Intra-articular primatised anti-CD4: Efficacy in resistant rheumatoid knees. A study of combined arthroscopy, magnetic resonance imaging, and histology

Annals of the Rheumatic Diseases

Volumn 58, Issue 6, 1999, Pages 342-349

  Veale, D J ^a   Reece, R J ^a   Parsons, W ^a   Radjenovic, A ^a   O'Connor, P J ^a   Orgles, C S ^a   Berry, E ^a   Ridgway, J P ^a   Mason, U ^a   Boylston, A W ^a   Gibbon, W ^a   Emery, P ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; CD20 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD68 ANTIGEN; CD8 ANTIGEN; CHIMERIC ANTIBODY; CORTICOSTEROID; CYCLOSPORIN; GADOLINIUM PENTETATE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; METHOTREXATE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY SB 210396 CE 9 1; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO; SALAZOSULFAPYRIDINE; SB 210396 CE 9 1; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FEMALE; HELPER CELL; HISTOPATHOLOGY; HUMAN; INTRAARTICULAR DRUG ADMINISTRATION; KNEE ARTHRITIS; KNEE ARTHROSCOPY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RHEUMATOID ARTHRITIS; SYNOVITIS;

EID: 0001601378     PISSN: 00034967     EISSN: None     Source Type: Journal    
DOI: 10.1136/ard.58.6.342     Document Type: Article

References (32)

1. 1 Panayi GS, Lanchbury JS, Kingsley GH. The importance of the T cell in initiating and maintaining the chronic synovitis of rheumatoid arthritis. Arthritis Rheum 1992;35:729-35.
2. 2 Paulus HE, Machleder HI, Levine S, Yu DT, MacDonald NS. Lymphocyte involvment in rheumatoid arthritis. Studies during thoracic duct drainage. Arthritis Rheum 1977;20:1249-62.
3. 3 Trentham DE, Belli JA, Anderson RJ, Buckley JA, Goetzl EJ, David JR, et al. Clinical and immunological effects of fractionated total lymphoid irradiation in refractory rheumatoid arthritis. N Engl J Med 1981;305:976-82.
4. 4 Tugwell P, Pincus T, Yocum D, Stein M, Gluck O, Kraang G. Combination therapy with cyclosporine and methotrexate in severe rheumatoid arthritis. N Engl J Med 1995;333: 137-42.
5. 5 Herzog C, Walker C, Muller W, Rieber P, Reiter C, Riethmuller G, et al. Anti-CD4 antibody treatment of patients with rheumatoid arthritis. I. Effect on clinical course and circulating T cells. J Autoimmun 1989;2:627-42.
6. 6 Horneff G, Burmester GR, Emmrich F, Kalden JR. Treatment of rheumatoid arthritis with an anti-CD4 monoclonal antibody. Arthritis Rheum 1991;34:129-40.
7. 7 Reiter C, Kakavand B, Rieber EP, Schattenkirchner M, Riethmuller G, Kruger K. Treatment of rheumatoid arthritis with monoclonal CD4 antibody M-T151: clinical results and immunopharmacologic effects in an open study, including repeated administration. Arthritis Rheum 1991;34:525-36.
8. 8 Goldberg D, Morel P, Chatenoud L, Boitard C, Joel Menkes C, Bertoye PH, et al. Immunological effects of high dose administration of anti-CD4 antibody in rheumatoid arthritis patients. J Autoimmun 1991;4:617-30.
9. 9 Wendling D, Racadot E, Morel-Fourrrier BJW. Treatment of rheumatoid arthritis with anti-CD4 monoclonal antibody: open study of 25 patients with the B-P5 clone. Clin Rheumatol 1992;11:542-7.
10. 10 Choy ES, Pitzalis C, Cauli A, Bijl JA, Schantz A, Woody J, et al. Percentage of anti-CD4 monoclonal antibody-coated lymphocytes in the rheumatoid joint is associated with clinical improvement: Implications for the development of immunotherapeutic dosing regimens. Arthritis Rheum 1996;39:52-6.
11. 11 Van der Lubbe PA, Reiter C, Breedveld FC, Kruger K, Schattenkirchner M, Sanders ME, et al. Chimeric CD4 monoclonal antinody cM-T412 as a therapeutic approach to rheumatoid arthritis. Arthritis Rheum 1993;36:1375-9.
12. 12 Moreland LW, Bucy RP, Tilden A, Pratt PW, LoBuglio AF, Khazaeli M, et al. Use of a chimeric monoclonal anti-CD4 monoclonal antibody in patients with refractory rheumatoid arthritis. Arthritis Rheum 1993;36:307-18.
13. 11 Moreland LW, Pratt PW, Mayes MD, Postlethwaite A, Weisman MH, Schnitzer T, et al. Double blind, placebo controlled, muti-center trial using chimeric monoclonal anti-CD4 antibody, cM-T412, in rheumatoid arthritis patients receiving concomitant methotrexate. Arthritis Rheum 1995;38:1581-8.
14. 14 Van der Lubbe PA, Dijkmans BAC, Markusse HM, Nassander U, Breedveld FC. A randomised, double blind, placebo controlled study of CD4 monoclonal antibody therapy in early rheumatoid arthritis. Arthritis Rheum 1995;38:1097-106.
15. 15 Choy EHS, Chikanza IC, Kingsley GH, Corrigall V, Panayi GS. Treatment of rheumatoid arthritis with single dose or weekly pulses of chimaeric anti-CD4 monoclonal antibody. Scand J Immunol 1942;36:291-8.
16. 16 Tak PP, Van der Lubbe PA, Cauli A, Daha MR, Smeets TJM, Kluin PM, et al. Reduction of synovial inflammation after anti-CD4 monoconal antibody treatment in early rheumatoid arthritis. Arthritis Rheum 1995;38:1457-65.
17. 17 Epstein WV. Expectation bias in rheumatoid arthritis clinical trials: The anti-CD4 monoclonal antibody experience. Arthritis Rheum 1996;39:1773-80.
18. 18 Gaffney K, Cookson J, Blake D, Coumbe A, Blades S. Quantification of rheumatoid synovitis by magnetic resonance imaging. Arthritis Rheum 1995;38:1610-17.
19. 19 Tamai K, Yamato M, Yamaguchi T, Ohno W. Dynamic magnetic resonance imaging for the evaluation of synovitis in patients with rheumatoid arthritis. Arthritis Rheum 1994;37:1151-7.
20. 20 Reece RJ, Emery P. Needle arthroscopy. Br J Rheumatol 1996;34:1102-4.
21. 21 Ike RW. Diagnostic arthroscopy. Baillieres Clin Rheumatol 1996;10:495-517.
22. 22 Foley-Nolan D, Stack JP, Ryan M, Redmond U, Barry C, Ennis J, et al. Magnetic resonance imaging in the assesment of rheumatoid arthritis - a comparison with plain film radiographs. Br J Rheumatol 1991;30:101-6.
23. 23 Gilkeson G, Polisson R, Sinclair H. Early detection of carpal erosions in patients with rheumatoid arthritis: a pilot study with magnetic resonance imaging. J Rheumatol 1988;15: 1361-6.
24. 24 Gramas DA, Antounlan FS, Peterfy CG, Genant HK, Lane NE. Assessment of needle arthroscopy, standard arthroscopy, physical examination and magnetic resonance imaging in knee pain: a pilot study. J Clin Rheumatol 1996;1:26-34.
25. 25 Bjorkengren AG, Geborek P, Rydholm U, Holtas S, Petterson H. Magnetic resonance imaging of the knee in acute rheumatoid arthritis: synovial uptake of gadolinium DPTA. Am J Roentgenol 1990;155:329-32.
26. 26 Ostergaard M, Stoltenberg M, Henriksen O, Lorenzen I. Quantitative assessment of synovial inflammation by dynamic gadolinium-enhanced magnetic resonance imaging: A study of the effect of intra-articular methylprednisolone on the rate of early synovial enhancement. Br J Rheumatol 1996;35:50-9.
27. 27 Konig H, Sieper J, Wolf KJ. Rheumatoid arthritis: evaluation of hypervascular and fibrous pannus with dynamic MR imaging enhanced with Gd-DPTA. Radiology 1990;176: 473-7.
28. 28 Levy R, Weisman M, Weisenhutter C, Yocum D, Schnitzer T, Goldman A, et al. Results ofa placebo-controlled multicenter trial using a primatized non-depleting, anti-CD4 monoclonal antibody in the treatment of rheumatoid arthritis. [Abstract]. Arthritis Rheum 1996;39:574.
29. 29 Robb RA, Hanson DP, Karwoski RA, Larson AG, Workman EL, Stacey MC. ANALYZE: A comprehensive, operator-interactive software package for multidimensional medical image display and analysis. Comput Med Imaging Graph 1989;13:433-54.
30. 30 Radjenovic A, Berry E, Ridgway JP, O'Connor P, Reece R, Gibbon WW, et al. Relationship between pharmacokinetic and black-box parameters in quantitative analysis of dynamic Gd-DTPA enhanced MRI. Berkely: International Society for Magnetic Resonance in Medicine 1997;330.
31. 31 Yanni G, Nabil M, Farahat MR, Poston RN, Panayi GS. Intramuscular gold decreases cytokine expression and macrophage numbers in the rheuamtoid synovial membrane. Ann Rheum Dis 1994;53:315-22.
32. 32 Tak PP, Taylor PC, Breedveld FC, Smeets TJM, Daha MR, Kluin PM, et al. Decrease in cellularity and expression of adhesion molecules by anti-tumor necrosis factor a monoclonal antibody treatment in patients with rheumatoid arthritis. Arthritis Rheum 1996;39:1077-81.