메뉴 건너뛰기




Volumn 103, Issue 9, 1999, Pages 1227-1230

The role of αv integrins during angiogenesis: Insights into potential mechanisms of action and clinical development

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN; CD51 ANTIGEN; LEUKOCYTE ANTIGEN;

EID: 0033121275     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI6869     Document Type: Review
Times cited : (626)

References (18)
  • 1
    • 0031745571 scopus 로고    scopus 로고
    • Signal transduction and signal modulation by cell adhesion receptors: The role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins
    • Aplin, A.E., Howe, A., Alahari, S.K., and Juliano, R.L. 1998. Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins. Pharmacol. Rev. 50:197-263.
    • (1998) Pharmacol. Rev. , vol.50 , pp. 197-263
    • Aplin, A.E.1    Howe, A.2    Alahari, S.K.3    Juliano, R.L.4
  • 3
    • 0028143758 scopus 로고
    • Confocal microscopic analysis of integrin expression on the microvasculature and its sprouts in the neonatal foreskin
    • Enenstein, J., and Kramer, R.H. 1994. Confocal microscopic analysis of integrin expression on the microvasculature and its sprouts in the neonatal foreskin. J. Invest. Dermatol. 103:381-386.
    • (1994) J. Invest. Dermatol. , vol.103 , pp. 381-386
    • Enenstein, J.1    Kramer, R.H.2
  • 4
    • 0028362876 scopus 로고
    • Requirement of vascular integrin αβ3 for angiogenesis
    • Brooks, P.C., Clark, R.A., and Cheresh, D.A. 1994. Requirement of vascular integrin αβ3 for angiogenesis. Science. 264:569-571.
    • (1994) Science , vol.264 , pp. 569-571
    • Brooks, P.C.1    Clark, R.A.2    Cheresh, D.A.3
  • 5
    • 0028670833 scopus 로고
    • Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
    • Brooks, P.C., et al. 1994. Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell. 79:1157-1164.
    • (1994) Cell , vol.79 , pp. 1157-1164
    • Brooks, P.C.1
  • 6
    • 0032893957 scopus 로고    scopus 로고
    • Decreased angiogenesis and arthritic disease in rabbits treated with an αvβ3 antagonist
    • Storgard, CM., et al. 1999. Decreased angiogenesis and arthritic disease in rabbits treated with an αvβ3 antagonist. J. Clin. Invest. 103:47-54.
    • (1999) J. Clin. Invest. , vol.103 , pp. 47-54
    • Storgard, C.M.1
  • 7
    • 0031862889 scopus 로고    scopus 로고
    • Detection of tumor angiogenesis in vivo by αvβ3-targeted magnetic resonance imaging
    • Sipkins, D.A., et al. 1998. Detection of tumor angiogenesis in vivo by αvβ3-targeted magnetic resonance imaging. Nat. Med. 4:623-626.
    • (1998) Nat. Med. , vol.4 , pp. 623-626
    • Sipkins, D.A.1
  • 8
    • 0028981497 scopus 로고
    • An antagonist of integrin αvβ3 prevents maturation of blood vessels during embryonic neovascularization
    • Drake, C.J., Cheresh, D.A., and Little, C.D. 1995. An antagonist of integrin αvβ3 prevents maturation of blood vessels during embryonic neovascularization. J. Cell Sci. 108:2655-2661.
    • (1995) J. Cell Sci. , vol.108 , pp. 2655-2661
    • Drake, C.J.1    Cheresh, D.A.2    Little, C.D.3
  • 9
    • 0028972105 scopus 로고
    • Antiintegrin αvβ3 blocks human breast cancer growth and angiogenesis in human skin
    • Brooks, P.C., et al. 1995. Antiintegrin αvβ3 blocks human breast cancer growth and angiogenesis in human skin. J. Clin. Invest. 96:1815-1822.
    • (1995) J. Clin. Invest. , vol.96 , pp. 1815-1822
    • Brooks, P.C.1
  • 10
    • 0029610677 scopus 로고
    • Definition of two angiogenic pathways by distinct av integrins
    • Friedlander, M., et al. 1995. Definition of two angiogenic pathways by distinct av integrins. Science. 270:1500-1502.
    • (1995) Science , vol.270 , pp. 1500-1502
    • Friedlander, M.1
  • 11
    • 0029925079 scopus 로고    scopus 로고
    • Subcutaneous injection of a cyclic peptide antagonist of vitronectin receptor-type integrins inhibits retinal neovascularization
    • Hammes, H.P., Brownlee, M. Jonczyk, A., Sutter, A., and Preissner, K.T. 1996. Subcutaneous injection of a cyclic peptide antagonist of vitronectin receptor-type integrins inhibits retinal neovascularization. Nat. Med. 2:529-533.
    • (1996) Nat. Med. , vol.2 , pp. 529-533
    • Hammes, H.P.1    Brownlee, M.2    Jonczyk, A.3    Sutter, A.4    Preissner, K.T.5
  • 12
    • 15844420283 scopus 로고    scopus 로고
    • Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin αvβ3
    • Brooks, P.C., et al. 1996. Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin αvβ3. Cell. 85:683-693.
    • (1996) Cell , vol.85 , pp. 683-693
    • Brooks, P.C.1
  • 13
    • 0010712792 scopus 로고    scopus 로고
    • Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity
    • Brooks, P.C., Silletti, S., von Schalscha, T.L., Friedlander, M., and Cheresh, D.A. 1998. Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity. Cell. 92:391-400.
    • (1998) Cell , vol.92 , pp. 391-400
    • Brooks, P.C.1    Silletti, S.2    Von Schalscha, T.L.3    Friedlander, M.4    Cheresh, D.A.5
  • 14
    • 0032514841 scopus 로고    scopus 로고
    • Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins
    • Bader, B.L., Rayburn, H., Crowley, D., and Hynes, R.O. 1998. Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins. Cell. 95:507-519.
    • (1998) Cell , vol.95 , pp. 507-519
    • Bader, B.L.1    Rayburn, H.2    Crowley, D.3    Hynes, R.O.4
  • 15
    • 0032590042 scopus 로고    scopus 로고
    • β3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival
    • Hodivala-Dilke, K.M., et al. 1999. β3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. J. Clin. Invest. 103:229-238.
    • (1999) J. Clin. Invest. , vol.103 , pp. 229-238
    • Hodivala-Dilke, K.M.1
  • 16
    • 0027371908 scopus 로고
    • Embryonic mesodermal defects in α5 integrin-deficient mice
    • Yang, J.T., Rayburn, H., and Hynes, R.O. 1993. Embryonic mesodermal defects in α5 integrin-deficient mice. Development. 119:1093-1105.
    • (1993) Development , vol.119 , pp. 1093-1105
    • Yang, J.T.1    Rayburn, H.2    Hynes, R.O.3
  • 17
    • 0032498640 scopus 로고    scopus 로고
    • Integrin αvβ3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis
    • Eliceiri, B.P., Klemke, R., Stromblad, S., and Cheresh, D.A. 1998. Integrin αvβ3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis. J. Cell Biol. 140:1255-1263.
    • (1998) J. Cell Biol. , vol.140 , pp. 1255-1263
    • Eliceiri, B.P.1    Klemke, R.2    Stromblad, S.3    Cheresh, D.A.4
  • 18
    • 0030038229 scopus 로고    scopus 로고
    • Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin αvβ3 during angiogenesis
    • Stromblad, S., Becker, J.C., Yebra, M., Brooks, P.C., and Cheresh, D.A. 1996. Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin αvβ3 during angiogenesis. J. Clin. Invest. 98:426-433.
    • (1996) J. Clin. Invest. , vol.98 , pp. 426-433
    • Stromblad, S.1    Becker, J.C.2    Yebra, M.3    Brooks, P.C.4    Cheresh, D.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.