Interleukin-1β converting enzyme inhibition blocks progression of type II collagen-induced arthritis in mice

Cytokine

Volumn 8, Issue 5, 1996, Pages 377-386

  Ku, George ^a   Faust, Ted ^a   Lauffer, Linda L ^a   Livingston, David J ^a   Harding, Matthew W ^a  

^a VERTEX PHARMACEUTICALS   (United States)

Author keywords

Arthritis; Inflammation; Interleukin 1 ; Interleukin 1 converting enzyme

Indexed keywords

ANTIINFLAMMATORY AGENT; CYSTEINE PROTEINASE; INDOMETACIN; INTERLEUKIN 1; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 1BETA CONVERTING ENZYME INHIBITOR; LIPOPOLYSACCHARIDE; PREDNISOLONE; UNCLASSIFIED DRUG; VE 13045; VE 16084;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; INFLAMMATORY CELL; INFLAMMATORY DISEASE; INTRAPERITONEAL DRUG ADMINISTRATION; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; SYNOVIUM;

ANIMALIA; MURINAE;

EID: 0029971948     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1006/cyto.1996.0052     Document Type: Article

References (53)

1. Dinarello CA, Wolff SM (1993) The role of interleukin-1 in disease. N Eng J Med 328:106-113.
2. Dinarello CA (1989) Interleukin-1 and its biologically related cytokines. Adv Immunol 44:153-205.
3. Dinerallo CA (1994) The interleukin-1 family: 10 years of discovery. FASEB J 8:1314-1325.
4. March CJ, Mosley B, Larsen A, Cerretti DP, Braedt G, Price V, Gillis S, Henney CS, Kronheim SR, Grabstein K, Colulon PJ, Hopp TP, Cosman D (1985) Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature 315:641-645.
5. Gray PW, Glaister D, Chen E, Goeddel DV, Pennica D (1986) Two interleukin-1 genes in the mouse: cloning and expression of the cDNA for murine interleukin-1β. J Immunol 137:3644-3648.
6. Dower SK, Krowheim SR, Hopp TP, Cantrell M, Deeley M, Gillis S, Henney CS, Urdal DL (1986) The cell surface receptors for IL-1 are identical. Nature 324:266-268.
7. Sims JE, Gayle MA, Slack JL, Alderson MR, Bird TA, Giri JG, Colotta F, Re F, Mantovani A, Shanebeck K, Grabstein KH, Dower SK (1993) Interleukin-1 signaling occurs exclusively via the type I receptor. Proc Natl Acad Sci USA 90:6155-6159.
8. Arend WA (1993) Interleukin-1 receptor antagonist. Adv Immunol 54:167-227.
9. Fanslow WC, Sims JE, Sassenfeld H, Morrissey PJ, Gillis S, Dower SK, Widmer MB (1990) Regulation of alloreactivity in vivo by a soluble form of the interleukin-1 receptor. Science 248:739-742.
10. Ohlsson K, Bjork P, Bergenfeldt M, Hageman R, Thompson RC (1990) Interleukin-1 receptor antagonist reduces mortality from endotoxin shock. Nature 348:550-552.
11. Alexander HR, Doherty GM, Buresh CM, Venzon DJ, Norton JA (1991) A recombinant human receptor antagonist for interleukin-1 improves survival after lethal endotoxemia in mice. J Exp Med 173:1029-1032.
12. Wakabayashi G, Gelfand JA, Burke JF, Thompson RC, Dinarello CA (1991) A specific receptor antagonist for interleukin-1 prevents Eschericia coli induced shock. FASEB J 5:338-343.
13. McCarthy PL, Abhyankar S, Neben S. et al. (1991) Inhibition of interleukin-1 by Interleukin-1 receptor antagonist presents graft vs host disease. Blood 78:1915-1918.
14. Wooley PH, Whalen JD, Chapman DL, Berger AE, Richard KA, Aspar DG, Stake ND (1993) The effect of an interleukin-1 receptor antagonist protein on Type II collagen-induced arthritis and antigen-induced in mice. Arthritis Rheum 36:1305-1314.
15. Schwab JH, Anderle SK, Brown RR, Dalldorf FG, Thompson RC (1991) Pro-and anti-inflammatory roles of interleukin-1 in recurrence of bacterial cell wall-induced arthritis in rats. Infect Immun 59:4436-4442.
16. Lewthwaite J, Blake SM, Hardingham TE, Warden PJ, Henderson B (1994) The effect of recombinant human interleukin-1 receptor antagonist on the induction phase of antigen induced arthritis in the rabbit. J Rheumatol 21:467-472.
17. Dreylow B, Capezio J, Lovis R, Jacobs C, Landay A, Pope RM (1993) Phase I study of recombinant human interleukin-1 receptor administered intra-articularly in active rheumatoid arthritis. Arthritis Rheum 36 (Suppl 9):S39.
18. Lebsack ME, Paul CC, Blocdow DC, Burch FX, Sack MA, Chase W, Catalano MA (1991) Subcutaneous IL-1 receptor antagonist in patients with rheumatoid arthritis. Arthritis Rheu 36 (Suppl 9):S45.
19. Lebsack ME, Paul CC, Martindale JJ, Catalano MA (1993) A dose and regimen ranging study of IL-1 receptor antagonist in patients with rheumatoid arthritis. Arthritis Rheum 36 (Suppl 9):S39.
20. Dinarello CA, Gelfand JA, Wolff SM (1993) Anticytokine strategies in the treatment of the systemic inflammatory response syndrome. JAMA 269:1829-1835.
21. Carruth LM, Dernczuk S, Mizel SB (1991) Involvement of a calpain-like protease in the processing of the murine interleukin-1α precursor. J Biol Chem 266:12162-12167.
22. Kobayashi Y, Yamamoto K, Saido T, Kawasaki H, Oppenheim JJ, Matsushima K (1990) Identification of calcium activated neural protease as a processing enzyme of human interleukin-1α. Proc Natl Acad Sci USA 87:5548-5552.
23. Black RA, Kronheim SR, Sleath PR (1989) Activation of interleukin-1β by a co-induced protease. FEBS Lett 247:386-390.
24. Kostura MJ, Tocci MJ, Limjuco G, Chin J, Vameron P, Hillman AG, Chartrain NA, Schmidt JA (1989) Identification of a monocyte specific pre-interleukin 1β convertase activity. Proc Natl Acad Sci USA 86:5227-5231.
25. Kurt-Jones EA, Beller DI, Mizel SM, Unanue ER (1985) Identification of a membrane-associated interleukin-1 macrophages. Proc Natl Acad Sci USA 82:1204-1208.
26. Fuhlbrigge RC, Fine SM, Unanue ER, Chaplin DD (1988) Expression of membrane interleukin-1 fibroblasts transfected with murine pro-interleukin-1α cDNA. Proc Natl Acad Scie USA 85:5649-5653.
27. Thornberry NA, Bull HG, Calaycay JR, Chapman KT, Howard AD, Kostura MJ, Miller DK, Molineaux SM, Weidner JR, Aunins J, Elliston KO, Ayala JM, Casano FJ, Chin J, Ding GJ-F, Egger LA, Gaffney EP, Limjuco G, Palyha OC, Raju SM, Rolando AM, Salley JP, Yamin T-T, Lee TD, Shively JE, MacCross M, Mumford RA, Schmidt JA, Tocci MJ (1992) A novel heterodimeric cysteine protease required for interleukin-1βprocessing in monocytes. Nature 356:768-774.
28. Ceretti DP, Kozlosky CJ, Mosley B, Nelson N, Van Ness K, Greenstreet TA, March CJ, Kronheim SR, Druck T, Cannizzaro LA, Huebner K, Black RA (1992) Molecular cloning of the IL-1β converting enzyme. Science 256:97-100.
29. Ayala JM, Yamin T-T, Egger LA, Chin J, KosturaMJ, Miller DK (1994) IL-1β converting enzyme is present in monocytic cells as an inactive 45-kDa precursor. J Immunol 153:2592-2599.
30. Wilson KP, Black JF, Thomson JA, Kim EE, Grifith JP, Navia MA, Murcko MA, Chambers SP, Aldape RA, Raybuck SA, Livingston DJ (1994) Structure and mechanism of interleukin-1β converting enzyme. Nature 370:270-275.
31. Walker NPC, Talanian RV, Brady KD, Lang LC, Bump NJ, Ferenz CR, Franklin S, Ghayur T, Hackett MC, Hammill LD, Herzog L, Hugunin M, Houy W, Mankovich JA, McGuiness L, Orlewicz E, Paskind M, Pratt CA, Reis P, Summani A, Terranova M, Welch JP, Xiong L, Moller A, Tracey DE, Kamen R, Wong WW (1994) Crystal structure of the cysteine protease interleukin-1β converting enzyme: A (p20/p10)2 homodimer. Cell 78:343-352.
32. Kuida K, Lippke JA, Ku G, Harding MW, Livingston DJ, Su MS-S, Flavell RA (1995) Altered cytokine export and apoptosis in mice deficient in interleukin-1β converting enzyme. Science 267:2000-2003.
33. Homdahl R, Andersson M, Goldschmidt TJ, Gustafsson K, Jansson L, Mo JA (1990) Type II collagen auto-immunity in animals and provocations leading to arthritis. Immunol Rev 118:193-232.
34. Vanden Berg WB, Joosten LAB, Helsen M, van de Loo FAS (1994) Amelioration of established murine collagen induced arthritis with anti-IL-1 treatment. Clin Exp Immnuol 95:237-243.
35. Geiger T, Towbin H, Cosenti-Vargas A, Zingle O, Arnold J, Rordorf C, Glatt M, Vosbeck K (1993) Neutralization of interleukin-1β activity in vivo with a monoclonal antibody alleviates collagen-induced arthritis in DBA/1 mice and prevents the associated acute-phase response. Clin Exp Rheum 11:515-522.
36. Perregaux D, Barberia J, Lanzetti AJ, Geoghegan KF, Carty TJ, Gabel CA (1992) IL-2β maturation: evidence that mature cytokine formation can be induced specifically by nigericin. J Immunol 119:1294-1303.
37. Wooley PH (1988) Collagen arthritis in the mouse. Methods Enzymol 162:361-373.
38. Miller BE, Krasney PA, Gauvin DM, Holbrook KB, Kounz DJ, Abruzzese RV, Miller RE, Pagani KA, Dolle RE, Ator MA, Gilman SC (1995) Inhibition of mature IL-1β production in murine macrophages and a murine model of inflammation by WIN 67694, an inhibitor of IL-1β converting enzyme. J Immunol 154:1331-1338.
39. Thorbecke GJ, Shah R, Leu CH, Kuruvilla AP, Hardis AM, Palladino MA (1992) Involvement of endogenous tumor necrosis factor alpha and transforming growth factor beta during induction of collagen type II arthritis in mice. Proc Natl Acad Sci USA 89:7375-7379.
40. Takai YN, Seki N, Senoh H, Yokota T, Lee F, Hamaoka T, Fujiwara H (1989) Enhanced production of interleukin-6 in mice with type II collagen-induced arthritis. Arthritis Rheum 32:594-600.
41. Mauritz NJ, Holmdahl R, Jonsson R, Van der Meide PH, Scheynius A, Klareskog L (1988) Treatment with gamma-interferon triggers the onset of collagen arthritis in mice. Arthritis Rheum 31:1297-1304.
42. Cooper SM, Sriram S, Ranges GE (1988) Suppression of murine collagen induced arthritis with monoclonal anti-Ia antibodies and agumentation with IFN-gamma. J Immunol 141:1958-1962.
43. Kasama T, Strietr RM, Lukacs NW, Lincoln PM, Burdick MD, Kunkel SL (1995) Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis. J Clin Invest 95:2868-2876.
44. Williams RO, Feldmann M, Maini RN (1992) Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis. Proc Natl Acad Sci USA 89:9784-9788.
45. Piguet PF, Grau GE, Vesin C, Wetscher H, Gentz R, Lesslauer W (1992) Evolution of collagen arthritis in mice is arrested by treatment with anti-tumor necrosis factor (TNF) antibody or a recombinant soluble TNF receptor. Immunol 77:510-514.
46. Wooley PH, Dutcher J, Widmer MB, Gillis S (1993) Influence of a recombinant human soluble tumour necrosis factor receptor Fc fusion protein on type II collagen-induced arthritis in mice. J Immunol 151:6602-6607.
47. Staite ND, Richard KA, Aspar DG, Franz KA, Galinet LA, Dunn CJ (1990) Induction of an acute erosive monarticular arthritis in mice by interleukin-1 and methylated bovine serum albumin. Arthritis Rheum 33:253-260.
48. Hom JT, Gliszczynski VL, Cole HW, Bendele AM (1991) Interleukin-1 mediated acceleration of type II collagen-induced arthritis: Effects of anti-inflammatory or anti-arthritis drugs. Agents Actions 33:300-309.
49. Cooper WO, Fava RA, Gates CA, Cremer MA, Townes AS (1992) Acceleration of onset of collagen-induced arthritis by intra-articular injection of tumor necrosis factor or transforming growth factor-beta. Clin Exp Immunol 89:244-250.
50. Keffer J, Probert L, Cazlaris H, Georgopoulos S, Kaslaris E, Kioussis D, Kollias G (1991) Transgenic mice expressing human tumor necrosis factor: a predictive genetic model of arthritis. EMBO J 10:4025-4031.
51. Arend WP, Dayer JM (1995) Inhibition of the production and effects of interleukin-1 and tumor necrosis factor a in rheumatoid arthritis. Arthritis Rheum 38:151-160.
52. Li P, Allen H, Banerjee S, Franklin S, Herzog L, Johnston C, McDowell J, Paskind M, Rodman L, Salfeld J, Towne E, Tracey D, Wardwell S, Wei F-Y, Wong W, Kamen R, Seshardi T (1995) Mice deficient in IL-1β converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock. Cell 80:401-411.
53. Alacerri ES, Fernandes-Alnmeri T, Litwack G (1995) Cloning and expression of four novel isoforms of human interleukin-1β converting enzyme with different apoptotic activities. J Biol Chem 270:4312-4316.