interleukin-1 receptor antagonist in combination with methotrexate (MTX) in rheumatoid arthritis (RA) patients [abstract] Arthritis Rheum 42 suppl 1999 S277
86. C.B. Cohick D.E. Furst S. Quagliata Analysis of elevated serum interleukin-6 levels in rheumatoid arthritis: Correlation with erythrocyte sedimentation rate or C-reactive protein J Lab Clin Med 123 1994 721 727
87. B. Combe B. Cosso J. Clot Human placenta-eluted gammaglobulins in immunomodulating treatment of rheumatoid arthritis Am J Med 78 1985 920 928
88. K. Connolly J.R. Roubinian D. Wofsy Development of murine lupus in CD4 depleted NZB/NZW mice: Sustained inhibition of residual CD4+ T-cells is required to suppress autoimmunity J Immunol 149 1992 3083 3088
89. S.M. Cooper D.L. Dier K.D. Roessner Diversity of rheumatoid synovial tissue T-cells by T cell receptor analysis: Oligoclonal expansion in interleukin-2 responsive cells Arthritis Rheum 34 1991 537 546
90. S.M. Cooper K.D. Roessner M. Naito-Hoopes Increased usage of Vβ2 and Vβ6 in rheumatoid synovial fluid T-cells Arthritis Rheum 37 1994 1627 1636
91. M.L. Corcoram W.G. Stetler-Stevenson P.D. Brown Interleukin-4 inhibition of prostaglandin E2 synthesis blocks interstitial collagenase and 92-kda type IV collagenase/gelatinase production by human monocytes J Biol Chem 267 1992 515 519
92. F. Cornelis L. Hardwick R.M. Flipo Association of rheumatoid arthritis with an amino acid allelic variation of the T cell receptor Arthritis Rheum 40 1997 1387 1390
93. D.E. Cressman L.E. Greenbaum R.A. DeAngelis Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice Science 274 1996 1379 1383
94. W.W. Cruikshank D.M. Center N. Nisar Molecular and functional analysis of a lymphocyte chemoattractant factor: Association of biologic function with CD4 expression Proc Natl Acad Sci USA 91 1994 5109 5113
95. J.J. Cush J.B. Splawski R. Thomas Elevated interleukin-10 levels in patients with rheumatoid arthritis Arthritis Rheum 38 1994 96 104
96. S.K. Datta S.L. Kalled CD40-CD40 ligand interaction in autoimmune disease Arthritis Rheum 40 1997 1735 1745
97. M. Davey D.D. Munkirs Patterns of T-cell receptor variable β gene expression by synovial fluid and peripheral blood T-cells in rheumatoid arthritis Clin Immunol Immunopathol 68 1993 79 87
98. L.S. Davis A.F. Kavanaugh L.A. Nichols Induction of persistent T cell hyporesponsiveness in vivo by monoclonal antibody to ICAM-1 in patients with rheumatoid arthritis J Immunol 154 1995 3525 3537
99. Dayer J.-M. de Rochemonteix B. B. Burrus Human recombinant interleukin-1 stimulates collagenase and prostaglandin E2 production by human synovial cells J Clin Invest 77 1986 645 648
100. De Keyser F. D. Elewaut J.P.M. Overmeer-Graus Dominant T cell receptor rearrangements in interleukin 2 expanded lymphocytes from rheumatoid nodules suggest antigen driven T cell activation in situ J Rheumatol 24 1997 1685 1689
101. de Waal M.R. P. Chomarat E. Vannier Balance of IL-1 receptor antagonist/IL-1B in rheumatoid synovium in its regulation by IL-4 and IL-10 J Immunol 154 1995 1432 1439
102. de Waal Malefyt R. C.G. Figdor R. Huijbens Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes. Comparison with IL-4 and modulation by IFN-gamma or IL-10 J Immunol 151 1993 6370 6381
103. J. Dechavet J. Briolay Rissoan M.-C. IL-4 inhibits growth factor-stimulated rheumatoid synoviocyte proliferation by blocking the early phases of the cell cycle J Immunol 151 1993 4908 4917
104. B. Deleuran L. Iversen M. Kristensen Interleukin-8 secretion and 15-lipoxygenase activity in rheumatoid arthritis: In vitro anti-inflammatory effects by interleukin-4 and interleukin-10, but not by interleukin-1 receptor antagonist protein Br J Rheumatol 33 1994 520 525
105. Der Simonian H. M. Sugita D.N. Glass Clonal Vα12.1+ T cell expansions in the peripheral blood of rheumatoid arthritis patients J Exp Med 177 1993 1623 1631
106. A. Desai-Mehta L. Lu R. Ramsey-Goldman Hyperexpression of CD40 ligand by B and T-cells in human lupus and its role in pathogenic autoantibody production J Clin Invest 97 1996 2063 2073
107. C.A. Dinarello Interleukin-1 and interleukin-1 antagonism Blood 77 1991 1627 1652
108. P.J. Doherty S.X. Yang R.M. Laxer Evidence for clonal expansion of T cell receptor VγII+ T-cells in the synovial fluid of patients with rheumatoid arthritis J Immunol 149 1992 295 299
109. R.P. Donnelly L.J. Crofford S.L. Freeman Tissue-specific regulation of IL-6 production by Il-4. Differential effects of IL-4 on nuclear factor-κB activity in monocytes and fibroblasts J Immunol 151 1993 5603 5612
110. S.K. Dower J. Wignall K. Schooley Retention of ligand binding activity by the extracellular domain of the IL-1 receptor J Immunol 142 1989 4314 4320
111. B. Drevlow J. Capezio R. Lovis Phase I study of recombinant human interleukin-1 receptor (rhu IL-1R) administered intra-articularly in active rheumatoid arthritis [abstract] Arthritis Rheum 36 suppl 1993 S39
112. B.E. Drevlow R. Lovis M.A. Haag Recombinant human interleukin-1 receptor, type I (rhuIL-1RI) in the treatment of patients with active rheumatoid arthritis Arthritis Rheum 39 1995 257 265
113. A.D. Duby A.K. Sinclair S.L. Osborne-Lawrence Clonal heterogeneity of synovial fluid T lymphocytes from patients with rheumatoid arthritis Proc Natl Acad Sci USA 86 1989 6206 6210
114. F.H. Durie A. Aruffo J. Ledbetter Antibody to the ligand of CD40, gp39, blocks the occurrence of the acute and chronic forms of graft-vs-host disease J Clin Invest 94 1994 1333 1338
115. F.H. Durie R.A. Fava T.M. Foy Prevention of collagen-induced arthritis with an antibody to gp39, the ligand for CD40 Science 261 1993 1328 1330
116. Dustin M.L. A.S. Shaw Costimulation: Building an immunological synapse Science 283 1999 649 650
117. D.R. Edwards G. Murphy J.J. Reynolds Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor EMBO J 6 1987 1899 1904
118. S.P. Eisenberg R.J. Evans W.P. Arend Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist Nature 343 1990 336 340
119. B.P. Eliceiri D.A. Cheresh The role of αv integrins during angiogenesis: Insights into potential mechanisms of action and clinical development J Clin Invest 103 1999 1227 1230
120. A.J. Ellis V.A. Curry E.K. Powell The prevention of collagen breakdown in bovine nasal cartilage by TIMP, TIMP-2 and low molecular weight synthetic inhibitor Biochem Biophys Res Commun 201 1994 94 101
121. H. Endo T. Akahoshi A. Nishimura Experimental arthritis induced by continuous infusion of IL-8 into rabbit knee joints Clin Exp Immunol 96 1994 31 35
122. C. Evans P.D. Robbins Prospects for treating arthritis by gene therapy J Rheumatol 21 1994 779 782
123. C.H. Evans S.C. Ghivizzani R. Kang Gene therapy for rheumatic diseases Arthritis Rheum 42 1999 1 16
124. D.A. Faherty V. Claudy J. Plocinski Failure of IL-1 receptor antagonist and monoclonal anti-IL-1 receptor antibody to inhibit antigen-specific immune responses in vivo J Immunol 148 1992 766 771
125. R.A. Fava V.J. Olsen G. Spencer-Green Vascular permeability factor/endothelial growth factor (VPF/VEGF). Accumulation and expression in human synovia fluids and rheumatoid synovial tissue J Exp Med 184 1994 341 346
126. D.T. Felson J.J. Anderson M. Boers The American College of Rheumatology preliminary core set of disease activity measures for rheumatoid arthritis clinical trials Arthritis Rheum 36 1993 729 740
127. M. Field C. Chu M. Feldman Interleukin-6 localisation in the synovial membrane in rheumatoid arthritis Rheumatol Int 11 1991 45 50
128. 1 mice J Clin Invest 94 1994 585 591
129. B.K. Finck P.S. Linsley D. Wofsy Treatment of murine lupus with CTLA4-Ig Science 265 1994 1225 1227
130. U. Fiocco L. Cozzi E. Cozzi Treatment of rheumatoid arthritis by murine antiidiotypic monoclonal antibodies to a syngeneic anti-HLA class II monoclonal antibody Br J Rheumatol 30 suppl 1991 90 94
131. D.F. Fiorentino A. Zlotnik T.R. Mosmann IL-10 inhibits cytokine production by activated macrophages J Immunol 147 1991 3815 3822
132. G.S. Firestein Novel therapeutic strategies involving animals, arthritis, and apoptosis Curr Opin Rheumatol 10 1998 236 241
133. G.S. Firstein M. Yeo N.J. Zvaifler Apoptosis in rheumatoid arthritis synovium J Clin Invest 96 1995 1631 1638
134. G.S. Firestein M.M. Paine B.H. Littman Gene expression (collagenase, tissue inhibitor of metalloproteinases, complement, and HLA-DR) in rheumatoid arthritis and osteoarthritis synovium: Quantitative analysis and effect of intraarticular corticosteroids Arthritis Rheum 34 1991 1094 1105
135. G.S. Firestein M.M. Paine D.L. Boyle Mechanisms of methotrexate action in rheumatoid arthritis. Selective decrease in synovial collagenase gene expression Arthritis Rheum 37 1994 193 200
136. G.S. Firestein D.L. Boyle C. Yu Synovial interleukin-1 receptor antagonist and interleukin-1 balance in rheumatoid arthritis Arthritis Rheum 37 1994 644 652
137. β transcripts in synovial fluid T-cells in early stages of rheumatoid arthritis Arthritis Rheum 39 1996 454 462
138. D.M. Fishwald V. Strand Administration of an anti-CD5 immunoconjugate to patients with rheumatoid arthritis: Effect on peripheral blood mononuclear cells and in vitro immune function J Rheumatol 21 1994 596 604
139. Forre O. The Norwegian Arthritis Study Group Radiologic evidence of disease modification in rheumatoid arthritis treated with cyclosporine. Results of a 48-week multicenter study comparing low-dose cyclosporine with placebo Arthritis Rheum 37 1994 1506 1512
140. F. Fossiez O. Djossou P. Chomarat T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines J Exp Med 183 1996 2593 2603
141. T.M. Foy D.M. Shepherd F.H. Durie In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD4, gp39 J Exp Med 178 1993 1567 1575
142. K. Fujii Y. Tanaka S. Hubscher Cross-linking of CD44 on rheumatoid synovial cells up-regulates VCAM-1 J Immunol 162 1999 2391 2398
143. Y. Fujisawa H. Asahara K. Okamoto Therapeutic effect of the anti-fas antibody on arthritis in HTLV-1 tax transgenic mice J Clin Invest 98 1996 271 278
144. A. Gaur R. Haspal J.P. Mayer Requirement for CD8+ cells in T cell receptor peptide-induced clonal unresponsiveness Science 259 1993 91 94
145. A.M. Gautam C.I. Pearson A.A. Sinha Inhibition of experimental autoimmune encephalomyelitis by a nonimmunogenic non-self peptide that binds to I-A J Immunol 148 1991 3049 3054
146. R.T. Gazzinelli I.P. Oswald S.L. James IL-10 inhibits parasite killing and nitric oxide production by IFN-gamma activated monocytes J Immunol 48 1992 1792 1796
147. T. Geiger H. Towbin A. Cosenti-Vargas Neutralization of interleukin-1β activity in vivo with a monoclonal antibody alleviates collagen-induced arthritis in DBA/1 mice and prevents the associated acute phase response Clin Exp Rheumatol 11 1993 515 522
148. L. Genestier R. Paillot S. Fournel Immunosuppressive properties of methotrexate: Apoptosis and clonal deletion of activated peripheral T-cells J Clin Invest 102 1998 322 328
149. C. Gérard C. Bruyns A. Marchant Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia J Exp Med 177 1993 547 550
150. T. Germann J. Szeliga H. Hess Administration of interleukin 12 in combination with type II collagen induces severe arthritis in DBA/l mice Proc Natl Acad Sci USA 92 1995 4823 4827
151. S.C. Ghivizzani R. Kang T. Muzzonigro Gene therapy for arthritis—treatment of the first three patients [abstract] Arthritis Rheum 40 1997 S223
152. K. Gijbels R.E. Galardy L. Steinman Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases J Clin Invest 94 1994 2177 2182
153. N.F. Go B.E. Castle R. Barrett Interleukin-10, a novel B-cell stimulatory factor. Unresponsiveness of x-chromosome-linked immunodeficiency B-cells J Exp Med 175 1990 671 682
154. L.M. Golub T. Sorsa Lee H.-M. Doxycycline inhibits neutrophil (PMN)-type matrix metalloproteinases in human adult periodontitis gingiva J Clin Periodontol 22 1995 100 109
155. R.M. Goodfellow A.S. Williams J.L. Levin Local therapy with soluble complement receptor 1 (sCR1) suppresses inflammation in rat mono-articular arthritis Clin Exp Immunol 110 1997 45 52
156. D.E. Goodkin Interferon β-1b Lancet 344 1994 1057 1060
157. R.G. Goodwin C.A. Smith The trail of death Apoptosis 3 1998 83 88
158. J.L. Gordon A.H. Drummond W.A. Galloway Metalloproteinase inhibitors as therapeutics Clin Exp Rheumatol 11 suppl 1993 S91 S94
159. J.J. Goronzy P. Bartz-Bazzanella W. Hu Dominant clonotypes in the repertoire of peripheral CD4+ T-cells in rheumatoid arthritis J Clin Invest 94 1994 2068 2076
160. R.A. Greenwald L.M. Golub B. Lavietes Tetracyclines inhibit human synovial collagenase in vivo and in vitro J Rheumatol 14 1987 28 32
161. r mice Autoimmunity 14 1993 221 229
162. A.A. Grom S.D. Thompson L. Luyrink Dominant T-cell receptor β chain variable region Vβ14+ clones in juvenile rheumatoid arthritis Proc Natl Acad Sci USA 90 1993 1104 1108
163. Guerne P.-A. D.A. Carson M. Lotz IL-6 production by human articular chondrocytes. Modulation of its synthesis by cytokines, growth factors, and hormones in vitro J Immunol 144 1990 499 505
164. F. Gunha S. Moncada F. Liew Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by IFN-gamma in murine macrophages Biochem Biophys Res Commun 182 1992 1155 1159
165. K. Gustafsson M. Karlsson L. Anderson Structures on the I-A molecule predisposing for susceptibility to type II collagen-induced autoimmune arthritis Eur J Immunol 20 1990 2127 2131
166. N.L. Gutstein D. Wofsy Administration of F(ab')2 fragments of monoclonal antibody to L3T4 inhibits humoral immunity in mice without depleting L3T4+ cells J Immunol 37 1986 3414 3419
167. B. Hahn F.M. Ebling Suppression of murine lupus nephritis by administration of an anti-idiotypic antibody to anti-DNA J Immunol 132 1984 187 190
168. T. Hanafusa L. Chiovato D. Doniach Aberrant expression of HLA-DR antigen on thyrocytes in Grave's disease: Relevance for autoimmunity Lancet 2 1983 1111 1115
169. C.H. Hannum C.J. Wilcox W.P. Arend Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor Nature 343 1990 341 346
170. T.T.M. Hao T. Hasunuma H. Aono Novel mechanisms of selective apoptosis in synovial T-cells of patients with rheumatoid arthritis J Rheumatol 23 1996 1332 1337
171. M. Harigai M. Hara S. Nakazawa Ligation of CD40 induced tumor necrosis factor-α in rheumatoid arthritis: A novel mechanism of activation of synoviocytes J Rheumatol 26 1999 1035 1043
172. E.D. Harris Rheumatoid arthritis. Pathophysiology and implications for therapy N Engl J Med 322 1990 1277 1289
173. P.H. Hart G.F. Vitti D.R. Burgess Potential antiinflammatory effects of interleukin 4: Suppression of human monocyte tumor necrosis factor α, interleukin-1 and prostaglandin E2 Proc Natl Acad Sci USA 86 1989 3803 3807
174. P.H. Hart M.J. Ahern C.A. Jones Synovial fluid macrophages and blood monocytes differ in their responses to IL-4 J Immunol 151 1993 3370 3380
175. P.H. Hart E.K. Hunt C.S. Bonder Regulation of surface and soluble TNF receptor expression on human monocytes and synovial fluid macrophages by IL-4 and IL-10 J Immunol 157 1996 3672 3680
176. G.A. Hashim A.A. Vandenbark A.B. Galang Antibodies specific for VB8 receptor peptide suppress experimental autoimmune encephalomyelitis J Immunol 144 1990 462 467
177. A. Hashiramoto H. Sano T. Maekawa C- MYC antisense oligodeoxynucleotides can induce apoptosis and down-regulate Fas expression in rheumatoid synoviocytes Arthritis Rheum 42 1999 954 962
178. T. Hasunuma N. Kayagaki H. Asahara Accumulation of soluble Fas in inflamed joints of patients with rheumatoid arthritis Arthritis Rheum 40 1997 80 86
179. M. Helle L. Boeije de Groot E. Sensitive ELISA for interleukin-6. Detection of IL-6 in biological fluids: Synovial fluids and sera J Immunol Methods 138 1991 47 56
180. B.R.C. Henderson T. Thompson T. Hardingham Inhibition of interleukin-1 induced synovitis and articular cartilage proteoglycan loss in the rabbit knee by recombinant human interleukin-1 receptor antagonist Cytokine 3 1991 246 249
181. P. Hensley P.J. McDevitt J. Brooks The soluble form of E-selectin is an asymmetric monomer. Expression, purification, and characterization of the recombinant protein J Biol Chem 269 1994 23949 23958
182. J.A. Hermann M.A. Hall R.N. Maini Important immunoregulatory role of interleukin-11 in the inflammatory process in rheumatoid arthritis Arthritis Rheum 41 1998 1388 1397
183. C. Herzog C. Walker W. Muller Anti-CD4 antibody treatment of patients with rheumatoid arthritis: I. Effect on clinical course and circulating T-cells J Autoimmun 2 1989 267 282
184. T. Hidaka A. Kitani M. Hara IL-4 down-regulates the surface expression of CD5 on B cells and inhibits spontaneous immunoglobulin and IgM rheumatoid factor production in patients with rheumatoid arthritis Clin Exp Immunol 89 1992 223 229
185. T.T.M. Hoa T. Hasunuma H. Aono Novel mechanisms of selective apoptosis in synovial T-cells of patients with rheumatoid arthritis J Rheumatol 23 1996 1332 1337
186. R. Holmdahl L. Klareskog K. Rubin T lymphocytes in collagen II induced arthritis in mice: Characterization of arthrogenic collagen II-specific T cell lines and clones Scand J Immunol 22 1985 295 306
187. J. Holoshitz H. Matitian I.R. Cohen Arthritis induced in rats by cloned T lymphocytes responsive to mycobacteria J Clin Invest 73 1984 211 215
188. J.T. Hom T. Estridge H. Cole Effects of various anti-T-cell receptor antibodies on the development of type II collagen-induced arthritis in mice Immunol Invest 22 1993 257 265
189. R. Horai S. Saijo H. Tanioka Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice J Exp Med 191 2000 313 320
190. G. Horneff G.R. Burnmester F. Emmrich Treatment of rheumatoid arthritis with an anti-CD4 monoclonal antibody Arthritis Rheum 34 1991 129 140
191. Houssiau F.A. Devogelaer J.-P. Van Damme J. Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides Arthritis Rheum 31 1988 784 788
192. L.M. Howard A.J. Miga C.L. Vanderlugt Mechanisms of immunotherapeutic intervention by anti-CD40L (CD154) antibody in an animal model of multiple sclerosis J Clin Invest 103 1999 281 290
193. M.D. Howell J.P. Diveley K.A. Lundeen Limited T-cell receptor B-chain heterogeneity among interleukin 2 receptor-positive synovial T-cells suggests a role for superantigen in rheumatoid arthritis Proc Natl Acad Sci USA 88 1991 10921 10925
194. C.S. Hsieh A.B. Heimberger J.S. Gold Differential regulation of T helper phenotype development by interleukins 4 and 10 in an αβ T-cell receptor transgenic system Proc Natl Acad Sci USA 89 1992 6065 6069
195. U. Hurtenbach E. Lier L. Adorini Prevention of autoimmune diabetes in non-obese diabetic mice by treatment with a class II major histocompatibility complex-binding peptide J Exp Med 177 1993 1499 1504
196. W. Hylton C. Smith-Burchnell B.K. Pelton Polyclonal origin of rheumatoid synovial T-lymphocytes Br J Rheumatol 31 1992 55 57
197. Y. Ikeda K. Masuko Y. Nakai High frequencies of identical T cell clonotypes in synovial tissues of rheumatoid arthritis patients suggest the occurrence of common antigen-driven immune responses Arthritis Rheum 39 1996 446 453
198. J.D. Isaacs V.K. Manna N. Rapson CAMPATH-1H in rheumatoid arthritis—an intravenous dose-ranging study Br J Rheumatol 35 1996 231 240
199. P. Isomaki R. Luukkainen R. Saario Interleukin-10 functions as an antiinflammatory cytokine in rheumatoid synovium Arthritis Rheum 39 1996 386 395
200. P. Isomaki R. Luukkainen P. Toivanen The presence of interleukin-13 in rheumatoid synovium and its antiinflammatory effects on synovial fluid macrophages from patients with rheumatoid arthritis Arthritis Rheum 39 1996 1693 1702
201. J.D. Issacs R.A. Watts B.L. Hazleman Humanized monoclonal antibody therapy for rheumatoid arthritis Lancet 340 1992 748 752
202. A. Ito Y. Itoh Y. Sasaguri Effects of interleukin-6 on the metabolism of connective tissue components in rheumatoid synovial fibroblasts Arthritis Rheum 35 1992 1197 1201
203. Y. Iwakura M. Tosu E. Yoshida Induction of inflammatory arthropathy resembling rheumatoid arthritis in mice transgenic for HTLV-1 Science 253 1991 1026 1028
204. J.A. Jabaily Effects of interferon β-1B in rheumatoid arthritis: A case report [letter] Arthritis Rheum 40 1997 1370
205. J.R. Jackson B. Bolognese L. Hillegass Pharmacological effects of SB 220025, a selective inhibitor of P38 mitogen-activated protein kinase, in angiogenesis and chronic inflammatory disease models J Pharmacol Exp Ther 284 1998 687 692
206. C.O. Jacob J. Holoshitz van der Meide P. Heterogeneous effects of IFN-gamma in adjuvant arthritis J Immunol 142 1989 1500 1505
207. R.I. Jain L.W. Moreland J.R. Caldwell A single dose, placebo controlled, double blind, phase I study of the humanized h5G1.1 in patients with rheumatoid arthritis [abstract] Arthritis Rheum 42 1999 S77
208. M.C. Jendro T. Ganten E.L. Matteson Emergence of oligoclonal T cell populations following therapeutic T cell depletion in rheumatoid arthritis Arthritis Rheum 38 1995 1242 1251
209. J.K. Jenkins M. Malyak W.P. Arend The effects of interleukin-10 on interleukin-1 receptor antagonist and interleukin-1 beta production in human monocytes and neutrophils Lymphokine Cytokine Research 13 1994 47 54
210. R.N. Jenkins A. Nikaein A. Zimmermann T cell receptor Vβ gene bias in rheumatoid arthritis J Clin Invest 2 1993 2688 2701
211. Y. Jiang H.K. Genant I. Watt A multicenter, double-blind, dose-ranging, randomized, placebo-controlled study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis Arthritis Rheum 43 2000 1001 1009
212. L.A.B. Joosten E. Lubberts M.M.A. Helsen Dural role of IL0-12 in early and late stages of murine collagen type II arthritis J Immunol 159 1997 4094 4102
213. C. Jorgensen F. Apparailly I. Couret Interleukin-4 and interleukin-10 are chondroprotective and decrease mononuclear cell recruitment in human rheumatoid synovium in vivo Immunology 93 1998 518 523
214. C. Jorgensen F. Apparailly F. Canovas Systemic viral interleukin-10 gene delivery prevents cartilage invasion by human rheumatoid synovial tissue engrafted in SCID mice Arthritis Rheum 42 1999 678 685
215. D.V. Jovanovic J.A. BiBattista J. Martel-Pelletier IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages J Immunol 160 1998 3513 3521
216. D.A. Joyce D. Gibbons P. Green Two inhibitors of proinflammatory cytokine release. IL-10 and IL-4 have contrasting effects on release of soluble p75 TNF receptor by cultured monocytes Eur J Immunol 24 1994 2699 2705
217. C.H. June J.A. Bluestone L.M. Nadler The B7 and CD28 receptor families Immunol Today 15 1994 321 331
218. K. Kakimoto M. Katsuki T. Hirofuji Isolation of T-cell line capable of protecting mice against collagen-induced arthritis J Immunol 140 1988 78 83
219. 1 mice with established nephritis: Preservation of kidney function J Immunol 160 1998 2158 2165
220. R.A. Kandel M. Petelycky C.A. Dinarello Comparison of the effect of interleukin-6 and interleukin-1 on collagenase and proteoglycan production by chondrocytes J Rheumatol 17 1990 953 957
221. J. Karsh J.H. Klippel P.H. Plotz Lymphapheresis in rheumatoid arthritis, a randomized trial Arthritis Rheum 24 1981 867 873
222. T. Kasama J. Yamazaki R. Hanaoka Biphasic regulation of the development of murine type II collagen-induced arthritis by interleukin-12 Arthritis Rheum 42 1999 100 109
223. T. Kasama R.M. Strieter N.W. Lukacs Interferon gamma modulates the expression of neutrophil-derived chemokines J Invest Med 43 1995 58 67
224. P.D. Katsikis C.Q. Chu F.M. Brennan Immunoregulatory role of interleukin-10 in rheumatoid arthritis J Exp Med 179 1994 1517 1527
225. A.F. Kavanaugh L.S. Davis R.I. Jain A phase I/II open label study of the safety and efficacy of an anti-ICAM-1 (intercellular adhesion molecule-1; CD54) monoclonal antibody in early rheumatoid arthritis J Rheumatol 23 1996 1338 1344
226. A.F. Kavanaugh H. Schulze-Koops L.S. Davis Repeat treatment of rheumatoid arthritis patients with a murine anti-intercellular adhesion molecular 1 monoclonal antibody Arthritis Rheum 40 1997 849 853
227. A.F. Kavanaugh L.S. Davis L.A. Nichols Treatment of refractory rheumatoid arthritis with a monoclonal antibody to intercellular adhesion molecule 1 Arthritis Rheum 37 1994 992 999
228. A. Kawakami K. Eguchi N. Matsuoka Inhibition of Fas antigen-mediated apoptosis of rheumatoid arthritis synovial cells in vitro by transforming growth factor β1 Arthritis Rheum 39 1996 1267 1276
229. S. Kawamura H. Miyahara U. Esaki Restricted TCR Vα repertoire in the T cell response to a tolerogenic determinant of type II collagen J Immunol 158 1997 6013 6018
230. E.C. Keystone M. Minden R. Klock Structure of T cell antigen receptor β chain genes in synovial fluid cells from patients with rheumatoid arthritis Arthritis Rheum 31 1988 1555 1557
231. T. Kieber-Emmons Q. Fang W. Cai Structural motifs in rheumatoid T-cell receptors DNA Cell Biol 17 1998 133 149
232. A.D. Kirk L.C. Burkly D.S. Batty Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates Nat Med 5 1999 686 693
233. P.A. Klimiuk J.J. Goronzy Weynand CM: IL-16 as an anti-inflammatory cytokine in rheumatoid synovitis J Immunol 162 1999 4393 4399
234. M. Kloppenburg F.C. Breedveld J.P. Terwiel Minocycline in active rheumatoid arthritis: A double-blind, placebo-controlled trial Arthritis Rheum 37 1994 629 636
235. D.B. Knoerzer R.W. Karr B.D. Schwartz Collagen-induced arthritis in the BB rat: Prevention of disease by treatment with CTLA-4-Ig J Clin Invest 96 1995 987 993
236. T. Kobayashi K. Okamoto T. Kobata Apomodulation as a novel therapeutic concept for the regulation of apoptosis in rheumatoid synoviocytes Curr Opin Rheumatol 11 1999 188 193
237. T. Kobayashi K. Okamoto T. Kobata Tumor necrosis factor α regulation of the Fas-mediated apoptosis-signaling pathway in synovial cells Arthritis Rheum 42 1999 519 526
238. A.E. Koch Angiogenesis; Implications for rheumatoid arthritis Arthritis Rheum 41 1998 951 962
239. A.E. Koch S.L. Kunkel S.W. Chensue Expression of interleukin-1 and interleukin-1 receptor antagonist by human rheumatoid synovial tissue macrophages Clin Immunol Immunopathol 65 1992 23 29
240. A.E. Koch P.J. Polverini S.L. Kunkel Interleukin-8 as a macrophage-derived mediator of angiogenesis Science 258 1992 1798 1801
241. A.E. Koch S.L. Kunkel J.C. Burrows Synovial tissue macrophage as a source of the chemotactic cytokine IL-8 J Immunol 147 1991 2187 2195
242. A.E. Koch L.A. Harlow G.K. Haines Vascular endothelial growth factor: A cytokine modulating endothelial function in rheumatoid arthritis J Immunol 152 1994 4149 4158
243. W.J. Koopman S. Gay Do nonimmunologically mediated pathways play a role in the pathogenesis of rheumatoid arthritis? Rheum Dis Clin North Am 19 1993 107 122
244. U. Korthauer B. Hennerkes H. Menninger Oligoclonal T-cells in rheumatoid arthritis: Identification strategy and molecular characterization of a clonal T-cell receptor Scand J Immunol 36 1992 855 863
245. M. Koshy D. Berger M.K. Crow Increased expression of CD40 ligand on systemic lupus erythematosus lymphocytes J Clin Invest 98 1996 826 837
246. G.L. Kotzin J. Kappler Targeting the T cell receptor in rheumatoid arthritis Arthritis Rheum 41 1998 1906 1910
247. G. Kramar S. Schurmans T. Aguado Anti-Ia treatment prevents lupus-like autoimmune syndrome in mice neonatally tolerized to alloantigens J Autoimmun 6 1993 27 37
248. T. Kraus A. Mehrabi J. Arnold Evaluation of soluble tumor necrosis factor receptors with orthotopic liver transplantation Transplant Proc 24 1992 2539 2541
249. U. Krawinkel G. Pluschke T cell receptor variable region repertoire in lymphocytes from rheumatoid arthritis patients Immunobiology 185 1992 483 491
250. G. Ku T. Faust L.L. Lauffer Interleukin-1β converting enzyme inhibition blocks progression of type II collagen-induced arthritis in mice Cytokine 8 1996 377 386
251. V.K. Kuchroo M.P. Das J.A. Brown B7-1 and B7-2 costimulatory molecules activate differentially the TH1/TH2 developmental pathways: Application to autoimmune disease therapy Cell 80 1995 707 718
252. A. Kuhröber R. Schirmbeck J. Reimann Vaccination with T cell receptor peptides primes anti-receptor cytotoxic T lymphocytes (CTL) and anergizes T-cells specifically recognized by these CTL Eur J Immunol 24 1994 1172 1180
253. V. Kumar E.E. Sercarz The involvement of T cell receptor peptide-specific regulatory CD4+ T-cells in recovery from antigen-induced autoimmune disease J Exp Med 178 1993 909 916
254. J.W. Kuplec-Weglinski T. Diamantstein N.L. Tilney Therapy with monoclonal antibody to interleukin-2 receptor spares suppressor T-cells and prevents or reverses acute allograft rejection in rats Proc Natl Acad Sci USA 83 1986 2624 2627
255. D. Kyburz M. Corr D.C. Brinson Human rheumatoid factor production is dependent on CD40 signaling and autoantigen J Immunol 163 1999 3116 3122
256. V. Kyle R.J. Coughlan H. Tighe Beneficial effects of monoclonal antibody to interleukin-2 receptor on activated T-cells in rheumatoid arthritis Ann Rheum Dis 48 1989 428 429
257. V. Kyle J. Roddy G. Hale Humanized monoclonal antibody treatment in rheumatoid arthritis J Rheumatol 18 1991 1737 1738
258. S. Lacraz L.P. Nicod R. Chicheportiche IL-10 inhibits metalloproteinase and stimulates TIMP-1 production in human mononuclear phagocytes J Clin Invest 96 1998 2304 2310
259. S. Lacraz N. Laurent G. Rochemonteix Suppression of metalloproteinase biosynthesis in human alveolar macrophages by interleukin-4 J Clin Invest 90 1992 382 388
260. E.K. Lakey E. Margoliash G. Flouret Peptides related to the antigenic determinant block T cell recognition of the native protein as processed by antigen presenting cells Eur J Immunol 16 1986 721 727
261. A.G. Lamont A. Sette H.M. Grey Inhibition of antigen presentation in vitro and in vivo by MHC antagonist peptides Int Rev Immunol 6 1990 49 59
262. A.G. Lamont A. Sette R. Fujinami Inhibition of experimental autoimmune encephalomyelitis induction in SJL/J mice using a peptide with high affinity for IA molecules J Immunol 145 1990 1687 1693
263. A. Lamour F. Jouen-Beades O. Lees Analysis of T-cell receptors in rheumatoid arthritis: The increased expression of HLA-DR antigen on circulating gamma delta + T-cells is correlated with disease activity Clin Exp Immunol 89 1992 217 222
264. A. Larson K. Dale M. Eek Radiographic evaluation for rheumatoid arthritis and related conditions by standard reference films Acta Radiol 18 1997 481 491
265. J. Le J. Vilcrek Interleukin-6: A multifunctional cytokine regulating immune reactions and the acute phase protein response Lab Invest 61 1989 588 602
266. J.C. Lee S. Kassis S. Kumar p38 mitogen-activated protein kinase inhibitors-mechanisms and therapeutic potentials Pharmacol Ther 82 1999 389 397
267. C.F. LeMaistre M.G. Rosenblum J.M. Reuben Therapeutic effects of genetically engineered toxin (DAB486IL-2) in patients with chronic lymphocytic leukaemia Lancet 337 1991 1124
268. E.M. Lemmel W. Gaus P.H. Hofschneider Multicenter double-blind trial of interferon-γ versus placebo in the treatment of rheumatoid arthritis Arthritis Rheum 34 1991 1621 1622
269. D.J. Lenschow A.I. Sperling M.P. Cooke Differential upregulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen J Immunol 153 1990-1997 1994
270. D.J. Lenschow S.C. Ho H. Sattar Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in nonobese diabetic mouse J Exp Med 181 1995 1145 1155
271. M.C. Levesque F.E. Ward D.R. Jeffery Interfeon-β1A-induced polyarthritis in a patient with the HLA-DRB1 0404 allele Arthritis Rheum 42 1999 569 573
272. R. Levy M. Weisman C. Wiesenhutter Results of a placebo-controlled multicenter trial using a primatized non-depleting, anti-CD4 monoclonal antibody in the treatment of rheumatoid arthritis [abstract] Arthritis Rheum 39 suppl 1996 122
273. E.J. Lewis J. Bishop K.M.K. Bottomley Ro 32-3555, or orally active collagenase inhibitor, prevents cartilage breakdown in vitro and in vivo Br J Pharmacol 121 1997 540 546
274. P. Li H. Allen S. Banerjee Mice deficient in IL-1β-converting enzyme are defective in production of mature Il-1β and resistant to endotoxic shock Cell 80 1995 401 411
275. O. Lider N. Karin M. Shinitsky Therapeutic vaccination against adjuvant arthritis using autoimmune T-cells treated with hydrostatic pressure Proc Natl Acad Sci USA 84 1987 4577 4580
276. P.S. Linsley W. Brady L. Grosmaire CTLA-4 is a second receptor for B cell activation antigen B7 J Exp Med 174 1991 561 570
277. A.F. LoBuglio R.H. Wheeler J. Trang Mouse/human chimeric monoclonal antibody in man: Kinetics and immune response Proc Natl Acad Sci USA 86 1989 4220 4224
278. M. Lotz P.A. Guerne Interleukin-6 induces the synthesis of tissue inhibitor of metalloproteinases-1/erythroid potentiating activity (TIMP-1/EPA) J Biol Chem 266 1991 2017 2020
279. M. Lotz L. Bober S. Narula IL-17 promotes cartilage degradation [abstract] Arthritis Rheum 39 suppl 1996 S120
280. C. Lunardi C. Marguerie A.K. So An altered repertoire of T cell receptor V gene expression by rheumatoid synovial fluid T lymphocytes Clin Exp Immunol 90 1992 440 446
281. K.P.A. MacDonald Y. Nishioka P.E. Lipsky Functional CD40 ligand is expressed by T-cells in rheumatoid arthritis J Clin Invest 100 1997 2404 2414
282. F. Mach U. Schonbeck G.K. Sukhova Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: Implications for CD40-CD40 ligand signaling in atherosclerosis Proc Natl Acad Sci USA 94 1997 1931 1936
283. K.P. Machold K. Neumann J.S. Smolen Recombinant human interferon γ in the treatment of rheumatoid arthritis: Double-blind placebo controlled study Ann Rheum Dis 51 1992 1039 1043
284. C.L. Mackall T.A. Fleisher M.R. Brown Age, thymopoiesis, and CD4+ T-lymphocyte regeneration after intensive chemotherapy N Engl J Med; 332 1995 143 149
285. R. Maier V. Ganu M. Lotz Interleukin-11, an inducible cytokine in human articular chondrocytes and synoviocytes, stimulates the production of the tissue inhibitor of metalloproteinases J Biol Chem 268 1993 21527 21532
286. R.N. Maini H. Paulus P.C. Breedveld HuIL-10 in subjects with active rheumatoid arthritis (RA): A phase I and cytokine response study [abstract] Arthritis Rheum 38 suppl 1997 S224
287. A. Malfait G. Verbruggen E.M. Veys Comparative and combined effects of interleukin-6, interleukin 1β, and tumor necrosis factor β on proteoglycan metabolism of human articular chondrocytes cultured in agarose J Rheumatol 21 1994 314 320
288. A.M. Malfait D.M. Butler D.H. Presky Blockade of IL-12 during the induction of collagen-induced arthritis (CIA) markedly attenuates the severity of the arthritis Clin Exp Immunol 111 1998 377 383
289. M. Malyak R.E. Swaney W.P. Arend Levels of synovial fluid interleukin-1 receptor antagonist in rheumatoid arthritis and other arthropathies Arthritis Rheum 36 1993 781 789
290. D.F. Mangan B. Robertson S.M. Wahl IL-4 enhances programmed cell death (apoptosis) in stimulated human monocytes J Immunol 148 1992 1812 1816
291. E. Marshall Gene therapy's growing pains Science 269 1995 1050 1055
292. J.S. Marshall I. Leal-Berumen L. Nielsen Interleukin (IL)-10 inhibits long-term IL-6 production but not preformed mediator release from rat peritoneal mast cells J Clin Invest 97 1996 1122 1128
293. A.K. Matsumoto L.W. Moreland V. Strand Results of phase IIb rheumatoid arthritis clinical trial using T-cell receptor peptides [abstract] Arthritis Rheum 42 suppl 1999 S281
294. H. Matsuno T. Sawai T. Nezuka Treatment of rheumatoid synovitis with anti-reshaping human interleukin-6 receptor monoclonal antibody. Use of rheumatoid arthritis tissue implants in the SCID mouse model Arthritis Rheum 41 1998 2014 2021
295. E.L. Matteson D.E. Yocum St Clair W. Treatment of active refractory rheumatoid arthritis with humanized monoclonal antibody CAMPATH-1H administered by daily subcutaneous injection Arthritis Rheum 38 1995 1187 1193
296. N.J. Mauritz R. Holmdahl R. Jonsson Treatment with gamma-interferon triggers the onset of collagen arthritis in mice Arthritis Rheum 31 1988 1297 1304
297. A. Mauviel Cytokine regulation of metalloproteinases gene expression J Cell Biochem 53 1993 288 295
298. F. Mazerolles A. Durandy D. Piatier-Tonneau Immunosuppressive properties of synthetic peptides derived from CD4 and HLA-DR antigens Cell 55 1988 497 504
299. I.B. McInnes F.Y. Liew Interleukin 15: A proinflammatory role in rheumatoid arthritis synovitis Immunol Today 19 1998 75 79
300. I.B. McInnes B.P. Leung R.D. Sturrock Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-α production in rheumatoid arthritis Nat Med 3 1997 189 195
301. I.B. McInnes J. Al-Mughales M. Field The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis Nat Med 2 1996 175 182
302. K.W. McIntyre D.J. Shuster K.M. Gillooly Reduced incidence and severity of collagen-induced arthritis in interleukins-12-deficient mice Eur J Immunol 26 1996 2933 2938
303. M. Mihara M. Ikuta Y. Koishihara Interleukin-6 inhibits delayed-type hypersensitivity and the development of adjuvant arthritis Eur J Immunol 21 1991 2327 2331
304. K. Mikecz F.R. Brennan J.H. Kim Anti-CD44 treatment abrogates tissue oedema and leukocyte infiltration in murine arthritis Nat Med 1 1995 558 563
305. K. Mikecz K. Dennis M. Shi Modulation of hyaluronan receptor (CD44) function in vivo in a murine model of rheumatoid arthritis Arthritis Rheum 42 1999 659 668
306. Miltenburg A.M.M. Van Laar J.J. M.R. Daha Dominant T-cell receptor β-chain gene rearrangements indicate clonal expansion in the rheumatoid joint Scand J Immunol 31 1990 121 125
307. Miltenburg A.M.M. van Laar J.M. de Kuiper R. Interleukin-6 activity in paired samples of synovial fluid. Correlation of synovial fluid interleukin-6 levels with clinical and laboratory parameters of inflammation Br J Rheumatol 30 1991 186 189
308. P. Miossec Interleukin-4; A potential anti-inflammatory agent Rev Rhum Engl Ed 60 1993 87 91
309. P. Miossec M. Naviliat A.D. D'Angeac Low levels of interleukin-4 and high levels of transforming growth factor β in rheumatoid synovitis Arthritis Rheum 33 1990 1180 1187
310. K.G. Moder H.S. Luthra R. Kubo Prevention of collagen induced arthritis in mice by treatment with an antibody directed against the T-cell receptor alpha beta framework Autoimmunity 11 1992 219 224
311. C. Mohan Y. Shi J.D. Laman Interaction between CD40 and its ligand gp39 in the development of murine lupus nephritis J Immunol 154 1995 1470 1480
312. F. Mor A.W. Lohse N. Karin Clinical modeling of T-cell vaccination against autoimmune disease in rats: Selection of antigen-specific T-cells using a mitogen J Clin Invest 85 1990 1594 1598
313. + T-lymphocytes in patients with rheumatoid arthritis treated with a depleting anti-CD4 monoclonal antibody N Engl J Med 322 1999 1651 1652
314. L.W. Moreland K.L. Sewell D.E. Trentham Diphtheria-interleukin-2 fusion protein (DAB486IL-2) in refractory rheumatoid arthritis: A double-blind placebo controlled trial with open label extension Arthritis Rheum 38 1995 1177 1186
315. L.W. Moreland P.W. Pratt M. Mayes Double-blind, placebo controlled multicenter trial using chimeric monoclonal anti-CD4 antibody in rheumatoid arthritis patients receiving concomitant methotrexate Arthritis Rheum 38 1995 1581 1588
316. L.W. Moreland T.P. Haverty M.C. Wacholtz Nondepleting humanized anti-CD4 monoclonal antibody in patients with refractory rheumatoid arthritis J Rheumatol 25 1998 221 228
317. L. Moreland W. Chase R. Fife Phase I/II study evaluating the safety and potential efficacy of recombinant interleukin-11 in patients with refractory rheumatoid arthritis [abstract] Arthritis Rheum 42 suppl 1999 S171
318. L.W. Moreland E.E. Morgan Adamson T.C. III T cell receptor peptide vaccination in rheumatoid arthritis: A placebo controlled trial using a combination of Vβ3, Vβ14, and Vβ17 peptides Arthritis Rheum 41 1998 1919 1929
319. L.W. Moreland P.W. Pratt R.P. Bucy Treatment of refractory rheumatoid arthritis with a chimeric anti-CD4 monoclonal antibody: Long-term follow-up of CD4+ T-cell counts Arthritis Rheum 37 1994 834 838
320. L.W. Moreland R.P. Bucy P.W. Pratt Use of a chimeric monoclonal anti-CD4 antibody in patients with refractory rheumatoid arthritis Arthritis Rheum 36 1993 307 318
321. L.W. Moreland L.W. Heck W.J. Koopman Vβ17 T-cell receptor peptide vaccine in rheumatoid arthritis: Results of a phase I dose escalation study J Rheumatol 23 1996 1353 1362
322. Y. Morita M. Yamamura K. Nishida Expression of interleukin-12 in synovial tissue from patients with rheumatoid arthritis Arthritis Rheum 41 1998 306 314
323. J.S. Mort G.R.M. Dodge P.J. Roughley Direct evidence for active metalloproteinases mediating matrix degradation in interleukin-1 stimulated human articular cartilage Matrix 13 1993 95 102
324. H. Mu P. Charmley King M.-C. Synergy between T cell receptor β gene polymorphism and HLA-DR4 in susceptibility to rheumatoid arthritis Arthritis Rheum 39 1996 931 937
325. U. Muller-Ladner C.H. Evans B.N. Franklin Gene transfer of cytokine inhibitors into human synovial fibroblasts in the SCID mouse model Arthritis Rheum 42 1999 490 497
326. M.S. Mulligan P.E. Desrochers A.M. Chinnaiyan In vivo suppression of immune complex induced alveolitis by secretory leukoproteinase inhibitor and tissue inhibitor of metalloproteinases 2 Proc Natl Acad Sci USA 90 1993 11523 11527
327. M.S. Mulligan M.L. Jones A.A. Vaporciyan Protective effects of IL-4 and IL-10 against immune complex induced lung-injury J Immunol 151 1993 5666 5674
328. L.K. Myers J.M. Seyer J.M. Stuart T-cell epitopes of type II collagen that regulate murine collagen-induced arthritis J Immunol 151 1993 500 505
329. G.H. Nabozny S.P. Cobbold H. Waldmann Suppression in murine experimental autoimmune thyroiditis: In vivo inhibition of CD4+ T-cell-mediated resistance by a nondepleting rat CD4 monoclonal antibody Cell Immunol 138 1991 185 196
330. H. Nakajima H. Takamori Y. Hiyama The effect of treatment with interferon-gamma on type II collagen-induced arthritis Clin Exp Immunol 81 1990 441 445
331. T. Nakajima H. Aono T. Hasunuma Apoptosis and functional Fas antigen in rheumatoid arthritis synoviocytes Arthritis Rheum 38 1995 485 491
332. T. Nanki H. Kohsaka N. Mizushima Genetic control of T cell receptor BJ gene expression in peripheral lymphocytes of normal and rheumatoid arthritis monozygotic twins J Clin Invest 98 1996 1594 1601
333. M.F. Neurath S. Petterson Meyer zum Buschenfelde K.-H. Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-κB abrogates established experimental colitis in mice Nat Med 2 1996 998 1004
334. Nicod L. Dayer J.-M. Effect of IL-1 receptor antagonist on mitogenic and antigenic response of human peripheral blood mononuclear cells in vitro J Immunol 4 1991 29 35
335. J. Nietfeld B. Wilbrink M. Helle Interleukin-1 induced interleukin-6 is required for the inhibition of proteoglycan synthesis by interleukin-1 in human articular cartilage Arthritis Rheum 33 1990 1695 1701
336. L.H. Nip V.J. Uitto L.M. Golub Inhibition of epithelial cell matrix metalloproteinases by tetracyclines J Periodontol Res 28 1993 379 385
337. K. Nishioka T. Hasunuma T. Kato Apoptosis in rheumatoid arthritis. A novel pathway in the regulation of synovial tissue Arthritis Rheum 41 1998 1 9
338. N. Nizushima H. Kohsaka T. Nanki HLA-dependent peripheral T cell receptor (TCR) repertoire formation and its modification by rheumatoid arthritis (RA) Clin Exp Immunol 110 1997 428 433
339. J.R. O'Dell C.E. Haire W. Palmer Treatment of early rheumatoid arthritis with minocycline or placebo: Results of a randomized, double-blind, placebo-controlled trial Arthritis Rheum 40 1997 842 848
340. J.R. O'Dell G. Paulsen C.E. Haire Treatment of early seropositive rheumatoid arthritis with minocycline Arthritis Rheum 42 1999 1691 1695
341. H.J. Obert P.H. Hofschneider Interferon for chronic polyarthritis. Positive effect in clinical evaluation Dtsch Med Wochenschr 110 1985 1766 1769
342. H. Offner G.A. Hashim A.A. Vandenbark T cell receptor peptide therapy triggers autoregulation of experimental encephalomyelitis Science 251 1991 430 432
343. A. O'Garra K. Murphy Role of cytokines in determining T-lymphocyte function Curr Opin Immunol 6 1994 458 466
344. J. Ogasawara R. Watanabe-Fukunaga M. Adachi Lethal effect of the anti-fas antibody in mice Nature 364 1993 806 809
345. S. Ohshima Y. Saeki T. Mima Interleukin 6 plays a key role in the development of antigen-induced arthritis Proc Natl Acad Sci USA 95 1998 8222 8226
346. K. Okamoto K. Fujisawa T. Hasunuma Selective activation of the JNK-AP-1 pathway in Fas-mediated apoptosis of rheumatoid arthritis synoviocytes Arthritis Rheum 40 1997 919 926
347. T. Okura L. Gong T. Kamitani Protection against Fas/APO-1- and tumor necrosis factor-mediated cell death by a novel protein, sentrin J Immunol 157 1996 4277 4281
348. C. Olive P.A. Gatenby S.W. Serjeantson Variable gene usage of T-cell receptor gamma- and delta-chain transcripts expressed in synovia and peripheral blood of patients with rheumatoid arthritis Clin Exp Immunol 87 1992 172 177
349. N.J. Olsen R.H. Brooks J.J. Cush A double-blind, placebo-controlled study of anti-CD5 immunoconjugate in patients with rheumatoid arthritis. The Xoma RA Investigator Group Arthritis Rheum 39 1996 1102 1108
350. S.M. Opal J. Keith Potential role for human interleukin-11 in bacterial sepsis Vicent J.-L. Yearbook of Intensive Care and Emergency Medicine 1996 Springer Berlin 111 118
351. G. Opdenakker S. Masure B. Grillet Cytokine-mediated regulation of human leukocyte gelatinases and role in arthritis Lymphokine Cytokine Research 10 1991 317 324
352. N. Oppenheimer-Marks P.E. Lipsky Adhesion molecules in rheumatoid arthritis Springer Semin Immunopathol 20 1998 95 114
353. L.E. Osman M. Toda O. Kanagawa Characterization of the T-cell receptor repertoire causing collagen arthritis in mice J Exp Med 177 1993 387 395
354. C.M. Overall J.L. Wrana J. Sodek Independent regulation of collagenase, 72-kDa progelatinase, and metalloendoproteinase inhibitor expression in human fibroblasts by transforming growth factor-beta J Biol Chem 264 1989 1860 1869
355. E.M. Paleolog S. Young A.C. Stark Modulation of angiogenic vascular endothelial growth factor by tumor necrosis factor α and interleukin-1 in rheumatoid arthritis Arthritis Rheum 41 1998 1258 1265
356. X. Paliard S. West J. Lafferty Evidence for the effects of a superantigen in rheumatoid arthritis Science 253 1991 325 329
357. G.S. Panayi J.S. Lanchbury G.H. Kingsley The importance of the T-cell in initiating and maintaining the chronic synovitis of rheumatoid arthritis Arthritis Rheum 35 1992 729 735
358. D.A. Papanicolaou R.L. Wilder S.C. Manolagas The pathophysiologic roles of interleukin-6 in human disease Ann Intern Med 128 1998 127 137
359. D.W. Paty D.K.B. Li UBC MS/MRI Study Group Interferon β-1b is effective in relapsing remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial Neurology 43 1993 662 667
360. J.C. Paulson Carbohydrate ligands of leukocyte adhesion molecules and their therapeutic potential Prog Brain Res 101 1994 179 184
361. H.E. Paulus H.I. Machleder S. Levine Lymphocyte involvement in rheumatoid arthritis: Studies during thoracic duct drainage Arthritis Rheum 20 1977 1249 1262
362. D.J. Peacock M.L. Banquerigo E. Brahn Angiogenesis inhibition suppresses collagen arthritis J Exp Med 175 1992 1135 1138
363. S.H. Pincus G.W. Cannon J.R. Ward In vivo administration of interferon-γ to patients with rheumatoid arthritis decreases numbers of circulating B cells J Rheumatol 17 1990 751 757
364. G. Pluschke G. Ricken H. Taube Biased T cell receptor Vα region repertoire in the synovial fluid of rheumatoid arthritis patients Eur J Immunol 21 1991 2749 2754
365. S. Qin J.B. Rottman P. Myers The chemokine receptors CXCR3 and CCR5 mark subsets of T-cells associated with certain inflammatory reactions J Clin Invest 101 1998 746 754
366. S. Qin G. LaRosa J.J. Campbell Expression of monocyte chemoattractant protein-1 and interleukin-8 receptors on subsets of T-cells: Correlation with transendothelial chemotactic potential Eur J Immunol 26 1996 640 647
367. P. Ralph I. Nakoinz A. Sampson-Johannes IL-10, T lymphocyte inhibitor of human blood cell production of IL-1 and tumor necrosis factor J Immunol 148 1992 808 814
368. G.E. Ranges S. Sriram S.M. Cooper Prevention of type II collagen-induced arthritis by in vivo treatment with anti-L3T4 J Exp Med 162 1985 1105 1110
369. P. Rathanaswami M. Hachicha W.L. Wong Synergistic effect of interleukin-1β and tumor necrosis factor α on interleukin-8 gene expression in synovial fibroblasts Arthritis Rheum 36 1993 1295 1304
370. C.A. Redlich X. Gao S. Rockwell IL-11 enhances survival and decreases TNF production after radiation-induced thoracic injury J Immunol 157 1996 1705 1710
371. H. Reiser M.J. Stadecker Costimulatory B7 molecules in the pathogenesis of infectious and autoimmune diseases Mechanisms of Disease 335 1996 1369 1377
372. C. Reiter B. Kakavand E.P. Rieber Treatment of rheumatoid arthritis with monoclonal CD4 antibody M-T151. Clinical results and immunopharmacologic effects in an open study, including repeated administration Arthritis Rheum 34 1991 525 536
373. D.G. Remick L.E. DeForge J.F. Sullivan Profile of cytokines in synovial fluid specimens from patients with arthritis. Interleukin-8 (IL-8) and IL-6 correlate with inflammatory arthritides Immunol Invest 21 1992 321 327
374. C.D. Richards R. Gauldie Role of cytokines in acute-phase response Aggarwal B.B. Puri R.K. Human Cytokines: Their Role in Disease and Therapy 1995 Blackwell Science Cambridge, MA 253 269
375. C.D. Richards M. Shoyab T.J. Brown Selective regulation of metalloproteinase inhibitor (TIMP-1) by oncostatin M in fibroblasts in culture J Immunol 150 1993 5596 5603
376. F.J. Roessler E.D. Allen J.M. Wilson Adenoviral-mediated gene transfer to rabbit synovium in vivo J Clin Invest 92 1993 1085 1092
377. F. Rosa M. Fellous The effect of gamma-interferon on MHC antigens Immunol Today 5 1984 261 262
378. T.M. Rose A.G. Bruce Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin-6 Proc Natl Acad Sci USA 88 1991 8641 8645
379. O. Rott B. Fleischer E. Cash Interleukin-10 prevents experimental allergic encephalomyelitis in rats Eur J Immunol 24 1994 1434 1440
380. M. Roy T. Waldschmidt A. Aruffo The regulation of the expression of gp39, the CD40 ligand, on normal and cloned CD4+ T-cells J Immunol 151 1993 2497 2510
381. L.A. Rubin D.L. Nelson The soluble interleukin-2 receptor: Biology, function, and clinical application Ann Intern Med 113 1990 619 627
382. E.M. Ruderman M.E. Weinblatt L.M. Thurmond Synovial tissue response to treatment with CAMPATH-1H Arthritis Rheum 38 1995 254 258
383. lck is required for lymphocyte chemoattractant factor-induced T lymphocyte migration J Biol Chem 270 1995 17081
384. U. Sack R.W. Kinne T. Marx Interleukin-6 in synovial fluid is closely associated with chronic synovitis in rheumatoid arthritis Rheumatol Int 13 1993 45 51
385. K. Sakai S.S. Zamvil D.J. Mitchell Prevention of experimental encephalomyelitis with peptides that block interaction of T-cells with major histocompatibility complex proteins Proc Natl Acad Sci USA 86 1989 9470 9474
386. M. Salmon D. Scheel-Toellner A.P. Huissoon Inhibition of T cell apoptosis in the rheumatoid synovium J Clin Invest 99 1997 439 446
387. M. Sasai Y. Saeki S. Ohshima Delayed onset and reduced severity of collagen-induced arthritis in interleukin-6 deficient mice Arthritis Rheum 42 1999 1635 1643
388. T. Sato A. Ito Y. Mori Interleukin 6 enhances the production of tissue inhibitor of metalloproteinases (TIMP) but not that of matrix metalloproteinases by human fibroblasts Biochem Biophys Res Commun 170 1990 824 829
389. C.M. Savill P.J. Delves D. Kioussis A minority of patients with rheumatoid arthritis show a dominant rearrangement of T-cell receptor β chain genes in synovial lymphocytes Scand J Immunol 25 1987 629 635
390. R. Schindler J. Mancilla S. Endres Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF Blood 75 1990 40 47
391. - T-cells from rheumatoid arthritis patients J Immunol 161 1998 1018 1025
392. T.J. Schnitzer D.E. Yocum M. Michalska Subcutaneous administration of CAMPATH-1H: Clinical and biological outcomes J Rheumatol 24 1997 1031 1036
393. K.H. Schorlemmer E.J. Kanzy K.D. Langner Immunomodulatory activity of recombinant IL-1 receptor (IL-1R) on models of experimental rheumatoid arthritis Agents Actions 39 1993 c113 c116
394. 486IL-2) in patients with refractory rheumatoid arthritis J Rheumatol 23 1996 1845 1848
395. H. Schulze-Koops L.S. Davis T.P. Haverty Reduction of Th1 cell activity in the peripheral circulation of patients with rheumatoid arthritis after treatment with a non-depleting humanized monoclonal antibody to CD4 J Rheumatol 25 1998 2065 2076
396. J.H. Schwab S.K. Anderle R.R. Brown Pro and anti-inflammatory roles of interleukin-1 in recurrence of bacterial cell wall-induced arthritis in rats Infect Immun 59 1991 4436 4442
397. R.A. Seder W.E. Paul M.M. Davis The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T-cells from T cell receptor transgenic mice J Exp Med 176 1992 1091 1098
398. M. Seitz P. Loetscher B. Dewald Production of interleukin-1 receptor antagonist, inflammatory chemotactic proteins, and prostaglandin E by rheumatoid and osteoarthritic synoviocytes—regulation by IFN-γ and IL-4 J Immunol 152 1994 2060 2065
399. M. Seitz B. Dewald N. Gerber Enhanced production of neutrophil-activating peptide-1/interleukin-8 in rheumatoid arthritis J Clin Invest 87 1991 463 469
400. M. Seitz G. Manz M. Franke Use of recombinant human interferon γ in patients with rheumatoid arthritis J Rheumatol 45 1986 92 99
401. C. Sekine H. Yagita N. Miyasaka Expression and function of CD40 in rheumatoid arthritis synovium J Rheumatol 25 1998 1048 1053
402. K.L. Sewell D.E. Trentham Rapid improvement in refractory rheumatoid arthritis by an interleukin-2 receptor targeted immunotherapy [abstract] Clinical Research 39 suppl 1991 314A
403. K.L. Sewell L.W. Moreland J.J. Cush Phase I/II, double blind, dose-response trial of a second fusion toxin, DAB389IL-2, in rheumatoid arthritis [abstract] Arthritis Rheum 36 suppl 1993 S130
404. M. Shingu Y. Nagai T. Isayama The effects of cytokines on metalloproteinase inhibitors (TIMP) and collagenase production by human chondrocytes and TIMP production by synovial cells and endothelial cells Clin Exp Immunol 94 1993 145 149
405. A. Shioi S.L. Teitelbaum F.P. Ross Interleukin-4 inhibits murine osteoclast formation in vitro J Cell Biochem 47 1991 272 277
406. B.V. Shlopov G.N. Smith Jr A.A. Cole Differential patterns of response to doxycycline and transforming growth factor β1 in the down-regulation of collagenases in osteoarthritis and normal human chondrocytes Arthritis Rheum 42 1999 719 727
407. F.P. Siegal N. Kadowaki M. Shodell The nature of the principal type 1 interferon-producing cells in human blood Science 284 1999 1835 1837
408. A.K. Simon E. Seipelt J. Sieper Divergent T-cell cytokine patterns in inflammatory arthritis Proc Natl Acad Sci USA 91 1994 8562 8566
409. T.J. Smeets J.M. Dayer M.C. Kraan The effects of interferon-beta treatment of synovial inflammation and expression of metalloproteinases in patients with rheumatoid arthritis Arthritis Rheum 43 2000 270 274
410. Smith G.N. Jr E.A. Mickler K.A. Hasty Specificity of inhibition of matrix metalloproteinase activity by doxycycline Arthritis Rheum 42 1999 1140 1146
411. K.A. Smith Interleukin-2: Inception, impact, and implications Science 240 1988 1169 1176
412. R.J. Smith J.E. Chin L.M. Sam Biologic effects of an interleukin-1 receptor antagonist protein of interleukin-1 stimulated cartilage erosion and chondrocyte responsiveness Arthritis Rheum 34 1991 78 83
413. A.M. Solinger D.E. Yocum J. Tesser Clinical activity in an early phase I trial of primatized IDEC-CE 9.1—an anti-CD4 monoclonal antibody in RA [abstract] Arthritis Rheum 37 suppl 1994 S337
414. A. Sottini L. Imberti R. Goria Restricted expression of T cell receptor Vβ but not Vα genes in rheumatoid arthritis Eur J Immunol 21 1991 461 466
415. St Clair E.W. Cohen S.B. Lee M.L. Treatment of rheumatoid arthritis with a DR4/1 peptide J Rheumatol 27 2000 1855 1863
416. I. Stamenkovic M. Stegagno K.A. Wright Clonal dominance among T-lymphocyte infiltrates in arthritis Proc Natl Acad Sci USA 85 1988 1179 1183
417. L. Steinman J.T. Rosenbaum S. Sriram In vivo effects of antibodies to immune response gene products: Prevention of experimental allergic encephalitis Proc Natl Acad Sci USA 78 1981 7111 7114
418. C.M. Storgard D.G. Stupack A. Jonczyk Decreased angiogenesis and arthritic disease in rabbits treated with an αvβ3 antagonist J Clin Invest 103 1999 47 54
419. V. Strand P.E. Lipsky G.W. Cannon Effects of administration of an anti-CD5 plus immunoconjugate in rheumatoid arthritis. Results of two phase II studies. The CD5 Plus Rheumatoid Arthritis Investigators Group Arthritis Rheum 36 1993 620 630
420. + T cell clones in the synovial fluid of patients with rheumatoid arthritis J Immunol 161 1998 4428 4436
421. S. Strober A. Tanay E. Field Efficacy of total lymphoid irradiation in intractable rheumatoid arthritis: A double-blind, randomized trial Ann Intern Med 102 1985 441 449
422. L. Struyk G.E. Hawes M.M. Mikkers Molecular analysis of the T-cell receptor β-chain repertoire in early rheumatoid arthritis: Heterogeneous TCRBV gene usage with shared amino acid profiles in CDR3 regions of T lymphocytes in multiple synovial tissue needle biopsies from the same joint Eur J Clin Invest 26 1996 1092 1102
423. L. Struyk J.T. Kurnick G.E. Hawes T-cell receptor V-gene usage in synovial fluid lymphocytes of patients with chronic arthritis Hum Immunol 37 1992 237 251
424. T. Sumida T.T.M. Hao H. Asahara T cell receptor of Fas-sensitive T-cells in rheumatoid synovium J Immunol 158 1997 1965 1970
425. H. Suzuki E. Sugiyama I.S. Tunru Suppressive effect of interleukin-4 (IL-4) on IL-6 production by adherent rheumatoid synovial cells Clin Immunol Immunopathol 66 1993 67 72
426. M. Suzuki T. Tetsuka S. Yoshida The role of p38 mitogen-activated protein kinase in IL-6 and IL-8 production from the TNF-alpha or IL-1beta-stimulated rheumatoid synovial fibroblasts FEBS Lett 465 2000 23 27
427. K. Svee J. White P. Vaillant Acute lung injury fibroblast migration and invasion of a fibrin matrix is mediated by CD44 J Clin Invest 98 1996 1713 1727
428. S.L. Swain A.D. Weinberg M. English IL-4 directs the development of Th2-like helper effectors J Immunol 45 1990 3796 3806
429. J.A. Symons J.A. Eastgate G.A. Duff Purification and characterization of a novel soluble receptor for interleukin-1 J Exp Med 174 1991 1251 1254
430. N. Takagi M. Mihara Y. Moriy Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis Arthritis Rheum 41 1998 2117 2121
431. A. Tarakhovsky S.B. Kanner J. Hornback A role for CD5 in TCR-mediated signal transduction and thymocyte selection Science 269 1995 535 537
432. T. Tatsuta J. Cheng J.D. Mountz Intracellular IL-1β is an inhibitor of Fas-mediated apoptosis J Immunol 157 1996 3949 3957
433. D.D. Taub P. Proost W.J. Murphy Monocyte chemotactic protein-1 (MCP-1), -2, and -3 are chemotactic for human T lymphocytes J Clin Invest 95 1995 1370 1376
434. Te Velde A.A. deWaal Malefyt R. R.J. Huubens IL-10 stimulates monocyte Fc gamma R surface expression and cytotoxic activity—distinct regulation of anti-dependent cellular cytotoxicity by INF-γ, IL-4, and IL-10 J Immunol 149 1992 4048 4052
435. J.R.P. Tesser C. Wiesenhutter R. Levy Treatment of rheumatoid arthritis with a primatized anti-CD4 monoclonal antibody, SB-210396 (IDEC-CE9.1)—results of an open label extension study in patients responding to induction therapy [abstract] Arthritis Rheum 40 suppl 1997 224
436. P.A. Tessier P. Cattaruzzi S.R. McColl Inhibition of lymphocyte adhesion to cytokine-activated synovial fibroblasts by glucocorticoids involves the attenuation of vascular cell adhesion molecule 1 and intercellular adhesion molecule 1 gene expression Arthritis Rheum 39 1996 226 234
437. The IFN-β Multiple Sclerosis Study Group Interferon β-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter randomized, double-blind, placebo-controlled trial Neurology 43 1993 655 661
438. A.C. Theodore D.M. Center J. Nicoll CD4 ligand IL-16 inhibits the mixed lymphocyte reaction J Immunol 157 1996 1958 1964
439. L.A. Tibbles J.R. Woodgett The stress-activated protein kinase pathways Cell Mol Life Sci 55 1999 1230 1254
440. H. Tilg E. Trehu M.B. Atkins Interleukin-6 (IL-6) as an anti-inflammatory cytokine: Induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55 Blood 83 1994 113 118
441. B.C. Tilley G.S. Alarcón S.P. Heyse Minocycline in rheumatoid arthritis. A 48-week, double-blind, placebo-controlled trial Ann Intern Med 122 1995 81 89
442. D.J. Topham B. Nag S. Arimilli A synthetic peptide from the third hypervariable region of major histocompatibility complex class II beta chain as a vaccine for treatment of experimental autoimmune encephalomyelitis Proc Natl Acad Sci USA 91 1994 8005 8009
443. Torsteinsdóttir I. Arvidson N.-G. R. Hällgren Monocyte activation in rheumatoid arthritis (RA): Increased integrin, Fcγ and complement receptor expression and the effect of glucocorticoids Clin Exp Immunol 115 1999 554 560
444. W.L. Trepicchio M. Bozza G. Pedneault Recombinant human IL-11 attenuates the inflammatory response through down-regulation of proinflammatory cytokine release and nitric oxide production J Immunol 157 1996 3627 3634
445. K.A. Triantaphyllopoulos R.O. Williams H. Tailor Amelioration of collagen-induced arthritis and suppression of interferon-gamma, interleukin-12, and TNF-alpha production by interferon-beta gene therapy Arthritis Rheum 42 1999 90 99
446. Y. Uematsu H. Wege A. Straus The T-cell-receptor repertoire in the synovial fluid of a patient with rheumatoid arthritis is polyclonal Proc Natl Acad Sci USA 88 1991 8534 8538
447. T.R. Ulich S. Yin K. Guo Intratracheal injection of endotoxin and cytokines. II. Interleukin-6 and transforming growth factor beta inhibit acute inflammation Am J Pathol 138 1991 1097 1101
448. Van Antwerp D.J. S.J. Martin T. Kafri Suppression of TNF-α-induced apoptosis by NF-κB Science 274 1996 787 789
449. van de Loo F.A. O.J. Arntz I.G. Otterness Protection against cartilage proteoglycan synthesis inhibition by antiinterleukin/antibodies in experimental arthritis J Rheumatol 19 1992 348 356
450. van den Berg W.B. A.B. Joosten M. Helsen Amelioration of established murine collagen-induced arthritis with anti-IL-1 treatment Clin Exp Immunol 95 1994 237 243
451. van den Bosch F. A. Russell E.C. Keystone rhuIL-4 in subjects with active rheumatoid arthritis (RA): A phase I dose escalating safety study Arthritis Rheum 41 suppl 1998 S56
452. van der Berg W.B. The role of cytokines and growth factors in cartilage destruction in osteoarthritis and rheumatoid arthritis Z Rheumatol 58 1999 136 141
453. van der Lubbe P.A. B.A.C. Dijkmans H.M. Markusse A randomized, double-blind, placebo-controlled study of CD4 monoclonal antibody therapy in early rheumatoid arthritis Arthritis Rheum 38 1995 1097 1106
454. Van Eden W. J. Holoshitz J. Nero Arthritis induced by a T-lymphocyte clone that responds to Mycobacterium tuberculosis and to cartilage proteoglycans Proc Natl Acad Sci USA 82 1985 5117 5120
455. Van Laar J.M. A.M.M. Miltenburg M.J.A. Verdonk Lack of T cell oligoclonality in enzyme-digested synovial tissue and in synovial fluid in most patients with rheumatoid arthritis Clin Exp Immunol 83 1991 352 358
456. van Roon J.A.G. van Roy J.L.A.M. F.H.J. Gmelig-Meyling Prevention and reversal of cartilage degradation in rheumatoid arthritis by interleukin-10 and interleukin-4 Arthritis Rheum 39 1996 829 835
457. A.A. Vandenbark Y.K. Chou R. Whitman Treatment of multiple sclerosis with T-cell receptor peptides: Results of a double-blind pilot trial Nat Med 2 1996 1109 1115
458. A.A. Vanderbark G. Hashim H. Offner Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis Nature 341 1989 541 544
459. Vanderborght A. Van der Aa A. P. Geusens Identification of overrepresented T cell receptor genes in blood and tissue biopsies by PCR-ELISA J Immunol Methods 223 1999 47 61
460. E. Vannier L.C. Miller C.A. Dinarello Coordinated antiinflammatory effects of interleukin-4: Interleukin-4 suppresses interleukin 1 production but upregulates gene expression and synthesis of interleukin-1 receptor antagonist Proc Natl Acad Sci USA 89 1992 4076 4080
461. D.J. Veale R.J. Reece W. Parsons Intra-articular primatised anti-CD4: Efficacy in resistant rheumatoid knees. A study of combined arthroscopy, magnetic resonance imaging, and histology Ann Rheum Dis 58 1999 342 349
462. G. Venn J.J. Nietfeld A.J. Duits Elevated synovial fluid levels of interleukin-6 and tumor necrosis factor associated with early experimental canine osteoarthritis Arthritis Rheum 36 1992 819 826
463. M. Verdrengh R. Holmdahl A. Tarkowski Administration of antibodies to hyaluronan receptor (CD44) delays the start and ameliorates the severity of collagen II arthritis Scand J Immunol 42 1995 353 358
464. E.M. Veys H. Mielants G. Vergruggen Thymic hormones and interferons in the treatment of rheumatoid arthritis Scand J Rheumatol Suppl 76 1988 297 304
465. E.M. Veys H. Mielants G. Verbruggen Interferon gamma in RA. A double-blind study comparing human recombinant interferon gamma with placebo J Rheumatol 15 1988 570 574
466. M.P. Vincenti I.M. Clark C.E. Brinckerhoff Using inhibitors of metalloproteinases to treat arthritis: Easier said than done? Arthritis Rheum 37 1994 1115 1126
467. A. Waage C. Kaufmann T. Espevik Interleukin-6 in synovial fluid from patients with arthritis Clin Immunol Immunopathol 50 1989 394 398
468. I. Waase C. Kayser P.J. Carlson Oligoclonal T cell proliferation in patients with rheumatoid arthritis and their unaffected siblings Arthritis Rheum 39 1996 904 913
469. A. Wadgymar S. Ritchie D.C. Cattran Patterns of HLA antigen expression in human kidney disease Transplant Proc 19 1987 3401 3404
470. S.A. Wadsworth D.E. Cavender S.A. Beers RWJ67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinase J Pharmacol Exp Ther 291 1999 680 687
471. S.M. Wahl J.B. Allen K. Ohura IFN-γ inhibits inflammatory cell recruitment and the evolution of bacterial cell wall-induced arthritis J Immunol 146 1991 95 100
472. S. Wakisaka N. Suzuki Y. Takeba Modulation by proinflammatory cytokines of Fas/Fas ligand-mediated apoptotic cell death by synovial cells in patients with rheumatoid arthritis (RA) Clin Exp Immunol 114 1998 119 128
473. T.A. Waldman I.H. Pastan O.A. Gansow The multichain interleukin-2 receptor: A target for immunotherapy Ann Intern Med 116 1992 148 160
474. M.K. Waldor S. Sriram H.O. McDevitt In vivo therapy with monoclonal antibody suppresses responses to acetylcholine receptor Proc Natl Acad Sci USA 80 1983 2713 2717
475. D. Wallace D. Goldfinger C. Lowe A double-blind, controlled study of lymphoplasmapheresis versus sham apheresis in rheumatoid arthritis N Engl J Med 306 1982 1406 1410
476. M. Walmsley P.D. Katsikis E. Abney Interleukin-10 inhibition of the progression of established collagen-induced arthritis Arthritis Rheum 39 1996 495 503
477. P. Wang P. Wu J.C. Anthes Interleukin-10 inhibits interleukin-8 production in human neutrophils Blood 83 1994 2678 2683
478. Y. Wang S.A. Rollins J.A. Madri Anti-C5 monoclonal antibody therapy prevents collagen-induced arthritis and ameliorates established disease Proc Natl Acad Sci USA 92 1995 8955 8959
479. K. Watanabe Y. Tanaka I. Morimoto Interleukin-4 as a potent inhibitor of bone resorption Biochem Biophys Res Commun 172 1990 1035 1041
480. D. Wendling E. Racadot J. Wigdenes Treatment of severe rheumatoid arthritis by anti-interleukin-6 monoclonal antibody J Rheumatol 20 1993 259 262
481. D. Wendling E. Racadot J. Wijdenes A randomized, double blind, placebo controlled multicenter trial of murine anti-CD4 monoclonal antibody therapy in rheumatoid arthritis J Rheumatol 25 1998 1457 1461
482. D. Wendling J. Wijdenes E. Rachadot Therapeutic use of monoclonal anti-CD4 antibody in rheumatoid arthritis J Rheumatol 18 1991 325 327
483. D.C. West I.N. Hampson F. Arnold Angiogenesis induced by degradation products of hyaluronic acid Science 228 1985 1324 1326
484. C.M. Weyand T.G. McCarthy J.J. Goronzy Correlation between disease phenotype and genetic heterogeneity in rheumatoid arthritis J Clin Invest 95 1995 2120 2126
485. C.M. Weyand C. Xie J.J. Goronzy Homozygosity for the HLA-DRB1 allele selects for extraarticular manifestations in rheumatoid arthritis J Clin Invest 89 1992 2033 2039
486. C.M. Weyand K.C. Hicok D.L. Conn The influence of HLA-DRB1 genes on disease severity in rheumatoid arthritis Ann Intern Med 117 1992 801 806
487. J.D. Whalen E.L. Lechman C.A. Carlos Adenoviral transfer of the viral IL-10 gene periarticularly to mouse paws suppresses development of collagen-induced arthritis in both injected and uninjected paws J Immunol 162 1999 3625 3632
488. D. Williams K. Parker P. Bacha Diphtheria toxin receptor binding domain with interleukin-2: Genetic construction and properties of a diphtheria toxin-related interleukin-2 fusion protein Protein Eng 1 1987 493 498
489. L.M. Williams D.L. Gibbons A. Gearing Paradoxical effects of a synthetic metalloproteinase inhibitor that blocks both p55 and p75 TNF receptor shedding and TNFα processing in RA synovial membrane cell cultures J Clin Invest 97 1996 2833 2841
490. W.V. Williams T. Kieber-Emmons Q. Fang Conserved motifs in rheumatoid arthritis synovial tissue T-cell receptor beta chains DNA Cell Biol 12 1993 425 434
491. W.V. Williams Q. Fang D. Demarco Restricted heterogeneity of T cell receptor transcripts in rheumatoid synovium J Clin Invest 90 1992 326 333
492. K.P. Wilson P.G. McCaffrey K. Hsiao The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase Chem Biol 4 1997 423 431
493. M.C. Wing T. Moreau J. Greenwood Mechanism of first-dose cytokine-release syndrome by CAMPATH 1-H: Involvement of CD16 (FcγRIII) and CD11a/CD18 (LFA-1) on NK cells J Clin Invest 98 1996 2819 2826
494. F. Wolfe M.A. Cathey D.J. Hawley Recombinant gamma interferon in rheumatoid arthritis [abstract] Arthritis Rheum 29 suppl 1986 S18
495. G.G. Wong S.C. Clark Multiple actions of interleukin-6 within a cytokine network Immunol Today 9 1988 137 139
496. H.L. Wong G.L. Costa M.T. Lotze Interleukin (IL) 4 differentially regulates monocyte IL-1 family gene expression and synthesis in vitro and in vivo J Exp Med 177 1993 775 781
497. P.H. Wooley J.D. Whalen D.L. Chapman The effect of an interleukin-1 receptor antagonist protein on type II collagen-induced arthritis and antigen-induced arthritis in mice Arthritis Rheum 36 1993 1305 1314
498. P.H. Wooley S. Sud J.D. Whalen Pristane-induced arthritis in mice. V. Susceptibility to pristane-induced arthritis is determined by the genetic regulation of the T cell repertoire Arthritis Rheum 41 1998 2022 2031
499. P.H. Wooley H.S. Luthra W.P. Lafuse Type II collagen-induced arthritis in mice: III. Suppression of arthritis by using monoclonal and polyclonal anti-Ia antisera J Immunol 134 1985 2366 2374
500. J.D. Woronicz X. Gao Z. Cao IκB kinase-β: NF-κB activation and complex formation with IκB kinase-α and NIK Science 278 1997 866 869
501. J.K. Wright T.E. Cawston B.L. Hazleman Transforming growth factor beta stimulates the production of the tissue inhibitor of metalloproteinases (TIMP) by human synovial and skin fibroblasts Biochim Biophys Acta 1094 1991 207 210
502. J.K. Wright I.M. Clark E. Cawston The secretion of the tissue inhibitor of metalloproteinases (TIMP) by human synovial fibroblasts is modulated by all-trans-retinoic acid Biochim Biophys Acta 1133 1991 25 30
503. M.X. Wu Z. Ao A.K.V.S. Prasad IEX-1L, an apoptosis inhibitor involved in NF-κB-mediated cell survival Science 281 1998 998 1001
504. Xia M.-Q. M. Tone L. Packman Characterization of the CAMPATH-1 antigen: Biochemical analysis and cDNA cloning revealing an unusually small peptide backbone Eur J Immunol 21 1991 1677 1684
505. H. Yamamoto T. Sekiguchi K. Itagaki Inflammatory polyarthritis in mice transgenic for human T cell leukemia virus type I Arthritis Rheum 36 1993 1612 1620
506. H. Yang H. Rittner C.M. Weyard Aberrations in the primary T-cell receptor repertoire as a predisposition for synovial inflammation in rheumatoid arthritis J Invest Med 47 1999 236 245
507. Z. Yao S.L. Painter W.C. Fanslow Human IL-17: A novel cytokine derived from T-cells J Immunol 155 1995 5483 5486
508. M.J. Yellin J. Brett D. Baum Functional interactions of T-cells with endothelial cells: The role of CD40L-CD40-mediated signals J Exp Med 182 1995 1857 1864
509. M.J. Yellin V. D'Agati G. Parkinson Immunohistologic analysis of renal CD40 and CD40L expression in lupus nephritis and other glomerulonephritides Arthritis Rheum 40 1997 124 134
510. D.E. Yocum A.M. Solinger J. Tesser Clinical and immunologic effects of a PRIMATIZED anti-CD4 monoclonal antibody in active rheumatoid arthritis: Results in a phase I, single dose, dose escalating trial J Rheumatol 25 1998 1257 1262
511. S. Yoshino J. Yoshino Enhancement of T-cell-mediated arthritis in mice by treatment with monoclonal antibody against interleukin-4 Cell Immunol 185 1998 153 157
512. S. Yoshino J. Yoshino Suppression of chronic antigen-induced arthritis in rats by a monoclonal antibody against the T-cell receptor αβ Cell Immunol 1144 1992 382 391
513. S. Yoshino E. Schlipkoter R. Kinne Suppression and prevention of adjuvant arthritis in rats by a monoclonal antibody to the α/β T cell receptor Eur J Immunol 20 1990 2805 2808
514. S. Yoshino R. Kinne T. Hüng The suppressive effect of an antibody to the αβ cell receptor in rat adjuvant arthritis: Studies on optimal treatment protocols Autoimmunity 7 1990 255 266
515. K. Yoshizaki N. Nishimoto M. Mihara Therapy of rheumatoid arthritis by blocking IL-6 signal transduction with a humanized anti-IL-6 receptor antibody Springer Semin Immunopathol 20 1998 247 259
516. P.P. Youssef J. Cormack C.A. Evill Neutrophil trafficking into inflamed joints in patients with rheumatoid arthritis, and the effects of methylprednisolone Arthritis Rheum 39 1996 216 225
517. D.T.Y. Yu R.J. Winchester S.M. Fu Peripheral blood Ia-positive T-cells: Increases in certain diseases and after immunization J Exp Med 151 1980 91 100
518. G. Zagon J.R. Tumang Y. Li Increased frequency of Vβ17-positive T-cells in patients with rheumatoid arthritis Arthritis Rheum 37 1994 1431 1440
519. H. Zhang Y. Yang J.L. Horton Amelioration of collagen-induced arthritis by CD95 (Apo-1/Fas) ligand gene transfer J Clin Invest 100 1997 1951 1957
520. L. Zheng G. Gisher R.E. Miller Induction of apoptosis in mature T-cells by tumour necrosis factor Nature 377 1995 348 351