Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin I receptor antagonist-deficient mice

Journal of Experimental Medicine

Volumn 191, Issue 2, 2000, Pages 313-320

  Horai, Reiko ^a   Saijo, Shinobu ^a   Tanioka, Hidetoshi ^b   Nakae, Susumu ^a   Sudo, Katsuko ^a   Okahara, Akihiko ^b   Ikuse, Toshimi ^b   Asano, Masahide ^a   Iwakura, Yoichiro ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b SANTEN PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Animal model; Autoimmunity; Cytokine; IL 1 receptor antagonist; Rheumatoid arthritis

Indexed keywords

COLLAGEN TYPE 2; CYTOKINE; DOUBLE STRANDED DNA; IMMUNOGLOBULIN ANTIBODY; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ARTHROPATHY; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; FEMALE; GENE TARGETING; GRANULATION TISSUE; HISTOPATHOLOGY; HOST RESISTANCE; IMMUNE SYSTEM; INFLAMMATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS;

ANIMALS; ANKLE JOINT; ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; AUTOIMMUNITY; CHRONIC DISEASE; FEMALE; IMMUNOGLOBULINS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-1; INTERLEUKIN-6; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, INTERLEUKIN-1; SIALOGLYCOPROTEINS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034677123     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.191.2.313     Document Type: Article

References (38)

1. Firestein, G.S., and N.J. Zvaifluer. 1992. Rheumatoid arthritis: a disease of disordered immunity. In Inflammation: Basic Principles and Clinical Correlates, 2nd ed. Raven Press, Ltd., New York. 959-975.
2. Feldmann, M., F.M. Brennan, and R.N. Maini. 1996. Role of cytokines in rheumatoid arthritis. Annu. Rev. Immunol. 14: 397-140.
3. Pettipher, E.R., G.A. Higgs, and B. Henderson. 1986. Interleukin 1 induces leukocyte infiltration and cartilage proteoglycan degradation in the synovial joint. Proc. Natl. Acad. Sci. USA. 83:8749-8753.
4. Marinova-Mutafchieva, L., R.O. Williams, L.J. Mason, C. Mauri, M. Feldmann, and R.N. Maini. 1997. Dynamics of proinflammatory cytokine expression in the joints of mice with collagen-induced arthritis (CIA). Clin. Exp. Immunol. 107:507-512.
5. van den Berg, W.D., L.A. Joosten, M. Helsen, and F.A. van de Loo. 1994. Amelioration of established murine collagen-induced arthritis with anti-IL-1 treatment. Clin. Exp. Immunol. 95:237-243.
6. Joosten, L.A., M.M. Helsen, F.A. van de Loo, and W.B. van den Berg. 1996. Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice. A comparative study using anti-TNF-α, anti-IL-1α/β, and IL-1Ra. Arthritis Rheum. 39:797-809.
7. Makarov, S.S., J.C. Olsen, W.N. Johnston, S.K. Anderle, R.R. Brown, A.S. Baldwin, Jr., J.S. Haskill, and J.H. Schwab. 1996. Suppression of experimental arthritis by gene transfer of interleukin 1 receptor antagonist cDNA. Proc. Nat. Acad. Sci. USA. 93:402-406.
8. Tocci, M.J., and J.A. Schmidt. 1997. Interleukin-1: structure and function. In Cytokines in Health and Disease. 2nd ed. D.G. Remick and J.S Friedland, editors. Marcel Dekker. Inc., New York. 1-27.
9. Sims, J.E., M.A. Gayle, J.L. Slack, M.R. Alderson, T.A. Bird, J.G. Giri, F. Colotta, F. Re, A. Mantovani, K. Shanebeck, et al. 1993. Interleukin 1 signaling occurs exclusively via the type I receptor. Proc. Natl. Acad. Sci. USA. 90:6155-6159.
10. Carter, D.B., M.R. Deibel, Jr., C.J. Dunn, C.-S.C. Tomich, A.L. Laborde, J.I. Slightom, A.E. Berger, M.J. Bienkowski, F.F. Sun, R.N. McEwan, et al. 1990. Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein. Nature. 344:633-638.
11. Hannum, C.H., C.J. Wilcox, W.P. Arend, F.G. Joslin, D.J. Dripps, P.L. Heimdal, L.G. Armes, A. Sommer, S.P. Eisenberg, and R.C. Thompson. 1990. Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor. Nature. 343:336-3411.
12. Colotta, F., F. Re, M. Muzio, R. Bertini, N. Polentarutti, M. Sironi, J.G. Gin, S.K. Dower, J.E. Sims, and A. Mantovani. 1993. Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4. Science. 261:472-475.
13. Haskill, S., G. Martin, L. Van Le, J. Morris, A. Peace, C.F. Bigler, G.J. Jaffe, C. Hammerberg, S.A. Sporn, S. Fong, et al. 1991. cDNA cloning ot an intracellular form ot the human interleukm 1 receptor antagonist associated with epithelium. Proc. Natl. Acad. Sci. USA. 88:3681-3685.
14. Muzio, M., N. Polentarutti, M. Sironi, G. Poli, L. De Gioia, M. Introna, A. Mantovani, and F. Colotta. 1995. Cloning and characterization of a new isoforn of the interleukin 1 receptor antagonist. J. Exp. Med. 182:623-628.
15. Malyak, M., M.F. Smith, Jr., A.A. Abel, K.R. Hance, and W.P. Arend. 1998. The differential production of three forms of IL-1 receptor antagonist by human neutrophils and monocytes. J. Immunol. 161:2004-2010.
16. Malyak, M., J.M. Guthridge, K.R. Hance, S.K. Dower, J.H. Freed, and W.P. Arend. 1998. Characterization of a low molecular weight isoform of IL-1 receptor antagonist. J. Immunol. 161:1997-2003.
17. Arend, W.P., M. Malyak, C.J. Guthridge, and C. Gabay. 1998. Interleukin-1 receptor antagonist: role in biology. Annu. Rev. Immunol. 16:27-55.
18. Horai, R., M. Asano, K. Sudo, H. Kanuka, M. Suzuki, M. Nishihara, M. Takahashi, and Y. Iwakura. 1998. Production of mice deficient in genes for interleukin (IL)-1α, IL-1β, IL-1α/β, and IL-1 receptor antagonist shows that IL-1β is crucial in turpentine-induced fever development and glucocorticoid secretion. J. Exp. Med. 187:1463-1475.
19. Dinarello, C.A. 1996. Biologic basis for interleukin-1 in disease. Blood. 87:2095-2147.
20. Durum, S.K., and J.J. Oppenheim. 1993. Proinflammatory cytokines and immunity. In Fundamental Immunology, 3rd ed. W.E. Paul, editor. Raven Press, Ltd., New York. 801-835.
21. Iwakura, Y., S. Saijo, Y. Kioka, J. Nakayama-Yamada, K. Itagaki, M. Tosu, M. Asano, Y. Kanai, and K. Kakimoto. 1995. Autoimmunity induction by human T cell leukemia virus type 1 in transgenic mice that develop chronic inflammatory arthropathy resembling rheumatoid arthritis in humans. J. Immunol. 155:1588-1598.
22. Ma, Y., S. Thornton, G.P. Boivin, D. Hirsh, R. Hirsch, and E. Hirsch. 1998. Altered susceptibility to collagen-induced arthritis in transgenic mice with aberrant expression of interleukin-1 receptor antagonist. Arthritis Rheum. 41:1798-1805.
23. Nicklin, M.J.H., D.E. Hughes, J.L. Barton, J.M. Ure, and G.W. Duff. 1999. Arterial inflammation in mice lacking the interleukin 1 receptor agonist gene. J. Exp. Med. 191:303-311.
24. McDowell, T.L., J.A. Symons, R. Ploski, O. Forre, and G.W. Duff. 1995. A genetic association between juvenile rheumatoid arthritis and a novel interleukin-1 α polymorphism. Arthritis Rheum. 38:221-228.
25. Mansfield, J.C., H. Holden, J.K. Tarlow, F.S. Di Giovine, T.L. McDowell, A.G. Wilson, C.D. Holdsworth, and G.W. Duff. 1994. Novel genetic association between ulcerative colitis and the anti-inflammatory cytokine interleukin-1 receptor antagonist, Gastroenterology. 106:637-642.
26. Blakemore, A.I., J.K. Tarlow, M.J. Cork, C. Gordon, P. Emery, and G.W. Duff. 1994. Interleukin-1 receptor antagonist gene polymorphism as a disease severity factor in systemic lupus erythematosus. Arthritis Rheum. 37:1380-1385.
27. Perrier, S., C. Coussediere, J.J. Dubost, E. Albuisson, and B. Sauvezie. 1998. IL-1 receptor antagonist (IL-1RA) gene polymorphism in Sjögren's syndrome and rheumatoid arthritis. Clin. Immunol. Immunopathol. 87:309-313.
28. Tarlow, J.K., M.J. Cork, F.E. Clay, M. Schmitt-Egenolf, A.M. Crane, C. Stierle, W.H. Boehncke, T.H. Eiermann, A.I. Blakemore, S.S. Bleehen, et al. 1997. Association between interleukni-1 receptor antagonist (IL-1ra) gene polymorphism and early and late-onset psoriasis. Br. J. Dematol. 136:147-148.
29. Clay, F.E., M.J. Cork, J.K. Tarlow, A.I. Blakemore, C.I. Harrington, F. Lewis, and C.W. Duff. 1994. Interleukin 1 receptor antagonist gene polymorphism association with lichen selerosus. Hum. Genet. 94:407-410.
30. Tarlow, J.K., F.E. Clay, M.J. Cork, A.I. Blakemore, A.J. McDonagh, A.G. Messenger, and G.W. Duff. 1994. Severity of alopecia areata is associated with a polymorphism in the interleukin-1 receptor antagonist gene. J. Invest. Dermatol. 103:387-390.
31. Firestem, G.S., D.L. Boyle, C. Yu, M.M. Paine, T.D. Whisenand, N.J. Zvaifler, and W.P. Arend. 1994. Synovial interleukin-1 receptor antagonist and interleukin-1 balance in rheumatoid arthritis. Arthritis Rheum. 37:644-652.
32. Chomarat, P., E. Vannier, J. Dechanet, M.C. Rissoan, J. Banchereau, C.A. Dinarello, and P. Miossec. 1995. Balance of IL-1 receptor antagonist/IL-1β in rheumatoid synovium and its regulation by IL-4 and IL-10. J. Immunol. 154:1432-1439.
33. Chikanza, I.C., P. Roux-Lombard, J.M. Dayer, and G.S. Panayi. 1995. Dysregulation of the in vivo production of interleukin-1 receptor antagonist in patients with rheumatoid arthritis. Pathogenetic implications. Arthritis Rheum. 38:642-648.
34. Trentham, D.E., A.S. Townes, and A.H. Kang. 1977. Autoimmunity to type II collagen: an experimental model of arthritis. J. Exp. Med. 146:857-868.
35. Pearson, C.M., B.H. Waksman, and J.T. Sharp. 1961. Studies of arthritis and other lesions induced in rats by injection of mycobacterial adjuvant. J. Exp. Med. 113:485-510.
36. Cromartie, W.J., J.G. Craddock, J.H. Schwab, S.K. Anderle, and C.H. Yang. 1977. Arthritis in rats after systemic injection of streptococcal cells or cell walls. J. Exp. Med. 146:1585-1602.
37. Hang, L., A.N. Theofilopoulos, and F.J. Dixon. 1982. A spontaneous rheumatoid arthritis-like disease in MRL/1 mice. J. Exp. Med. 155:1690-1701.
38. Iwakura, Y., M. Tosu, E. Yoshida, M. Takiguchi, K. Sato, I. Kitajima, K. Nishioka, K. Yamamoto, T. Takeda, M. Hatanaka, et al. 1991. Induction of inflammatory arthropathy resembling rheumatoid arthritis in mice transgenic for HTLV-I. Science. 253:1026-1028.