Intracellular IL-1β Is an Inhibitor of Fas-Mediated Apoptosis

Journal of Immunology

Volumn 157, Issue 9, 1996, Pages 3949-3957

  Tatsuta, Toru ^a   Cheng, Jianhua ^b   Mountz, John D ^b  

^a DAIICHI SANKYO CO   (Japan)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL ASPARTYL GLUTAMYL VALYL ASPARTAL; ACETYL-ASPARTYL-GLUTAMYL-VALYL-ASPARTAL; CYSTEINE PROTEINASE; FAS ANTIGEN; HYBRID PROTEIN; INTERLEUKIN 1; INTERLEUKIN 1BETA CONVERTING ENZYME; N ACETYL TYROSYL VALYL ALANYL ASPARTYL CHLOROMETHYL KETONE; N-ACETYL-TYROSYL-VALYL-ALANYL-ASPARTYL CHLOROMETHYL KETONE; OLIGOPEPTIDE; PEPTIDE CHLOROMETHYL KETONE; PROTEIN PRECURSOR; PROTEINASE INHIBITOR;

APOPTOSIS; ARTICLE; B LYMPHOCYTE; BURKITT LYMPHOMA; CELL CULTURE; CELL STRAIN HL 60; COMPARATIVE STUDY; ENZYME INDUCTION; GENETIC TRANSFECTION; GENETICS; HELA CELL; HUMAN; INTRACELLULAR FLUID; LARGE CELL LYMPHOMA; METABOLISM; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; T CELL LEUKEMIA; T LYMPHOCYTE;

AMINO ACID CHLOROMETHYL KETONES; ANTIGENS, CD95; APOPTOSIS; B-LYMPHOCYTES; BURKITT LYMPHOMA; CASPASE 1; CYSTEINE ENDOPEPTIDASES; ENZYME INDUCTION; HELA CELLS; HL-60 CELLS; HUMANS; INTERLEUKIN-1; INTRACELLULAR FLUID; LEUKEMIA, T-CELL, ACUTE; LYMPHOMA, LARGE-CELL, DIFFUSE; OLIGOPEPTIDES; PROTEASE INHIBITORS; PROTEIN PRECURSORS; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0030292768     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Yonehara, S., A. Ishii, and M. Yonehara. 1989. A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor. J. Exp. Med. 169:1747.
2. Trauth, B. C., C. Klas, A. M. J. Peters, S. Matzku, P. Moller, W. Falk, K. M. Debatin, and P. H. Krammer. 1989. Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science 245:301.
3. Itoh, N., S. Yonehara, A. Ishii, M. Yonehara, S.-I. Mizushima, M. Sameshima, A. Hase, Y. Seto, and S. Nagata. 1991. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 66:233.
4. Suda, T., T. Takahashi, P. Goldstein, and S. Nagata. 1993. Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 75:1169.
5. Watanabe-Fukunaga, R., C. I. Brannan, N. G. Copeland, N. A. Jenkins, and S. Nagata. 1992. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356:314.
6. Lynch, D. H., M. L. Watson, M. R. Alderson, P. R. Baum, R. E. Miller, T. Tough, M. Gibson, T. Davis-Smith, C. A. Smith, K. Hunter, D. Bhat, W. Din, R. G. Goodwin, and M. F. Seldin. 1994. The mouse Fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster. Immunity 1:131.
7. Takahashi, T., M. Tanaka, C. I. Brannan, N. A. Jenkins, N. G. Copeland, T. Suda, and S. Nagata. 1994. Generalized lymphoproliferative disease in mice caused by a point mutation in the Fas ligand. Cell 76:969.
8. Sato, T., S. Irie, S. Kitada, and J. C. Reed. 1995. Fap-1: a protein tyrosine phosphatase that associates with Fas. Science 268:411.
9. Tepper, C. G., S. Jayadev, B. Liu, A. Bielawska, R. Wolff, S. Yonehara, Y. A. Hannun, and M. F. Seldin. 1995. Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity. Proc. Natl. Acad. Sci. USA 92:8443.
10. Gulbins, E., R. Bissonnette, A. Mahboubi, S. Martin, W. Nishioka, T. Brunner, G. Baier, G. Bittterlich-Baier, C. Byyd, F. Lang, R. Kolesnick, A. Atman, and D. Green. 1995. FAS-induced apoptosis is mediated via aceramide-initiated RAS signaling pathway. Immunity 2:1.
11. Su, X., T. Zhou, Z. Wang, P. A. Yang, R. S. Jope, and J. D. Mountz. 1995. Defective expression of hematopoietic cell protein phosphatase (HCP) in lymphoid cells blocks Fas-mediated apoptosis. Immunity 2:353.
12. Tewari, M., and V. M. Dixit. 1995. Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product. J. Biol. Chem. 270:3255.
13. Los, M., M. V. D. Craen, L. C. Penninig, H. Schenk, M. Westendorp, P. A. Baeuerle, W. Droege, P. H. Krammer, W. Fiers, and K. Schulze-Osthoff. 1995. Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis. Nature 375:3255.
14. Enari, M., H. Hug, and S. Nagata. 1995. Involvement of an ICE-like protease in Fas-mediated apoptosis. Nature 375:81.
15. Tewari, M., L. T. Quan, K. O'Rourke, S. Desnoyers, Z. Zeng, D. R. Beidler, G. G. Poirier, G. S. Salvesen, and V. M. Dixit. 1995. Yama/CPP32b, a mammalian homology of CED-3, is a crmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell 81:801.
16. Yuan, J., S. Shaham, S. Ledoux, H. M. Ellis, and H. R. Horvitz. 1993. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme. Cell 75:641.
17. Miura, M., H. Zhu, R. Rotello, E. A. Hartwieg, and J. Yuan. 1993. Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C elegant cell death gene ced-3. Cell 75:653.
18. Fernandes-Alnemri, T., G. Litwack, and E. S. Alnemri. 1994. CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. J. Biol. Chem. 269:30761.
19. Nicholson, D. W., A. All, N. A. Thornberry, J. P. Vallancourt, C. K. Ding, M. Gallant, Y. Gareau, P. R. Griffin, M. Labelle, Y. A. Lazebnik, N. A. Munday, R. M. Raj, M. E. Smulson, T. T. Yamin, V. L. Yu, and D. K. Miller. 1995. Identification and inhibition of the ICE/Ced-3 protease necessary for mammalian apoptosis. Nature 376:37.
20. Wang, L., M. Miura, L. Bergeron, H. Zhu, and J. Yuan. 1994. Ich-1, an ICE/ ced-3-related gene, encodes both positive and negative regulators of programmed cell death. Cell 78:739.
21. Alnemri, E. S., T. Fernandes-Alnemri, and G. Litwack. 1995. Cloning and expression of four novel isoforms of human interleukin-1 beta converting enzyme with different apoptotic activities. J. Biol. Chem. 270:4312.
22. Faucheu, C., A. Diu, A. W. Chan, A. M. Blanchet, C. Miossec, F. Herve, V. Collard-Dutilleul, Y. Gu, R. A. Aldape, and J. A. Lippke. 1995. A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells. EMBO J. 14:1914.
23. Mashima, T., M. Naito, S. Kataoka, H. Kawai, and T. Tsuruo. 1995. Aspartate-based inhibitor of interleukin-1 beta-converting enzyme prevents antitumor agent-induced apoptosis in human myeloid leukemia U937 cells. Biochem. Biophys. Res. Commun. 209:907.
24. Boldin, M. P., E. E. Varfolomeev, Z. Pancer, I. L. Mett, J. H. Camonis, and D. Wallach. 1995. Activation of the apoptosis protease CPP32 by cytotoxic T cell-derived granzyme B. Nature 377:446.
25. Tewari, M., D. R. Beidler, and V. M. Dixit. 1995. CrmA-inhibitable cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein during Fas- and tumor necrosis factor-induced apoptosis. j. Biol. Chem. 270:18738.
26. Casciola-Rosen, L. A., G. J. Anhalt, and A. Rosen. 1995. DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis. J. Exp. Med 182:1625.
27. Thornberry, N. A., E. P. Peterson, J. J. Zhao, A. D. Howard, P. R. Griffin, and K. T. Chapman. 1994. Inactivation of interleukin-1β converting enzyme by peptide (aclyloxy)methyl ketones. Biochemistry 33:3934.
28. Schmid, I., C. H. Uittenbogaart, B. Keld, and J. V. Giorgi. 1994. A rapid method for measuring apoptosis and dual-color immunofluorescence. J. Immunol. Methods 170:145.
29. Philpott, N. J., A. J. C. Turner, J. Scopes, M. Westby, J. C. W. Marsh, E. C. Gordon-Smith, and A. G. Dalgleish. 1996. The use of 7-amino actinomycin D in identifying apoptosis: simplicity of use and broad spectrum of application compared with other techniques. Blood 87:2244.
30. Molineaux, S. M., F. J. Casano, A. M. Rolando, E. P. Reterson, G. Limjuco, J. Chin, P. R. Griffin, J. R. Calaycay, G. J. -F Ding, T. T. Yamin, O. C. Payyha, S. Luell, D. Fletcher, D. K. Miller, A. D. Howard, N. A. Thornberry, and M. J. Kostura. 1993. Interleukin-1β (IL-1β) processing in murine macrophages requires a structurally conserved homologue of human IL-1β converting enzyme. Proc. Natl. Acad. Sci. USA 90:1809.
31. Bump, N. J., M. Hacket, M. Hugunin, S. Seshagiri, K. Brady, P. Chen, C. Ferenz, S. Franklin, T. Ghayur, P. Li, P. Licari, J. Mankovich, L. Shi, A. H. Greenberg, L. K. Miller, and W. W. Wong. 1995. Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35. Science 269:1885.
32. March, C. J., B. Mosley, A. Larsen, D. P. Cerretti, G. Braedt, V. Price, S. Gillis, C. S. Henney, S. R. Kronheim, K. Grabstein, P. J. Conlon, T. P. Hopp, and D. Cosman. 1985. Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature 315:641.
33. Howard, A. D., M. J. Kostura, N. A. Thornberry, G. J.-F. Ding, G. Limjuco, J. Weidner, J. P. Salley, K. A. Hogquist, D. D. Chaplin, R. A. Mumford, J. A. Schmidt, and M. J. Tocci. 1991. IL-1β converting enzyme requires aspartic acid residues for processing of the IL-1β precursor at two distinct sites and does not cleave 31-kDa IL-1α. J. Immunol. 146:2964.
34. Howard, A. D., O. C. Palyha, P. R. Griffin, E. P. Peterson, A. B. Lenny, G. J.-F. Ding, D. J. Pickup, N. A. Thronberry, J. A. Schmidt, and M. J. Tocci. 1995. Human IL-1β processing and secretion in recombinant baculovirus-induced Sf9 cells is blocked by the cowpox virus serpin crmA. J. Immunol. 154:2321.
35. Kuida, K., J. A. Lippke, G. Ku, M. W. Harding, D. J. Livingston, M. S. Su, and R. A. Flavell. 1995. Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science 267:2000.
36. Kaneto, H., J. Fujii, H. G. Seo, K. Suzuki, T. Matsuoka, M. Nakamura, H. Tatsumi, Y. Yamasaki, T. Kamada, and N. Taniguchi. 1995. Apoptotic cell death triggered by nitric oxide in pancreatic beta cells. Diabetes 44:733.
37. Ankarcrona, M., J. M. Dypbukt, B. Brune, and P. Nicolera. Interleukin-1 beta-induced nitric oxide production activates apoptosis in pancreatic RINm5F cells. 1994. Exp. Cell Res. 213:172.
38. Darmon, A. J., D. W. Nicholson, and R. C. Bleackley. 1995. Activation of the apoptosis protease CPP32 by cytotoxic T cell-derived granzyme B. Nature 377: 446.
39. Siders, W. M., and S. B. Mizel. 1995. Interleukin-1β secretion. J. Biol. Chem. 270:16258.
40. Singer, I. I., S. Scott, J. Chin, E. K. Bayne, G. Limjuco, J. Weinder, D. K. Miller, K. Chapman, and M. J. Kostura. 1995. The interleukin-1β converting enzyme (ICE) is localized on the external cell surface membranes and in the cytoplasmic ground substance of human monocytes by immune-electron microscopy. J. Exp. Med. 182:1447.
41. Xue, D., and H. R. Horvitz. 1995. Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein. Nature 377:248.