Specificity of inhibition of matrix metalloproteinase activity by doxycycline: Relationship to structure of the enzyme

Arthritis and Rheumatism

Volumn 42, Issue 6, 1999, Pages 1140-1146

  Smith Jr , Gerald N ^a   Mickler, Elizabeth A ^a   Hasty, Karen A ^b   Brandt, Kenneth D ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 2; COLLAGENASE; COLLAGENASE 3; DOXYCYCLINE; HEMOPEXIN; MATRIX METALLOPROTEINASE; NEUTROPHIL COLLAGENASE; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG SENSITIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME STRUCTURE; INHIBITION KINETICS; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; COLLAGEN; COLLAGENASES; DOXYCYCLINE; HUMANS; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASE 8; MOLECULAR SEQUENCE DATA; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 0344483895     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(199906)42:6<1140::AID-ANR10>3.0.CO;2-7     Document Type: Article

References (40)

1. Matrisian LM. The matrix-degrading metalloproteinases. Bioessays 1992;14:455-63.
2. Birkedahl-Hansen H, Moore WG, Bodden MK, Windsor LJ, Birkedal-Hansen B, DeCarlo A, et al. Matrix metalloproteinases: a review. Crit Rev Oral Biol Med 1993;4:197-250.
3. Hasty KA, Pourmotabbed TF, Goldberg GI, Thompson JP, Spinella DG, Stevens RM, et al. Human neutrophil collagenase: a distinct gene product with homology to other matrix metalloproteinases. J Biol Chem 1990;265:11421-4.
4. Cole AA, Chubinskaya S, Schumacher B, Huch K, Szabo G, Yao J, et al. Chondrocyte matrix metalloproteinase-8: human articular chondrocytes express neutrophil collagenase. J Biol Chem 1996; 271:11023-6.
5. Roswit WT, Halme J, Jeffrey JJ. Purification and properties of rat uterine procollagenase. Arch Biochem Biophys 1983;225:285-95.
6. Freije JM, Diez-Itza I, Balbin M, Sanchez LM, Blasco R, Tolivia J, et al. Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas. J Biol Chem 1994;269:16766-73.
7. Mitchell PG, Magna HA, Reeves LM, Lopresti-Morrow LL, Yocum SA, Rosner PJ, et al. Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage. J Clin Invest 1996;97:761-8.
8. Clark IM, Cawston TE. Fragments of human fibroblast collagenase: purification and characterization. Biochem J 1989;263: 201-6.
9. Murphy G, Allan JA, Willenbrock F, Cockett MI, O'Connell JP, Docherty AJP. The role of the C-terminal domain in collagenase and stromelysin specificity. J Biol Chem 1992;267:9612-8.
10. Hirose T, Patterson C, Pourmotabbed T, Mainardi CL, Hasty KA. Structure-function relationship of human neutrophil collagenase: identification of regions responsible for substrate specificity and general proteinase activity. Proc Natl Acad Sci U S A 1993;90: 2569-73.
11. Golub LM, Ramamurthy NS, McNamara TF, Gomes B, Wolff M, Casino AA, et al. Tetracyclines inhibit tissue collagenase activity: a new mechanism in the treatment of periodontal disease. J Periodontal Res 1984;19:651-5.
12. Burns FR, Stack MS, Gray RD, Paterson CA. Inhibition of alkali-induced corneal ulceration and perforation by a thiol peptide. Invest Ophthalmol Vis Sci 1989;30:1569-75.
13. Greenwald RA, Moak SA, Ramamurthy NS, Golub LM. Tetracyclines suppress matrix metalloproteinase activity in adjuvant arthritis and in combination with flurbiprofen, ameliorate bone damage. J Rheumatol 1992;19:927-38.
14. Suomalainen K, Sorsa T, Ingman T, Lindy O, Golub LM. Tetracycline inhibition identifies the cellular origin of interstitial collagenases in human periodontal diseases in vivo. Oral Microbiol Immunol 1992;7:121-3.
15. Smith GN Jr, Brandt KD, Hasty KA. Activation of recombinant human neutrophil procollagenase in the presence of doxycycline results in fragmentation of the enzyme and loss of enzyme activity. Arthritis Rheum 1996;39:235-44.
16. Yu LP Jr, Smith GN Jr, Hasty KA, Brandt KD. Doxycycline inhibits type XI collagenolytic activity in human osteoarthritic cartilage. J Rheumatol 1991;18:1450-2.
17. Nip LH, Uitto V-J, Golub LM. Inhibition of epithelial cell matrix metalloproteinases by tetracyclines. J Periodontal Res 1993;28: 379-85.
18. Arsenis CA, Greenwald RA, Moak SA, Laskin RS. Inhibition of neutral metalloproteinase activities (MTP) in epiphyseal and articular cartilages by tetracyclines (TETs) both in vivo and in vitro [abstract]. Trans Orthop Res Soc 1990;15:268.
19. Weingarten H, Martin R, Feder J. Synthetic substrates of vertebrate collagenase. Biochemistry 1985;24:6730-4.
20. Weingarten H, Feder J. Spectrophotometric assay for vertebrate collagenase. Anal Biochem 1989;147:437-40.
21. Bergmeyer HU, Gawehn K. Principles of enzymatic analysis. New York: Verlag Chemie; 1978.
22. Modr Z, Dvorzhachek K, Schmidt O, Nechaskova A. Pharmokinetics of doxycycline on its repeated oral administration. Antibiot Khimiotr 1974;19:1063-7.
23. Sorsa T, Ding Y, Salo T, Lauhio A, Teronen O, Ingman T, et al. Effects of tetracyclines on neutrophil, gingival, and salivary collagenases: a functional and western-blot assessment with special reference to their cellular sources in periodontal diseases. Ann N Y Acad Sci 1994;732:112-31.
24. Lovejoy B, Hassell AM, Luther MA, Weigl D, Jordan SR. Crystal structures of recombinant 19-kDa human fibroblast collagenase complexed to itself. Biochemistry 1994;33:8207-17.
25. Spurlino JC, Smallwood AM, Carlton DD, Banks TM, Vavra KJ, Johnson JS, et al. 1.56 A structure of mature truncated human fibroblast collagenase. Proteins 1994;19:98-109.
26. Lovejoy B, Cleasby A, Hassell AM, Longley K, Luther MA, Weigl D, et al. Structure of the catalytic domain of fibroblast collagenase complexed with an inhibitor. Science 1994;263:375-7.
27. Borkakoti N, Winkler FK, Williams DH, D'Arcy A, Broadhurst MJ, Brown PA, et al. Structure of the catalytic domain of human fibroblast collagenase complexed with an inhibitor. Nat Struct Biol 1994;1:106-10.
28. Stams T, Spurlino JC, Smith DL, Wahl RC, Ho TF, Qoronfleh MW, et al. Structure of human neutrophil collagenase reveals large S1′ specificity pocket. Nat Struct Biol 1994;1:119-23.
29. Bode W, Reinemer P, Huber R, Kleine T, Schnierer S, Tschesche H. The x-ray crystal structure of the catalytic domain of human neutrophil collagenase inhibited by a substrate analogue reveals the essentials for catalysis and specificity. EMBO J 1992;13: 1263-9.
30. Reinemer P, Grams F, Huber R, Kleine T, Schnierer S, Piper M, et al. Structural implications for the role of the N terminus in the 'superactivation' of collagenases: a crystallographic study. FEBS Lett 1994;338:227-33.
31. Li J, Brick P, O'Hare MC, Skarzynski T, Lloyd LF, Curry VA, et al. Structure of full-length porcine synovial collagenase reveals a C-terminal domain containing a calcium-linked, four-bladed beta-propeller. Structure 1995;3:541-54.
32. Gomis-Ruth FX, Gohlke U, Betz M, Knauper V, Murphy G, Lopez-Otin C, et al. The helping hand of collagenase-3 (MMP-13): 2.7 A crystal structure of its C-terminal haemopexin-like domain. J Mol Biol 1996;64:556-66.
33. Greenwald RA. Treatment of destructive arthritic disorders with MMP inhibitors: potential role of tetracyclines. Ann N Y Acad Sci 1994;732:181-98.
34. Yu LP Jr, Smith GN Jr, Brandt KD, Myers SL, O'Connor BL, Brandt DA. Reduction of the severity of canine osteoarthritis by prophylactic treatment with oral doxycycline. Arthritis Rheum 1992;35:1150-9.
35. Yu LP Jr, Smith GN Jr, Brandt KD, O'Connor B, Myers SL. Therapeutic administration of doxycycline (DOXY) slows the progression of cartilage destruction in canine osteoarthritis (OA) [abstract]. Trans Orthop Res Soc 1993;18:724.
36. Smith GN Jr, Yu LP Jr, Brandt KD, Capello WN. Oral administration of doxycycline reduces collagenase and gelatinase activities in extracts of human osteoarthritic cartilage. J Rheumatol 1998; 25:532-5.
37. Greenwald RA, Golub LM, Ramamurthy NS, Chowdhury M, Moak SA, Sorsa T. In vitro sensitivity of the three mammalian collagenases to tetracycline inhibition: relationship to bone and cartilage degradation. Bone 1998;22:33-8.
38. Jonat C, Chung FZ, Baragi VM. Transcriptional downregulation of stromelysin by tetracycline. J Cell Biochem 1996;60:341-7.
39. Shlopov BV, Smith GN Jr, Cole AA, Hasty KA. Differential patterns of response to doxycycline and transforming growth factor β1 in down-regulation of collagenases in osteoarthritic and normal human chondrocytes. Arthritis Rheum 1999;42:719-27.
40. Davies SR, Cole AA, Schmid TM. Doxycycline inhibits type X collagen synthesis in avian hypertrophic chondrocyte cultures. J Biol Chem 1996;271:25966-70.