메뉴 건너뛰기




Volumn 2, Issue 9, 1996, Pages 998-1004

Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-κB abrogates established experimental colitis in mice

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CORTICOSTEROID; MESALAZINE; PREDNISOLONE; SYNAPTOTAGMIN; TRANSCRIPTION FACTOR; TRINITROBENZENESULFONIC ACID;

EID: 0029836444     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0996-998     Document Type: Article
Times cited : (783)

References (47)
  • 1
    • 0026432216 scopus 로고
    • Inflammatory bowel disease
    • Podolsky, D.K Inflammatory bowel disease. N. Engl. J. Med. 325, 928-935 (1995).
    • (1995) N. Engl. J. Med. , vol.325 , pp. 928-935
    • Podolsky, D.K.1
  • 2
    • 0001947699 scopus 로고
    • Immunological diseases of the gastrointestinal tract
    • (ed. Rich, R.R.) Mosby, St. Louis
    • Strober, W. & Neurath, M.F. Immunological diseases of the gastrointestinal tract. in Clinical Immunology (ed. Rich, R.R.) 1401-1428 (Mosby, St. Louis, 1995).
    • (1995) Clinical Immunology , pp. 1401-1428
    • Strober, W.1    Neurath, M.F.2
  • 3
    • 0027422089 scopus 로고
    • Chronic intestinal inflammation: An unexpected outcome on cytokine or T cell receptor mutant mice
    • Strober, W. & Ehrhardt, R.O. Chronic intestinal inflammation: an unexpected outcome on cytokine or T cell receptor mutant mice. Cell 75, 203-205 (1993).
    • (1993) Cell , vol.75 , pp. 203-205
    • Strober, W.1    Ehrhardt, R.O.2
  • 4
    • 0025633436 scopus 로고
    • Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human β2m: An animal model of HLAB-27-associated human disorders
    • Hammer, R.E. et al. Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human β2m: An animal model of HLAB-27-associated human disorders. Cell 63, 1099-1112 (1990)
    • (1990) Cell , vol.63 , pp. 1099-1112
    • Hammer, R.E.1
  • 5
    • 0028972499 scopus 로고
    • Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin
    • Hermiston, M L. & Gordon, J I Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin. Science 270, 1203-1207 (1995)
    • (1995) Science , vol.270 , pp. 1203-1207
    • Hermiston, M.L.1    Gordon, J.I.2
  • 6
    • 0029102210 scopus 로고
    • Severe colitis in mice with aberrant thymic selection
    • Hollander, G.A et al. Severe colitis in mice with aberrant thymic selection. Immunity 3, 27-38 (1995).
    • (1995) Immunity , vol.3 , pp. 27-38
    • Hollander, G.A.1
  • 7
    • 0027369395 scopus 로고
    • Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
    • Sadlack, B. et al. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75, 253-261 (1993)
    • (1993) Cell , vol.75 , pp. 253-261
    • Sadlack, B.1
  • 8
    • 0027521572 scopus 로고
    • Interleukin-10-deficient mice develop chronic enterocolitis
    • Kühn, R., Lohler, J., Rennick, D., Rajewsky, K & Müller, W Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75, 263-274 (1993).
    • (1993) Cell , vol.75 , pp. 263-274
    • Kühn, R.1    Lohler, J.2    Rennick, D.3    Rajewsky, K.4    Müller, W.5
  • 9
    • 0029061801 scopus 로고
    • 12-deficient mice
    • 12-deficient mice Nature Genet. 10, 143-146 (1995).
    • (1995) Nature Genet. , vol.10 , pp. 143-146
    • Rudolph, U.1
  • 10
    • 0027922467 scopus 로고
    • Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice
    • Mombaerts, P et al. Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice. Cell 75, 275-282 (1993).
    • (1993) Cell , vol.75 , pp. 275-282
    • Mombaerts, P.1
  • 11
    • 0028519015 scopus 로고
    • + T cells
    • + T cells. Immunity 1, 553-562 (1994).
    • (1994) Immunity , vol.1 , pp. 553-562
    • Powrie, F.1
  • 12
    • 0028861975 scopus 로고
    • Antibodies to IL-12 abrogate established experimental colitis in mice
    • Neurath, M.F., Fuss, I., Kelsall, B L., Stuber, E. & Strober, W. Antibodies to IL-12 abrogate established experimental colitis in mice. J. Exp. Med 182, 1280-1289 (1995).
    • (1995) J. Exp. Med , vol.182 , pp. 1280-1289
    • Neurath, M.F.1    Fuss, I.2    Kelsall, B.L.3    Stuber, E.4    Strober, W.5
  • 13
    • 0030029222 scopus 로고    scopus 로고
    • Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of Th1-T cells through the inhibition of IL-12 secretion
    • Stuber, E., Strober, W. & Neurath, M.F. Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of Th1-T cells through the inhibition of IL-12 secretion. J Exp. Med. 183, 693-698 (1996).
    • (1996) J Exp. Med. , vol.183 , pp. 693-698
    • Stuber, E.1    Strober, W.2    Neurath, M.F.3
  • 14
    • 0024580741 scopus 로고
    • Functionally distinct NF-κB binding sites in the Ig kappa and IL-2 receptor alpha chain genes
    • Cross, S L. et al. Functionally distinct NF-κB binding sites in the Ig kappa and IL-2 receptor alpha chain genes Science 244, 466-469 (1989).
    • (1989) Science , vol.244 , pp. 466-469
    • Cross, S.L.1
  • 15
    • 0028972845 scopus 로고
    • Mechanistic aspects of NF-κB regulation the emerging role of phosphorylation and proteolysis
    • Finco, T.S. & Baldwin, A S. Mechanistic aspects of NF-κB regulation The emerging role of phosphorylation and proteolysis. Immunity 3, 263-272 (1995)
    • (1995) Immunity , vol.3 , pp. 263-272
    • Finco, T.S.1    Baldwin, A.S.2
  • 16
    • 0024475227 scopus 로고
    • NF-κB: A pleiotropic activator of inducible and tissue specific gene control
    • Lenardo, M J. & Baltimore, D. NF-κB: A pleiotropic activator of inducible and tissue specific gene control. Cell 58, 227-237 (1989).
    • (1989) Cell , vol.58 , pp. 227-237
    • Lenardo, M.J.1    Baltimore, D.2
  • 17
    • 0028174061 scopus 로고
    • Function and activation of NF-κB in the immune system
    • Baeuerle, P.A. & Henkel, T. Function and activation of NF-κB in the immune system. Annu Rev. Immunol. 12, 141-179 (1994).
    • (1994) Annu Rev. Immunol. , vol.12 , pp. 141-179
    • Baeuerle, P.A.1    Henkel, T.2
  • 18
    • 0028804551 scopus 로고
    • Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
    • Sha, W et al Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses. Cell 80, 321-330 (1995).
    • (1995) Cell , vol.80 , pp. 321-330
    • Sha, W.1
  • 19
    • 0028817585 scopus 로고
    • Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family
    • Weih, F et al. Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family. Cell 80, 331-340 (1995).
    • (1995) Cell , vol.80 , pp. 331-340
    • Weih, F.1
  • 20
    • 0029150389 scopus 로고
    • Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression
    • Kontgen, F et al. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev. 9, 1965-1977 (1995).
    • (1995) Genes Dev. , vol.9 , pp. 1965-1977
    • Kontgen, F.1
  • 21
    • 0028952482 scopus 로고
    • Expression of relB is required for the development of thymic medulla and dendritic cells
    • Burkly, L. et al. Expression of relB is required for the development of thymic medulla and dendritic cells. Nature 373, 531-536 (1995)
    • (1995) Nature , vol.373 , pp. 531-536
    • Burkly, L.1
  • 22
    • 0025186678 scopus 로고
    • κB-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor α gene in primary macrophages
    • Shakhov, A N. et al. κB-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor α gene in primary macrophages J. Exp. Med 171, 35-47 (1990).
    • (1990) J. Exp. Med , vol.171 , pp. 35-47
    • Shakhov, A.N.1
  • 23
    • 0025343895 scopus 로고
    • Activation of interleukin-6 gene expression through the NF-κB transcription factor
    • Libermann, T.A. & Baltimore, D Activation of interleukin-6 gene expression through the NF-κB transcription factor. Mol. Cell Biol. 10, 2327-2334 (1990).
    • (1990) Mol. Cell Biol. , vol.10 , pp. 2327-2334
    • Libermann, T.A.1    Baltimore, D.2
  • 24
    • 0027377107 scopus 로고
    • Antisense inhibition of the p65 subunit of NF-κB blocks tumorigenicity and causes tumor regression
    • Higgins, K.A. et al. Antisense inhibition of the p65 subunit of NF-κB blocks tumorigenicity and causes tumor regression. Proc. Natl. Acad. Sci. USA 90, 9901-9905 (1993)
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 9901-9905
    • Higgins, K.A.1
  • 25
    • 0027058137 scopus 로고
    • Ablation of transplanted HTLV-I Tax-transformed tumors in mice by antisense inhibition of NF-κB
    • Kitajima, I. et al Ablation of transplanted HTLV-I Tax-transformed tumors in mice by antisense inhibition of NF-κB. Science 258, 1792-1795 (1992).
    • (1992) Science , vol.258 , pp. 1792-1795
    • Kitajima, I.1
  • 26
    • 0028931102 scopus 로고
    • CpG motifs in bacterial DNA trigger direct B cell activation
    • Krieg, A M CpG motifs in bacterial DNA trigger direct B cell activation. Nature 374, 546-549 (1995).
    • (1995) Nature , vol.374 , pp. 546-549
    • Krieg, A.M.1
  • 27
    • 0024199289 scopus 로고
    • Delivery of c-myc antisense phosphorothioate oligodeoxynucleotides to hematapoietic cells in culture by liposome fusion Specific reduction in c-Myc protein expression correlates with inhibition of cell growth and DNA synthesis
    • Loke, S L et al. Delivery of c-myc antisense phosphorothioate oligodeoxynucleotides to hematapoietic cells in culture by liposome fusion Specific reduction in c-Myc protein expression correlates with inhibition of cell growth and DNA synthesis. Curr Top. Microbiol. Immunol 141, 282-288 (1988).
    • (1988) Curr Top. Microbiol. Immunol , vol.141 , pp. 282-288
    • Loke, S.L.1
  • 28
    • 0025365349 scopus 로고
    • Inhibition of T-cell proliferation of a Myb antisense oligomer is accompanied by selective down-regulation of DNA polymerase alpha expression
    • Venturelli, D., Travali, S & Calabretta, B Inhibition of T-cell proliferation of a Myb antisense oligomer is accompanied by selective down-regulation of DNA polymerase alpha expression. Proc. Natl. Acad Sci USA 87, 5963-5967 (1990).
    • (1990) Proc. Natl. Acad Sci USA , vol.87 , pp. 5963-5967
    • Venturelli, D.1    Travali, S.2    Calabretta, B.3
  • 29
    • 0025762508 scopus 로고
    • Antisense myb inhibition of purified erythroid progenitors in development and differentiation is linked to cyclin activity and expression of DNA polymerase alpha
    • Voltieri, M. et al. Antisense myb inhibition of purified erythroid progenitors in development and differentiation is linked to cyclin activity and expression of DNA polymerase alpha. Blood 77, 1181-1190 (1991).
    • (1991) Blood , vol.77 , pp. 1181-1190
    • Voltieri, M.1
  • 30
    • 0001597247 scopus 로고
    • Inducible production of c-fos antisense RNA inhibits 3T3 cell proliferation
    • Holt, J.T. et al. Inducible production of c-fos antisense RNA inhibits 3T3 cell proliferation. Proc. Natl Acad. Sci. USA 83, 4794-4798 (1986).
    • (1986) Proc. Natl Acad. Sci. USA , vol.83 , pp. 4794-4798
    • Holt, J.T.1
  • 31
    • 0023125528 scopus 로고
    • Antisense RNA of proto-oncogene c-fos blocks renewed growth of quiescent 3T3 cells
    • Nishikura, K. & Murray, J M. Antisense RNA of proto-oncogene c-fos blocks renewed growth of quiescent 3T3 cells. Mol. Cell. Biol. 7, 639-648 (1987)
    • (1987) Mol. Cell. Biol. , vol.7 , pp. 639-648
    • Nishikura, K.1    Murray, J.M.2
  • 32
    • 0028196601 scopus 로고
    • The B cell specific transcription factor BSAP regulates B cell proliferation
    • Wakatsuki, Y., Neurath, M.F., Max, E.E. & Strober, W. The B cell specific transcription factor BSAP regulates B cell proliferation. J. Exp. Med. 179, 1099-1108 (1994)
    • (1994) J. Exp. Med. , vol.179 , pp. 1099-1108
    • Wakatsuki, Y.1    Neurath, M.F.2    Max, E.E.3    Strober, W.4
  • 33
    • 0028827269 scopus 로고
    • Antisense has growing pains
    • Gura, T. Antisense has growing pains. Science 270, 575-577 (1995).
    • (1995) Science , vol.270 , pp. 575-577
    • Gura, T.1
  • 34
    • 0027246678 scopus 로고
    • Antisense gene inhibition by oligonucleotides containing C-5 propyne pyrimidines
    • Wagner, R.W et al Antisense gene inhibition by oligonucleotides containing C-5 propyne pyrimidines Science 260, 1510-1514 (1993)
    • (1993) Science , vol.260 , pp. 1510-1514
    • Wagner, R.W.1
  • 35
    • 0028019410 scopus 로고
    • Gene inhibition using antisense oligodeoxynucleotides
    • Wagner, R.W. Gene inhibition using antisense oligodeoxynucleotides. Nature 372, 333-335 (1994).
    • (1994) Nature , vol.372 , pp. 333-335
    • Wagner, R.W.1
  • 36
    • 0029050664 scopus 로고
    • A single-injection protein kinase A-directed antisense treatment to inhibit tumour growth
    • Nesterova, M & Cho-Chung Y.S. A single-injection protein kinase A-directed antisense treatment to inhibit tumour growth. Nature Med. 1, 528-533 (1995).
    • (1995) Nature Med. , vol.1 , pp. 528-533
    • Nesterova, M.1    Cho-Chung, Y.S.2
  • 37
    • 0029050018 scopus 로고
    • A 'senseless' immune response to DNA
    • Holt, J T. A 'senseless' immune response to DNA. Nature Med. 1, 407-408 (1995)
    • (1995) Nature Med. , vol.1 , pp. 407-408
    • Holt, J.T.1
  • 38
    • 0029866569 scopus 로고    scopus 로고
    • Inhibition of endothelial cell activation by adenovirus-mediated expression of IκBα, an inhibitor of the transcription factor NF-κB
    • Wrighton, C.J et al. Inhibition of endothelial cell activation by adenovirus-mediated expression of IκBα, an inhibitor of the transcription factor NF-κB. J. Exp. Med. 183, 1013-1022 (1996).
    • (1996) J. Exp. Med. , vol.183 , pp. 1013-1022
    • Wrighton, C.J.1
  • 39
    • 0029050742 scopus 로고
    • Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2)
    • van Dullemen, H M. et al. Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2). Gastroenterology 109, 129-135 (1995).
    • (1995) Gastroenterology , vol.109 , pp. 129-135
    • Van Dullemen, H.M.1
  • 40
    • 0025690778 scopus 로고
    • Role of intestinal microflora in initiation and perpetuation of inflammatory bowel disease
    • Sartor, R B Role of intestinal microflora in initiation and perpetuation of inflammatory bowel disease. Can. J Gastroenterol 4, 271-277 (1990).
    • (1990) Can. J Gastroenterol , vol.4 , pp. 271-277
    • Sartor, R.B.1
  • 41
    • 0029993786 scopus 로고    scopus 로고
    • Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin-10 or antibodies to interleukin-12
    • Duchmann, R , Schmitt, E., Knolle, P., Meyer zum Büschenfelde, K.-H. & Neurath, M.F. Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin-10 or antibodies to interleukin-12 Eur J. Immunol. 26, 934-938 (1996).
    • (1996) Eur J. Immunol. , vol.26 , pp. 934-938
    • Duchmann, R.1    Schmitt, E.2    Knolle, P.3    Meyer Zum Büschenfelde, K.-H.4    Neurath, M.F.5
  • 42
    • 0028948176 scopus 로고
    • Interleukin (IL)-10 inhibits nuclear factor B (NF kappa B) activation in human monocytes: IL-10 and IL-4 suppress cytokine synthesis by different mechanisms
    • Wang, P , Wu, P., Siegel, M.I., Egan, R.W. & Billah, M M. Interleukin (IL)-10 inhibits nuclear factor B (NF kappa B) activation in human monocytes: IL-10 and IL-4 suppress cytokine synthesis by different mechanisms. J. Biol. Chem. 270, 9558-9563 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 9558-9563
    • Wang, P.1    Wu, P.2    Siegel, M.I.3    Egan, R.W.4    Billah, M.M.5
  • 43
    • 0028879819 scopus 로고
    • Role of transcriptional activation of IκBα in mediation of immunosuppression by glucocorticoids
    • Scheinman, R.I., Cogswell, P.C., Lofquist, A.K. & Baldwin, A.S. Role of transcriptional activation of IκBα in mediation of immunosuppression by glucocorticoids. Science 270, 283-286 (1995).
    • (1995) Science , vol.270 , pp. 283-286
    • Scheinman, R.I.1    Cogswell, P.C.2    Lofquist, A.K.3    Baldwin, A.S.4
  • 44
    • 0028867899 scopus 로고
    • Immunosuppression by glucocorticoids: Inhibition of NF-κB activity through induction of IκBα synthesis
    • Auphan, N , DiDonato, J.A., Rosette, C., Helmberg, A. & Karin, M. Immunosuppression by glucocorticoids: inhibition of NF-κB activity through induction of IκBα synthesis. Science 270, 286-290 (1995).
    • (1995) Science , vol.270 , pp. 286-290
    • Auphan, N.1    DiDonato, J.A.2    Rosette, C.3    Helmberg, A.4    Karin, M.5
  • 45
    • 0029075493 scopus 로고
    • Pax5 (BSAP) regulates the murine immunoglobulin 3′α enhancer by affecting binding of NF-αP, a protein that controls heavy chain transcription
    • Neurath, M.F., Max E.E & Strober W. Pax5 (BSAP) regulates the murine immunoglobulin 3′α enhancer by affecting binding of NF-αP, a protein that controls heavy chain transcription Proc Natl Acad. Sci. USA 92, 5336-5340 (1995).
    • (1995) Proc Natl Acad. Sci. USA , vol.92 , pp. 5336-5340
    • Neurath, M.F.1    Max, E.E.2    Strober, W.3
  • 46
    • 0027476430 scopus 로고
    • Identification and analysis of all components of a gel retardation assay by combination with immunoblotting
    • Demczuk, S , Harbers, M. & Vennstrom, B Identification and analysis of all components of a gel retardation assay by combination with immunoblotting. Proc. Natl. Acad. Sci. USA 90, 2574-2578 (1993).
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 2574-2578
    • Demczuk, S.1    Harbers, M.2    Vennstrom, B.3
  • 47
    • 0017646342 scopus 로고
    • Isolation and functional characterization of human intestinal mucosal mononuclear cells
    • Bull, D.M. & Bookman, M A Isolation and functional characterization of human intestinal mucosal mononuclear cells. J. Clin. Invest. 59, 966-974 (1977).
    • (1977) J. Clin. Invest. , vol.59 , pp. 966-974
    • Bull, D.M.1    Bookman, M.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.