The ins and outs of Notch signaling

Molecular and Cellular Neurosciences

Volumn 9, Issue 2, 1997, Pages 91-102

  Weinmaster, Gerry ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE PROTEIN;

CAENORHABDITIS ELEGANS; CELL SPECIFICITY; DROSOPHILA; LIGAND BINDING; MOLECULAR BIOLOGY; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; REVIEW; SIGNAL TRANSDUCTION;

CAENORHABDITIS ELEGANS; INVERTEBRATA; VERTEBRATA;

EID: 0030748716     PISSN: 10447431     EISSN: None     Source Type: Journal    
DOI: 10.1006/mcne.1997.0612     Document Type: Review

References (121)

1. Artavanis-Tsakonas S., Matsuno K., Fortini M. E. Notch signaling. Science. 268:1995;225-232.
2. Aster J., Pear W., Hasserjian R., Erba H., Davi F., Luo B., Scott M., Baltimore D., Sklar J. Functional analysis of the TAN-1 gene, a human homolog of Drosophila notch. Cold Spring Harbor Symp. Quant. Biol. 59:1994;125-136.
3. Austin C. P., Feldman D. E., Ida J. A. Jr., Cepko C. L. Vertebrate retinal ganglion cells are selected from competent progenitors by the action of Notch. Development. 121:1995;3637-3650.
4. Axelrod J. D., Matsuno K., Artavanis-Tsakonas S., Perrimon N. Interaction between Wingless and Notch signaling pathways mediated by dishevelled. Science. 271:1996;1826-1832.
5. Bailey A. M., Posakony J. W. Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity. Genes Dev. 9:1995;2609-2622.
6. Bang A. G., Bailey A. M., Posakony J. W. Hairless promotes stable commitment to the sensory organ precursor cell fate by negatively regulating the activity of the Notch signaling pathway. Dev. Biol. 172:1995;479-494.
7. Bang A. G., Posakony J. W. The Drosophila gene Hairless encodes a novel basic protein that controls alternative cell fates in adult sensor organ development. Genes Dev. 6:1992;1752-1769.
8. Berry L. W., Westlund B., Schedl B. Germ-line tumor formation caused by activation of glp-1, a Caenorhabdtis elegans member of the Notch family of receptors. Development. 124:1997;925-936.
9. Bettenhausen B., de Angelis M. H., Simon D., Guenet J. L., Gossler A. Transient and restricted expression during mouse embryogenesis of Dl11, a murine gene closely related to Drosophila Delta. Development. 121:1995;2407-2418.
10. Brou C., Logeat F., Lecourtois M., Vandekerckhove J., Kourilsky P., Schweisguth F., Israel A. Inhibition of the DNA-binding activity of Drosophila suppressor of hairless and of its human homolog, KBF2/RBP-J kappa, by direct protein-protein interaction with Drosophila hairless. Genes Dev. 8:1994;2491-2503.
11. Busseau I., Diederich R. J., Xu T., Artavanis-Tsakonas S. A member of the Notch group of interacting loci, deltex encodes a cytoplasmic basic protein. Genetics. 136:1994;585-596.
12. Campos-Ortega J. A. Numb diverts notch pathway off the tramtrack. Neuron. 17:1996;1-4.
13. Chitnis A., Henrique D., Lewis J., Ish-Horowicz D., Kintner C. Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta. Nature. 375:1995;761-766.
14. Chitnis A., Kintner C. Sensitivity of proneural genes to lateral inhibition affects the pattern of primary neurons in Xenopus embryos. Development. 122:1996;2295-2301.
15. Christensen S., Kodoyianni V., Bosenberg M., Friedman L., Kimble J. lag-1, a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su(H). Development. 122:1996;1373-1383.
16. Coffman C. R., Skoglund P., Harris W. A., Kintner C. R. Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos. Cell. 73:1993;659-671.
17. Couso J. P., Bishop S. A., Martinez Arias A. The wingless signalling pathway and the patterning of the wing margin in Drosophila. Development. 120:1994;621-636.
18. Couso J. P., Knust E., Martinez Arias A. Serrate and wingless cooperate to induce vestigial gene expression and wing formation in Drosophila. Curr. Biol. 5:1995;1437-1448.
19. Crittenden S. L., Troemel E. R., Evans T. C., Kimble J. GLP-1 is localized to the mitotic region of the C. elegans germ line. Development. 120:1994;2901-2911.
20. de la Pompa J. L., Wakeham A., Correia K. M., Samper E., Brown S., Aguilera R. J., Nakano T., Honjo T., Mak T. W., Rossant J., Conlon R. A. Conservation of the Notch signalling pathway in mammalian neurogenesis. Development. 124:1997;1139-1148.
21. Diederich R. J., Matsuno K., Hing H., Artavanis-Tsakonas S. Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway. Development. 120:1994;473-481.
22. Doherty D., Feger G., Younger-Shepherd S., Jan L. Y., Jan Y. N. Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation. Genes Dev. 10:1996;421-434.
23. Dorsky R. I., Chang W. S., Rapaport D. H., Harris W. A. Regulation of neuronal diversity in the Xenopus retina by Delta signalling. Nature. 385:1997;67-70.
24. Dorsky R. I., Rapaport D. H., Harris W. A. Xotch inhibits cell differentiation in the Xenopus retina. Neuron. 14:1995;487-496.
25. Fehon R. G., Johansen K., Rebay I., Artavanis-Tsakonas S. Complex cellular and subcellular regulation of Notch expression during embryonic and imaginal development of Drosophila: Implications for Notch function. J. Cell Biol. 113:1991;657-669.
26. Fehon R. G., Kooh P. J., Rebay I., Regan C. L., Xu T., Muskavitch M. A., Artavanis-Tsakonas S. Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila. Cell. 61:1990;523-534.
27. Fitzgerald K., Greenwald I. Interchangeability of Caenorhabditis elegans DSL proteins and intrinsic signalling activity of their extracellular domains in vivo. Development. 121:1995;4275-4282.
28. Fitzgerald K., Wilkinson H. A., Greenwald I. glp-1 can substitute for lin-12 in specifying cell fate decisions in Caenorhabditis elegans. Development. 119:1993;1019-1027.
29. Fortini M. E., Artavanis-Tsakonas S. The Suppressor of Hairless protein participates in Notch receptor signaling. Cell. 79:1994;273-282.
30. Fortini M. E., Rebay I., Caron L. A., Artavanis-Tsakonas S. An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye. Nature. 365:1993;555-557.
31. Gao D., Kimble J. APX-1 can substitute for its homolog LAG-2 to direct cell interactions throughout Caenorhabditis elegans development. Proc. Natl. Acad. Sci. USA. 92:1995;9839-9842.
32. Gho M., Lecourtois M., Geraud G., Posakony J. W., Schweisguth F. Subcellular localization of Suppressor of Hairless in Drosophila sense organ cells during Notch signalling. Development. 122:1996;1673-1682.
33. Gonzalez-Gaitan M., Jackle H. Invagination centers within the Drosophila stomatogastric nervous system anlage are positioned by Notch-mediated signaling which is spatially controlled through wingless. Development. 121:1995;2313-2325.
34. Grant B., Greenwald I. The Caenorhabditis elegans sel-1 gene, a negative regulator of lin-12 and glp-1, encodes a predicted extracellular protein. Genetics. 143:1996;237-247.
35. Grant B., Greenwald I. Structure, function, and expression of SEL-1, a negative regulator of LIN-12 and GLP-1 in C. elegans. Development. 124:1997;637-644.
36. Greenwald I. Structure/function studies of lin-12/Notch proteins. Curr. Opin. Genet. Dev. 4:1994;556-562.
37. Greenwald I., Rubin G. M. Making a difference: The role of cell-cell interactions in establishing separate identities for equivalent cells. Cell. 68:1992;271-281.
38. Greenwald I., Seydoux G. Analysis of gain-of-function mutations of the lin-12 gene of Caenorhabditis elegans. Nature. 346:1990;197-199.
39. Gridley T. Notch signaling in vertebrate development and disease. Mol. Cell. Neurosci. 9:1997;103-108.
40. Gu Y., Hukriede N. A., Fleming R. J. Serrate expression can functionally replace Delta activity during neuroblast segregation in the Drosophila embryo. Development. 121:1995;855-865.
41. Guo M., Bier E., Jan L. Y., Jan Y. N. tramtrack acts downstream of numb to specify distinct daughter cell fates during asymmetric cell divisions in the Drosophila PNS. Neuron. 14:1995;913-925.
42. Guo M., Jan L. Y., Jan Y. N. Control of daughter cell fates during asymmetric division: Interaction of Numb and Notch. Neuron. 17:1996;27-41.
43. Haenlin M., Kramatschek B., Campos-Ortega J. A. The pattern of transcription of the neurogenic gene Delta of Drosophila melanogaster. Development. 110:1990;905-914.
44. Haenlin M., Kunisch M., Kramatschek B., Campos-Ortega J. A. Genomic regions regulating early embryonic expression of the Drosophila neurogenic gene Delta. Mech. Dev. 47:1994;99-110.
45. Hartley D. A., Xu T. A., Artavanis-Tsakonas S. The embryonic expression of the Notch locus of Drosophila melanogaster and the implications of point mutations in the extracellular EGF-like domain of the predicted protein. EMBO J. 6:1987;3407-3417.
46. Heitzler P., Bourouis M., Ruel L., Carteret C., Simpson P. Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila. Development. 122:1996;161-171.
47. Heitzler P., Simpson P. The choice of cell fate in Drosophila neuroepithelium. Cell. 64:1991;1083-1092.
48. Heitzler P., Simpson P. Altered epidermal growth factor-like sequences provide evidence for a role of Notch as a receptor in cell fate decisions. Development. 117:1993;1113-1123.
49. Henderson S. T., Gao D., Lambie E. J., Kimble J. lag-2 may encode a signaling ligand for the GLP-1 and LIN-12 receptors of C. elegans. Development. 120:1994;2913-2924.
50. Henrique D., Adam J., Myat A., Chitnis A., Lewis J., Ish-Horowicz D. Expression of a Delta homologue in prospective neurons in the chick. Nature. 375:1995;787-790.
51. Hill R. J., Sternberg P. W. Cell fate patterning during C. elegans vulval development. Development. Suppl:1993;9-18.
52. Honjo T. The shortest path from the surface to the nucleus: RBP-Jκ/Su(H) transcription factor. Genes Cells. 1:1996;1-9.
53. Hsieh J. J., Hayward S. D. Masking of the CBF1/RBPJ kappa transcriptional repression domain by Epstein-Barr virus EBNA2. Science. 268:1995;560-563.
54. Hsieh J. J., Henkel T., Salmon P., Robey E., Peterson M. G., Hayward S. D. Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2. Mol. Cell. Biol. 16:1996;952-959.
55. Hsieh J. J.-D., Nofziger D., Weinmaster G., Hayward S. D. Epstein-Barr virus immortalization: Notch2 interacts with CBF1 and blocks differentiation. J. Virol. 71:1997;1616-1625.
56. Hubbard E. J., Dong Q., Greenwald I. Evidence for physical and functional association between EMB-5 and LIN-12 in Caenorhabditis elegans. Science. 273:1996;112-115.
57. Jan Y. N., Jan L. Y. Maggot's hair and bug's eye: Role of cell interactions and intrinsic factors in cell fate specification. Neuron. 14:1995;1-5.
58. Jarriault S., Brou C., Logeat F., Schroeter E. H., Kopan R., Israel A. Signalling downstream of activated mammalian Notch. Nature. 377:1995;355-358.
59. Jen W.-C., Wettstein D., Turner D., Chitnis A., Kintner C. The Notch ligand, X-Delta-2, mediates segmentation of the paraxial mesoderm in Xenopus embryos. Development. 124:1997;1169-1178.
60. Jennings B., deCelis J., Delidakis C., Priess A., Bray S. Role of Notch and achaete-scute complex in the expression of Enhancer of split bHLH proteins. Development. 121:1995;3745-3752.
61. Jennings B., Preiss A., Delidakis C., Bray S. The Notch signalling pathway is required for Enhancer of split bHLH protein expression during neurogenesis in the Drosophila embryo. Development. 120:1994;3537-3548.
62. Johansen K. M., Fehon R. G., Artavanis-Tsakonas S. TheNotch. J. Cell Biol. 109:1989;2427-2440.
63. Jonsson F., Knust E. Distinct functions of the Drosophila genes Serrate and Delta revealed by ectopic expression during wing development. Dev. Genes Evol. 206:1996;91-101.
64. Kelley M. R., Kidd S., Deutsch W. A., Young M. W. Mutations altering the structure of epidermal growth factor-like coding sequences at the Drosophila Notch locus. Cell. 51:1987;539-548.
65. Kenyon C. A perfect vulva every time: Gradient and signaling cascades in C. elegans. Cell. 82:1995;171-174.
66. Kidd S., Baylies M. K., Gasic G. P., Young M. W. Structure and distribution of the Notch protein in developing Drosophila. Genes Dev. 3:1989;1113-1129.
67. Kooh P. J., Fehon R. G., Muskavitch M. A. Implications of dynamic patterns of Delta and Notch expression for cellular interactions during Drosophila development. Development. 117:1993;493-507.
68. Kopan R., Nye J. S., Weintraub H. The intracellular domain of mouse Notch: A constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD. Development. 120:1994;2385-2396.
69. Kopan R., Schroeter E. H., Weintraub H., Nye J. S. Signal transduction by activated mNotch: Importance of proteolytic processing and its regulation by the extracellular domain. Proc. Natl. Acad. Sci. USA. 93:1996;1683-1688.
70. Kopan R., Turner D. L. The Notch pathway: Democracy and aristocracy in the selection of cell fate. Curr. Opin. Neurobiol. 6:1996;594-601.
71. Kunisch M., Haenlin M., Campos-Ortega J. A. Lateral inhibition mediated by the Drosophila neurogenic gene Delta is enhanced by proneural proteins. Proc. Natl. Acad. Sci. USA. 91:1994;10139-10143.
72. Lambie E. J., Kimble J. Two homologous regulatory genes, lin-12 and glp-1, have overlapping functions. Development. 112:1991;231-240.
73. Lardelli M., Williams R., Lendahl U. Notch-related genes in animal development. Int. J. Dev. Biol. 39:1995;769-780.
74. Lardelli M., Williams R., Mitsiadis T., Lendahl U. Expression of the Notch3 intracellular domain in mouse central nervous system progenitor cells is lethal and leads to disturbed neural tube development. Mech. Dev. 59:1996;177-190.
75. Lecourtois M., Schweisguth F. The neurogenic Suppressor of Hairless DNA-binding protein mediates the transcriptional activation of the Enhancer of split complex genes triggered by Notch signaling. Genes Dev. 9:1995;2598-2608.
76. Lee J. E. Basic helix-loop-helix genes in neural development. Curr. Opin. Neurobiol. 7:1997;13-20.
77. Levitan D., Doyle T. G., Brousseau D., Lee M. K., Thinakaran G., Slunt H. H., Sisodia S. S., Greenwald I. Assessment of normal and mutant human presenilin function in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA. 93:1996;14940-14944.
78. Levitan D., Greenwald I. Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature. 377:1995;351-354.
79. Lewis J. Neurogenic genes and vertebrate neurogenesis. Curr. Opin. Neurobiol. 6:1996;3-10.
80. Lieber T., Kidd S., Alcamo E., Corbin V., Young M. W. Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei. Genes Dev. 7:1993;1949-1965.
81. Lindsell C. E., Boutler J., diSibio G., Gossler A., Weinmaster G. Expression patterns of Jagged, Delta1, Notch1, Notch2, and Notch3 genes identify ligand-receptor pairs that may function in neural development. Mol. Cell. Neurosci. 8:1996;14-27.
82. Lindsell C. E., Shawber C. J., Boulter J., Weinmaster G. Jagged: A mammalian ligand that activates Notch1. Cell. 80:1995;909-917.
83. Lyman D., Young M. W. Further evidence for function of the Drosophila Notch protein as a transmembrane receptor. Proc. Natl. Acad. Sci. USA. 90:1993;10395-10399.
84. Ma Q., Kintner C., Anderson D. J. Identification of neurogenin, a vertebrate neuronal determination gene. Cell. 87:1996;43-52.
85. Mango S. E., Maine E. M., Kimble J. Carboxy-terminal truncation activates glp-1 protein to specify vulval fates in Caenorhabditis elegans. Nature. 352:1991;811-815.
86. Markopoulou K., Artavanis-Tsakonas S. The expression of the neurogenic locusNOTCHDrosophila melanogaster. J. Neurogenet. 6:1989;11-26.
87. Marx J. Dissecting how presenilins function - and malfunction. Science. 274:1996;1838-1840.
88. Matsuno K., Diederich R. J., Go M. J., Blaumueller C. M., Artavanis-Tsakonas S. Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats. Development. 121:1995;2633-2644.
89. Mello C. C., Draper B. W., Priess J. R. The maternal genes apx-1 and glp-1 and establishment of dorsal-ventral polarity in the early C. elegans embryo. Cell. 77:1994;95-106.
90. Milner L. A., Bigas A., Kopan R., Brashem-Stein C., Bernstein I. D., Martin D. I. Inhibition of granulocytic differentiation by mNotch1. Proc. Natl. Acad. Sci. USA. 93:1996;13014-13019.
91. Mitsiadis T. A., Henrique D., Thesleff I., Lendahl U. Mouse Serrate-1 (Jagged-1): Expression in the developing tooth is regulated by epithelial-mesenchymal interactions and fibroblast growth factor-4. Development. 124:1997;1473-1483.
92. Muskavitch M. A. Delta-Notch signaling andDrosophila. Dev. Biol. 166:1994;415-430.
93. Myat A., Henrique D., Ish-Horowicz D., Lewis J. A chick homologue of Serrate and its relationship with Notch and Delta homologues during central neurogenesis. Dev. Biol. 174:1996;233-247.
94. Nye J. S., Kopan R., Axel R. An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells. Development. 120:1994;2421-2430.
95. Paroush Z., Finley R. L., Kidd T., Wainwright M., Ingham P. W., Brent R., Ish-Horowicz D. Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins. Cell. 79:1994;805-815.
96. Pawson T. Protein modules and signaling networks. Nature. 373:1995;573-580.
97. Posakony J. W. Nature versus nurture: Asymmetric cell divisions in Drosophila bristle development. Cell. 76:1994;415-418.
98. Rebay I., Fehon R. G., Artavanis-Tsakonas S. Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor. Cell. 74:1993;319-329.
99. Rebay I., Fleming R. J., Fehon R. G., Cherbas L., Cherbas P., Artavanis-Tsakonas S. Specific EGF repeats of Notch mediate interactions with Delta and Serrate: Implications for Notch as a multifunctional receptor. Cell. 67:1991;687-699.
100. Robey E., Chang D., Itano A., Cado D., Alexander H., Lans D., Weinmaster G., Salmon P. An activated form of Notch influences the choice between CD4 and CD8 T cell lineages. Cell. 87:1996;483-492.
101. Roehl H., Bosenberg M., Blelloch R., Kimble J. Roles of the RAM and ANK domains in signaling by the C. elegans GLP-1 receptor. EMBO J. 15:1996;7002-7012.
102. Roehl H., Kimble J. Control of cell fate in C. elegans by a GLP-1 peptide consisting primarily of ankyrin repeats. Nature. 364:1993;632-635.
103. Rogers S., Wells R., Rechsteiner M. Amino acid sequences common to rapidly degraded proteins: The PEST hypothesis. Science. 234:1986;364-368.
104. Sakai T., Furukawa T., Iwanari H., Oka C., Nakano T., Kawaichi M., Honjo T. Loss of immunostaining of the RBP-J kappa transcription factor upon F9 cell differentiation induced by retinoic acid. J. Biochem. (Tokyo). 118:1995;621-628.
105. Shawber C., Boulter J., Lindsell C. E., Weinmaster G. Jagged2: A Serrate-like gene expressed during rat embryogenesis. Dev. Biol. 180:1996;370-376.
106. Shawber C., Nofziger D., Hsieh J. J.-D., Lindsell C., Bogler O., Hayward D., Weinmaster G. Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway. Development. 122:1996;3765-3773.
107. Speicher S. A., Thomas U., Hinz U., Knust E. The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginal discs: Control of cell proliferation. Development. 120:1994;535-544.
108. Struhl G., Fitzgerald K., Greenwald I. Intrinsic activity of the lin-12 and Notch intracellular domains in vivo. Cell. 74:1993;331-345.
109. Sun X., Artavanis-Tsakonas S. The intracellular deletions of Delta and Serrate define dominant negative forms of the Drosophila Notch ligands. Development. 122:1996;2465-2474.
110. Tamura K., Taniguchi Y., Minoguchi S., Sakai T., Tun T., Furukawa T., Honjo T. Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H). Curr. Biol. 5:1995;1416-1423.
111. Tax F. E., Yeargers J. J., Thomas J. H. Sequence of C. elegans lag-2 reveals a cell-signalling domain shared with Delta and Serrate of Drosophila. Nature. 368:1994;150-154.
112. Uyttendaele H., Marazzi G., Wu G., Yan Q., Sassoon D., Kitajewski J. Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene. Development. 122:1996;2251-2259.
113. Vassin H., Vielmetter J., Campos-Ortega J. A. Genetic interactions in early neurogenesis of Drosophila melanogaster. J. Neurogenet. 2:1985;291-308.
114. Washburn T., Schweighoffer E., Gridley T., Chang D., Fowlkes B., Cado D., Salmon P., Robey E. Notch activity influences the αβ vs. γδ T cell lineage decision. Cell. 88:1997;833-843.
115. Wettstein D. A., Turner D. L., Kintner C. The Xenopus homolog of Drosophila Suppressor of Hairless mediates Notch signaling during primary neurogenesis. Development. 124:1997;693-702.
116. Wilkinson H. A., Fitzgerald K., Greenwald I. Reciprocal changes in expression of the receptor lin-12 and its ligand lag-2 prior to commitment in a C. elegans cell fate decision. Cell. 79:1994;1187-1198.
117. Xu T., Artavanis-Tsakonas S. deltex, a locus interacting with the neurogenic genes, Notch, Delta and mastermind in Drosophila melanogaster. Genetics. 126:1990;665-677.
118. Xu T., Rebay I., Fleming R. J., Scottgale T. N., Artavanis-Tsakonas S. The Notch locus and the genetic circuitry involved in early Drosophila neurogenesis. Genes Dev. 4:1990;464-475.
119. Zagouras P., Stifani S., Blaumueller C. M., Carcangiu M. L., Artavanis-Tsakonas S. Alterations in Notch signaling in neoplastic lesions of the human cervix. Proc. Natl. Acad. Sci. USA. 92:1995;6414-6418.
120. Zhong W., Feder J. N., Jiang M. M., Jan L. Y., Jan Y. N. Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis. Neuron. 17:1996;43-53.
121. Zimber-Strobl U., Strobl L. J., Meitinger C., Hinrichs R., Sakai T., Furukawa T., Honjo T., Bornkamm G. W. Epstein-Barr virus nuclear antigen 2 exerts its transactivating function through interaction with recombination signal binding protein RBP-J kappa, the homologue of Drosophila Suppressor of Hairless. EMBO J. 13:1994;4973-4982.