Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-α production in rheumatoid arthritis

Nature Medicine

Volumn 3, Issue 2, 1997, Pages 189-195

  Mcinnes, Iain B ^a   Leung, Bernard P ^a   Sturrock, Roger D ^a   Field, Max ^a   Liew, Foo Y ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD69 ANTIGEN; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; HUMAN; HUMAN CELL; MACROPHAGE; PATHOGENESIS; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID; T LYMPHOCYTE;

ARTHRITIS, RHEUMATOID; CELLS, CULTURED; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-15; LYMPHOCYTE ACTIVATION; SYNOVIAL MEMBRANE; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0031042456     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0297-189     Document Type: Article

References (11)

1. Burmester, G. et al. The tissue architecture of synovial membrane in inflammatory and non-inflammatory joint diseases. Rheum. Int. 3, 173-180 (1983).
2. Miossec, P., Chomarat, P. & Dechanet, J. Bypassing the antigen to control rheumatoid arthritis. Immunol. Today 17, 170-173 (1996).
3. Feldmann, M., Brennan, F.M. & Maini, R.N. Role of cytokines in rheumatoid arthritis. Annu. Rev. Immunol. 14, 397-440 (1996).
4. Firestein, G.S. & Zwaifler, N.J. How important are T cells in chronic rheumatoid synovitis? Arthritis Rheum. 33, 768-773 (1990).
5. Simon, K., Seipelt, E. & Sieper, J. Divergent T cell cytokine patterns in inflammatory arthritis. Proc. Natl. Acad. Sci. USA 91, 8562-8566 (1994).
6. Ulfgren, A.-K., Lindblad, S., KlaresKog, L., Andersson, J. & Andersson, U. Detection of cytokine producing cells in the synovial membrane from patients with rheumatoid arthritis. Ann. Rheum. Dis. 54, 654-661 (1995).
7. Firestein, G. et al. Cytokines in chronic inflammatory arthritis: Failure to detect T cell lymphokines (IL-2 and IL-3) and presence of macrophage colony stimulating factor (CSF-1) and a novel mast cell growth factor in rheumatoid synovitis. J. Exp. Med. 168, 1573-1586 (1988).
8. Panayi, G.S., Lanchbury, J.S. & Kingsley, G.H. The importance of the T cell in initiating and maintaining the chronic synovitis of rheumatoid arthritis. Arthritis Rheum. 35, 729-735 (1992).
9. Staines, N. & Wooley, P.H. Collagen arthritis - what can it teach us? Br. J. Rheum. 33, 798-807 (1994).
10. Harrison, W.B. Cyclosporin. in Second-Line Agents in the Treatment of Rheumatic Diseases, (eds. Dixon, J.S. & Furst, D.E.) (Dekker, New York, 1992).
11. Gregerson, P.K., Silver, J. & Winchester, R.J. The shared epitope hypothesis: An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum. 30, 1205-1213 (1987).