Functional replacement of the intracellular region of the Notch1 receptor by Epstein-Barr virus nuclear antigen 2

Journal of Virology

Volumn 72, Issue 7, 1998, Pages 6034-6039

  Sakai, Takashi ^a,c   Taniguchi, Yoshihito ^a   Tamura, Kumiko ^a,d   Minoguchi, Shigeru ^a   Fukuhara, Takataro ^a   Strobl, Lothar J ^b   Zimber Strobl, Ursula ^b   Bornkamm, George W ^b   Honjo, Tasuku ^a  

^a KYOTO UNIVERSITY   (Japan)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c UNIVERSITY OF TOKUSHIMA   (Japan)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS ANTIGEN; VIRUS RECEPTOR;

ARTICLE; BINDING SITE; CELL TRANSFORMATION; DNA SEQUENCE; EPSTEIN BARR VIRUS; GENE ACTIVATION; GENE CONTROL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; RECEPTOR OCCUPANCY; TARGET CELL; TRANSACTIVATION;

EID: 0031746565     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.7.6034-6039.1998     Document Type: Article

References (29)

1. Artavanis-Tsakonas, S., K. Matsuno, and M. E. Fortini. 1995. Notch signaling. Science 268:225-232.
2. Aster, J. C., E. S. Robertson, R. B. Hasserjian, J. R. Turner, E. Kieff, and J. Sklar. 1997. Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jκ or nuclear localization sequences retain the ability to associate with RBP-Jκ and activate transcription. J. Biol. Chem. 272:11336-11343.
3. Chung, C. N., Y. Hamaguchi, T. Honjo, and M. Kawaichi. 1994. Site-directed mutagenesis study on DNA binding regions of the mouse homologue of Suppressor of Hairless, RBP-Jκ. Nucleic Acids Res. 22:2938-2944.
4. Cohen, J. I., F. Wang, J. Mannick, and E. Kieff. 1989. Epstein-Barr virus nuclear protein 2 is a key determinant of lymphocyte transformation. Proc. Natl. Acad. Sci. USA 86:9558-9562.
5. Ellisen, L. W., J. Bird, D. C. West, A. L. Soreng, T. C. Reynolds, S. D. Smith, and J. Sklar. 1991. TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 66:649-661.
6. Grossman, S. R., E. Johannsen, X. Tong, R. Yalamanchili, and E. Kieff. 1994. The Epstein-Barr virus nuclear antigen 2 transactivator is directed to response elements by the Jκ recombination signal binding protein. Proc. Natl. Acad. Sci. USA 91:7568-7572.
7. Hamaguchi, Y., N. Matsunami, Y. Yamamoto, and T. Honjo. 1989. Purification and characterization of a protein that binds to the recombination signal sequence of the immunoglobulin Jκ segment. Nucleic Acids Res. 17: 9015-9026.
8. Hammerschmidt, W., and B. Sugden. 1989. Genetic analysis of immortalizing functions of Epstein-Barr virus in human B lymphocytes. Nature 340: 393-397.
9. Henkel, T., P. D. Ling, S. D. Hayward, and M. G. Peterson. 1994. Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein Jκ. Science 265:92-95.
10. Hsieh, J. J., and S. D. Hayward. 1995. Masking of the CBF1/RBPJκ transcriptional repression domain by Epstein-Barr virus EBNA2. Science 268: 560-563.
11. Hsieh, J. J., D. E. Nofziger, G. Weinmaster, and S. D. Hayward. 1997. Epstein-Barr virus immortalization: Notch2 interacts with CBF1 and blocks differentiation. J. Virol. 71:1938-1945.
12. Jarriault, S., C. Brou, F. Logeat, E. H. Schroeter, R. Kopan, and A. Israel. 1995. Signalling downstream of activated mammalian Notch. Nature 377: 355-358.
13. Kato, H., T. Sakai, K. Tamura, S. Minoguchi, Y. Shirayoshi, Y. Hamada, Y. Tsujimoto, and T. Honjo. 1996. Functional conservation of mouse Notch receptor family members. FEBS Lett. 395:221-224.
14. Kato, H., Y. Taniguchi, H. Kurooka, S. Minoguchi, T. Sakai, S. Nomura-Okazaki, K. Tamura, and T. Honjo. Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives. 1997. Development 124: 4133-4141.
15. Kopan, R., J. S. Nye, and H. Weintraub. 1994. The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD. Development 120:2385-2396.
16. Ling, P. D., D. R. Rawlins, and S. D. Hayward. 1993. The Epstein-Barr virus immortalizing protein EBNA-2 is targeted to DNA by a cellular enhancer-binding protein. Proc. Natl. Acad. Sci. USA 90:9237-9241.
17. Matsunami, N., Y. Hamaguchi, Y. Yamamoto, and T. Honjo. 1989. A protein binding to the Jκ recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif. Nature 342:934-937.
18. Minoguchi, S., Y. Taniguchi, H. Kato, T. Okazaki, L. J. Strobl, U. Zimber-Strobl, G. W. Bornkamm, and T. Honjo. 1997. RBP-L, a transcription factor related to RBP-Jκ. Mol. Cell. Biol. 17:2679-2687.
19. Mizushima, S., and S. Nagata. 1990. pEF-BOS, a powerful mammalian expression vector. Nucleic Acids Res. 18:5322.
20. Muskavitch, M. A. 1994. Delta-notch signaling and Drosophila cell fate choice. Dev. Biol. 166:415-430.
21. Takebayashi, K., Y. Sasai, Y. Sakai, T. Watanabe, S. Nakanishi, and R. Kageyama. 1994. Structure, chromosomal locus, and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-1. Negative autoregulation through the multiple N box elements. J. Biol. Chem. 269:5150-5156.
22. Tamura, K., Y. Taniguchi, S. Minoguchi, T. Sakai, T. Tun, T. Furukawa, and T. Honjo. 1995. Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-Jκ/Su(H). Curr. Biol. 5:1416-1423.
23. Tun, T., Y. Hamaguchi, N. Matsunami, T. Furukawa, T. Honjo, and M. Kawaichi. 1994. Recognition sequence of a highly conserved DNA binding protein RBP-Jκ. Nucleic Acids Res. 22:965-971.
24. Vojtek, A. B., S. M. Hollenberg, and J. A. Cooper. 1993. Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell 74:205-214.
25. Waltzer, L., F. Logeat, C. Brou, A. Israel, A. Sergeant, and E. Manet. 1994. The human Jκ recombination signal sequence binding protein (RBP-Jκ) targets the Epstein-Barr virus EBNA2 protein to its DNA responsive elements. EMBO J. 13:5633-5638.
26. White, E. 1996. Life, death, and the pursuit of apoptosis. Genes Dev. 10: 1-15.
27. Yalamanchili, R., X. Tong, S. Grossman, E. E. Johannsen, G. Mosialos, and E. Kieff. 1994. Genetic and biochemical evidence that EBNA2 interaction with a 63-kDa cellular GTG-binding protein is essential for B lymphocyte growth transformation by EBV. Virology 204:634-641.
28. Zimber-Strobl, U., E. Kremmer, F. Grasser, G. Marschall, G. Laux, and G. W. Bornkamm. 1993. The Epstein-Barr virus nuclear antigen 2 interacts with an EBNA2 responsive cis-element of the terminal protein 1 gene promoter. EMBO J. 12:167-175.
29. Zimber-Strobl, U., L. J. Strobl, C. Meitinger, R. Hinrichs, T. Sakai, T. Furukawa, T. Honjo, and G. W. Bornkamm. 1994. Epstein-Barr virus nuclear antigen 2 exerts its transactivating function through interaction with recombination signal binding protein RBP-Jκ, the homologue of Drosophila Suppressor of Hairless. EMBO J. 13:4973-4982.