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Volumn 2, Issue 10, 1996, Pages 1109-1115

Treatment of multiple sclerosis with T-cell receptor peptides: Results of a double-blind pilot trial

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; T LYMPHOCYTE RECEPTOR; VACCINE;

EID: 16044361810     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1096-1109     Document Type: Article
Times cited : (183)

References (50)
  • 1
    • 0021285402 scopus 로고
    • Idiotypic networks and other preconceived ideas
    • Jerne, N.K. Idiotypic networks and other preconceived ideas. Immunol. Rev. 79, 5-24 (1984).
    • (1984) Immunol. Rev. , vol.79 , pp. 5-24
    • Jerne, N.K.1
  • 2
    • 0026033502 scopus 로고
    • Autoimmunity, microbial immunity and the immunological homunculus
    • Cohen, I.R. & Young, D.B. Autoimmunity, microbial immunity and the immunological homunculus. Immunol. Today 12, 105-110 (1991).
    • (1991) Immunol. Today , vol.12 , pp. 105-110
    • Cohen, I.R.1    Young, D.B.2
  • 4
    • 0023720148 scopus 로고
    • T-cell antigen receptor genes and T-cell recognition
    • Davis, M.M. & Bjorkman, P.J. T-cell antigen receptor genes and T-cell recognition. Nature 334, 395-402 (1988).
    • (1988) Nature , vol.334 , pp. 395-402
    • Davis, M.M.1    Bjorkman, P.J.2
  • 5
    • 0024255812 scopus 로고
    • The antigen-major histocompatibility complex-T-cell receptor interaction: A structural analysis
    • Williams, W.V., Weiner, D.B., Wadsworth, S. & Greene, M.I. The antigen-major histocompatibility complex-T-cell receptor interaction: A structural analysis. Immunol. Rev. 7, 339-344 (1988).
    • (1988) Immunol. Rev. , vol.7 , pp. 339-344
    • Williams, W.V.1    Weiner, D.B.2    Wadsworth, S.3    Greene, M.I.4
  • 6
    • 0029930328 scopus 로고    scopus 로고
    • T cell receptor peptides in treatment of autoimmune disease: Rationale and potential
    • Vandenbark, A.A., Hashim, G.A. & Offner, H. T cell receptor peptides in treatment of autoimmune disease: Rationale and potential. J. Neurosci. Res. 43, 391-402 (1996).
    • (1996) J. Neurosci. Res. , vol.43 , pp. 391-402
    • Vandenbark, A.A.1    Hashim, G.A.2    Offner, H.3
  • 7
    • 45149146393 scopus 로고
    • The V-region disease hypothesis: Evidence from autoimmune encephalomyelitis
    • Heber-Katz, E. & Acha-Orbea, H. The V-region disease hypothesis: Evidence from autoimmune encephalomyelitis. Immunol. Today 10, 164-169 (1989).
    • (1989) Immunol. Today , vol.10 , pp. 164-169
    • Heber-Katz, E.1    Acha-Orbea, H.2
  • 8
    • 0023864061 scopus 로고
    • Anti-idiotypic network induced by T cell vaccination against experimental autoimmune encephalomyelitis
    • Lider, O., Reshef, T., Beraud, E., Ben-Nun, A. & Cohen, I.R. Anti-idiotypic network induced by T cell vaccination against experimental autoimmune encephalomyelitis. Science 239, 181-183 (1988).
    • (1988) Science , vol.239 , pp. 181-183
    • Lider, O.1    Reshef, T.2    Beraud, E.3    Ben-Nun, A.4    Cohen, I.R.5
  • 9
    • 0024425273 scopus 로고
    • Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis
    • Vandenbark, A.A., Hashim, G. & Offner, H. Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis. Nature 341, 541-544 (1989).
    • (1989) Nature , vol.341 , pp. 541-544
    • Vandenbark, A.A.1    Hashim, G.2    Offner, H.3
  • 10
    • 0025969733 scopus 로고
    • T cell receptor peptide therapy triggers autoregulation of experimental encephalomyelitis
    • Offner, H., Hashim, G.A. & Vandenbark, A.A. T cell receptor peptide therapy triggers autoregulation of experimental encephalomyelitis. Science 251, 430-432 (1991).
    • (1991) Science , vol.251 , pp. 430-432
    • Offner, H.1    Hashim, G.A.2    Vandenbark, A.A.3
  • 11
    • 0024468234 scopus 로고
    • Vaccination against experimental allergic encephalomyelitis with T cell receptor peptides
    • Howell, M.D. et al. Vaccination against experimental allergic encephalomyelitis with T cell receptor peptides. Science 246, 668-670 (1989).
    • (1989) Science , vol.246 , pp. 668-670
    • Howell, M.D.1
  • 12
    • 0026527285 scopus 로고
    • Studies of Vβ8 T cell receptor peptide treatment in experimental autoimmune encephalomyelitis
    • Stevens, D.B., Karpus, W.J., Gould, K.E. & Swanborg, R.H. Studies of Vβ8 T cell receptor peptide treatment in experimental autoimmune encephalomyelitis. J. Neuroimmunol. 37, 123-129 (1991).
    • (1991) J. Neuroimmunol. , vol.37 , pp. 123-129
    • Stevens, D.B.1    Karpus, W.J.2    Gould, K.E.3    Swanborg, R.H.4
  • 13
    • 0027249369 scopus 로고
    • + T cells in recovery from antigen-induced autoimmune disease
    • + T cells in recovery from antigen-induced autoimmune disease. J. Exp. Med. 178, 909-916 (1993).
    • (1993) J. Exp. Med. , vol.178 , pp. 909-916
    • Kumar, V.1    Sercarz, E.E.2
  • 14
    • 9044245102 scopus 로고
    • Two distinct T cell receptor peptides independently regulate experimental autoimmune neuritis
    • Gregorian, S.K., Lee, W.P., Doudikian, N. & Amento, E.P. Two distinct T cell receptor peptides independently regulate experimental autoimmune neuritis. Am. Assoc. Immunol. 150, 28A (1993).
    • (1993) Am. Assoc. Immunol. , vol.150
    • Gregorian, S.K.1    Lee, W.P.2    Doudikian, N.3    Amento, E.P.4
  • 15
    • 0028237299 scopus 로고
    • CDR1 T-cell receptor β-chain peptide induces major histocompatibility complex class II-restricted T-T cell interactions
    • Broeren, C.P.M. et al. CDR1 T-cell receptor β-chain peptide induces major histocompatibility complex class II-restricted T-T cell interactions. Proc. Natl. Acad. Sci. USA 91, 5997-6001 (1994).
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 5997-6001
    • Broeren, C.P.M.1
  • 16
    • 0028348386 scopus 로고
    • T cell receptor peptide therapy for autoimmune encephalomyelitis: Stronger immunization is necessary for effective vaccination
    • Matsumoto, Y., Tsuchida, M., Hanawa, H. & Abo, T. T cell receptor peptide therapy for autoimmune encephalomyelitis: Stronger immunization is necessary for effective vaccination. Cell. Immunol. 153, 468-478 (1994).
    • (1994) Cell. Immunol. , vol.153 , pp. 468-478
    • Matsumoto, Y.1    Tsuchida, M.2    Hanawa, H.3    Abo, T.4
  • 17
    • 0028295323 scopus 로고
    • Vaccination with T cell receptor peptides primes anti-receptor cytotoxic T lymphocytes (CTL) and anergizes T cells specifically recognized by these CTL
    • Kuhrober, A., Schirmbeck, R. & Reimann, J. Vaccination with T cell receptor peptides primes anti-receptor cytotoxic T lymphocytes (CTL) and anergizes T cells specifically recognized by these CTL. Eur. J. Immunol. 24, 1172-1180 (1994).
    • (1994) Eur. J. Immunol. , vol.24 , pp. 1172-1180
    • Kuhrober, A.1    Schirmbeck, R.2    Reimann, J.3
  • 18
    • 84920302794 scopus 로고
    • Immunization with TCR Vβ region peptides completely prevents the induction of collagen induced arthritis
    • Haqqui, T.M., Qu, X.-M., Ma, J. & Sy, M.S. Immunization with TCR Vβ region peptides completely prevents the induction of collagen induced arthritis. Ninth Int. Cong. Immunol. Abstr. 5014, 845 (1995).
    • (1995) Ninth Int. Cong. Immunol. Abstr. , vol.5014 , pp. 845
    • Haqqui, T.M.1    Qu, X.-M.2    Ma, J.3    Sy, M.S.4
  • 19
    • 0026042680 scopus 로고
    • Preferential T cell receptor Vβ gene usage in myelin basic protein reactive T cell clones from patients with multiple sclerosis
    • Kotzin, B.L. et al. Preferential T cell receptor Vβ gene usage in myelin basic protein reactive T cell clones from patients with multiple sclerosis. Proc. Natl. Acad. Sci. U. S. A. 88, 9161-9165 (1991).
    • (1991) Proc. Natl. Acad. Sci. U. S. A. , vol.88 , pp. 9161-9165
    • Kotzin, B.L.1
  • 20
    • 0027406406 scopus 로고
    • Selection of T-cell receptor Vβ-Dβ-Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis
    • Oksenberg, J.R. et al. Selection of T-cell receptor Vβ-Dβ-Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis. Nature 362, 68-70 (1993).
    • (1993) Nature , vol.362 , pp. 68-70
    • Oksenberg, J.R.1
  • 21
    • 0029073606 scopus 로고
    • Characterization of T-cell receptor Vβ usage in the brain of a subject with multiple sclerosis
    • Shimonkevitz, R., Murray, R. & Kotzin, B. Characterization of T-cell receptor Vβ usage in the brain of a subject with multiple sclerosis. Ann. N. Y. Acad. Sci. 756, 305-306 (1995).
    • (1995) Ann. N. Y. Acad. Sci. , vol.756 , pp. 305-306
    • Shimonkevitz, R.1    Murray, R.2    Kotzin, B.3
  • 22
    • 0028221789 scopus 로고
    • Immunity to T cell receptor peptides in multiple sclerosis. I. Successful immunization of patients with synthetic Vβ5.2 and Vβ6.1 CDR2 peptides
    • Bourdette, D.N. et al. Immunity to T cell receptor peptides in multiple sclerosis. I. Successful immunization of patients with synthetic Vβ5.2 and Vβ6.1 CDR2 peptides. J. Immunol. 152, 2510-2519 (1994).
    • (1994) J. Immunol. , vol.152 , pp. 2510-2519
    • Bourdette, D.N.1
  • 23
    • 0025325226 scopus 로고
    • Shared human T cell receptor Vβ usage to immunodominant regions of myelin basic protein
    • Wucherpfennig, K.W. et al. Shared human T cell receptor Vβ usage to immunodominant regions of myelin basic protein. Science 248, 1016-1019 (1990).
    • (1990) Science , vol.248 , pp. 1016-1019
    • Wucherpfennig, K.W.1
  • 24
    • 0026068885 scopus 로고
    • Restricted T-cell receptor Vβ gene usage by myelin basic protein- Specific T-cell clones in multiple sclerosis: Predominant genes vary in individuals
    • Ben-Nun, A. et al. Restricted T-cell receptor Vβ gene usage by myelin basic protein- specific T-cell clones in multiple sclerosis: Predominant genes vary in individuals. Proc. Natl. Acad. Sci. USA 88, 2466-2470 (1991).
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 2466-2470
    • Ben-Nun, A.1
  • 25
    • 0026653697 scopus 로고
    • TCR peptide therapy decreases the frequency of encephalitogenic T cells in the periphery and the central nervous system
    • Vandenbark, A.A., Vainiene, M., Celnik, B., Hashim, G. & Offner, H. TCR peptide therapy decreases the frequency of encephalitogenic T cells in the periphery and the central nervous system. J. Neuroimmunol. 39, 251-260 (1992).
    • (1992) J. Neuroimmunol. , vol.39 , pp. 251-260
    • Vandenbark, A.A.1    Vainiene, M.2    Celnik, B.3    Hashim, G.4    Offner, H.5
  • 26
    • 0025879955 scopus 로고
    • T cell receptor peptide immunization leads to enhanced and chronic experimental allergic encephalomyelitis
    • Desquenne-Clark, L., Esch, T.R., Otvos, L., Jr., & Heber-Katz, E. T cell receptor peptide immunization leads to enhanced and chronic experimental allergic encephalomyelitis. Proc. Natl. Acad. Sci. USA 88, 7219-7223 (1991).
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 7219-7223
    • Desquenne-Clark, L.1    Esch, T.R.2    Otvos Jr., L.3    Heber-Katz, E.4
  • 27
    • 10144236520 scopus 로고    scopus 로고
    • MHC-restriction, cytokine profile, and immunoregulatory effects of human T cells specific for TCR Vβ CDR2 peptides: Comparison with myelin basic protein-specific T cells
    • in the press
    • Chou, Y.K. et al. MHC-restriction, cytokine profile, and immunoregulatory effects of human T cells specific for TCR Vβ CDR2 peptides: Comparison with myelin basic protein-specific T cells. J. Neurosci. Res. (in the press).
    • J. Neurosci. Res.
    • Chou, Y.K.1
  • 28
    • 0029030470 scopus 로고
    • Self tolerance to T cell receptor Vβ sequences
    • Falcioni, F. et al. Self tolerance to T cell receptor Vβ sequences. J. Exp. Med. 182, 249-254 (1995).
    • (1995) J. Exp. Med. , vol.182 , pp. 249-254
    • Falcioni, F.1
  • 29
    • 0028283010 scopus 로고
    • Letter to the editor
    • Vandenbark, A.A. [Letter to the editor]. J. Immunol. 153, 910 (1994).
    • (1994) J. Immunol. , vol.153 , pp. 910
    • Vandenbark, A.A.1
  • 30
    • 0029932899 scopus 로고    scopus 로고
    • The specificity and orientation of a TCR to its peptide-MHC class II ligands
    • Sant'Angelo, D.B. et al. The specificity and orientation of a TCR to its peptide-MHC class II ligands. Immunity 4, 367-376 (1996).
    • (1996) Immunity , vol.4 , pp. 367-376
    • Sant'Angelo, D.B.1
  • 31
    • 0027292039 scopus 로고
    • T helper 1 (Th1) functional phenotype of human myelin basic protein-specific T lymphocytes
    • Voskuhl, R.R. et al. T helper 1 (Th1) functional phenotype of human myelin basic protein-specific T lymphocytes. Autoimmunity 15, 137-143 (1993).
    • (1993) Autoimmunity , vol.15 , pp. 137-143
    • Voskuhl, R.R.1
  • 32
    • 0028221790 scopus 로고
    • Immunity to T cell receptor peptides in multiple sclerosis. II. T cell recognition of Vβ5.2and Vβ6.1 CDR2 peptides
    • Chou, Y.K. et al. Immunity to T cell receptor peptides in multiple sclerosis. II. T cell recognition of Vβ5.2and Vβ6.1 CDR2 peptides. J. Immunol. 152, 2520-2529 (1994).
    • (1994) J. Immunol. , vol.152 , pp. 2520-2529
    • Chou, Y.K.1
  • 33
    • 0025138302 scopus 로고
    • T cells responsive to myelin basic protein in patients with multiple sclerosis
    • Allegretta, M., Nicklas, J.A., Sriram, S. & Albertini, R.J. T cells responsive to myelin basic protein in patients with multiple sclerosis. Science 247, 718-721 (1990).
    • (1990) Science , vol.247 , pp. 718-721
    • Allegretta, M.1    Nicklas, J.A.2    Sriram, S.3    Albertini, R.J.4
  • 34
    • 0027372901 scopus 로고
    • Episodic changes in T cell frequencies to myelin basic protein in patients with multiple sclerosis
    • Vandenbark, A.A. et al. Episodic changes in T cell frequencies to myelin basic protein in patients with multiple sclerosis. Neurology 43, 2416-2417 (1993).
    • (1993) Neurology , vol.43 , pp. 2416-2417
    • Vandenbark, A.A.1
  • 35
    • 0027957780 scopus 로고
    • Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis
    • Zhang, J. et al. Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. J. Exp. Med. 179, 973-984 (1994).
    • (1994) J. Exp. Med. , vol.179 , pp. 973-984
    • Zhang, J.1
  • 36
    • 0027467440 scopus 로고
    • Double-blind pilot trial of oral tolerization with myelin antigens in multiple sclerosis
    • Weiner, H.L. et al. Double-blind pilot trial of oral tolerization with myelin antigens in multiple sclerosis. Science 259, 1321-1324 (1993).
    • (1993) Science , vol.259 , pp. 1321-1324
    • Weiner, H.L.1
  • 37
    • 0027448708 scopus 로고
    • MHC-restricted depletion of human myelin basic protein-reactive T cells by T cell vaccination
    • Zhang, J., Medaer, R., Stinissen, P., Hafler, D.A. & Raus, J.C.M. MHC-restricted depletion of human myelin basic protein-reactive T cells by T cell vaccination. Science 261, 1451-1454 (1993).
    • (1993) Science , vol.261 , pp. 1451-1454
    • Zhang, J.1    Medaer, R.2    Stinissen, P.3    Hafler, D.A.4    Raus, J.C.M.5
  • 38
    • 0027142439 scopus 로고
    • Epitopes of myelin basic protein that trigger TGF-β release after oral tolerization are distinct from encephalitogenic epitopes and mediate epitope-driven bystander suppression
    • Miller, A., Al-Sabagh, A., Santos, L.M.B., Prabhu-Das, M. & Weiner, H.L. Epitopes of myelin basic protein that trigger TGF-β release after oral tolerization are distinct from encephalitogenic epitopes and mediate epitope-driven bystander suppression. J. Immuno. 151, 7307-7315 (1993).
    • (1993) J. Immuno. , vol.151 , pp. 7307-7315
    • Miller, A.1    Al-Sabagh, A.2    Santos, L.M.B.3    Prabhu-Das, M.4    Weiner, H.L.5
  • 39
    • 0025978235 scopus 로고
    • + suppressor cells inhibit the function of effector cells of EAE through a mechanism involving transforming growth factor-beta
    • + suppressor cells inhibit the function of effector cells of EAE through a mechanism involving transforming growth factor-beta. J. Immunol. 146, 1163-1168 (1991).
    • (1991) J. Immunol. , vol.146 , pp. 1163-1168
    • Karpus, W.J.1    Swanborg, R.H.2
  • 41
    • 0028116618 scopus 로고
    • Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease
    • Racke, M.K. et al. Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease. J. Exp. Med. 180, 1961-1966 (1994).
    • (1994) J. Exp. Med. , vol.180 , pp. 1961-1966
    • Racke, M.K.1
  • 42
    • 0026707402 scopus 로고
    • Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery
    • Kennedy, M.K., Torrance, D.S., Picha, K.S. & Mohler, K.M. Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery. J. Immunol. 149, 2496-2505 (1992).
    • (1992) J. Immunol. , vol.149 , pp. 2496-2505
    • Kennedy, M.K.1    Torrance, D.S.2    Picha, K.S.3    Mohler, K.M.4
  • 43
    • 0028245010 scopus 로고
    • Interleukin-10 prevents experimental allergic encephalomyelitis in rats
    • Rott, O., Fleischer, B. & Cash, E. Interleukin-10 prevents experimental allergic encephalomyelitis in rats. Eur. J. Immunol. 24, 1434-1440 (1994).
    • (1994) Eur. J. Immunol. , vol.24 , pp. 1434-1440
    • Rott, O.1    Fleischer, B.2    Cash, E.3
  • 44
    • 0020686503 scopus 로고
    • New Diagnostic criteria for multiple sclerosis: Guidelines for research protocols
    • Poser, C.M. et al. New Diagnostic criteria for multiple sclerosis: Guidelines for research protocols. Ann. Neurol. 13, 227-236 (1983).
    • (1983) Ann. Neurol. , vol.13 , pp. 227-236
    • Poser, C.M.1
  • 45
    • 0021646499 scopus 로고
    • Enzymatic and nonenzymatic degradation of myelin basic protein
    • Diebler, G.E., Boyd, L.F. & Kies, M.W. Enzymatic and nonenzymatic degradation of myelin basic protein. Neurochemistry 9, 1371-1385 (1984).
    • (1984) Neurochemistry , vol.9 , pp. 1371-1385
    • Diebler, G.E.1    Boyd, L.F.2    Kies, M.W.3
  • 46
    • 0026027158 scopus 로고
    • Rapid typing of DNA sequence polymorphism at the HLA-DRB1 locus using the polymerase chain reaction and nonradioactive probes
    • Scharf, S.J., Griffith, R.L. & Erlich, H.A. Rapid typing of DNA sequence polymorphism at the HLA-DRB1 locus using the polymerase chain reaction and nonradioactive probes. Hum. Immunol. 30, 190-201 (1991).
    • (1991) Hum. Immunol. , vol.30 , pp. 190-201
    • Scharf, S.J.1    Griffith, R.L.2    Erlich, H.A.3
  • 47
    • 0019468220 scopus 로고
    • Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis
    • Taswell, C. Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis. J. Immunol. 26, 1614-1619 (1981).
    • (1981) J. Immunol. , vol.26 , pp. 1614-1619
    • Taswell, C.1
  • 48
    • 0001024349 scopus 로고
    • Further notes on disability evaluation in multiple sclerosis with scale modification
    • Kurtzke, J.F. Further notes on disability evaluation in multiple sclerosis with scale modification. Neurology 15, 654-662 (1965).
    • (1965) Neurology , vol.15 , pp. 654-662
    • Kurtzke, J.F.1
  • 49
    • 0020683886 scopus 로고
    • Intensive immunosuppression in progressive multiple sclerosis: A randomized, three-arm study of high-dose intravenous cyclophosphamide, plasma exchange, and ACTH
    • Hauser, S.L., Dawson, D.M. & Lehrich, J. C. Intensive immunosuppression in progressive multiple sclerosis: A randomized, three-arm study of high-dose intravenous cyclophosphamide, plasma exchange, and ACTH. N. Engl. J. Med. 308, 173-180 (1983).
    • (1983) N. Engl. J. Med. , vol.308 , pp. 173-180
    • Hauser, S.L.1    Dawson, D.M.2    Lehrich, J.C.3
  • 50
    • 0028906384 scopus 로고
    • Low-dose (7.5 mg) oral methotrexate reduces the rate of progression in chronic progressive multiple sclerosis
    • Goodkin, D.E. et al. Low-dose (7.5 mg) oral methotrexate reduces the rate of progression in chronic progressive multiple sclerosis. Ann. Neurol. 37, 30-40 (1995).
    • (1995) Ann. Neurol. , vol.37 , pp. 30-40
    • Goodkin, D.E.1


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