Notch signaling in T cell development

Current Opinion in Immunology

Volumn 12, Issue 2, 2000, Pages 166-172

  Deftos, Michael L ^a   Bevan, Michael J ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; NOTCH RECEPTOR; TRANSCRIPTION FACTOR;

CELL LINEAGE; LYMPHOCYTE DIFFERENTIATION; LYMPHOPOIESIS; ONCOGENE; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

EID: 0034011914     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(99)00067-9     Document Type: Review

References (47)

1. von Boehmer H., Aifantis I., Feinberg J., Lechner O., Saint-Ruf C., Walter U., Buer J., Azogui O. Pleiotropic changes controlled by the pre-T-cell receptor. Curr Opin Immunol. 11:1999;135-142.
2. Jameson S., Bevan M. T-cell selection. Curr Opin Immunol. 10:1998;214-219.
3. Artavanis-Tsakonas S., Rand M.D., Lake R.J. Notch signaling: cell fate control and signal integration in development. Science. 284:1999;770-776.
4. Ellisen L.W., Bird J., West D.C., Soreng L.A., Reynolds T.C., Smith S.D., Sklar J. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell. 66:1991;649-661.
5. Weinmaster G., Roberts V.J., Lemke G. A homolog of Drosophila Notch expressed during mammalian development. Development. 113:1991;199-205.
6. Weinmaster G., Roberts V.J., Lemke G. Notch2: a second mammalian Notch gene. Development. 116:1992;931-941.
7. del Amo F.F., Gendron-Maguire M., Swiatek P.J., Jenkins N.A., Copeland N.G., Gridley T. Cloning, analysis, and chromosomal localization of Notch-1, a mouse homolog of Drosophila Notch. Genomics. 15:1993;259-264.
8. Lardelli M., Lendahl U. Motch A and Motch B - two mouse Notch homologues coexpressed in a wide variety of tissues. Exp Cell Res. 204:1993;364-372.
9. Lardelli M., Dahlstrand J., Lendahl U. The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium. Mech Dev. 46:1994;123-136.
10. Uyttendaele H., Marazzi G., Wu G., Yan Q., Sassoon D., Kitajewski J. Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene. Development. 122:1996;2251-2259.
11. Gallahan D., Callahan R. The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4). Oncogene. 14:1997;1883-1890.
12. Lindsell C.E., Shawber C.J., Boulter J., Weinmaster G. Jagged: a mammalian ligand that activates Notch1. Cell. 80:1995;909-917.
13. Bettenhausen B., Hrabe de Angelis M., Simon D., Guenet J.L., Gossler A. Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta. Development. 121:1995;2407-2418.
14. Shawber C., Boulter J., Lindsell C.E., Weinmaster G. Jagged2: a serrate-like gene expressed during rat embryogenesis. Dev Biol. 180:1996;370-376.
15. Luo B., Aster J.C., Hasserjian R.P., Kuo F., Sklar J. Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor. Mol Cell Biol. 17:1997;6057-6067.
16. Dunwoodie S.L., Henrique D., Harrison S.M., Beddington R.S. Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo. Development. 124:1997;3065-3076.
17. Li L., Milner L.A., Deng Y., Iwata M., Banta A., Graf L., Marcovina S., Friedman C., Trask B.J., Hood L., Torok-Storb B. The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1. Immunity. 8:1998;43-55.
18. Kopan R., Schroeter E.H., Weintraub H., Nye J.S. Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain. Proc Natl Acad Sci USA. 93:1996;1683-1688.
19. Schroeter E.H., Kisslinger J.A., Kopan R. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature. 393:1998;382-386.
20. Chan Y.M., Jan Y.N. Roles for proteolysis and trafficking in notch maturation and signal transduction. Cell. 94:1998;423-426.
21. Hsieh J.J., Henkel T., Salmon P., Robey E., Peterson M.G., Hayward S.D. Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2. Mol Cell Biol. 16:1996;952-959.
22. Struhl G., Adachi A. Nuclear access and action of notch in vivo. Cell. 93:1998;649-660.
23. Lecourtois M., Schweisguth F. Indirect evidence for Delta-dependent intracellular processing of notch in Drosophila embryos. Curr Biol. 8:1998;771-774.
24. Kao H.Y., Ordentlich P., Koyano N.N., Tang Z., Downes M., Kintner C.R., Evans R.M., Kadesch T. A histone deacetylase corepressor complex regulates the Notch signal transduction pathway. Genes Dev. 12:1998;2269-2277.
25. Kimble J., Simpson P. The LIN-12/Notch signaling pathway and its regulation. Annu Rev Cell Dev Biol. 13:1997;333-361.
26. Aster J., Pear W., Hasserjian R., Erba H., Davi F., Luo B., Scott M., Baltimore D., Sklar J. Functional analysis of the TAN-1 gene, a human homolog of Drosophila notch. Cold Spring Harb Symp Quant Biol. 59:1994;125-136.
27. Pear W.S., Aster J.C., Scott M.L., Hasserjian R.P., Soffer B., Sklar J., Baltimore D. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles. J Exp Med. 183:1996;2283-2291.
28. Hasserjian R.P., Aster J.C., Davi F., Weinberg D.S., Sklar J. Modulated expression of Notch1 during thymocyte development. Blood. 88:1996;970-976.
29. Robey E. Regulation of T cell fate by Notch. Annu Rev Immunol. 17:1999;283-295.
30. Kondo M., Weissman I.L., Akashi K. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell. 91:1997;661-672.
31. - stage. The majority of these cells in the thymus phenotypically resembled immature bone marrow B cells. There was no effect on the development of other hematopoietic lineages.
32. Pui J.C., Allman D., Xu L., DeRocco S., Karnell F.G., Bakkour S., Lee J.Y., Kadesch T., Hardy R.R., Aster J.C., Pear W.S. Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity. 11:1999;299-308. Bone marrow stem cells were infected with retroviruses expressing a GFP (green fluorescent protein) reporter and constitutively active Notch-1, and their contribution to different hematopoietic cell lineages was determined by FACS (fluorescence-activated cell sorter) analysis. Constitutively active Notch-1 had no effect on differentiation into granulocytes or macrophages whereas differentiation into the B cell lineage was almost completely blocked. A thymus-independent population of T cells developed in the bone marrow as early as 22 days following reconstitution. These cells expressed variable levels of CD4, CD8 and CD3, and some had undergone TCRβ rearrangement. The mice eventually developed T cell leukemia.
33. - stage. There is no effect on the development of B cells, myeloid cells or erythrocytes in the fetal liver.
34. Washburn T., Schweighoffer E., Gridley T., Chang D., Fowlkes B.J., Cado D., Robey E. Notch activity influences the alpha beta versus gamma delta T cell lineage decision. Cell. 88:1997;833-843.
35. Jiang R., Lan Y., Chapman H.D., Shawber C., Norton C.R., Serreze D.V., Weinmaster G., Gridley F. Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice. Genes Dev. 12:1998;1046-1057. Analysis of mice deficient in Jagged-2. Examination of αβ and γδ T cells in the fetal thymus (embryonic day 18) revealed that there is a 50% reduction in the number of γδ T cells but normal numbers of αβ T cells.
36. Robey E., Chang D., Itano A., Cado D., Alexander H., Lans D., Weinmaster G., Salmon P. An activated form of Notch influences the choice between CD4 and CD8 T cell lineages. Cell. 87:1996;483-492.
37. - T cell clones. Constitutively active Notch-1 also inhibits CD4 expression in T cell clones although in this case the effect is not dependent upon the CD4 silencer.
38. Sawada S., Scarborough J.D., Killeen N., Littman D.R. A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development. Cell. 77:1994;917-929.
39. Siu G., Wurster A.L., Duncan D.D., Soliman T.M., Hedrick S.M. A transcriptional silencer controls the developmental expression of the CD4 gene. EMBO J. 13:1994;3570-3579.
40. + SP thymocytes.
41. Matsuno K., Diederich R.J., Go M.J., Blaumueller C.M., Artavanis-Tsakonas S. Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats. Development. 121:1995;2633-2644.
42. Sentman C.L., Shutter J.R., Hockenbery D., Kanagawa O., Korsmeyer S.J. Bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell. 67:1991;879-888.
43. Linette G.P., Grusby M.J., Hedrick S.M., Hansen T.H., Glimcher L.H., Korsmeyer S.J. Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points. Immunity. 1:1994;197-205.
44. Itano A., Salmon P., Kioussis D., Tolaini M., Corbella P., Robey E. The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells. J Exp Med. 183:1996;731-741.
45. Matechak E.O., Killeen N., Hedrick S.M., Fowlkes B.J. MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent. Immunity. 4:1996;337-347.
46. Blaumueller C.M., Qi H., Zagouras P., Artavanis-Tsakonas S. Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane. Cell. 90:1997;281-291.
47. Logeat F., Bessia C., Brou C., LeBail O., Jarriault S., Seidah N.G., Israel A. The Notch1 receptor is cleaved constitutively by a furin-like convertase. Proc Natl Acad Sci USA. 95:1998;8108-8112.