Structure and function of phosphoinositide 3-kinases

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1436, Issue 1-2, 1998, Pages 127-150

  Wymann, Matthias P ^a   Pirola, Luciano ^a  

^a UNIVERSITY OF FRIBOURG   (Switzerland)

Author keywords

Phosphoinositide; Phosphoinositide 3 kinase; Protein phosphorylation; Ras; SH2 domain; SH3 domain; Signal transduction; Structure function relationship

Indexed keywords

CELL SURFACE RECEPTOR; DIACYLGLYCEROL; GUANOSINE TRIPHOSPHATASE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C; PROTEIN KINASE C; PROTEIN SERINE KINASE; PROTEIN TYROSINE KINASE; RECEPTOR PROTEIN; ISOENZYME; PROTEIN KINASE; HRAS PROTEIN, HUMAN; PHOSPHATIDYLINOSITOL 3,4 BISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5-TRIPHOSPHATE; PHOSPHATIDYLINOSITOL 3,4-DIPHOSPHATE; POLYPHOSPHOINOSITIDE; PROTEIN P21;

ENZYME ACTIVITY; ENZYME STRUCTURE; FLY; HUMAN; MITOGENESIS; MOULD; NEMATODE; NONHUMAN; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; REVIEW; SECOND MESSENGER; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; TRANSGENIC ANIMAL; CELL SURVIVAL; ENZYME ACTIVATION; ENZYME METABOLISM; KNOCKOUT MOUSE; ANIMAL; CHEMISTRY; GENETICS; METABOLISM;

CAENORHABDITIS ELEGANS; DROSOPHILA MELANOGASTER; HEXAPODA; MAMMALIA; MELANOGASTER; MYXOGASTRIA; NEMATODA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ENZYME ACTIVATION; HUMANS; PHOSPHATIDYLINOSITOL PHOSPHATES; PROTO-ONCOGENE PROTEINS P21(RAS); SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032497832     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0005-2760(98)00139-8     Document Type: Review

References (311)

1. [1] M.J. Berridge, R.F. Irvine, Nature 312 (1984) 315-321.
2. [2] Y. Nishizuka, Science 258 (1992) 607-614.
3. [3] N. Divecha, R.F. Irvine, Cell 80 (1995) 269-278.
4. [4] M.D. Bootman, M.J. Berridge, Cell 83 (1995) 675-678.
5. [5] M. Whitman, D.R. Kaplan, B. Schaffihausen, L. Cantley, T.M. Roberts, Nature 315 (1985) 239-242.
6. [6] Y. Sugimoto, M. Whitman, L.C. Cantley, R.L. Erikson, Proc. Natl. Acad. Sci. U.S.A. 81 (1984) 2117-2121.
7. [7] I.G. Macara, G.V. Marinetti, P.C. Balduzzi, Proc. Natl. Acad. Sci. U.S.A. 81 (1984) 2728-2732.
8. [8] D.R. Kaplan, M. Whitman, B. Schafmausen, D.C. Pallas, M. White, L. Cantley, T.M. Roberts, Cell 50 (1987) 1021-1029.
9. [9] A.E. Traynor-Kaplan, A.L. Harris, B.L. Thompson, P. Taylor, L.A. Sklar, Nature 334 (1988) 353-356.
10. [10] M. Whitman, C.P. Downes, M. Keeler, T. Keller, L. Cantley, Nature 332 (1988) 644-646.
11. [11] L.C. Cantley, K.R. Auger, C. Carpenter, B. Duckworth, A. Graziani, R. Kapeller, S. Soltoff, Cell 64 (1991) 281-302.
12. [12] K.R. Auger, L.A. Serunian, S.P. Soltoff, P. Libby, L.C. Cantley, Cell 57 (1989) 167-175.
13. [13] Y. Fukui, H. Hanafusa, Mol. Cell. Biol. 9 (1989) 1651-1658.
14. [14] T.O. Chan, A. Tanaka, J.D. Bjorge, D.J. Fujita, Mol. Cell. Biol. 10 (1990) 3280-3283.
15. [15] K.R. Auger, L.C. Cantley, Cancer Cells 3 (1991) 263-270.
16. [16] J.A. Escobedo, S. Navankasattusas, W.M. Kavanaugh, D. Milfay, V.A. Fried, L.T. Williams, Cell 65 (1991) 75-82.
17. [17] E.Y. Skolnik, B. Margolis, M. Mohammadi, E. Lowenstein, R. Fischer, A. Drepps, A. Ullrich, J. Schlessinger, Cell 65 (1991) 83-90.
18. [18] M. Otsu, I. Hues, I. Gout, M.J. Fry, F. Ruiz-Larrea, G. Panayotou, A. Thompson, R. Dhand, J. Hsuan, N. Totty et al., Cell 65 (1991) 91-104.
19. [19] I.D. Hues, M. Otsu, S. Volinia, M.J. Fry, I. Gout, R. Dhand, G. Panayotou, F. Ruiz-Larrea, A. Thompson, N.F. Totty et al., Cell 70 (1992) 419-429.
20. [20] P. Hu, A. Mondino, E.Y. Skolnik, J. Schlessinger, Mol. Cell. Biol. 13 (1993) 7677-7688.
21. [21] P.K. Herman, S.D. Emr, Mol. Cell. Biol. 10 (1990) 6742-6754.
22. [22] P.V. Schu, K. Takegawa, M.J. Fry, J.H. Stack, M.D. Waterfield, S.D. Emr, Science 260 (1993) 88-91.
23. [23] M.J. Zvelebil, L. MacDougall, S. Leevers, S. Volinia, B. Vanhaesebroeck, I. Gout, G. Panayotou, J. Domin, R. Stein, F. Pages et al., Phil. Trans. R. Soc. Lond. B 351 (1996) 217-223
24. [24] J. Domin, M.D. Waterfield, FEBS Lett. 410 (1997) 91-95.
25. [25] B. Vanhaesebroeck, S.J. Leevers, G. Panayotou, M.D. Waterfield, Trends Biochem. Sci. 22 (1997) 267-272.
26. [26] A. Toker, L.C. Cantley, Nature 387 (1997) 673-676.
27. [27] K. Hinchliffe, R. Irvine, Nature 390 (1997) 123-124.
28. [28] L.R. Stephens, K.T. Hughes, R.F. Irvine, Nature 351 (1991) 33-39.
29. [29] P.T. Hawkins, T.R. Jackson, L.R. Stephens, Nature 358 (1992) 157-159.
30. [30] P. De Camilli, S.D. Emr, P.S. McPherson, P. Novick, Science 271 (1996) 1533-1539.
31. [31] T. Hunter, Cell 83 (1995) 1-4.
32. [32] J. Kunz, R. Henriquez, U. Schneider, R.M. Deuter, N.R. Movva, M.N. Hall, Cell 73 (1993) 585-596.
33. [33] E.J. Brown, P.A. Seal, C.T. Keith, J. Chen, T.B. Shin, S.L. Schreiber, Nature 377 (1995) 441-445.
34. [34] D.M. Sabatini, H. Erdjument-Bromage, M. Lui, P. Tempst, S.H. Snyder, Cell 78 (1994) 35-43.
35. [35] K. Savitsky, A. Bar-Shira, S. Gilad, G. Rotman, Y. Ziv, L. Vanagaite, D.A. Tagle, S. Smith, T. Uziel, S. Sfez et al., Science 268 (1995) 1749-1753.
36. [36] M.F. Lavin, K.K. Khanna, H. Beamish, K. Spring, D. Watters, Y. Shiloh, Trends Biochem. Sci. 20 (1995) 382-383.
37. [37] N.J. Bentley, D.A. Holtzman, G. Flaggs, K.S. Keegan, A. DeMaggio, J.C. Ford, M. Hoekstra, A.M. Carr, EMBO J. 15 (1996) 6641-6651.
38. [38] K.O. Hartley, D. Gell, G.C. Smith, H. Zhang, N. Divecha, M.A. Connelly, A. Admon, S.P. Lees-Miller, C.W. Anderson, S.P. Jackson, Cell 82 (1995) 849-856.
39. [39] C.H. Westphal, Curr. Biol. 7 (1997) R789-92.
40. [40] W.A. Cliby, C.J. Roberts, K.A. Cimprich, C.M. Stringer, J.R. Lamb, S.L. Schreiber, S.H. Friend, EMBO J. 17 (1998) 159-169.
41. [41] J.A. Wright, K.S. Keegan, D.R. Herendeen, N.J. Bentley, A.M. Carr, M.F. Hoekstra, P. Concannon, Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 7445-7450.
42. [42] G.W. Booker, I. Gout, A.K. Downing, P.C. Driscoll, J. Boyd, M.D. Waterfield, I.D. Campbell, Cell 73 (1993) 813-822.
43. [43] S. Koyama, H. Yu, D.C. Dalgarno, T.B. Shin, L.D. Zydowsky, S.L. Schreiber, Cell 72 (1993) 945-952.
44. [44] J. Liang, J.K. Chen, S.T. Schreiber, J. Clardy, J. Mol. Biol. 257 (1996) 632-643.
45. [45] G.B. Cohen, R. Ren, D. Baltimore, Cell 80 (1995) 237-248.
46. [46] H. Yu, J.K. Chen, S. Feng, D.C. Dalgarno, A.W. Brauer, S.L. Schreiber, Cell 76 (1994) 933-945.
47. [47] R. Kapeller, K.V. Prasad, O. Janssen, W. Hou, B.S. Schaffhausen, C.E. Rudd, L.C. Cantley, J. Biol. Chem. 269 (1994) 1927-1933.
48. [48] D. Harrison-Findik, M. Susa, L. Varticovski, Oncogene 10 (1995) 1385-1391.
49. [49] S.P. Soltoff, L.C. Cantley, J. Biol. Chem. 271 (1996) 563-567.
50. [50] P.M. Dombrosky-Ferlan, S.J. Corey, Oncogene 14 (1997) 2019-2024.
51. [51] S. Hunter, B.L. Koch, S.M. Anderson, Mol. Endocrinol. 11 (1997) 1213-1222.
52. [52] X. Liu, L.E. Marengere, C.A. Koch, T. Pawson, Mol. Cell. Biol. 13 (1993) 5225-5232.
53. [53] K.V. Prasad, O. Janssen, R. Kapeller, M. Raab, L.C. Cantley, C.E. Rudd, Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 7366-7370.
54. [54] C.M. Pleiman, W.M. Hertz, J.C. Cambier, Science 263 (1994) 1609-1612.
55. [55] J. Wang, K.R. Auger, L. Jarvis, Y. Shi, T.M. Roberts, J. Biol. Chem. 270 (1995) 12774-12780.
56. [56] P. Mak, Z. He, T. Kurosaki, FEBS Lett. 397 (1996) 183-185.
57. [57] G.W. Booker, A.L. Breeze, A.K. Downing, G. Panayotou, I. Gout, M.D. Waterfield, I.D. Campbell, Nature 358 (1992) 684-687.
58. [58] R.T. Nolte, M.J. Eck, J. Schlessinger, S.E. Shoelson, S.C. Harrison, Nat. Struct. Biol. 3 (1996) 364-374.
59. [59] G. Siegal, B. Davis, S.M. Kristensen, A. Sankar, J. Linacre, R.C. Stein, G. Panayotou, M.D. Waterfield, P.C. Driscoll, J. Mol. Biol. 276 (1998) 461-478.
60. [60] R.B. Russell, J. Breed, G.J. Barton, FEBS Lett. 304 (1992) 15-20.
61. [61] A.L. Breeze, B.V. Kara, D.G. Barratt, M. Anderson, J.C. Smith, R.W. Luke, J.R. Best, S.A. Cartlidge, EMBO J. 15 (1996) 3579-3589.
62. [62] S. Zhou, L.C. Cantley, Trends Biochem. Sci. 20 (1995) 470-475.
63. [63] C. Ponzetto, A. Bardelli, F. Maina, P. Longati, G. Panayotou, R. Dhand, M.D. Waterfield, P.M. Comoglio, Mol. Cell. Biol. 13 (1993) 4600-4608.
64. [64] T.C. He, H. Zhuang, N. Jiang, M.D. Waterfield, D.M. Wojchowski, Blood 82 (1993) 3530-3538.
65. [65] H. Shigematsu, H. Iwasaki, T. Otsuka, Y. Ohno, F. Arima, Y. Niho, J. Biol. Chem. 272 (1997) 14334-14340.
66. [66] D. Diekmann, S. Brill, M.D. Garrett, N. Totty, J. Hsuan, C. Monfries, C. Hall, L. Lim, A. Hall, Nature 351 (1991) 400-402.
67. [67] Y. Zheng, S. Bagrodia, R.A. Cerione, J. Biol. Chem. 269 (1994) 18727-18730.
68. [68] K.F. Tolias, L.C. Cantley, C.L. Carpenter, J. Biol. Chem. 270 (1995) 17656-17659.
69. [69] A. Musacchio, L.C. Cantley, S.C. Harrison, Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 14373-14378.
70. [70] S. Ahmed, J. Lee, L.P. Wen, Z. Zhao, J. Ho, A. Best, R. Kozma, L. Lim, J. Biol. Chem. 269 (1994) 17642-17648.
71. [71] A. Klippel, J.A. Escobedo, Q. Hu, L.T. Williams, Mol. Cell. Biol. 13 (1993) 5560-5566.
72. [72] R. Dhand, K. Hara, I. Miles, B. Bax, I. Gout, G. Panayotou, M.J. Fry, K. Yonezawa, M. Kasuga, M.D. Waterfield, EMBO J. 13 (1994) 511-521.
73. [73] K.H. Holt, L. Olson, W.S. Moye-Rowley, J.E. Pessin, Mol. Cell. Biol. 14 (1994) 42-49.
74. [74] A. Klippel, J.A. Escobedo, M. Hirano, L.T. Williams, Mol. Cell. Biol. 14 (1994) 2675-2685.
75. [75] G. Panayotou, B. Bax, I. Gout, M. Federwisch, B. Wroblowski, R. Dhand, M.J. Fry, T.L. Blundell, A. Wollmer, M.D. Waterfield, EMBO J. 11 (1992) 4261-4272.
76. [76] S. Pons, T. Asano, E. Glasheen, M. Miralpeix, Y. Zhang, T.L. Fisher, M.G.J. Myers, X.J. Sun, M.F. White, Mol. Cell. Biol. 15 (1995) 4453-4465.
77. [77] B.R. Dey, R.W. Furlanetto, S.P. Nissley, Gene 209 (1998) 175-183.
78. [78] K. Inukai, M. Anai, E. Van Breda, T. Hosaka, H. Katagiri, M. Funaki, Y. Fukushima, T. Ogihara, Y. Yazaki, M. Kikuchi, Y. Oka, T. Asano, J. Biol. Chem. 271 (1996) 5317-5320.
79. [79] D.A. Antonetti, P. Algenstaedt, C.R. Kahn, Mol. Cell. Biol. 16 (1996) 2195-2203.
80. [80] D.A. Fruman, L.C. Cantley, C.L. Carpenter, Genomics 37 (1996) 113-121.
81. [81] K. Inukai, M. Funaki, T. Ogihara, H. Katagiri, A. Kanda, M. Anai, Y. Fukushima, T. Hosaka, M. Suzuki, B.C. Shin, K. Takata, Y. Yazaki, M. Kikuchi, Y. Oka, T. Asano, J. Biol. Chem. 272 (1997) 7873-7882.
82. [82] S. Pons, T. Asano, E. Glasheen, M. Miralpeix, A. Weiland, Y. Zhang, T.L. Fisher, M.G. Myers Jr, X.J. Sun, M.F. White, Mol. Cell. Biol. 15 (1996) 4453-4465.
83. [83] K. Baltensperger, L.M. Kozma, S.R. Jaspers, M.P. Czech, J. Biol. Chem. 269 (1994) 28937-28946.
84. [84] C.L. Carpenter, K.R. Auger, B.C. Duckworth, W.M. Hou, B. Schafmausen, L.C. Cantley, Mol. Cell. Biol. 13 (1993) 1657-1665.
85. [85] R. Dhand, I. Hiles, G. Panayotou, S. Roche, M.J. Fry, I. Gout, N.F. Totty, O. Truong, P. Vicendo, K. Yonezawa et al., EMBO J. 13 (1994) 522-533.
86. [86] S. Stoyanova, G. Bulgarelli-Leva, C. Kirsch, T. Hanck, R. Klinger, R. Wetzker, M.P. Wymann, Biochem. J. 324 (1997) 489-495.
87. [87] B. Vanhaesebroeck, M.J. Welham, K. Kotani, R. Stein, P.H. Warne, M.J. Zvelebil, K. Higashi, S. Volinia, J. Downward, M.D. Waterfield, Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 4330-4335.
88. [88] P. End, I. Gout, M.J. Fry, G. Panayotou, R. Dhand, K. Yonezawa, M. Kasuga, M.D. Waterfield, J. Biol. Chem. 268 (1993) 10066-10075.
89. [89] H. Hayashi, Y. Nishioka, S. Kamohara, F. Kanai, K. Ishii, Y. Fukui, F. Shibasaki, T. Takenawa, H. Kido, N. Katsunuma et al., J. Biol. Chem. 268 (1993) 7107-7117.
90. [90] W.M. Kavanaugh, C.W. Turck, A. Klippel, L.T. Williams, Biochemistry 33 (1994) 11046-11050.
91. [91] M. von Willebrand, S. Williams, M. Saxena, J. Gilman, P. Tailor, T. Jascur, G.P. Amarante-Mendes, D.R. Green, T. Mustelin, J. Biol. Chem. 273 (1998) 3994-4000.
92. [92] L.E. Rameh, C.S. Chen, L.C. Cantley, Cell 83 (1995) 821-830.
93. [93] P. van der Geer, T. Hunter, EMBO J. 12 (1993) 5161-5172.
94. [94] I. Gout, R. Dhand, I.D. Hiles, M.J. Fry, G. Panayotou, P. Das, O. Truong, N.F. Totty, J. Hsuan, G.W. Booker et al., Cell 75 (1993) 25-36.
95. [95] A. Klippel, C. Reinhard, W.M. Kavanaugh, G. Apell, MA. Escobedo, L.T. Williams, Mol. Cell. Biol. 16 (1996) 4117-4127.
96. [96] A. Klippel, J.A. Escobedo, W.J. Fantl, L.T. Williams, Mol. Cell. Biol. 12 (1992) 1451-1459.
97. [97] T. Rordorf-Nikolic, D.J. Van Horn, D. Chen, M.F. White, J.M. Backer, J. Biol. Chem. 270 (1995) 3662-3666.
98. [98] Q. Hu, A. Klippel, A.J. Muslin, W.J. Fantl, L.T. Williams, Science 268 (1995) 100-102.
99. [99] T.F. Franke, D.R. Kaplan, L.C. Cantley, A. Toker, Science 275 (1997) 665-668.
100. [100] F.X. Yu, H.Q. Sun, P.A. Janmey, H.L. Yin, J. Biol. Chem. 267 (1992) 14616-14621.
101. [101] G. Kular, M. Loubtchenkov, P. Swigart, J. Whatmore, A. Ball, S. Cockcroft, R. Wetzker, Biochem. J. 325 (1997) 299-301.
102. [102] S.S. Singh, A. Chauhan, N. Murakami, V.P. Chauhan, Biochemistry 35 (1996) 16544-16549.
103. [103] M. Chellaiah, K. Hruska, Mol. Biol. Cell 7 (1996) 743-753.
104. [104] M. Chellaiah, C. Fitzgerald, U. Alvarez, K. Hruska, J. Biol. Chem. 273 (1998) 11908-11916.
105. [105] J. Zhang, W.G. King, S. Dillon, A. Hall, L. Feig, S.E. Rittenhouse, J. Biol. Chem. 268 (1993) 22251-22254.
106. [106] J. Zhang, J. Zhang, J.L. Benovic, M. Sugai, R. Wetzker, I. Gout, S.E. Rittenhouse, J. Biol. Chem. 270 (1995) 6589-6594.
107. [107] P. Rodriguez-Viciana, P.H. Warne, R. Dhand, B. Vanhaesebroeck, I. Gout, M.J. Fry, M.D. Waterfield, J. Downward, Nature 370 (1994) 527-532.
108. [108] X. Tang, C.P. Downes, J. Biol. Chem. 272 (1997) 14193-14199.
109. [109] O. Hazeki, T. Okada, H. Kurosu, S. Takasuga, T. Suzuki, T. Katada, Life Sci. 62 (1998) 1555-1559.
110. [110] J.L. Joyal, D.J. Burks, S. Pons, W.F. Matter, C.J. Vlahos, M.F. White, D.B. Sacks, J. Biol. Chem. 272 (1997) 28183-28186.
111. [111] S.S. Taylor, D.R. Knighton, J. Zheng, L.F. Ten Eyck, J.M. Sowadski, Annu. Rev. Cell Biol. 8 (1992) 429-462.
112. [112] J. Zheng, D.R. Knighton, L.F. ten Eyck, R. Karlsson, N. Xuong, S.S. Taylor, J.M. Sowadski, Biochemistry 32 (1993) 2154-2161.
113. [113] S.S. Taylor, D.R. Knighton, J. Zheng, J.M. Sowadski, C.S. Gibbs, M.J. Zoller, Trends Biochem. Sci. 18 (1993) 84-89.
114. [114] S.R. Hubbard, L. Wei, L. Ellis, W.A. Hendrickson, Nature 372 (1994) 746-754.
115. [115] S.R. Hubbard, M. Mohammadi, J. Schlessinger, J. Biol. Chem. 273 (1998) 11987-11990.
116. [116] M.P. Wymann, G. Bulgarelli-Leva, M.J. Zvelebil, L. Pirola, B. Vanhaesebroeck, M.D. Waterfield, G. Panayotou, Mol. Cell. Biol. 16 (1996) 1722-1733.
117. [117] A. Arcaro, M.P. Wymann, Biochem. J. 296 (1993) 297-301.
118. [118] H. Yano, S. Nakanishi, K. Kimura, N. Hanai, Y. Saitoh, Y. Fukui, Y. Nonomura, Y. Matsuda, J. Biol. Chem. 268 (1993) 25846-25856.
119. [119] G.J. Brunn, J. Williams, C. Sabers, G. Wiederrecht, J.C.J. Lawrence, R.T. Abraham, EMBO J. 15 (1996) 5256-5267.
120. [120] C.J. Vlahos, W.F. Matter, K.Y. Hui, R.F. Brown, J. Biol. Chem. 269 (1994) 5241-5248.
121. [121] C.A. Flanagan, E.A. Schnieders, A.W. Emerick, R. Kunisawa, J.W. Thorner, A. Admon, Science 262 (1993) 1444-1448.
122. [122] A.J. Molendijk, R.F. Irvine, Plant Mol. Biol. 37 (1998) 53-66.
123. [123] J. Yu, Y. Zhang, J. McIlroy, T. Rordorf-Nikolic, G.A. Orr, J.M. Backer, Mol. Cell. Biol. 18 (1998) 1379-1387.
124. [124] T. Kodaki, R. Woscholski, B. Hallberg, P. Rodriguez-Viciana, J. Downward, P.J. Parker, Curr. Biol. 4 (1994) 798-806.
125. [125] A.E. Traynor-Kaplan, B.L. Thompson, A.L. Harris, P. Taylor, G.M. Omann, L.A. Sklar, J. Biol. Chem. 264 (1989) 15668-15673.
126. [126] L. Stephens, A. Eguinoa, S. Corey, T. Jackson, P.T. Hawkins, EMBO J. 12 (1993) 2265-2273.
127. [127] L. Stephens, A. Smrcka, F.T. Cooke, T.R. Jackson, P.C. Sternweis, P.T. Hawkins, Cell 77 (1994) 83-93.
128. [128] P.A. Thomason, S.R. James, P.J. Casey, C.P. Downes, J. Biol. Chem. 269 (1994) 16525-16528.
129. [129] B. Stoyanov, S. Volinia, T. Hanck, I. Rubio, M. Loubtchenkov, D. Malek, S. Stoyanova, B. Vanhaesebroeck, R. Dhand, B. Nurnberg et al., Science 269 (1995) 690-693.
130. [130] L.R. Stephens, A. Eguinoa, H. Erdjument-Bromage, M. Lui, F. Cooke, J. Coadwell, A.S. Smrcka, M. Thelen, K. Cadwallader, P. Tempst, P.T. Hawkins, Cell 89 (1997) 105-114.
131. [131] S. Krugmann, A. Eguinoa, A.H. McGregor, P.T. Hawkins, L.R. Stephens, Biochem. Soc. Trans. 25 (1997) S604.
132. [132] D. Leopoldt, T. Hanck, T. Exner, U. Maier, R. Wetzker, B. Nurnberg, J. Biol. Chem. 273 (1998) 7024-7029.
133. [133] T. Bondeva, L. Pirola, G. Bulgarelli-Leva, I. Rubio, R. Wetzker, M.P. Wymann, Science 282 (1998) 293-296.
134. [134] M. Lopez-Ilasaca, O.S. Kular, J.R. Slupsky, C.K. Weber, T. Bondeva, U.R. Rapp, R. Wetzker (1998) submitted.
135. [135] A.J. Whitmarsh, J. Cavanagh, C. Tournier, J. Yasuda, R.J. Davis, Science 281 (1998) 1671-1674.
136. [136] H.J. Schaeffer, A.D. Catling, S.T. Eblen, L.S. Collier, A. Krauss, M.J. Weber, Science 281 (1998) 1668-1671.
137. [137] A. Sjolander, K. Yamamoto, B.E. Huber, E.G. Lapetina, Proc. Natl. Acad. Sci. U.S.A. 88 (1991) 7908-7912.
138. [138] P. Rodriguez-Viciana, P.H. Warne, B. Vanhaesebroeck, M.D. Waterfield, J. Downward, EMBO J. 15 (1996) 2442-2451.
139. [139] T. Satoh, W.J. Fantl, J.A. Escobedo, L.T. Williams, Y. Kaziro, Mol. Cell. Biol. 13 (1993) 3706-3713.
140. [140] M. Valius, A. Kazlauskas, Cell 73 (1993) 321-334.
141. [141] L.A. Feig, B. Schaffliausen, Nature 370 (1994) 508-509.
142. [142] P. Rodriguez-Viciana, P.H. Warne, A. Khwaja, B.M. Marte, D. Pappin, P. Das, M.D. Waterfield, A. Ridley, J. Downward, Cell 89 (1997) 457-467.
143. [143] B.M. Marte, P. Rodriguez-Viciana, S. Wennstrom, P.H. Warne, J. Downward, Curr. Biol. 7 (1997) 63-70.
144. [144] A. Klippel, M.A. Escobedo, M.S. Wachowicz, G. Apell, T.W. Brown, M.A. Giedlin, W.M. Kavanaugh, L.T. Williams, Mol. Cell. Biol. 18 (1998) 5699-5711.
145. [145] I. Rubio, P. Rodriguez-Viciana, J. Downward, R. Wetzker, Biochem. J. 326 (1997) 891-895.
146. [146] I. Rubio, U. Wittig, C. Meyer, R. Heinze, J. Downward, R. Wetzker (1998) submitted.
147. [147] L. Zheng, J. Eckerdal, I. Dimitrijevic, T. Andersson, J. Biol. Chem. 272 (1997) 23448-23454.
148. [148] L. Yenush, M.F. White, BioEssays 19 (1997) 491-500.
149. [149] M. Holgado-Madruga, O.K. Moscatello, D.R. Emlet, R. Dieterich, A.J. Wong, Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 12419-12424.
150. [150] G. Superti-Furga, S.A. Courtneidge, BioEssays 17 (1995) 321-330.
151. [151] W.J. Leonard, J.J. O'Shea, Annu. Rev. Immunol. 16 (1998) 293-322.
152. [152] M. Exley, L. Varticovski, M. Peter, J. Sancho, C. Terhorst, J. Biol. Chem. 269 (1994) 15140-15146.
153. [153] M. Daeron, Annu. Rev. Immunol. 15 (1997) 203-234.
154. [154] S.G. Ward, C.H. June, D. Olive, Immunol. Today 17 (1996) 187-197.
155. [155] C. Murga, L. Laguinge, R. Wetzker, A. Cuadrado, J.S. Gutkind, J. Biol. Chem. 273 (1998) 19080-19085.
156. [156] A.J. Melendez, D.J. Gillooly, M.M. Harnett, J.M. Allen, Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 2169-2174.
157. [157] L.K. MacDougall, J. Domin, M.D. Waterfield, Curr. Biol. 5 (1995) 1404-1415.
158. [158] J. Domin, F. Pages, S. Volinia, S.E. Rittenhouse, M.J. Zvelebil, R.C. Stein, M.D. Waterfield, Biochem. J. 326 (1997) 139-147.
159. [159] R.A. Brown, L.K. Ho, S.J. Weber-Hall, J.M. Shipley, M.J. Fry, Biochem. Biophys. Res. Commun. 233 (1997) 537-544.
160. [160] R.B. Sutton, B.A. Davletov, A.M. Berghuis, T.C. Sudhof, S.R. Sprang, Cell 80 (1995) 929-938.
161. [161] H. Misawa, M. Ohtsubo, N.G. Copeland, D.J. Gilbert, N.A. Jenkins, A. Yoshimura, Biochem. Biophys. Res. Commun. 244 (1998) 531-539.
162. [162] L. Molz, Y.W. Chen, M. Hirano, L.T. Williams, J. Biol. Chem. 271 (1996) 13892-13899.
163. [163] F. Ono, T. Nakagawa, S. Saito, Y. Owada, H. Sakagami, K. Goto, M. Suzuki, S. Matsuno, H. Kondo, J. Biol. Chem. 273 (1998) 7731-7736.
164. [164] K. Takegawa, D.B. DeWald, S.D. Emr, J. Cell Sci. 108 (1995) 3745-3756.
165. [165] P. Welters, K. Takegawa, S.D. Emr, M.J. Chrispeels, Proc. Natl. Acad. Sci. U.S.A. 91 (1994) 11398-11402.
166. [166] C. Linassier, L.K. MacDougall, J. Domin, M D. Waterfield, Biochem. J. 321 (1997) 849-856.
167. [167] L. Roggo, M. Zetka, V. Bernard, F. Savoy, A. Rose, F. Müller, M.P. Wymann, in preparation.
168. [168] L. Stephens, F.T. Cooke, R. Walters, T Jackson, S. Volinia, I. Gout, M.D. Waterfield, P.T. Hawkins, Curr. Biol. 4 (1994) 203-214.
169. [169] S. Volinia, R. Dhand, B. Vanhaesebroeck, L.K. MacDougall, R. Stein, M.J. Zvelebil, J. Domin, C. Panaretou, M.D. Waterfield, EMBO J. 14 (1995) 3339-3348.
170. [170] J.H. Stack, P.K. Herman, P.V. Schu, S.D. Emr, EMBO J. 12 (1993) 2195-2204.
171. [171] J.H. Stack, S.D. Emr, J. Biol. Chem. 269 (1994) 31552-31562.
172. [172] J.H. Stack, D.B. DeWald, K. Takegawa, S.D. Emr, J. Cell Biol. 129 (1995) 321-334.
173. [173] C. Panaretou, J. Domin, S. Cockcroft, M.D. Waterfield, J. Biol. Chem. 272 (1997) 2477-2485.
174. [174] H.W. Davidson, J. Cell Biol. 130 (1995) 797-805.
175. [175] W.J. Brown, D.B. DeWald, S.D. Emr, H. Plutner, W.E. Balch, J. Cell Biol. 130 (1995) 781-796.
176. [176] B. Singer-Kruger, H. Stenmark, M. Zerial, J. Cell Sci. 108 (1995) 3509-3521.
177. [177] V. Rybin, O. Ullrich, M. Rubino, K. Alexandrov, I. Simon, C. Seabra, R. Goody, M. Zerial, Nature 383 (1996) 266-269.
178. [178] G. Li, C. D'Souza-Schorey, M.A. Barbieri, R.L. Roberts, A. Klippel, L.T. Williams, P.D. Stahl, Proc. Natl. Acad. Sci. U.S.A. 92 (1995) 10207-10211.
179. [179] H. Shpetner, M. Joly, D. Hartley, S. Corvera, J. Cell Biol. 132 (1996) 595-605.
180. [180] A.T. Jones, I.G. Mills, A.J. Scheidig, K. Alexandrov, M.J. Clague, Mol. Biol. Cell 9 (1998) 323-332.
181. [181] V. Patki, J. Virbasius, W.S. Lane, B.H. Toh, H.S. Shpetner, S. Corvera, Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 7326-7330.
182. [182] H. Stenmark, R. Aasland, B.H. Toh, A. D'Arrigo, J. Biol. Chem. 271 (1996) 24048-24054.
183. [183] J.M. Gaullier, A. Simonsen, A. D'Arrigo, B. Bremnes, H. Stenmark, R. Aasland, Nature 394 (1998) 432-433.
184. [184] V. Patki, D.C. Lawe, S. Corvera, J.V. Virbasius, A. Chawla, Nature 394 (1998) 433-434.
185. [185] C.G. Burd, S.D. Emr, Mol. Cell 2 (1998) 157-162.
186. [186] A. Simonsen, R. Lippe, S. Christoforidis, J.M. Gaullier, A. Brech, J. Callaghan, B.H. Toh, C. Murphy, M. Zerial, H. Stenmark, Nature 394 (1998) 494-498.
187. [187] C. Wiedemann, S. Cockcroft, Nature 394 (1998) 426-427.
188. [188] M. Joly, A. Kazlauskas, F.S. Fay, S. Corvera, Science 263 (1994) 684-687.
189. [189] M. Joly, A. Kazlauskas, S. Corvera, J. Biol. Chem. 270 (1995) 13225-13230.
190. [190] N.J. Brunskill, J. Stuart, A.B. Tobin, J. Walls, S. Nahorski, J. Clin. Invest. 101 (1998) 2140-2150.
191. [191] I. Gaidarov, Q. Chen, J.R. Falck, K.K. Reddy, J.H. Keen, J. Biol. Chem. 271 (1996) 20922-20929.
192. [192] I. Rapoport, M. Miyazaki, W. Boll, B. Duckworth, L.C. Cantley, S. Shoelson, T. Kirchhausen, EMBO J. 16 (1997) 2240-2250.
193. [193] I. Rapoport, Y.C. Chen, P. Cupers, S.E. Shoelson, T. Kirchhausen, EMBO J. 17 (1998) 2148-2155.
194. [194] R. Woscholski, P.J. Parker, Trends Biochem. Sci. 22 (1997) 427-431.
195. [195] A. Toker, Curr. Opin. Cell Biol. 10 (1998) 254-261.
196. [196] M.J. Rebecchi, S. Scarlata, Annu. Rev. Biophys. Biomol. Struct. 27 (1998) 503-528.
197. [197] G. Shaw, BioEssays 18 (1996) 35-46.
198. [198] M. Andjelkovic, D.R. Alessi, R. Meier, A. Fernandez, N.J. Lamb, M. Frech, P. Cron, P. Cohen, J.M. Lucocq, B.A. Hemmings, J. Biol. Chem. 272 (1997) 31515-31524.
199. [199] D.R. Alessi, M. Andjelkovic, B. Caudwell, P. Cron, N. Morrice, P. Cohen, B.A. Hemmings, EMBO J. 15 (1996) 6541-6551.
200. [200] M. Andjelkovic, T. Jakubowicz, P. Cron, X.F. Ming, J.W. Man, B.A. Hemmings, Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 5699-5704.
201. [201] A. Klippel, W.M. Kavanaugh, D. Pot, L.T. Williams, Mol. Cell. Biol. 17 (1997) 338-344.
202. [202] D.R. Alessi, S.R. James, C.P. Downes, A.B. Holmes, P.R. Gaffney, C.B. Reese, P. Cohen, Curr. Biol. 7 (1997) 261-269.
203. [203] D.R. Alessi, M. Deak, A. Casamayor, F.B. Caudwell, N. Morrice, D.G. Norman, P. Gaffney, C.B. Reese, C.N. MacDougall, D. Harbison, A. Ashworth, M. Bownes, Curr. Biol. 7 (1997) 776-789.
204. [204] D. Stokoe, L.R. Stephens, T. Copeland, P.R. Gaffney, C.B. Reese, G.F. Painter, A.B. Holmes, F. McCormick, P.T. Hawkins, Science 277 (1997) 567-570.
205. [205] L. Stephens, K. Anderson, D. Stokoe, H. Erdjument-Bromage, G.F. Painter, A.B. Holmes, P.R. Gaffney, C.B. Reese, F. McCormick, P. Tempst, J. Coadwell, P.T. Hawkins, Science 279 (1998) 710-714.
206. [206] M.M. Chou, W. Hou, J. Johnson, L.K. Graham, M.H. Lee, C.-S. Chen, A.C. Newton, B.S. Schaffhausen, A. Toker, Curr. Biol. 8 (1998) 1069-1077.
207. [207] J.A. Le Good, W.H. Ziegler, D.B. Parekh, D.R. Alessi, P. Cohen, P.J. Parker, Science 281 (1998) 2042-2045.
208. [208] G.E. Hannigan, C. Leung-Hagesteijn, L. Fitz-Gibbon, M.G. Coppolino, G. Radeva, J. Filmus, J.C. Bell, S. Dedhar, Nature 379 (1996) 91-96.
209. [209] M. Delcommenne, C. Tan, V. Gray, L. Rue, J. Woodgett, S. Dedhar, Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 11211-11216.
210. [210] D.A. Cross, D.R. Alessi, P. Cohen, M. Andjelkovich, B.A. Hemmings, Nature 378 (1995) 785-789.
211. [211] S.R. Datta, H. Dudek, X. Tao, S. Masters, H. Fu, Y. Gotoh, M.E. Greenberg, Cell 91 (1997) 231-241.
212. [212] L. del Peso, M. Gonzalez-Garcia, C. Page, R. Herrera, G. Nunez, Science 278 (1997) 687-689.
213. [213] H.A. Lane, A. Fernandez, N.J. Lamb, G. Thomas, Nature 363 (1993) 170-172.
214. [214] J. Chung, T.C. Grammer, K.P. Lemon, A. Kazlauskas, J. Blenis, Nature 370 (1994) 71-75.
215. [215] J.W. Han, R.B. Pearson, P.B. Dennis, G. Thomas, J. Biol. Chem. 270 (1995) 21396-21403.
216. [216] P.E. Burnett, R.K. Barrow, N.A. Cohen, S.H. Snyder, D.M. Sabatini, Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 1432-1437.
217. [217] T. Kitamura, W. Ogawa, H. Sakaue, Y. Hino, S. Kuroda, M. Takata, M. Matsumoto, T. Maeda, H. Konishi, U. Kikkawa, M. Kasuga, Mol. Cell. Biol. 18 (1998) 3708-3717.
218. [218] K. Reif, B.M. Burgering, D.A. Cantrell, J. Biol. Chem. 272 (1997) 14426-14433.
219. [219] N. Pullen, P.B. Dennis, M. Andjelkovic, A. Dufner, S.C. Kozma, B.A. Hemmings, G. Thomas, Science 279 (1998) 707-710.
220. [220] D.R. Alessi, M.T. Kozlowski, Q.P. Weng, N. Morrice, J. Avruch, Curr. Biol. 8 (1998) 69-81.
221. [221] M.M. Chou, J. Blenis, Cell 85 (1996) 573-583.
222. [222] H. Welch, A. Eguinoa, L.R. Stephens, P.T. Hawkins, J. Biol. Chem. 273 (1998) 11248-11256.
223. [223] C.G. Proud, Trends Biochem. Sci. 21 (1996) 181-185.
224. [224] G. Thomas, M.N. Hall, Curr. Opin. Cell Biol. 9 (1997) 782-787.
225. [225] P.T. Hawkins, A. Eguinoa, R.G. Qiu, D. Stokoe, F.T. Cooke, R. Walters, S. Wennstrom, L. Claesson-Welsh, T. Evans, M. Symons et al., Curr. Biol. 5 (1995) 393-403.
226. [226] J. Han, K. Luby-Phelps, B. Das, X. Shu, Y. Xia, R.D. Mosteller, U.M. Krishna, J.R. Falck, M.A. White, D. Broek, Science 279 (1998) 558-560.
227. [227] D. Cantrell, Curr. Biol. 8 (1998) R535-R538.
228. [228] S. Wennstrom, P. Hawkins, F. Cooke, K. Hara, K. Yonezawa, M. Kasuga, T. Jackson, L. Claesson-Welsh, L. Stephens, Curr. Biol. 4 (1994) 385-393.
229. [229] M. Wymann, A. Arcaro, Biochem. J. 298 (1994) 517-520.
230. [230] P.J. Keely, J.K. Westwick, I.P. Whitehead, C.J. Der, L.V. Parise, Nature 390 (1997) 632-636.
231. [231] L.M. Shaw, I. Rabinovitz, H.H. Wang, A. Toker, A.M. Mercurio, Cell 91 (1997) 949-960.
232. [232] A.D. Ma, A. Metjian, S. Bagrodia, S. Taylor, C.S. Abrams, Mol. Cell. Biol. 18 (1998) 4744-4751.
233. [233] A.W. Segal, A. Abo, Trends Biochem. Sci. 18 (1993) 43-47.
234. [234] M. Baggiolini, B. Dewald, J. Schnyder, W. Ruch, P.H. Cooper, T.G. Payne, Exp. Cell Res. 169 (1987) 408-418.
235. [235] L.P. Hammonds-Odie, T.R. Jackson, A.A. Profit, I.J. Blader, C.W. Turck, G.D. Prestwich, A.B. Theibert, J. Biol. Chem. 271 (1996) 18859-18868.
236. [236] P.J. Lu, W.R. Shieh, S.G. Rhee, H.L. Yin, C.S. Chen, Biochemistry 35 (1996) 14027-14034.
237. [237] J.K. Klarlund, A. Guilherme, J.J. Holik, J.V. Virbasius, A. Chawla, M.P. Czech, Science 275 (1997) 1927-1930.
238. [238] Z. Li, M.I. Wahl, A. Eguinoa, L.R. Stephens, P.T. Hawkins, O.N. Witte, Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 13820-13825.
239. [239] L.E. Rameh, A. Ak, K.L.R. Carraway, A.D. Couvillon, G. Rathbun, A. Crompton, B. VanRenterghem, M.P. Czech, K.S. Ravichandran, S.J. Burakoff, D.S. Wang, C.S. Chen, L.C. Cantley, J. Biol. Chem. 272 (1997) 22059-22066.
240. [240] P. Chardin, S. Paris, B. Antonny, S. Robineau, S. Beraud-Dufour, C.L. Jackson, M. Chabre, Nature 384 (1996) 481-484.
241. [241] M. de Weers, R.G. Mensink, M.E. Kraakman, R.K. Schuurman, R.W. Hendriks, Hum. Mol. Genet. 3 (1994) 161-166.
242. [242] R.W. Hendriks, M.F. de Bruijn, A. Maas, G.M. Dingjan, A. Karis, F. Grosveld, EMBO J. 15 (1996) 4862-4872.
243. [243] S.R. James, C.P. Downes, Cell. Signal. 9 (1997) 329-336.
244. [244] M. Falasca, S.K. Logan, V.P. Lehto, G. Baccante, M.A. Lemmon, J. Schlessinger, EMBO J. 17 (1998) 414-422.
245. [245] Y.S. Bae, L.G. Cantley, C.S. Chen, S.R. Kim, K.S. Kwon, S.G. Rhee, J. Biol. Chem. 273 (1998) 4465-4469.
246. [246] A.M. Scharenberg, O. El-Hillal, D.A. Fruman, L.O. Beitz, Z. Li, S. Lin, I. Gout, L.C. Cantley, D.J. Rawlings, J.P. Kinet, EMBO J. 17 (1998) 1961-1972.
247. [247] A.C. Fluckiger, Z. Li, R.M. Kato, M.I. Wahl, H.D. Ochs, R. Longnecker, J.P. Kinet, O.N. Witte, A.M. Scharenberg, D.J. Rawlings, EMBO J. 17 (1998) 1973-1985.
248. [248] A.M. Scharenberg, J.P. Kinet, Cell 94 (1998) 5-8.
249. [249] S. Bolland, R.N. Pearse, T. Kurosaki, J.V. Ravetch, Immunity 8 (1998) 509-516.
250. [250] K. Lam, C.L. Carpenter, N.B. Ruderman, J.C. Friel, K.L. Kelly, J. Biol. Chem. 269 (1994) 20648-20652.
251. [251] S. Uddin, E.N. Fish, D.A. Sher, C. Gardziola, M.F. White, L.C. Platanias, J. Immunol. 158 (1997) 2390-2397.
252. [252] L. Pirola, G. Bulgarelli-Leva, M. Zvelebil, M.D. Waterfield, M.P. Wymann, in preparation.
253. [253] M. Lopez-Ilasaca, P. Crespo, P.G. Pellici, J.S. Gutkind, R. Wetzker, Science 275 (1997) 394-397.
254. [254] K.Y. Choi, B. Satterberg, D.M. Lyons, E.A. Elion, Cell 78 (1994) 499-512.
255. [255] B.C. Duckworth, L.C. Cantley, J. Biol. Chem. 272 (1997) 27665-27670.
256. [256] K. Zhou, K. Takegawa, S.D. Emr, R.A. Firtel, Mol. Cell. Biol. 15 (1995) 5645-5656.
257. [257] G. Buczynski, B. Grove, A. Nomura, M. Kleve, J. Bush, R.A. Firtel, J. Cardelli, J. Cell Biol. 136 (1997) 1271-1286.
258. [258] D. Weinkove, S.J. Leevers, L.K. MacDougall, M.D. Waterfield, J. Biol. Chem. 272 (1997) 14606-14610.
259. [259] A.H. Brand, N. Perrimon, Development 118 (1993) 401-415.
260. [260] S.J. Leevers, D. Weinkove, L.K. MacDougall, E. Hafen, M.D. Waterfield, EMBO J. 15 (1996) 6584-6594.
261. [261] R. Fernandez, D. Tabarini, N. Azpiazu, M. Frasch, J. Schlessinger, EMBO J. 14 (1995) 3373-3384.
262. [262] Y. Ruan, C. Chen, Y. Cao, R.S. Garofalo, J. Biol. Chem. 270 (1995) 4236-4243.
263. [263] L. Yenush, R. Fernandez, M.G.J. Myers, T.C. Grammer, X.J. Sun, J. Blenis, J.H. Pierce, J. Schlessinger, M.F. White, Mol. Cell. Biol. 16 (1996) 2509-2517.
264. [264] C. Chen, J. Jack, R.S. Garofalo, Endocrinology 137 (1996) 846-856.
265. [265] J.Z. Morris, H.A. Tissenbaum, G. Ruvkun, Nature 382 (1996) 536-539.
266. [266] K.D. Kimura, H.A. Tissenbaum, Y. Liu, G. Ruvkun, Science 277 (1997) 942-946.
267. [267] W. Roush, Science 277 (1997) 897-898.
268. [268] L. Bi, I. Okabe, D.J. Bernard, W.J. Pavan, A. Wynshaw-Boris, R.L. Nussbaum (1998) submitted.
269. [269] D.A. Fruman, L.C. Cantley (1998) submitted.
270. [270] Y. Terauchi, T. Kadowaki et al. (1998) submitted.
271. [271] H. Suzuki, Y. Terauchi, M. Fujiwara, S. Aizawa, Y. Yazaki, T. Kadowaki, S. Koyasu (1998) submitted.
272. [272] V.D. Rao, S. Misra, I.V. Boronenkov, R.A. Anderson, J.H. Hurley, Cell 94 (1998) 829-839.
273. [273] P.J. Lu, C.S. Chen, J. Biol. Chem. 272 (1997) 466-472.
274. [274] K. Venkateswarlu, P.B. Oatey, J.M. Tavare, P.J. Cullen, Curr. Biol. 8 (1998) 463-466.
275. [275] T. Jiang, G. Sweeney, M.T. Rudolf, A. Klip, A. Traynor-Kaplan, R.Y. Tsien, J. Biol. Chem. 273 (1998) 11017-11024.
276. [276] S. Raffioni, R.A. Bradshaw, Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 9121-9125.
277. [277] N.B. Ruderman, R. Kapeller, M.F. White, L.C. Cantley, Proc. Natl. Acad. Sci. U.S.A. 87 (1990) 1411-1415.
278. [278] K. Kotani, K. Yonezawa, K. Hara, H. Ueda, Y. Kitamura, H. Sakaue, A. Ando, A. Chavanieu, B. Calas, F. Grigorescu et al., EMBO J. 13 (1994) 2313-2321.
279. [279] H. Husson, B. Mograbi, H. Schmid-Antomarchi, S. Fischer, B. Rossi, Oncogene 14 (1997) 2331-2338.
280. [280] P. Blume-Jensen, R. Janknecht, T. Hunter, Curr. Biol. 8 (1998) 779-782.
281. [281] K. Igarashi, T. Isohara, T. Kato, K. Shigeta, T. Yamano, I. Uno, Biochem. Biophys. Res. Commun. 246 (1998) 95-99.
282. [282] A. Graziani, D. Gramaglia, L.C. Cantley, P.M. Comoglio, J. Biol. Chem. 266 (1991) 22087-22090.
283. [283] K.M. Weidner, S. Di Cesare, M. Sachs, V. Brinkmann, J. Behrens, W. Birchmeier, Nature 384 (1996) 173-176.
284. [284] A. Bardelli, P. Longati, D. Gramaglia, M.C. Stella, P.M. Comoglio, Oncogene 15 (1997) 3103-3111.
285. [285] C.D. Kontos, T.P. Stauffer, W.P. Yang, J.D. York, L. Huang, M.A. Blanar, T. Meyer, K.G. Peters, Mol. Cell. Biol. 18 (1998) 4131-4140.
286. [286] A. Pandey, D.F. Lazar, A.R. Saltiel, V.M. Dixit, J. Biol. Chem. 269 (1994) 30154-30157.
287. [287] T.D. Bartley, R.W. Hunt, A.A. Welcher, W.J. Boyle, V.P. Parker, R.A. Lindberg, H.S. Lu, A.M. Colombero, R.L. Elliott, B.A. Guthrie et al., Nature 368 (1994) 558-560.
288. [288] T. Yamauchi, Y. Kaburagi, K. Ueki, Y. Tsuji, G.R. Stark, I.M. Kerr, T. Tsushima, Y. Akanuma, I. Komuro, K. Tobe, Y. Yazaki, T. Kadowaki, J. Biol. Chem. 273 (1998) 15719-15726.
289. [289] M.S. Burfoot, N.C. Rogers, D. Watling, J.M. Smith S. Pons, G. Paonessaw, S. Pellegrini, M.F. White, I.M. Kerr, J. Biol. Chem. 272 (1997) 24183-24190.
290. [290] J.A. Johnston, L.M. Wang, E.P. Hanson, X.J. Sun, M.F. White, S.A. Oakes, J.H. Pierce, J.J. O'Shea, J. Biol. Chem. 270 (1995) 28527-28530.
291. [291] M. Takahashi-Tezuka, M. Hibi, Y. Fujitani, T. Fukada, T. Yamaguchi, T. Hirano, Oncogene 14 (1997) 2273-2282.
292. [292] M. Takahashi-Tezuka, Y. Yoshida, T. Fukada, T. Ohtani, Y. Yamanaka, K. Nishida, K. Nakajima, M. Hibi, T. Hirano, Mol. Cell. Biol. 18 (1998) 4109-4117.
293. [293] N. Sharfe, C.M. Roifman, J. Immunol. 159 (1997) 1107-1114.
294. [294] S. Uddin, L. Yenush, X.J. Sun, M.E. Sweet, M.F. White, L.C. Platanias, J. Biol. Chem. 270 (1995) 15938-15941.
295. [295] L.C. Platanias, S. Uddin, A. Yetter, X.J. Sun, M.F. White, J. Biol. Chem. 271 (1996) 278-282.
296. [296] O. Miura, N. Nakamura, J.N. Ihle, N. Aoki, J. Biol. Chem. 269 (1994) 614-620.
297. [297] U. Klingmuller, Eur. J. Biochem. 249 (1997) 637-647.
298. [298] B.R. Avalos, Blood 88 (1996) 761-777.
299. [299] M.G. Hunter, B.R. Avalos, J. Immunol. 160 (1998) 4979-4987.
300. [300] J.S. Gutkind, P.M. Lacal, K.C. Robbins, Mol. Cell. Biol. 10 (1990) 3806-3809.
301. [301] N.R. Geltz, J.A. Augustine, Blood 91 (1998) 930-939.
302. [302] H.C. Chen, P.A. Appeddu, H. Isoda, J.L. Guan, J. Biol. Chem. 271 (1996) 26329-26334.
303. [303] W.G. King, M.D. Mattaliano, T.O. Chan, P.N. Tsichlis, J.S. Brugge, Mol. Cell. Biol. 17 (1997) 4406-4418.
304. [304] Y. Shimizu, S.W.R. Hunt, Immunol. Today 17 (1996) 565-573.
305. [305] M. Raab, Y.C. Cai, S.C. Bunnell, S.D. Heyeck, L.J. Berg, C.E. Rudd, Proc. Natl. Acad. Sci. U.S.A. 92 (1995) 8891-8895.
306. [306] G.L. Kucera, S.E. Rittenhouse, J. Biol. Chem. 265 (1990) 5345-5348.
307. [307] C.J. Vlahos, W.F. Matter, FEBS Lett. 309 (1992) 242-248.
308. [308] T. Okada, L. Sakuma, Y. Fukui, O. Hazeki, M. Ui, J. Biol. Chem. 269 (1994) 3563-3567.
309. [309] M. Wilson, A.R. Burt, G. Milligan, N.G. Anderson, J. Biol. Chem. 271 (1996) 8537-8540.
310. [310] J.V. Virbasius, A. Guilherme, M.P. Czech, J. Biol. Chem. 271 (1996) 13304-13307.
311. [311] P. van der Geer, T. Hunter, R.A. Lindberg, Annu. Rev. Cell Biol. 10 (1994) 251-337.