Interleukin-10 functions as an antiinflammatory cytokine in rheumatoid synovium

Arthritis and Rheumatism

Volumn 39, Issue 3, 1996, Pages 386-395

  Isomäki, Pia ^a   Luukkainen, Reijo ^b   Saario, Riitta ^c   Toivanen, Paavo ^a   Punnonen, Juha ^a,d  

^a TURKU UNIVERSITY   (Finland)

^b Satalinnan Sairaala   (Finland)

^c TURKU UNIVERSITY HOSPITAL   (Finland)

^d MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTIRHEUMATIC AGENT; CD16 ANTIGEN; CYTOKINE; FC RECEPTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HLA DR ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 1BETA; MESSENGER RNA; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; NONSTEROID ANTIINFLAMMATORY AGENT; RECOMBINANT INTERLEUKIN 10; RECOMBINANT INTERLEUKIN 2; STEROID; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CELL FUNCTION; CELL PROLIFERATION; CLINICAL ARTICLE; CLINICAL FEATURE; DNA SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOREGULATION; MALE; MEDICAL RECORD; MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID;

ADULT; AGED; ANTI-INFLAMMATORY AGENTS; ANTIBODIES, MONOCLONAL; ARTHRITIS, RHEUMATOID; BASE SEQUENCE; CELL DIVISION; CYTOKINES; FEMALE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HLA-DR ANTIGENS; HUMANS; INTERLEUKIN-1; INTERLEUKIN-10; JOINT DISEASES; MACROPHAGES; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; NEUTRALIZATION TESTS; OLIGONUCLEOTIDE PROBES; RNA, MESSENGER; SYNOVIAL MEMBRANE; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0029928567     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.1780390306     Document Type: Article

References (47)

1. Miyasaka N, Sato K, Goto M, Sasano M, Natsuyama M, Inoue K, Nishioka K: Augmented interleukin-1 production and HLA-DR expression in the synovium of rheumatoid arthritis patients: possible involvement in joint destruction. Arthritis Rheum 31:480-486, 1988
2. Buchan G, Barrett K, Turner M, Chantry D, Maini RN, Feldmann M: Interleukin-1 and tumour necrosis factor mRNA expression in rheumatoid arthritis: prolonged production of IL-1α. Clin Exp Immunol 73:449-455, 1988
3. Chu CQ, Field M, Feldmann M, Maini RN: Localization of tumor necrosis factor α in synovial tissues and at the cartilage-pannus junction in patients with rheumatoid arthritis. Arthritis Rheum 34:1125-1132, 1991
4. Haworth C, Brennan FM, Chantry D, Turner M, Maini RN, Feldmann M: Expression of granulocyte macrophage colony-stimulating factor in rheumatoid arthritis: regulation by tumor necrosis factor α. Eur J Immunol 21:2575-2579, 1991
5. Dayer J-M, de Rochemonteix B, Burrus B, Demczuk S, Dinarello CA: Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by human synovial cells. J Clin Invest 77:645-648, 1986
6. Dayer J-M, Beutler B, Cerami A: Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts. J Exp Med 162:2163-2168, 1985
7. Campbell IK, Piccoli DS, Roberts MJ, Muirden KD, Hamilton JA: Effects of tumor necrosis factor α and β on resorption of human articular cartilage and production of plasminogen activator by human articular chondrocytes. Arthritis Rheum 33: 542-552, 1990
8. Alvaro-Gracia JM, Zvaifler NJ, Firestein GS: Cytokines in chronic inflammatory arthritis. IV. Granulocyte/macrophage colony-stimulating factor-mediated induction of class II MHC antigen on human monocytes: possible role in rheumatoid arthritis. J Exp Med 170:865-875, 1989
9. Pettipher ER, Higgs GA, Henderson B: Interleukin 1 induces leukocyte infiltration and cartilage proteoglycan degradation in the synovial joint. Proc Natl Acad Sci U S A 83:8749-8753, 1986
10. Horn JT, Bendele AM, Carlson DG: In vivo administration with IL-1 accelerates the development of collagen-induced arthritis in mice. J Immunol 141:834-841, 1988
11. Wooley PH, Whalen JD, Chapman DL, Berger AE, Richard KA, Aspar DG, Staite ND: The effect of an interleukin-1 receptor antagonist protein on type II collagen-induced arthritis and antigen-induced arthritis in mice. Arthritis Rheum 36:1305-1314, 1993
12. Keffer J, Lesley P, Cazlaris H, Georgopoulos S, Kaslaris E, Kioussis D, Kollias G: Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. EMBO J 10:4025-4031, 1991
13. Williams RO, Feldmann M, Maini RN: Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis. Proc Natl Acad Sci U S A 89:9784-9788, 1992
14. Elliott MJ, Maini RN, Feldmann M, Long-Fox A, Charles P, Katsikis P, Brennan FM, Walker J, Bijl H, Ghrayeb J, Woody JN: Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor α. Arthritis Rheum 36:1681-1690, 1993
15. Elliott MJ, Maini RN, Feldmann M, Kalden JR, Antoni C, Smolen JS, Leeb B, Breedveld FC, Macfarlane JD, Bijl H, Woody JN: Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor α (cA2) versus placebo in rheumatoid arthritis. Lancet 344:1105-1110, 1994
16. Vieira P, de Waal Malefyt R, Dang M-N, Johnson KE, Kastelein R, Fiorentino DF, de Vries JE, Roncarolo M-G, Mosmann TR, Moore KW: Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI. Proc Natl Acad Sci U S A 88:1172-1176, 1991
17. Yssel H, de Waal Malefyt R, Roncarolo M-G, Abrams JS, Lahesmaa R, Spits H, de Vries JE: IL-10 is produced by subsets of human CD4+ T cell clones and peripheral blood T cells. J Immunol 149:2378-2384, 1992
18. Fiorentino DF, Bond MW, Mosmann TR: Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med 170:2081-2095, 1989
19. De Waal Malefyt R, Abrams J, Bennett B, Fidgor CG, de Vries JE: Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 174:1209-1220, 1991
20. De Waal Malefyt R, Haanen J, Spits H, Roncarolo M-G, te Velde A, Figdor C, Johnson K, Kastelein R, Yssel H, de Vries JE: Interleukin-10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J Exp Med 174:915-924, 1991
21. De Waal Malefyt R, Yssel H, de Vries JE: Direct effects of IL-10 on subsets of human CD4+ T cell clones and resting T cells. J Immunol 150:4754-4765, 1993
22. Punnonen J, de Waal Malefyt R, van Vlasselaer P, Gauchat J-F, de Vries JE: IL-10 and viral IL-10 prevent IL-4-induced IgE synthesis by inhibiting the accessory cell function of monocytes. J Immunol 151:1280-1289, 1993
23. Rousset F, Garcia E, Defrance T, Peronne C, Vezzio N, Hsu D-H, Kastelein R, Moore KW, Banchereau J: IL-10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc Natl Acad Sci U S A 89:1890-1893, 1992
24. Kuhn R, Löhler J, Rennick D, Rajewsky K, Muller W: Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75: 263-274, 1993
25. Kasama T, Strieter RM, Lukacs NW, Lincoln PM, Burdick MD: Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis. J Clin Invest 95:2868-2876, 1995
26. Howard M, Muchamuel T, Andrade S, Menon S: Interleukin 10 protects mice from lethal endotoxemia. J Exp Med 177:1205-1208, 1993
27. Rott O, Fleicher B, Cash E: Interleukin-10 prevents experimental allergic encephalomyelitis in rats. Eur J Immunol 24:1434-1440, 1994
28. Katsikis PD, Chu C-Q, Brennan FM, Maini RN, Feldmann M: Immunoregulatory role of interleukin 10 in rheumatoid arthritis. J Exp Med 179:1517-1527, 1994
29. Cohen SBA, Katsikis PD, Chu C-Q, Thomssen H, Webb LMC, Maini RN, Londei M, Feldmann M: High level of interleukin-10 production by the activated T cell population within the rheumatoid synovial membrane. Arthritis Rheum 38:946-952, 1995
30. Llorente L, Richaud-Patin Y, Fior R, Alcocer-Varela J, Wijdenes J, Fourrier BM, Galanaud P, Emilie D: In vivo production of interleukin-10 by non-T cells in rheumatoid arthritis, Sjögren's syndrome, and systemic lupus erythematosus. Arthritis Rheum 37:1647-1655, 1994
31. Cush JJ, Splawski JB, Thomas R, McFarlin JE, Schulze-Koops H, Davis LS, Fujita K, Lipsky PE: Elevated interleukin-10 levels in patients with rheumatoid arthritis. Arthritis Rheum 38:96-104, 1995
32. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, Medsger TA Jr, Mitchell DM, Neustadt DH, Pinals RS, Schaller JG, Sharp JT, Wilder RL, Hunder GG: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315-324, 1988
33. Abrams JS, Roncarolo M-G, Yssel H, Andersson U, Gleich GJ, Silver JE: Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples. Immunol Rev 127:5-24, 1992
34. Bacchetta R, de Vaal Malefyt R, Huijbens RJF, de Vries JE, Figdor CG: Host-reactive CD4+ and CD8+ T cell clones isolated from a human chimera produce IL5, IL2, IFNγ, and granulocyte/macrophage-colony-stimulating factor but not IL4. J Immunol 144:902-908, 1990
35. Chirgwin JM, Przybyla AE, MacDonald RJ, Rutter WJ: Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294-5299, 1979
36. Krug MS, Berger SI: First-strand cDNA synthesis primed with oligo(dT). Methods Enzymol 152:316-325, 1987
37. Ridley MG, Kingsley G, Pitzalis C, Panayi GS: Monocyte activation in rheumatoid arthritis: evidence for in situ activation and differentiation in joints. Br J Rheumatol 29:84-88, 1990
38. Wahl SM, Allen JB, Welch GR, Wong HL: Transforming growth factor-β in synovial fluids modulates FcγRIII (CD16) expression on mononuclear phagocytes. J Immunol 148:485-490, 1992
39. Spits H, de Waal Malefyt R: Functional characterization of human IL-10. Int Arch Allerg Immunol 99:8-15, 1992
40. Taga K, Tosato G: IL-10 inhibits human T cell proliferation and IL-2 production. J Immunol 148:1143-1148, 1992
41. Hamilton JA: Rheumatoid arthritis: opposing actions of haemopoietic growth factors and slow-acting anti-rheumatic drugs. Lancet 342:536-539, 1993
42. Howell MD, Diveley JP, Lundeen KA, Esty A, Winters ST, Carlo DJ, Brostoff SW: Limited T-cell receptor β-chain heterogeneity among interleukin 2 receptor-positive synovial T cells suggests a role for superantigen in rheumatoid arthritis. Proc Natl Acad Sci U S A 88:10921-10925, 1991
43. Paliard X, West SG, Lafferty JA, Clements JR, Kappler JW, Marrack P, Kotzin BL: Evidence for the effects of a superantigen in rheumatoid arthritis. Science 253:325-329, 1991
44. Te Velde AA, de Waal Malefijt R, Juijbens JF, de Vries JE, Figdor CG: IL-10 stimulates monocyte FcγR surface expression and cytotoxic activity. J Immunol 149:4048-4052, 1992
45. Sylvestre DL, Ravetch JV: Fc receptors initiate the Arthus reaction: redefining the inflammatory cascade. Science 265: 1095-1098, 1994
46. Barcy S, Wettendorff M, Leo O, Urbain J, Kruger M, Ceuppens JL, de Boer M: FcR cross-linking on monocytes results in impaired T cell stimulatory capacity. Int Immunol 7:179-189, 1995
47. Chernoff AE, Granowitz EV, Shapiro L, Vannier E, Lonnemann G, Angel JB, Kennedy JS, Rabson AR, Wolff SM, Dinarello CA: A randomized, controlled trial of IL-10 in humans. J Immunol 154:5492-5499, 1995